Research Topics
Genomes and Genes
| Nancy L SacconeSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Genome screen for platelet monoamine oxidase (MAO) activityN L Saccone
Department of Psychiatry, Washington University, St Louis, Missouri, USA
Am J Med Genet 88:517-21. 1999..1 and 1.4 for the two regions on chromosome 2. These results are consistent with linkage, but do not provide definitive evidence. We are currently creating a denser map in these regions and have begun genotyping a second sample in COGA...- A genome screen of maximum number of drinks as an alcoholism phenotypeN L Saccone
Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
Am J Med Genet 96:632-7. 2000..The present analysis on log(M) allows more individuals to be included and thus is potentially more powerful... 
Genetic analysis of maximum cigarette-use phenotypesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA
BMC Genet 4:S105. 2003..Adjustments were made for the significant covariates of gender and year of birth, and sib-pair based linkage analysis was performed...- Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sampleNancy L Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Alcohol Clin Exp Res 26:603-9. 2002..These families were recruited as part of the Collaborative Study on the Genetics of Alcoholism (COGA)... - Genetic analysis workshop 13: Summary of analyses of alcohol and cigarette use phenotypes in the Framingham Heart StudyNancy L Saccone
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 25:S90-7. 2003..quantitative traits, and consideration of transformations and covariates... - A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependenceRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
Biol Psychiatry 64:922-9. 2008..The goal of this study was to examine the association of this variant with cocaine dependence... - In search of causal variants: refining disease association signals using cross-population contrastsNancy L Saccone
Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
BMC Genet 9:58. 2008..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up... - Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009.... - Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genesLi Shiun Chen
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Drug Alcohol Depend 123:S42-51. 2012..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence... - Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genesRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Addict Biol 15:346-57. 2010..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery... - The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-AmericansNancy L Saccone
Department of Genetics, Washington University, St Louis, Missouri 63110, UA
Cancer Res 69:6848-56. 2009..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations... - Chronic ethanol drinking by alcohol-preferring rats increases the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanolZachary A Rodd
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indiana University, 791 Union Drive, Indianapolis, IN 46202, USA
Alcohol Clin Exp Res 29:358-66. 2005..The objective of this study was to test the hypothesis that chronic ethanol drinking increases the sensitivity of the posterior VTA to the reinforcing effects of ethanol... - Variants in nicotinic receptors and risk for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
Am J Psychiatry 165:1163-71. 2008.... - Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine DependenceArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 104:471-7. 2009..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes... - Effects of repeated alcohol deprivations on operant ethanol self-administration by alcohol-preferring (P) ratsZachary A Rodd
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Neuropsychopharmacology 28:1614-21. 2003..The results suggest that repeated cycles of alcohol deprivation and alcohol access increased the reinforcing effects of ETOH in the P rats... - Regional heterogeneity for the intracranial self-administration of ethanol and acetaldehyde within the ventral tegmental area of alcohol-preferring (P) rats: involvement of dopamine and serotoninZachary A Rodd
Department of Psychiatry, Institute of Psychiatric Research, Indiana University Purdue University at Indianapolis, Indianapolis, IN, USA
Neuropsychopharmacology 30:330-8. 2005..Furthermore, activation of 5-HT3 receptors within the posterior VTA is involved in the self-infusion of EtOH, but not ACD... - Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: II. Adult exposureZachary A Rodd-Henricks
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
Alcohol Clin Exp Res 26:1642-52. 2002..The objective of the present study was to determine if EtOH consumption during adulthood produced similar effects on subsequent operant behaviors... 
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 103:1027-38. 2008....- Novel genes identified in a high-density genome wide association study for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
Hum Mol Genet 16:24-35. 2007..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community... - A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependenceLaura Jean Bierut
School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
Am J Med Genet A 124:19-27. 2004..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence... - Effects of ethanol exposure on subsequent acquisition and extinction of ethanol self-administration and expression of alcohol-seeking behavior in adult alcohol-preferring (P) rats: I. Periadolescent exposureZachary A Rodd-Henricks
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis 46202 4887, USA
Alcohol Clin Exp Res 26:1632-41. 2002.... - The reinforcing effects of acetaldehyde in the posterior ventral tegmental area of alcohol-preferring ratsZachary A Rodd-Henricks
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
Pharmacol Biochem Behav 72:55-64. 2002..P rats maintained similar numbers of infusions and infusion patterns under both time-out schedules. Overall, the data indicate that ACD is a potent reinforcer within the posterior VTA of the P rat... - A genome-wide association study of alcohol dependenceLaura J Bierut
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:5082-7. 2010..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence... - Effects of concurrent access to a single concentration or multiple concentrations of ethanol on ethanol intake by periadolescent high-alcohol-drinking ratsRichard L Bell
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, Indianapolis, IN 46202, USA
Alcohol 33:107-15. 2004.... - Comparison of intracranial self-administration of ethanol within the posterior ventral tegmental area between alcohol-preferring and Wistar ratsZachary A Rodd
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
Alcohol Clin Exp Res 28:1212-9. 2004.... - Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25Li Shiun Chen
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 36:340-51. 2012..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments... - Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5Jen C Wang
Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
Hum Mol Genet 18:3125-35. 2009.... - Heart rate and motor-activating effects of orally self-administered ethanol in alcohol-preferring (P) ratsRichard L Bell
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
Alcohol Clin Exp Res 26:1162-70. 2002..This study examined changes in heart rate (HR) and motor activity before and during limited-access to ethanol, saccharin, or water in adult male alcohol-preferring (P) rats... - Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screensScott F Saccone
Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA
Genet Epidemiol 30:459-70. 2006..This work is a concrete example of how empirical LD phase may be used to benefit study design... - A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease lociYing Liu
Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Genet 4:e1000041. 2008..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)... - Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sampleArpana Agrawal
Washington University School of Medicine, St Louis, MO 63110, USA
Drug Alcohol Depend 93:12-20. 2008..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence... - Effects of long-term episodic access to ethanol on the expression of an alcohol deprivation effect in low alcohol-consuming ratsRichard L Bell
Indiana University School of Medicine, Department of Psychiatry, Institute of Psychiatric Research, 791 Union Drive, Indianapolis, IN 46202 4887, USA
Alcohol Clin Exp Res 28:1867-74. 2004..In addition, both P and HAD rats display an alcohol deprivation effect (ADE). This study was undertaken to test whether the NP, LAD-1, and LAD-2 lines of rats could display an ADE as well... - Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokersSarah M Hartz
Washington University School of Medicine, St Louis, Missouri, USA
Arch Gen Psychiatry 69:854-60. 2012..Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968... - Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependenceROBERT C CULVERHOUSE
Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
Hum Genet 129:177-88. 2011..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects... - Systematic biological prioritization after a genome-wide association study: an application to nicotine dependenceScott F Saccone
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Bioinformatics 24:1805-11. 2008..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance... - Linkage disequilibrium between the beta frequency of the human EEG and a GABAA receptor gene locusBernice Porjesz
Department of Psychiatry, State University of New York, Health Science Center, Brooklyn, NY 11203, USA
Proc Natl Acad Sci U S A 99:3729-33. 2002..Uncovering the genes influencing brain oscillations provides a better understanding of the neural function involved in information processing... - Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPsScott F Saccone
Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Hum Mol Genet 16:36-49. 2007..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies... - Genetic analysis of the maximum drinks phenotypeScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
BMC Genet 6:S124. 2005..The evidence suggests that chromosome 7 may harbor an additional locus influencing the maximum drinks consumption phenotype... - Inclusion of African Americans in genetic studies: what is the barrier?Sarah M Hartz
Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Am J Epidemiol 174:336-44. 2011..0001). The results of this study suggest that increasing the number of African Americans in genetic databases may be achieved by increasing efforts to locate and contact them... - Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of AlcoholismLaura Jean Bierut
Washington University School of Medicine, St. Louis, Missouri, USA
Alcohol Res Health 26:208-13. 2002..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further... - Regional CNS densities of serotonin 1A and dopamine D2 receptors in periadolescent alcohol-preferring P and alcohol-nonpreferring NP rat pupsWendy N Strother
Department of Psychiatry, Institute of Psychiatric Research, Indiana University Medical Center, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
Pharmacol Biochem Behav 74:335-42. 2003.... - Prolonged increase in the sensitivity of the posterior ventral tegmental area to the reinforcing effects of ethanol following repeated exposure to cycles of ethanol access and deprivationZachary A Rodd
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, 46202, USA
J Pharmacol Exp Ther 315:648-57. 2005..Chronic alcohol drinking by P rats increased the reinforcing effects of ethanol within the posterior VTA, and repeated alcohol deprivations produced a further increase in these reinforcing effects of ethanol... - Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation successLi Shiun Chen
Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
Am J Psychiatry 169:735-42. 2012.... - Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigmScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
PLoS ONE 4:e5225. 2009..This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions... - Modeling complex genetic and environmental influences on comorbid bipolar disorder with tobacco use disorderRichard C McEachin
Department of Psychiatry, University of Michigan, Ann Arbor, MI, USA
BMC Med Genet 11:14. 2010..Therefore, we hypothesized a common underlying genetic etiology, interacting with nicotine exposure, influencing susceptibility to both BD and TUD... - Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals?Tae Hwi Schwantes-An
Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA
Genet Epidemiol 37:301-9. 2013..Also, it can connect association findings that may seem disparate due to lack of high correlations among the associated SNPs... - Age and birth cohort effects on rates of alcohol dependenceJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Alcohol Clin Exp Res 27:93-9. 2003..This suggests additional influences of birth cohort or period effects so that individuals in later-born cohorts have an increased lifetime risk... - Model-based methods for linkage analysisJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Adv Genet 60:155-73. 2008..We may still learn from the LOD score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes... - Maintaining steady state arterial alcohol levels in rats by using a physiologically based pharmacokinetic modelSandra L Morzorati
Department of Psychiatry, Institute of Psychiatric Research, Indiana University School of Medicine, 791 Union Drive, Indianapolis, IN 46202 4887, USA
Alcohol 28:189-95. 2002..The PBPK model-based method seems to be improved over the earlier method. Maintaining steady state AACs in rats is useful for studies in which fluctuating alcohol levels may confound experimental results... - Endophenotypes successfully lead to gene identification: results from the collaborative study on the genetics of alcoholismDanielle M Dick
Washington University School of Medicine, St Louis, MO, USA
Behav Genet 36:112-26. 2006..Our results provide an illustration of the successful use of endophenotypes to identify genes involved in the predisposition to a complex psychiatric phenotype, a strategy originally proposed by Gottesman and Shields in 1972... - The immunogenetics of smallpox vaccinationSamuel L Stanley
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Infect Dis 196:212-9. 2007.... - Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCRCynthia Helms
Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St Louis, Missouri, 63110, USA
Hum Genet 118:466-76. 2005..The introduction of a potential binding site for the RUNX/AML family of transcription factors in intron 7, is also specific to these HLA-C alleles. These variants need to be investigated further for their role as PSORS1... - Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortificationPeter Nagele
Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
Pharmacogenet Genomics 21:426-31. 2011..This investigation sought to determine the impact of folate fortification on the relative contribution of environmental and genetic factors to the variability of plasma tHcy... - Application of Bayesian network structure learning to identify causal variant SNPs from resequencing dataChristopher E Schlosberg
Division of Biology and Biomedical Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8226, St, Louis, MO 63110, USA
BMC Proc 5:S109. 2011..We conclude that this method, as currently applied, is not effective for identifying causal SNPs that follow the simulation model for the GAW17 data set, which includes many rare causal SNPs... - Artificial neural networks for linkage analysis of quantitative gene expression phenotypes and evaluation of gene x gene interactionsYing Liu
Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, Box 8232, St, Louis, Missouri 63110, USA
BMC Proc 1:S47. 2007..However, for the approach implemented here, optimizing the ANNs and obtaining stable results remains challenging... - Using the cue-availability paradigm to assess cue reactivityDena Davidson
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA
Alcohol Clin Exp Res 27:1251-6. 2003..The cue-availability paradigm is a modification of the conventional cue-reactivity paradigm and is intended to increase the sensitivity of measuring cue-reactivity to alcohol in humans... - The reinforcing properties of salsolinol in the ventral tegmental area: evidence for regional heterogeneity and the involvement of serotonin and dopamineZachary A Rodd
Institute of Psychiatric Research, Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana 46202 4887, USA
Alcohol Clin Exp Res 32:230-9. 2008..The current study examined SAL self-infusions into the VTA, and determined the involvement of dopamine neurons and 5-HT3 receptors in this process... - A Systematic single nucleotide polymorphism screen to fine-map alcohol dependence genes on chromosome 7 identifies association with a novel susceptibility gene ACN9Danielle M Dick
Washington University in St Louis, St Louis, Missouri, USA
Biol Psychiatry 63:1047-53. 2008..To follow up on this linkage region, we systematically screened single nucleotide polymorphisms (SNPs) across a 2 LOD support interval surrounding the alcohol dependence peak...
Research Grants
- HUMAN GENETIC VARIATION IN SMOKING AND ADDICTION RISKNancy L Saccone; Fiscal Year: 2010..Explaining more of the genetic architecture that underlies this extremely important public health problem will inform continued efforts to prevent and control smoking and other substance addiction. ..
- Quantitative Analysis Methods for Complex Trait GeneticsNancy Saccone; Fiscal Year: 2006..The candidate has designed a program of coursework and mentoring to accomplish these research and training goals and thereby achieve research independence by the end of the award period...