Research Topics
Genomes and Genes
| Nancy L SacconeSummaryAffiliation: Washington University School of Medicine Country: USA Publications
| Collaborators
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Detail Information
Publications
The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-AmericansNancy L Saccone
Department of Genetics, Washington University, St Louis, Missouri 63110, UA
Cancer Res 69:6848-56. 2009..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...- Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European AmericansN L Saccone
Department of Genetics, Washington University, Saint Louis, MO 63110, USA
Genes Brain Behav 9:741-50. 2010..Multiple nicotinic receptor subunit genes outside chromosome 15q25 are likely to be important in the biological processes and development of nicotine dependence, and some of these risks may be shared across diverse populations... - Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009.... - In search of causal variants: refining disease association signals using cross-population contrastsNancy L Saccone
Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
BMC Genet 9:58. 2008..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up... - Variants in nicotinic receptors and risk for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
Am J Psychiatry 165:1163-71. 2008.... - A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependenceRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
Biol Psychiatry 64:922-9. 2008..The goal of this study was to examine the association of this variant with cocaine dependence... - Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genesLi Shiun Chen
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Drug Alcohol Depend 123:S42-51. 2012..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence... - Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genesRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Addict Biol 15:346-57. 2010..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery... - Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine DependenceArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 104:471-7. 2009..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes... - Novel genes identified in a high-density genome wide association study for nicotine dependenceLaura Jean Bierut
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
Hum Mol Genet 16:24-35. 2007..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community... 
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 103:1027-38. 2008....- Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sampleArpana Agrawal
Washington University School of Medicine, St Louis, MO 63110, USA
Drug Alcohol Depend 93:12-20. 2008..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence... - Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPsScott F Saccone
Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
Hum Mol Genet 16:36-49. 2007..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies... - Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25Li Shiun Chen
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 36:340-51. 2012..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments... - Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5Jen C Wang
Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
Hum Mol Genet 18:3125-35. 2009.... - A genome-wide association study of alcohol dependenceLaura J Bierut
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:5082-7. 2010..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence... 
Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screensScott F Saccone
Department of Psychiatry, Washington University, St. Louis, Missouri 63110, USA
Genet Epidemiol 30:459-70. 2006..This work is a concrete example of how empirical LD phase may be used to benefit study design...- A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependenceLaura Jean Bierut
School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
Am J Med Genet A 124:19-27. 2004..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence... - Systematic biological prioritization after a genome-wide association study: an application to nicotine dependenceScott F Saccone
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Bioinformatics 24:1805-11. 2008..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance... - A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease lociYing Liu
Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS Genet 4:e1000041. 2008..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)... - Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokersSarah M Hartz
Washington University School of Medicine, St Louis, Missouri, USA
Arch Gen Psychiatry 69:854-60. 2012..Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968... - Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependenceROBERT C CULVERHOUSE
Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
Hum Genet 129:177-88. 2011..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects... - Genetic analysis of the maximum drinks phenotypeScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
BMC Genet 6:S124. 2005..The evidence suggests that chromosome 7 may harbor an additional locus influencing the maximum drinks consumption phenotype... - Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigmScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
PLoS ONE 4:e5225. 2009..This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions... - Inclusion of African Americans in genetic studies: what is the barrier?Sarah M Hartz
Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri 63110, USA
Am J Epidemiol 174:336-44. 2011..0001). The results of this study suggest that increasing the number of African Americans in genetic databases may be achieved by increasing efforts to locate and contact them... - Genetic analysis of maximum cigarette-use phenotypesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA
BMC Genet 4:S105. 2003..Adjustments were made for the significant covariates of gender and year of birth, and sib-pair based linkage analysis was performed... - Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation successLi Shiun Chen
Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
Am J Psychiatry 169:735-42. 2012.... - Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCRCynthia Helms
Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St Louis, Missouri, 63110, USA
Hum Genet 118:466-76. 2005..The introduction of a potential binding site for the RUNX/AML family of transcription factors in intron 7, is also specific to these HLA-C alleles. These variants need to be investigated further for their role as PSORS1... - Model-based methods for linkage analysisJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Adv Genet 60:155-73. 2008..We may still learn from the LOD score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes... - The immunogenetics of smallpox vaccinationSamuel L Stanley
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Infect Dis 196:212-9. 2007.... - Application of Bayesian network structure learning to identify causal variant SNPs from resequencing dataChristopher E Schlosberg
Division of Biology and Biomedical Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8226, St, Louis, MO 63110, USA
BMC Proc 5:S109. 2011..We conclude that this method, as currently applied, is not effective for identifying causal SNPs that follow the simulation model for the GAW17 data set, which includes many rare causal SNPs... - Artificial neural networks for linkage analysis of quantitative gene expression phenotypes and evaluation of gene x gene interactionsYing Liu
Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, Box 8232, St, Louis, Missouri 63110, USA
BMC Proc 1:S47. 2007..However, for the approach implemented here, optimizing the ANNs and obtaining stable results remains challenging... - Genetic analysis workshop 13: Summary of analyses of alcohol and cigarette use phenotypes in the Framingham Heart StudyNancy L Saccone
Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
Genet Epidemiol 25:S90-7. 2003..quantitative traits, and consideration of transformations and covariates... - Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortificationPeter Nagele
Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
Pharmacogenet Genomics 21:426-31. 2011..This investigation sought to determine the impact of folate fortification on the relative contribution of environmental and genetic factors to the variability of plasma tHcy... - Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of AlcoholismLaura Jean Bierut
Washington University School of Medicine, St. Louis, Missouri, USA
Alcohol Res Health 26:208-13. 2002..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further...