Nancy L Saccone

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
    N L Saccone
    Department of Genetics, Washington University, Saint Louis, MO 63110, USA
    Genes Brain Behav 9:741-50. 2010
  2. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
  3. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
  4. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
  5. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
  6. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
  7. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
  8. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
  9. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
  10. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004

Collaborators

Detail Information

Publications42

  1. pmc Multiple cholinergic nicotinic receptor genes affect nicotine dependence risk in African and European Americans
    N L Saccone
    Department of Genetics, Washington University, Saint Louis, MO 63110, USA
    Genes Brain Behav 9:741-50. 2010
    ..Multiple nicotinic receptor subunit genes outside chromosome 15q25 are likely to be important in the biological processes and development of nicotine dependence, and some of these risks may be shared across diverse populations...
  2. pmc Multiple distinct risk loci for nicotine dependence identified by dense coverage of the complete family of nicotinic receptor subunit (CHRN) genes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 150:453-66. 2009
    ....
  3. pmc The CHRNA5-CHRNA3-CHRNB4 nicotinic receptor subunit gene cluster affects risk for nicotine dependence in African-Americans and in European-Americans
    Nancy L Saccone
    Department of Genetics, Washington University, St Louis, Missouri 63110, UA
    Cancer Res 69:6848-56. 2009
    ..The nonsynonymous SNP rs16969968, a known risk variant in populations of European-descent, is also significantly associated with risk in African-Americans. Additional SNPs contribute to risk in distinct ways in these two populations...
  4. pmc In search of causal variants: refining disease association signals using cross-population contrasts
    Nancy L Saccone
    Department of Genetics, Washington University, Campus Box 8232, 4566 Scott Avenue, Saint Louis, Missouri, USA
    BMC Genet 9:58. 2008
    ..The challenge we address is to distinguish among these correlated loci to highlight potential functional variants and prioritize them for follow-up...
  5. pmc A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependence
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    Biol Psychiatry 64:922-9. 2008
    ..The goal of this study was to examine the association of this variant with cocaine dependence...
  6. pmc Variants in nicotinic receptors and risk for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
    Am J Psychiatry 165:1163-71. 2008
    ....
  7. pmc Nicotine dependence and comorbid psychiatric disorders: examination of specific genetic variants in the CHRNA5-A3-B4 nicotinic receptor genes
    Li Shiun Chen
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Drug Alcohol Depend 123:S42-51. 2012
    ..We examined whether these genetic variants were associated with comorbid disorders and whether comorbid psychiatric disorders modified the genetic risk of nicotine dependence...
  8. pmc Incorporating age at onset of smoking into genetic models for nicotine dependence: evidence for interaction with multiple genes
    Richard A Grucza
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Addict Biol 15:346-57. 2010
    ..Incorporation of logically chosen interaction parameters, such as AOS, into genetic models of substance use disorders may increase the degree of explained phenotypic variation and constitutes a promising avenue for gene discovery...
  9. pmc Further evidence for an association between the gamma-aminobutyric acid receptor A, subunit 4 genes on chromosome 4 and Fagerström Test for Nicotine Dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 104:471-7. 2009
    ..In the present report, we extend the previous study by expanding our genotyping efforts significantly for these two genes...
  10. ncbi request reprint A genomic scan for habitual smoking in families of alcoholics: common and specific genetic factors in substance dependence
    Laura Jean Bierut
    School of Medicine, Washington University School of Medicine, 4940 Children s Place, St Louis, MO 63110, USA
    Am J Med Genet A 124:19-27. 2004
    ..Finally, there is also evidence of an area on chromosome 2 that may reflect a common genetic vulnerability locus to both habitual smoking and alcohol dependence...
  11. doi request reprint Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control study
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1027-38. 2008
    ....
  12. pmc Novel genes identified in a high-density genome wide association study for nicotine dependence
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, Box 8134, St Louis, MO 63110, USA
    Hum Mol Genet 16:24-35. 2007
    ..This work anticipates the future directions of large-scale genome wide association studies with state-of-the-art methodological approaches and sharing of data with the scientific community...
  13. pmc Cholinergic nicotinic receptor genes implicated in a nicotine dependence association study targeting 348 candidate genes with 3713 SNPs
    Scott F Saccone
    Department of Psychiatry, Box 8134, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Hum Mol Genet 16:36-49. 2007
    ..Other genes among the top signals were KCNJ6 and GABRA4. This study represents one of the most powerful and extensive studies of nicotine dependence to date and has found novel risk loci that require confirmation by replication studies...
  14. pmc Linkage scan for quantitative traits identifies new regions of interest for substance dependence in the Collaborative Study on the Genetics of Alcoholism (COGA) sample
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 93:12-20. 2008
    ..0 on chromosome 2 (3.2, 234 cM), 10 (2.4 and 2.6 at 60 cM and 116 cM) and 13 (2.1 at 64 cM). These regions may harbor genes that contribute to the biological basis of alcohol and drug dependence...
  15. pmc Interplay of genetic risk factors (CHRNA5-CHRNA3-CHRNB4) and cessation treatments in smoking cessation success
    Li Shiun Chen
    Department of Psychiatry and the Department of Genetics, Washington University School of Medicine, St Louis, MO, USA
    Am J Psychiatry 169:735-42. 2012
    ....
  16. pmc Smoking and genetic risk variation across populations of European, Asian, and African American ancestry--a meta-analysis of chromosome 15q25
    Li Shiun Chen
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 36:340-51. 2012
    ..Using the cross-population study paradigm provides valuable insights to narrow regions of interest and inform future biological experiments...
  17. pmc A genome-wide association study of alcohol dependence
    Laura J Bierut
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5082-7. 2010
    ..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
  18. pmc Risk for nicotine dependence and lung cancer is conferred by mRNA expression levels and amino acid change in CHRNA5
    Jen C Wang
    Department of Psychiatry, Washington University, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Hum Mol Genet 18:3125-35. 2009
    ....
  19. ncbi request reprint Power-based, phase-informed selection of single nucleotide polymorphisms for disease association screens
    Scott F Saccone
    Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
    Genet Epidemiol 30:459-70. 2006
    ..This work is a concrete example of how empirical LD phase may be used to benefit study design...
  20. pmc Systematic biological prioritization after a genome-wide association study: an application to nicotine dependence
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Bioinformatics 24:1805-11. 2008
    ..A challenging problem after a genome-wide association study (GWAS) is to balance the statistical evidence of genotype-phenotype correlation with a priori evidence of biological relevance...
  21. pmc Interpreting joint SNP analysis results: when are two distinct signals really two distinct signals?
    Tae Hwi Schwantes-An
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri, USA
    Genet Epidemiol 37:301-9. 2013
    ..Also, it can connect association findings that may seem disparate due to lack of high correlations among the associated SNPs...
  22. pmc Genetic analysis of maximum cigarette-use phenotypes
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA
    BMC Genet 4:S105. 2003
    ..Adjustments were made for the significant covariates of gender and year of birth, and sib-pair based linkage analysis was performed...
  23. pmc A genome-wide association study of psoriasis and psoriatic arthritis identifies new disease loci
    Ying Liu
    Division of Human Genetics, Department of Genetics, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Genet 4:e1000041. 2008
    ..This region harbors the interleukin 2 (IL2) and interleukin 21 (IL21) genes and was recently shown to be associated with four autoimmune diseases (Celiac disease, Type 1 diabetes, Grave's disease and Rheumatoid Arthritis)...
  24. pmc Increased genetic vulnerability to smoking at CHRNA5 in early-onset smokers
    Sarah M Hartz
    Washington University School of Medicine, St Louis, Missouri, USA
    Arch Gen Psychiatry 69:854-60. 2012
    ..Recent studies have shown an association between cigarettes per day (CPD) and a nonsynonymous single-nucleotide polymorphism in CHRNA5, rs16969968...
  25. pmc Uncovering hidden variance: pair-wise SNP analysis accounts for additional variance in nicotine dependence
    ROBERT C CULVERHOUSE
    Division of General Medical Sciences, Department of Medicine, Washington University, Saint Louis, MO 63110, USA
    Hum Genet 129:177-88. 2011
    ..Methodologies that limit analyses of joint effects to variants that demonstrate association in single SNP analyses, or require a significant interaction term, will likely miss important joint effects...
  26. ncbi request reprint Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism
    Laura Jean Bierut
    Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 26:208-13. 2002
    ..Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further...
  27. pmc Genetic analysis of the maximum drinks phenotype
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    BMC Genet 6:S124. 2005
    ..The evidence suggests that chromosome 7 may harbor an additional locus influencing the maximum drinks consumption phenotype...
  28. pmc Supplementing high-density SNP microarrays for additional coverage of disease-related genes: addiction as a paradigm
    Scott F Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    PLoS ONE 4:e5225. 2009
    ..This combination of biological prioritization scores and LD tagging annotation will enable addiction researchers to supplement commercial SNP microarrays to ensure comprehensive coverage of biologically relevant regions...
  29. pmc Inclusion of African Americans in genetic studies: what is the barrier?
    Sarah M Hartz
    Department of Psychiatry, School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Am J Epidemiol 174:336-44. 2011
    ..0001). The results of this study suggest that increasing the number of African Americans in genetic databases may be achieved by increasing efforts to locate and contact them...
  30. pmc ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    JAMA Psychiatry 70:325-33. 2013
    ..The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging...
  31. ncbi request reprint Localization of PSORS1 to a haplotype block harboring HLA-C and distinct from corneodesmosin and HCR
    Cynthia Helms
    Department of Genetics, Washington University School of Medicine, Box 8232, 4566 Scott Avenue, St Louis, Missouri, 63110, USA
    Hum Genet 118:466-76. 2005
    ..The introduction of a potential binding site for the RUNX/AML family of transcription factors in intron 7, is also specific to these HLA-C alleles. These variants need to be investigated further for their role as PSORS1...
  32. pmc Protocol for a collaborative meta-analysis of 5-HTTLPR, stress, and depression
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, St, Louis, MO, USA
    BMC Psychiatry 13:304. 2013
    ..Meta-analyses of multiple studies have also reached differing conclusions...
  33. doi request reprint Model-based methods for linkage analysis
    John P Rice
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Adv Genet 60:155-73. 2008
    ..We may still learn from the LOD score method as we explore new methods in molecular biology and genetic analysis to utilize the complete human DNA sequence and the cataloging of all human genes...
  34. ncbi request reprint Genetic analysis workshop 13: Summary of analyses of alcohol and cigarette use phenotypes in the Framingham Heart Study
    Nancy L Saccone
    Department of Genetics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 25:S90-7. 2003
    ..quantitative traits, and consideration of transformations and covariates...
  35. pmc Multiple distinct CHRNB3-CHRNA6 variants are genetic risk factors for nicotine dependence in African Americans and European Americans
    ROBERT C CULVERHOUSE
    Department of Medicine, Washington University School of Medicine, Saint Louis, MO, USA Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
    Addiction 109:814-22. 2014
    ..We investigate whether this generalizes to African Americans, whether the association is specific to nicotine dependence and whether this region contains additional genetic contributors to nicotine dependence...
  36. ncbi request reprint The immunogenetics of smallpox vaccination
    Samuel L Stanley
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Infect Dis 196:212-9. 2007
    ....
  37. pmc Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pharmacogenet Genomics 21:426-31. 2011
    ..This investigation sought to determine the impact of folate fortification on the relative contribution of environmental and genetic factors to the variability of plasma tHcy...
  38. ncbi request reprint Age and birth cohort effects on rates of alcohol dependence
    John P Rice
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 27:93-9. 2003
    ..This suggests additional influences of birth cohort or period effects so that individuals in later-born cohorts have an increased lifetime risk...
  39. pmc A glimpse into the future - Personalized medicine for smoking cessation
    Laura Jean Bierut
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 South Euclid Avenue, St Louis, MO 63110, USA Electronic address
    Neuropharmacology 76:592-9. 2014
    ..This article is part of a Special Issue entitled 'NIDA 40th Anniversary Issue'...
  40. pmc Application of Bayesian network structure learning to identify causal variant SNPs from resequencing data
    Christopher E Schlosberg
    Division of Biology and Biomedical Sciences, Washington University School of Medicine, 660 South Euclid Avenue, Box 8226, St, Louis, MO 63110, USA
    BMC Proc 5:S109. 2011
    ..We conclude that this method, as currently applied, is not effective for identifying causal SNPs that follow the simulation model for the GAW17 data set, which includes many rare causal SNPs...
  41. pmc Artificial neural networks for linkage analysis of quantitative gene expression phenotypes and evaluation of gene x gene interactions
    Ying Liu
    Department of Genetics, Washington University School of Medicine, 4566 Scott Avenue, Box 8232, St, Louis, Missouri 63110, USA
    BMC Proc 1:S47. 2007
    ..However, for the approach implemented here, optimizing the ANNs and obtaining stable results remains challenging...
  42. ncbi request reprint Linkage for platelet monoamine oxidase (MAO) activity: results from a replication sample
    Nancy L Saccone
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 26:603-9. 2002
    ..These families were recruited as part of the Collaborative Study on the Genetics of Alcoholism (COGA)...