Y Rudy

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
    Thomas O'Hara
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA
    PLoS Comput Biol 7:e1002061. 2011
  2. pmc Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University, One Brookings Dr, St Louis, MO 63130 4899, USA
    Circ Res 112:863-74. 2013
  3. pmc Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes
    Leonid Livshitz
    Cardiac Bioelectricity and Arrhythmia Centre, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Physiol 590:4423-46. 2012
  4. ncbi request reprint Lessons learned about slow discontinuous conduction from models of impulse propagation
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Electrocardiol 38:52-4. 2005
  5. doi request reprint Molecular basis of cardiac action potential repolarization
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, MO 63130, USA
    Ann N Y Acad Sci 1123:113-8. 2008
  6. ncbi request reprint Modelling the molecular basis of cardiac repolarization
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, 290 Whitaker Hall, Campus Box 1097, One Brookings Drive, St Louis, MO 63130 4899, USA
    Europace 9:vi17-9. 2007
  7. pmc Computational biology in the study of cardiac ion channels and cell electrophysiology
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University, St Louis, MO 63130 489, USA
    Q Rev Biophys 39:57-116. 2006
  8. pmc Modelling and imaging cardiac repolarization abnormalities
    Y Rudy
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Intern Med 259:91-106. 2006
  9. ncbi request reprint Noninvasive electrocardiographic imaging in humans
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, MO 63130 4899, USA
    J Electrocardiol 38:138-9. 2005
  10. ncbi request reprint Electrotonic cell-cell interactions in cardiac tissue: effects on action potential propagation and repolarization
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, Missouri 63130 4899, USA
    Ann N Y Acad Sci 1047:308-13. 2005

Research Grants

  1. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2004
  2. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2006
  3. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2007
  4. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2007
  5. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2009
  6. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2009
  7. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2010
  8. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2005
  9. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2004
  10. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2003

Detail Information

Publications74

  1. pmc Simulation of the undiseased human cardiac ventricular action potential: model formulation and experimental validation
    Thomas O'Hara
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA
    PLoS Comput Biol 7:e1002061. 2011
    ..APD shortening during restitution was primarily dependent on reduced late Na(+) and I(CaL) currents due to inactivation at short diastolic intervals, with additional contribution from elevated I(Kr) due to incomplete deactivation...
  2. pmc Noninvasive electrocardiographic imaging of arrhythmogenic substrates in humans
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University, One Brookings Dr, St Louis, MO 63130 4899, USA
    Circ Res 112:863-74. 2013
    ..Examples include heart failure, myocardial infarction scar, atrial fibrillation, and abnormal ventricular repolarization...
  3. pmc Data-based theoretical identification of subcellular calcium compartments and estimation of calcium dynamics in cardiac myocytes
    Leonid Livshitz
    Cardiac Bioelectricity and Arrhythmia Centre, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Physiol 590:4423-46. 2012
    ..The I(NCX)-based method provided a good estimate for the descending phase of Ca(t). Thus, application of both methods in combination provides the best estimate of the entire Ca(t) time course...
  4. ncbi request reprint Lessons learned about slow discontinuous conduction from models of impulse propagation
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Electrocardiol 38:52-4. 2005
    ..Such conduction is highly discontinuous and is supported by the L-type calcium current. We also show that gap junction coupling and the associated load has a strong effect on spatial repolarization gradients in cardiac tissue...
  5. doi request reprint Molecular basis of cardiac action potential repolarization
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, MO 63130, USA
    Ann N Y Acad Sci 1123:113-8. 2008
    ..By doing so, IKs can provide repolarizing current when other currents (e.g., IKr) are compromised by disease or drugs, thus preventing excessive AP prolongation and arrhythmic activity...
  6. ncbi request reprint Modelling the molecular basis of cardiac repolarization
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, 290 Whitaker Hall, Campus Box 1097, One Brookings Drive, St Louis, MO 63130 4899, USA
    Europace 9:vi17-9. 2007
    ..To study the properties of ion-channel gating (I(Ks), the slow delayed rectifier K+ channel) that underlie the channel's participation in rate-dependent repolarization of the cardiac action potential (AP)...
  7. pmc Computational biology in the study of cardiac ion channels and cell electrophysiology
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University, St Louis, MO 63130 489, USA
    Q Rev Biophys 39:57-116. 2006
    ....
  8. pmc Modelling and imaging cardiac repolarization abnormalities
    Y Rudy
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Intern Med 259:91-106. 2006
    ..A new noninvasive imaging modality (electrocardiographic imaging) is shown to image cardiac repolarization on the epicardial surface, suggesting its possible role in risk stratification, diagnosis and treatment of LQT syndrome...
  9. ncbi request reprint Noninvasive electrocardiographic imaging in humans
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, MO 63130 4899, USA
    J Electrocardiol 38:138-9. 2005
  10. ncbi request reprint Electrotonic cell-cell interactions in cardiac tissue: effects on action potential propagation and repolarization
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, Missouri 63130 4899, USA
    Ann N Y Acad Sci 1047:308-13. 2005
    ..These interactions modulate the ionic mechanism of conduction and influence conduction velocity and robustness. Cell-cell interactions also have a strong effect on the dispersion of repolarization in cardiac tissue...
  11. pmc Systems approach to understanding electromechanical activity in the human heart: a national heart, lung, and blood institute workshop summary
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, The Fred Saigh Distinguished Professor, Washington University, Campus Box 1097, Whitaker Hall Room 290B, One Brookings Dr, St Louis, MO 63130 4899, USA
    Circulation 118:1202-11. 2008
    ..The recommendations can be found on the NHLBI Web site at http://www.nhlbi.nih.gov/meetings/workshops/electro.htm...
  12. ncbi request reprint Cardiac repolarization: insights from mathematical modeling and electrocardiographic imaging (ECGI)
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, Missouri 63130 4899, USA
    Heart Rhythm 6:S49-55. 2009
    ..ECGI can noninvasively image human cardiac repolarization and its alteration by disease and interventions. This property makes it a potential tool for noninvasive risk stratification and evaluation of treatment by drugs and devices...
  13. pmc Noninvasive electrocardiographic imaging of cardiac resynchronization therapy in patients with heart failure
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, MO 63130 4899, USA
    J Electrocardiol 39:S28-30. 2006
    ....
  14. doi request reprint Noninvasive imaging of cardiac electrophysiology and arrhythmia
    Yoram Rudy
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, Missouri 63130, USA
    Ann N Y Acad Sci 1188:214-21. 2010
    ..Here we describe such a noninvasive imaging modality, electrocardiographic imaging (ECGI), and provide examples of its application in various (normal and abnormal) cardiac rhythms...
  15. pmc Rate dependence and regulation of action potential and calcium transient in a canine cardiac ventricular cell model
    Thomas J Hund
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130 4899, USA
    Circulation 110:3168-74. 2004
    ....
  16. ncbi request reprint Electrocardiographic imaging: II. Effect of torso inhomogeneities on noninvasive reconstruction of epicardial potentials, electrograms, and isochrones
    C Ramanathan
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA
    J Cardiovasc Electrophysiol 12:241-52. 2001
    ..CONCLUSION: The results demonstrate that, in the clinical application, it is not necessary to include torso inhomogeneities for noninvasive reconstructions of epicardial potentials, EGMs, and activation sequences...
  17. ncbi request reprint Imaging dispersion of myocardial repolarization, II: noninvasive reconstruction of epicardial measures
    R N Ghanem
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, and University Hospitals of Cleveland, Cleveland, Ohio, USA
    Circulation 104:1306-12. 2001
    ..Its clinical significance lies in the possibility of noninvasive risk stratification and in guidance and evaluation of therapy...
  18. ncbi request reprint Mechanistic insights into very slow conduction in branching cardiac tissue: a model study
    J P Kucera
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 89:799-806. 2001
    ..It could also support reentrant excitation in diseased myocardium where the substrate is structurally complex...
  19. pmc Noninvasive electrocardiographic imaging (ECGI): application of the generalized minimal residual (GMRes) method
    Charulatha Ramanathan
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Ann Biomed Eng 31:981-94. 2003
    ..Simultaneous use of these two complementary methods in clinical ECGI will ensure reliability and maximal extraction of diagnostic information in the absence of a priori information about a patient's condition...
  20. ncbi request reprint Electrocardiographic imaging: I. Effect of torso inhomogeneities on body surface electrocardiographic potentials
    C Ramanathan
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA
    J Cardiovasc Electrophysiol 12:229-40. 2001
    ..CONCLUSION: Effects of torso inhomogeneities on 12-lead ECGs are minimal, and the associated ECG changes fall within the range of normal interindividual variations...
  21. ncbi request reprint From genome to physiome: integrative models of cardiac excitation
    Y Rudy
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Ann Biomed Eng 28:945-50. 2000
    ..Using a multicellular fiber model, we have shown that slow conduction is very stable and, in contrast to normal conduction which depends solely on INa, requires a major contribution from ICa(L) (Shaw and Rudy, Circ. Res. 81:727, 1997)...
  22. pmc Regulation of Ca2+ and electrical alternans in cardiac myocytes: role of CAMKII and repolarizing currents
    Leonid M Livshitz
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, Missouri 63130 4899, USA
    Am J Physiol Heart Circ Physiol 292:H2854-66. 2007
    ..The simulations identify combined CaMKII inhibition and I(Kr) enhancement as a possible antiarrhythmic intervention...
  23. pmc Na(+) channel mutation that causes both Brugada and long-QT syndrome phenotypes: a simulation study of mechanism
    Colleen E Clancy
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circulation 105:1208-13. 2002
    ..Coexistence of these syndromes is seemingly paradoxical; LQT is associated with enhanced Na(+) channel function, and Brugada with reduced function...
  24. pmc Properties and ionic mechanisms of action potential adaptation, restitution, and accommodation in canine epicardium
    Keith F Decker
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University in St Louis, St Louis, Missouri, USA
    Am J Physiol Heart Circ Physiol 296:H1017-26. 2009
    ..arrhythmia). Accurate simulation of rate-dependent phenomena and increased understanding of their mechanistic basis will lead to more realistic multicellular simulations of arrhythmia and identification of molecular therapeutic targets...
  25. pmc Application of the method of fundamental solutions to potential-based inverse electrocardiography
    Yong Wang
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, St Louis, Missouri, 63130 4899, USA
    Ann Biomed Eng 34:1272-88. 2006
    ..3. Elimination of complex singular integrals that must be carefully computed in BEM. 4. Simpler implementation. These properties of MFS enhance the practical application of ECGI as a clinical diagnostic tool...
  26. pmc Uniqueness and stability of action potential models during rest, pacing, and conduction using problem-solving environment
    Leonid Livshitz
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, Missouri, USA
    Biophys J 97:1265-76. 2009
    ..6), Using the AP computed based on 1-5 above, an efficient scheme is developed for computing propagation in multicellular models...
  27. pmc Cardiac memory in patients with Wolff-Parkinson-White syndrome: noninvasive imaging of activation and repolarization before and after catheter ablation
    Subham Ghosh
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    Circulation 118:907-15. 2008
    ..ECG imaging (ECGI) is a novel imaging modality for noninvasive electroanatomic mapping of epicardial activation and repolarization...
  28. pmc Ionic current basis of electrocardiographic waveforms: a model study
    Kazutaka Gima
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 90:889-96. 2002
    ..5) Activation of the ATP-sensitive potassium current, I(K(ATP)), is sufficient to cause ST elevation during acute ischemia. These principles provide a mechanistic cellular basis for interpretation of electrocardiographic waveforms...
  29. pmc Endocardial mapping of electrophysiologically abnormal substrates and cardiac arrhythmias using a noncontact nonexpandable catheter
    Ping Jia
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    J Cardiovasc Electrophysiol 13:888-95. 2002
    ..Here we extend the approach to hearts with structural disease and examine its ability to detect and characterize abnormal electrophysiologic (EP) substrates and to map ventricular arrhythmias on a beat-by-beat basis...
  30. ncbi request reprint Reentry: insights from theoretical simulations in a fixed pathway
    Y Rudy
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    J Cardiovasc Electrophysiol 6:294-312. 1995
    ..g., beat-to-beat alternans) to the underlying kinetics of membrane ionic channels. Effects on reentry of inhomogeneities in refractoriness, excitability, cellular coupling at gap junctions, and fiber cross-section are also studied...
  31. pmc Heart-surface reconstruction and ECG electrodes localization using fluoroscopy, epipolar geometry and stereovision: application to noninvasive imaging of cardiac electrical activity
    Raja N Ghanem
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    IEEE Trans Med Imaging 22:1307-18. 2003
    ..Results demonstrate the feasibility of this approach for clinical noninvasive imaging of cardiac arrhythmias in the interventional EP laboratory...
  32. ncbi request reprint Imaging dispersion of myocardial repolarization, I: comparison of body-surface and epicardial measures
    J E Burnes
    Cardiac Bioelectricity Research and Training Center, Department of Biomedical Engineering, Cleveland, Ohio, USA
    Circulation 104:1299-305. 2001
    ..In contrast, measures based on epicardial electrograms (ARI or epicardial QRST integral maps) provide physiologically relevant information about myocardial repolarization and can locate regions of increased dispersion...
  33. pmc Calsequestrin mutation and catecholaminergic polymorphic ventricular tachycardia: a simulation study of cellular mechanism
    Gregory M Faber
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Cardiovasc Res 75:79-88. 2007
    ..In this theoretical study, we investigate a potential mechanism by which CASQ2(D307H) manifests its pro-arrhythmic consequences in patients...
  34. pmc Subunit interaction determines IKs participation in cardiac repolarization and repolarization reserve
    Jonathan Silva
    Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130 4899, USA
    Circulation 112:1384-91. 2005
    ..The role of IKs, the slow delayed rectifier K+ current, in cardiac ventricular repolarization has been a subject of debate...
  35. pmc A multiscale model linking ion-channel molecular dynamics and electrostatics to the cardiac action potential
    Jonathan R Silva
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 106:11102-6. 2009
    ..This framework allows integration of multiscale observations to study the molecular basis of excitation and its alteration by disease...
  36. pmc Modeling subunit cooperativity in opening of tetrameric ion channels
    Ali Nekouzadeh
    Cardiac Bioelectricity and Arrhythmia Center and Department of Biomedical Engineering, Washington University in Saint Louis, Saint Louis, Missouri, USA
    Biophys J 95:3510-20. 2008
    ..Implementation of the direct approach is simple and its computational time is orders-of-magnitude shorter than the equivalent expanded model...
  37. ncbi request reprint Meshless methods in potential inverse electrocardiography
    Yong Wang
    Dept of Biomed Eng, Washington Univ, St Louis, MO 63130, USA
    Conf Proc IEEE Eng Med Biol Soc 1:2558-9. 2006
    ..This study shows that MFS is a promising meshless alternative to BEM and FEM in PIE...
  38. pmc Noninvasive electrocardiographic imaging (ECGI) of a univentricular heart with Wolff-Parkinson-White syndrome
    Subham Ghosh
    Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130 4899, USA
    Heart Rhythm 5:605-8. 2008
  39. pmc Statistical properties of ion channel records. Part II: estimation from the macroscopic current
    Ali Nekouzadeh
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, 290 Whitaker Hall, Campus Box 1097, One Brooking Drive, St Louis, MO 63130 4899, USA
    Math Biosci 210:315-34. 2007
    ..Experimental single channel records of inactivating BK potassium channels are used to evaluate how accurately this procedure reconstructs measured single channel sweeps...
  40. pmc Statistical properties of ion channel records. Part I: relationship to the macroscopic current
    Ali Nekouzadeh
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, 290 Whitaker Hall, Campus Box 1097, One Brooking Drive, St Louis, MO 63130 4899, USA
    Math Biosci 210:291-314. 2007
    ..This filtering leads to more accurate measurement of transition times and less amount of missed events...
  41. pmc Application of L1-norm regularization to epicardial potential solution of the inverse electrocardiography problem
    Subham Ghosh
    Department of Biomedical Engineering, Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, 290 Whitaker Hall, Campus Box 1097, One Brookings Dr, Saint Louis, MO 63130 4899, USA
    Ann Biomed Eng 37:902-12. 2009
    ....
  42. pmc Ionic mechanisms of electrophysiological heterogeneity and conduction block in the infarct border zone
    Keith F Decker
    Cardiac Bioelectricity and Arrhythmia Center, Department of Biomedical Engineering, Washington University, St Louis, Missouri 63130 4899, USA
    Am J Physiol Heart Circ Physiol 299:H1588-97. 2010
    ....
  43. pmc Accuracy of quadratic versus linear interpolation in noninvasive Electrocardiographic Imaging (ECGI)
    Subham Ghosh
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University in St Louis, 290 Whitaker Hall, Campus Box 1097, St Louis, MO 63130 4899, USA
    Ann Biomed Eng 33:1187-201. 2005
    ..97, LI approximately 0.92). We also applied QI to ECGI reconstructions in human subjects during cardiac pacing, where QI locates ventricular pacing sites with higher accuracy (< or = 10 mm) than LI (< or = 18 mm)...
  44. pmc Noninvasive electrocardiographic imaging (ECGI) of epicardial activation before and after catheter ablation of the accessory pathway in a patient with Ebstein anomaly
    Subham Ghosh
    Cardiac Bioelectricity and Arrhythmia Center CBAC, Washington University, St Louis, Missouri, USA
    Heart Rhythm 5:857-60. 2008
  45. pmc Noninvasive electrocardiographic imaging (ECGI) of scar-related atypical atrial flutter
    Yong Wang
    Cardiac Bioelectricity and Arrhythmia Center, Washington University in St Louis, St Louis, Missouri 63130 4899, USA
    Heart Rhythm 4:1565-7. 2007
  46. pmc Noninvasive characterization of epicardial activation in humans with diverse atrial fibrillation patterns
    Phillip S Cuculich
    Cardiac Bioelectricity Center, One Brookings Drive, St Louis, MO 63130 4899, USA
    Circulation 122:1364-72. 2010
    ..In this article, we present continuous biatrial epicardial activation sequences of AF in humans using noninvasive electrocardiographic imaging (ECGI)...
  47. pmc Cardiac resynchronization therapy in pediatric congenital heart disease: insights from noninvasive electrocardiographic imaging
    Jennifer N A Silva
    Division of Pediatric Cardiology, Washington University School of Medicine St Louis Children s Hospital, Washington University, St Louis, Missouri 63130 4899, USA
    Heart Rhythm 6:1178-85. 2009
    ..Electrocardiographic imaging (ECGI) is a novel electrophysiologic imaging modality that may help guide patient selection and lead placement for cardiac resynchronization therapy (CRT)...
  48. pmc Role of activated CaMKII in abnormal calcium homeostasis and I(Na) remodeling after myocardial infarction: insights from mathematical modeling
    Thomas J Hund
    Department of Surgery, Washington University in St Louis, St Louis, MO, USA
    J Mol Cell Cardiol 45:420-8. 2008
    ..Our experimental and theoretical findings establish abnormal CaMKII signaling as an important component of remodeling in the canine BZ...
  49. pmc Kinetic properties of the cardiac L-type Ca2+ channel and its role in myocyte electrophysiology: a theoretical investigation
    Gregory M Faber
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio, USA
    Biophys J 92:1522-43. 2007
    ..2 is greater at negative potentials, when VDI is weak; and 5), loss of VDI due to the Ca(V)1.2 mutation G406R (linked to the Timothy syndrome) results in APD prolongation and increased CaT...
  50. pmc Ionic charge conservation and long-term steady state in the Luo-Rudy dynamic cell model
    T J Hund
    Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106-7207, USA
    Biophys J 81:3324-31. 2001
    ..Such studies are essential for mechanistic understanding of arrhythmogenesis, since cells are subjected to rapid periodic stimulation during many arrhythmias...
  51. pmc Focal atrial tachycardia after pulmonary vein isolation: noninvasive mapping with electrocardiographic imaging (ECGI)
    Yong Wang
    Cardiac Bioelectricity and Arrhythmia Center, Washington University School of Medicine, St Louis, Missouri, USA
    Heart Rhythm 4:1081-4. 2007
  52. pmc Hypertrophic cardiomyopathy with preexcitation: insights from noninvasive electrocardiographic imaging (ECGI) and catheter mapping
    Subham Ghosh
    Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, Missouri 63130 4899, USA
    J Cardiovasc Electrophysiol 19:1215-7. 2008
    ..Hypertrophic Cardiomyopathy and Preexcitation...
  53. pmc State-dependent electrostatic interactions of S4 arginines with E1 in S2 during Kv7.1 activation
    Dick Wu
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Washington University, St Louis, MO 63130, USA
    J Gen Physiol 135:595-606. 2010
    ..These electrostatic interactions contribute energetically to voltage-dependent gating and are important in setting the limits for S4 movement...
  54. pmc A model of canine purkinje cell electrophysiology and Ca(2+) cycling: rate dependence, triggered activity, and comparison to ventricular myocytes
    Pan Li
    Department of Biomedical Engineering and Cardiac Bioelectricity and Arrhythmia Center, Campus Box 1097, Washington University in St Louis, 1 Brookings Drive, St Louis, MO 63112, USA
    Circ Res 109:71-9. 2011
    ..Steeper rate dependence of action potential and Ca(2+) transients, central peripheral heterogeneity of Ca(2+) cycling, and distinct ion channel profile underlie greater arrhythmic vulnerability of Pcell compared to Vcell...
  55. ncbi request reprint Comments on: "Role of individual ionic current systems in ventricular cells hypothesized by a model study" by Matsuoka S, Sarai N, Kuratomi S, Ono K, and Noma A. Jpn J Physiol 53: 105-123, 2003
    Thomas O'Hara
    Jpn J Physiol 54:505-7; author reply 507-8. 2004
  56. pmc Electrocardiographic imaging of cardiac resynchronization therapy in heart failure: observation of variable electrophysiologic responses
    Ping Jia
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio, USA
    Heart Rhythm 3:296-310. 2006
    ..Being an electrical approach, detailed electrical information during CRT is critical to resolving these issues. However, electrical data from patients have been limited because of the requirement for invasive mapping...
  57. pmc Noninvasive electrocardiographic imaging (ECGI): comparison to intraoperative mapping in patients
    Raja N Ghanem
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio, USA
    Heart Rhythm 2:339-54. 2005
    ..Here, images obtained by noninvasive ECGI are compared to invasive direct epicardial mapping in open heart surgery patients...
  58. pmc Activation and repolarization of the normal human heart under complete physiological conditions
    Charulatha Ramanathan
    Biomedical Engineering, Case Western Reserve University, Cleveland, OH 44106, USA
    Proc Natl Acad Sci U S A 103:6309-14. 2006
    ..The repolarization sequence was determined by local repolarization properties rather than by the activation sequence, and significant dispersion of repolarization was observed between RV and LV and from apex to base...
  59. pmc Localization of sodium channels in intercalated disks modulates cardiac conduction
    Jan P Kucera
    Department of Physiology, University of Bern, Switzerland
    Circ Res 91:1176-82. 2002
    ..Conversely, by supporting moderately slow conduction, this mechanism could also promote arrhythmias...
  60. pmc Mechanism of pacemaking in I(K1)-downregulated myocytes
    Jonathan Silva
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Circ Res 92:261-3. 2003
    ..Simulations of betaAS demonstrate such responsiveness, which depends on I(NaCa) expression. However, a simultaneous betaAS-mediated increase in the slow delayed rectifier, I(Ks), limits betaAS sensitivity...
  61. pmc Physiological properties of hERG 1a/1b heteromeric currents and a hERG 1b-specific mutation associated with Long-QT syndrome
    Harinath Sale
    Department of Physiology, University of Wisconsin, Madison, WI, USA
    Circ Res 103:e81-95. 2008
    ..Thus, mutations specifically disrupting hERG 1b function are expected to reduce cardiac I Kr and enhance drug sensitivity, and represent a potential mechanism underlying inherited or acquired LQTS...
  62. pmc Pharmacogenetics and anti-arrhythmic drug therapy: a theoretical investigation
    Colleen E Clancy
    Dept of Physiology and Biophysics, Insitute for Computational Biomedicine, Weill Medical College of Cornell Univeristy, 1300 York Ave, LC 501E, New York, NY 10021, USA
    Am J Physiol Heart Circ Physiol 292:H66-75. 2007
    ..The simulations also suggest that inactivation state block by lidocaine is less effective in restoring normal repolarization and adversely suppresses peak Na(+) current...
  63. ncbi request reprint Genetic defects, ionic currents and electrocardiographic alterations
    Yoram Rudy
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, 509 Wickenden Building, Cleveland, OH 44106 7207, USA
    Ann Med 36:15-21. 2004
    ..Examples are provided from the congenital long QT syndrome and the Brugada syndrome...
  64. ncbi request reprint Basic mechanisms of cardiac impulse propagation and associated arrhythmias
    André G Kléber
    Department of Physiology, University of Bern, Buhlplatz 5, CH 3012 Bern, Switzerland
    Physiol Rev 84:431-88. 2004
    ..This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart...
  65. ncbi request reprint Electrocardiographic imaging of patients with heart failure with left bundle branch block and response to cardiac resynchronization therapy
    Niraj Varma
    Cardiac Bioelectricity Research Department, Case Western Reserve University, Cleveland, OH, USA
    J Electrocardiol 40:S174-8. 2007
    ..To determine this, we used electrocardiographic imaging (ECGI), which maps epicardial ventricular excitation noninvasively...
  66. pmc Placebo CRT
    Niraj Varma
    Cardiac Bioelectricity Research and Training Center, Case Western Reserve University, Cleveland, Ohio, USA
    J Cardiovasc Electrophysiol 19:878. 2008
  67. ncbi request reprint From genetics to cellular function using computational biology
    Yoram Rudy
    Cardiac Bioelectricity Center, 509 Wickenden Building, Case Western Reserve University, Cleveland, OH 44106 7207, USA
    Ann N Y Acad Sci 1015:261-70. 2004
    ..Results provide insights into the cellular mechanisms of QT-interval prolongation on the ECG in the long QT syndrome and of ST-segment elevation in the right precordial leads in the Brugada syndrome...
  68. pmc Noninvasive electrocardiographic imaging for cardiac electrophysiology and arrhythmia
    Charulatha Ramanathan
    Cardiac Bioelectricity Research and Training Center, and Department of Biomedical Engineering, Case Western Reserve University, Cleveland, Ohio 44106 7207, USA
    Nat Med 10:422-8. 2004
    ....
  69. pmc Subepicardial phase 0 block and discontinuous transmural conduction underlie right precordial ST-segment elevation by a SCN5A loss-of-function mutation
    Marketa Bebarova
    Dept of Cardiology, Cardiovascular Research Institute Maastricht, Academic Hospital Maastricht, 6202 AZ, Maastricht, The Netherlands
    Am J Physiol Heart Circ Physiol 295:H48-58. 2008
    ..The late slow-upstroke action potentials at the subepicardium produce T-wave inversion in the computed ECG waveform, in line with the clinical ECG...
  70. pmc Impulse propagation in synthetic strands of neonatal cardiac myocytes with genetically reduced levels of connexin43
    Stuart P Thomas
    Department of Physiology, University of Bern, Bühlplatz5, CH 3012 Bern, Switzerland
    Circ Res 92:1209-16. 2003
    ..The lack of changes in theta in this tissue is explained by the dominating role of myoplasmic resistance and the compensatory increase of dV/dtmax...
  71. ncbi request reprint Conductive bridges in cardiac tissue: a beneficial role or an arrhythmogenic substrate?
    Yoram Rudy
    Circ Res 94:709-11. 2004
  72. pmc Electrocardiographic imaging (ECGI), a novel diagnostic modality used for mapping of focal left ventricular tachycardia in a young athlete
    Anselma Intini
    Department of Medicine Cardiology, Case Western Reserve University University Hospitals of Cleveland, 11100 Euclid Avenue, Cleveland, OH 44106, USA
    Heart Rhythm 2:1250-2. 2005
    ..This correlated with subsequent maps obtained using standard techniques. We describe the first case that used ECGI to guide diagnosis and therapy of a clinical tachyarrhythmia...
  73. ncbi request reprint From vulnerable plaque to vulnerable patient--Part III: Executive summary of the Screening for Heart Attack Prevention and Education (SHAPE) Task Force report
    Morteza Naghavi
    Association for Eradication of Heart Attack, Houston, Texas 77005, USA
    Am J Cardiol 98:2H-15H. 2006
    ....
  74. ncbi request reprint Comments on "A model for human ventricular tissue"
    Leonid Livshitz
    Am J Physiol Heart Circ Physiol 288:H453; author reply H453-4. 2005

Research Grants23

  1. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2004
    ..abstract_text> ..
  2. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2006
    ..abstract_text> ..
  3. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2007
    ..abstract_text> ..
  4. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2007
    ..abstract_text> ..
  5. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2009
    ..The proposed research is aimed at understanding the disease processes that cause cardiac rhythm disorders so that mechanism-based diagnosis, prevention and treatment can be developed and applied. ..
  6. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2009
    ....
  7. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2010
    ..The proposed research is aimed at understanding the disease processes that cause cardiac rhythm disorders so that mechanism-based diagnosis, prevention and treatment can be developed and applied. ..
  8. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2005
    ..abstract_text> ..
  9. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2004
    ..abstract_text> ..
  10. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2003
    ..abstract_text> ..
  11. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 1999
    ..5) To characterize the properties of reentrant propagation and the processes of initiation and termination of reentry in the anisotropic myocardium. ..
  12. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 1993
    ....
  13. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2000
    ..5) To characterize the properties of reentrant propagation and the processes of initiation and termination of reentry in the anisotropic myocardium. ..
  14. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2001
    ..5) To characterize the properties of reentrant propagation and the processes of initiation and termination of reentry in the anisotropic myocardium. ..
  15. CARDIAC EXCITATION AND ARRHYTHMIAS
    Yoram Rudy; Fiscal Year: 2002
    ..5) To characterize the properties of reentrant propagation and the processes of initiation and termination of reentry in the anisotropic myocardium. ..
  16. INVERSE AND FORWARD PROBLEMS IN ELECTROCARDIOGRAPHY
    Yoram Rudy; Fiscal Year: 2010
    ....