DAVID RUDNICK

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
    D A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:8885-90. 2001
  2. ncbi request reprint Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 39:1048-55. 2004
  3. ncbi request reprint Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Hepatology 44:976-82. 2006
  4. pmc Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Pediatr Transplant 13:223-30. 2009
  5. ncbi request reprint Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice
    Yunjun Liao
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, MO, USA
    J Biol Chem 279:43107-16. 2004
  6. ncbi request reprint Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice
    Eyal Shteyer
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 40:1322-32. 2004
  7. ncbi request reprint Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease
    David A Rudnick
    Department of Pediatics, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 42:514-21. 2005
  8. pmc Characterization and outcomes of young infants with acute liver failure
    Shikha S Sundaram
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 159:813-818.e1. 2011
  9. pmc Murine functional liver mass is reduced following partial small bowel resection
    Zhaohua Qiu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gastrointest Surg 13:2176-82. 2009
  10. ncbi request reprint Rosiglitazone inhibits mouse liver regeneration
    Yumirle P Turmelle
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    FASEB J 20:2609-11. 2006

Research Grants

  1. LIVER REGENERATION IN PEDIATRIC LIVER DISEASE
    DAVID RUDNICK; Fiscal Year: 2004
  2. LIVER REGENERATION IN PEDIATRIC LIVER DISEASE
    DAVID RUDNICK; Fiscal Year: 2004
  3. Hepatobiliary Pathophysiology of Liver Regeneration
    DAVID RUDNICK; Fiscal Year: 2007
  4. Hepatobiliary Pathophysiology of Liver Regeneration
    DAVID RUDNICK; Fiscal Year: 2009

Collaborators

Detail Information

Publications13

  1. pmc Prostaglandins are required for CREB activation and cellular proliferation during liver regeneration
    D A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:8885-90. 2001
    ....
  2. ncbi request reprint Analyses of hepatocellular proliferation in a mouse model of alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 39:1048-55. 2004
    ..This selective proliferation suggests that hepatocellular transplantation may be applicable for treatment of this and other slowly progressive metabolic liver diseases...
  3. ncbi request reprint Indomethacin increases liver damage in a murine model of liver injury from alpha-1-antitrypsin deficiency
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, St Louis, MO 63110, USA
    Hepatology 44:976-82. 2006
    ....
  4. pmc Serum alpha-NH-butyric acid may predict spontaneous survival in pediatric acute liver failure
    David A Rudnick
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Pediatr Transplant 13:223-30. 2009
    ..These data indicate that Aab and the Aab:Leu ratio may predict clinical outcomes in PALF...
  5. ncbi request reprint Delayed hepatocellular mitotic progression and impaired liver regeneration in early growth response-1-deficient mice
    Yunjun Liao
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, MO, USA
    J Biol Chem 279:43107-16. 2004
    ..Taken together these data define a novel functional role for EGR-1 in regulating hepatocellular mitotic progression through the spindle assembly checkpoint during liver regeneration...
  6. ncbi request reprint Disruption of hepatic adipogenesis is associated with impaired liver regeneration in mice
    Eyal Shteyer
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 40:1322-32. 2004
    ....
  7. ncbi request reprint Alpha-1-antitrypsin deficiency: a new paradigm for hepatocellular carcinoma in genetic liver disease
    David A Rudnick
    Department of Pediatics, Washington University School of Medicine, St Louis, MO, USA
    Hepatology 42:514-21. 2005
    ..Further, this paradigm may apply to other genetic and infectious liver diseases that are predisposed to hepatocellular carcinoma...
  8. pmc Characterization and outcomes of young infants with acute liver failure
    Shikha S Sundaram
    Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, The Children s Hospital, University of Colorado School of Medicine, Aurora, CO, USA
    J Pediatr 159:813-818.e1. 2011
    ..To characterize infants aged ≤ 90 days enrolled in an international, multicenter, prospective registry of children aged < 18 years with acute liver failure (ALF)...
  9. pmc Murine functional liver mass is reduced following partial small bowel resection
    Zhaohua Qiu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Gastrointest Surg 13:2176-82. 2009
    ..Previous investigations suggest that signals from the bowel may play an important role. The purpose of the studies reported here was to determine the effect of proximal partial small bowel resection on liver mass in a murine model...
  10. ncbi request reprint Rosiglitazone inhibits mouse liver regeneration
    Yumirle P Turmelle
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    FASEB J 20:2609-11. 2006
    ..These studies provide the first evidence linking regulation of PPARgamma activity and the hepatic regenerative response...
  11. pmc Evidence for non-traditional activation of complement factor C3 during murine liver regeneration
    Amelia Clark
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, United States
    Mol Immunol 45:3125-32. 2008
    ..In vitro analysis raises the possibility that plasmin may contribute to non-traditional complement activation during liver regeneration in vivo...
  12. pmc p21 is required for dextrose-mediated inhibition of mouse liver regeneration
    Alexander Weymann
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hepatology 50:207-15. 2009
    ....
  13. pmc Dyskerin ablation in mouse liver inhibits rRNA processing and cell division
    Jingping Ge
    Division Hematology, Department Internal Medicine, Washington University School of Medicine, 660 S Euclid Ave, Box 8125, St Louis, MO 63110, USA
    Mol Cell Biol 30:413-22. 2010
    ..We conclude that hepatocytes can survive without dyskerin but that the role of dyskerin in RNA modification is essential for cellular proliferation...

Research Grants8

  1. LIVER REGENERATION IN PEDIATRIC LIVER DISEASE
    DAVID RUDNICK; Fiscal Year: 2004
    ..abstract_text> ..
  2. LIVER REGENERATION IN PEDIATRIC LIVER DISEASE
    DAVID RUDNICK; Fiscal Year: 2004
    ..In this grant we propose to determine the effects of prostaglandins on ROS synthesis, expression of genes regulating ROS metabolism, and expression and activity of negative regulators of cytokine signaling during liver regeneration. ..
  3. Hepatobiliary Pathophysiology of Liver Regeneration
    DAVID RUDNICK; Fiscal Year: 2007
    ..abstract_text> ..
  4. Hepatobiliary Pathophysiology of Liver Regeneration
    DAVID RUDNICK; Fiscal Year: 2009
    ..abstract_text> ..