Joshua B Rubin

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Chemokine signaling in cancer: one hump or two?
    Joshua B Rubin
    Department of Pediatrics Division of Pediatric Hematology and Oncology, Campus Box 8208, 660 South Euclid Avenue, Washington University School of Medicine, St Louis, MO 63110, USA rubin
    Semin Cancer Biol 19:116-22. 2009
  2. pmc Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma
    Melissa Frei-Jones
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 2:125-9. 2008
  3. doi request reprint Only in congenial soil: the microenvironment in brain tumorigenesis
    Joshua B Rubin
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 19:144-9. 2009
  4. ncbi request reprint Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies
    B Mark Woerner
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 65:11392-9. 2005
  5. ncbi request reprint Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1
    Nicole M Warrington
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:8588-95. 2007
  6. pmc CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice
    Tao Sun
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroimmunol 224:108-13. 2010
  7. doi request reprint Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma
    Balazs Hegedus
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 68:1520-8. 2008
  8. ncbi request reprint Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity
    Robyn S Klein
    Division of Infectious Diseases, Departments of Pathology and Immunology and Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Trends Immunol 25:306-14. 2004
  9. doi request reprint Brainstem glioma presenting as pruritus in children with neurofibromatosis-1
    Rachel S Darken
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63119, USA
    J Pediatr Hematol Oncol 31:972-6. 2009
  10. pmc Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
    Patricia Goldhoff
    Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:7717-25. 2008

Collaborators

  • Arie Perry
  • David H Gutmann
  • Robyn S Klein
  • David Piwnica-Worms
  • David B Mansur
  • Robert E Schmidt
  • David D Limbrick
  • Andrew J Hope
  • B Mark Woerner
  • Nicole M Warrington
  • Ian G Dorward
  • Tao Sun
  • Rachel S Darken
  • Jeffrey R Leonard
  • Erin Jackson
  • Robert C McKinstry
  • Balazs Hegedus
  • Erin E McCandless
  • Joel R Garbow
  • Erich L Kiehl
  • Melissa Frei-Jones
  • Patricia Goldhoff
  • Jingqin Luo
  • Scott M Gianino
  • Jeffrey Leonard
  • Ray Bogitch
  • Laura Piccio
  • Daniel A Low
  • Anne H Cross
  • Debasish Banerjee
  • Kathleen T Malinowski
  • Enrique W Izaguirre
  • Divya Khullar
  • Tae Sung Park
  • Parag J Parikh
  • Stefan Rothermich
  • Tu Hsueh Yeh
  • Sarah C Jost
  • Joseph O Deasy
  • Strahinja Stojadinovic
  • Girish C Daginakatte
  • Biplab Dasgupta
  • Andrew L Kung

Detail Information

Publications13

  1. pmc Chemokine signaling in cancer: one hump or two?
    Joshua B Rubin
    Department of Pediatrics Division of Pediatric Hematology and Oncology, Campus Box 8208, 660 South Euclid Avenue, Washington University School of Medicine, St Louis, MO 63110, USA rubin
    Semin Cancer Biol 19:116-22. 2009
    ..The importance of testing this hypothesis lies in the possibility that targeting abnormal CXCR4 signaling might provide an anti-tumor effect without disturbing normal CXCR4 functions...
  2. pmc Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma
    Melissa Frei-Jones
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 2:125-9. 2008
    ..The authors present the case of an infant born with a life-threatening, unresectable intracranial hemangioma in which treatment with thalidomide resulted in a good clinical outcome...
  3. doi request reprint Only in congenial soil: the microenvironment in brain tumorigenesis
    Joshua B Rubin
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 19:144-9. 2009
    ..Each of these brain tumors is faithfully modeled in genetically engineered mice and the use of these mouse models to investigate the role of the microenvironment should yield exciting new insights into this important field of study...
  4. ncbi request reprint Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies
    B Mark Woerner
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 65:11392-9. 2005
    ....
  5. ncbi request reprint Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1
    Nicole M Warrington
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:8588-95. 2007
    ..Collectively, these studies provide a mechanism for the unique pattern of NF1-associated glioma growth...
  6. pmc CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice
    Tao Sun
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroimmunol 224:108-13. 2010
    ..Forced CXCL12 expression induced glioma at a low frequency. Further, treatment of Nf1 OPG mice with AMD3100, a CXCR4 antagonist, did not attenuate glioma growth. Thus, it appears, CXCL12 alone cannot promote gliomagenesis in NF1 mice...
  7. doi request reprint Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma
    Balazs Hegedus
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 68:1520-8. 2008
    ..Collectively, these findings suggest that this Nf1 optic glioma model may be a potential preclinical benchmark for identifying novel therapies that have a high likelihood of success in human clinical trials...
  8. ncbi request reprint Immune and nervous system CXCL12 and CXCR4: parallel roles in patterning and plasticity
    Robyn S Klein
    Division of Infectious Diseases, Departments of Pathology and Immunology and Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8051, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Trends Immunol 25:306-14. 2004
  9. doi request reprint Brainstem glioma presenting as pruritus in children with neurofibromatosis-1
    Rachel S Darken
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63119, USA
    J Pediatr Hematol Oncol 31:972-6. 2009
    ..This unusual presentation emphasizes the importance of appreciating subtle, often hard to localize, symptoms in this high-risk population...
  10. pmc Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
    Patricia Goldhoff
    Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:7717-25. 2008
    ..Previously, we identified the cyclic AMP phosphodiesterase-4 (PDE4) inhibitor Rolipram as a potent antitumor agent. Here, we investigate the role of PDE4 in brain tumors and examine the utility of PDE4 as a therapeutic target...
  11. pmc Feasibility of small animal cranial irradiation with the microRT system
    Erich L Kiehl
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Med Phys 35:4735-43. 2008
    ..To develop and validate methods for small-animal CNS radiotherapy using the microRT system...
  12. pmc Pathological expression of CXCL12 at the blood-brain barrier correlates with severity of multiple sclerosis
    Erin E McCandless
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Am J Pathol 172:799-808. 2008
    ....
  13. doi request reprint Postoperative imaging surveillance in pediatric pilocytic astrocytomas
    Ian G Dorward
    Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 6:346-52. 2010
    ..Whereas several reports recommend no postoperative imaging, one study proposed surveillance MR imaging studies to detect delayed recurrences...