T Rice

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Familial clustering of multiple measures of adiposity and fat distribution in the Québec Family Study: a trivariate analysis of percent body fat, body mass index, and trunk-to-extremity skinfold ratio
    T Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Int J Obes Relat Metab Disord 19:902-8. 1995
  2. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
  3. ncbi request reprint Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
  4. pmc Application of collapsing methods for continuous traits to the Genetic Analysis Workshop 17 exome sequence data
    Yun Ju Sung
    Division of Biostatistics, Washington University School of Medicine, 660 S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Proc 5:S121. 2011
  5. pmc Application of three-level linear mixed-effects model incorporating gene-age interactions for association analysis of longitudinal family data
    Gang Shi
    Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St, Louis, Missouri 63110, USA
    BMC Proc 3:S89. 2009
  6. pmc Comparison between single-marker analysis using Merlin and multi-marker analysis using LASSO for Framingham simulated data
    Yun Ju Sung
    Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St, Louis, Missouri 63110 1093, USA
    BMC Proc 3:S27. 2009
  7. pmc QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    BMC Med Genet 9:103. 2008
  8. pmc An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study
    Jun Wu
    Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO 63108, USA
    BMC Genet 8:60. 2007
  9. ncbi request reprint A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:848-55. 2002
  10. pmc Genome-wide association analysis of Framingham Heart Study data for the Genetics Analysis Workshop 16: effects due to medication use
    Treva K Rice
    Division of Biostatistics, Washington University School of Medicine, Box 8067, 660 South Euclid Avenue, St Louis, Missouri 63110 USA
    BMC Proc 3:S52. 2009

Collaborators

Detail Information

Publications77

  1. ncbi request reprint Familial clustering of multiple measures of adiposity and fat distribution in the Québec Family Study: a trivariate analysis of percent body fat, body mass index, and trunk-to-extremity skinfold ratio
    T Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Int J Obes Relat Metab Disord 19:902-8. 1995
    ..To assess whether independent or common (pleiotropic) familial factors (i.e., genetic and/or common environment) underlie the observed associations among measures of body mass, body fat, and its distribution...
  2. ncbi request reprint A quantitative trait locus on 7q31 for the changes in plasma insulin in response to exercise training: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Diabetes 52:1583-7. 2003
    ..The present findings may be important in identifying individuals at increased risk of developing type 2 diabetes and who are most likely to benefit from a physically active lifestyle...
  3. ncbi request reprint Meta-analysis of genome-wide scans for hypertension and blood pressure in Caucasians shows evidence of susceptibility regions on chromosomes 2 and 3
    Liisa Koivukoski
    Department of Endocrinology, Malmo University Hospital, Lund University, SE 205 02 Malmo, Sweden
    Hum Mol Genet 13:2325-32. 2004
    ..We conclude that modest or non-significant linkage on chromosomes 3p14.1-q12.3 and 2p12-q22.1 in each individual study translates into genome-wide significant or highly suggestive linkages to HT and DBP in our GSMA analysis...
  4. pmc Application of collapsing methods for continuous traits to the Genetic Analysis Workshop 17 exome sequence data
    Yun Ju Sung
    Division of Biostatistics, Washington University School of Medicine, 660 S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Proc 5:S121. 2011
    ..We also found that a large number of noncausal genes had high correlations with causal genes for Q1 and Q2, which may account for inflated false positives...
  5. pmc Application of three-level linear mixed-effects model incorporating gene-age interactions for association analysis of longitudinal family data
    Gang Shi
    Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St, Louis, Missouri 63110, USA
    BMC Proc 3:S89. 2009
    ..Gene-age interactions were evaluated under the same framework for detecting genetic effects that are modulated by age...
  6. pmc Comparison between single-marker analysis using Merlin and multi-marker analysis using LASSO for Framingham simulated data
    Yun Ju Sung
    Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St, Louis, Missouri 63110 1093, USA
    BMC Proc 3:S27. 2009
    ..The main difference between the two methods was that for the 14 SNPs near the causal SNPs, p-values from Merlin were the next smallest, whereas LASSO often excluded these non-causal neighboring SNPs entirely from the first 10,000 models...
  7. pmc QTLs of factors of the metabolic syndrome and echocardiographic phenotypes: the hypertension genetic epidemiology network study
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, Saint Louis, MO, USA
    BMC Med Genet 9:103. 2008
    ....
  8. pmc An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study
    Jun Wu
    Division of Statistical Genomics, Washington University School of Medicine, Campus Box 8506, 4444 Forest Park Boulevard, Saint Louis, MO 63108, USA
    BMC Genet 8:60. 2007
    ..We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis...
  9. ncbi request reprint A genomewide linkage scan for abdominal subcutaneous and visceral fat in black and white families: The HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 51:848-55. 2002
    ..Additional work in an independent sample is needed to verify the linkages for baseline AVF as well as the response measures...
  10. pmc Genome-wide association analysis of Framingham Heart Study data for the Genetics Analysis Workshop 16: effects due to medication use
    Treva K Rice
    Division of Biostatistics, Washington University School of Medicine, Box 8067, 660 South Euclid Avenue, St Louis, Missouri 63110 USA
    BMC Proc 3:S52. 2009
    ..In summary, we confirm that failure to properly account for medication usage can have a profound impact on genetic associations...
  11. ncbi request reprint Familial aggregation of blood lipid response to exercise training in the health, risk factors, exercise training, and genetics (HERITAGE) Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 105:1904-8. 2002
    ..Fasting levels of plasma lipids and lipoproteins are reported to improve with regular exercise training. However, little is known on whether the training responses are influenced by heritable factors...
  12. ncbi request reprint Familial resemblance for plasma leptin: sample homogeneity across adiposity and ethnic groups
    Treva Rice
    Division of Biostatistics, Departments of Genetics, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Obes Res 10:351-60. 2002
    ..Therefore, the purpose of this study was to investigate heterogeneity hypotheses across ethnic groups and by adiposity level, using the same statistical methods...
  13. ncbi request reprint Heritability of HR and BP response to exercise training in the HERITAGE Family Study
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Med Sci Sports Exerc 34:972-9. 2002
    ..The heritability of the response to exercise training in resting blood pressure (BP) and heart rate (HR) was assessed in 482 Caucasian individuals comprising 98 families participating in the HERITAGE Family Study...
  14. ncbi request reprint Genomewide linkage scan of resting blood pressure: HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Hypertension 39:1037-43. 2002
    ....
  15. ncbi request reprint Genome-wide linkage analysis of systolic and diastolic blood pressure: the Québec Family Study
    T Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 102:1956-63. 2000
    ..While some loci affecting BP variation are known (eg, angiotensinogen), there are likely to be novel signals that can be detected with a genome scan approach...
  16. ncbi request reprint Familial aggregation of body mass index and subcutaneous fat measures in the longitudinal Québec family study
    T Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 16:316-34. 1999
    ..In summary, simple univariate familial correlation analysis of the change scores and bivariate analysis of the longitudinal measures are useful in delineating the underlying factors leading to both change and stability across time...
  17. ncbi request reprint Segregation analysis of body mass index in a large sample selected for obesity: the Swedish Obese Subjects study
    T Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Obes Res 7:246-55. 1999
    ..The probands were recruited as part of an intervention trial assessing whether mortality and morbidity were improved after surgical intervention for obesity as part of the Swedish Obese Subjects (SOS) study...
  18. ncbi request reprint Genome-wide linkage scan to detect loci influencing levels of dehydroepiandrosterones in the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 50:1315-22. 2001
    ..This is the first genome-wide linkage scan searching for genomic regions influencing human DHEA levels. Several potential candidate genes are located in these genomic regions, which warrant further studies in HERITAGE and other cohorts...
  19. ncbi request reprint Familial clustering of insulin and abdominal visceral fat: the HERITAGE Family Study
    Y Hong
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Clin Endocrinol Metab 83:4239-45. 1998
    ..Genes involved in the regulation of lipid storage and mobilization in the abdominal fat depot are potential candidates for these genetic pleiotropic effects...
  20. ncbi request reprint Evidence of a major locus for lipoprotein lipase (LPL) activity in addition to a pleiotropic locus for both LPL and fasting insulin: results from the HERITAGE Family Study
    Y Hong
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Atherosclerosis 144:393-401. 1999
    ....
  21. ncbi request reprint Complex segregation analysis of blood pressure and heart rate measured before and after a 20-week endurance exercise training program: the HERITAGE Family Study
    P An
    Department of Genetics and Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Hypertens 13:488-97. 2000
    ..No familiality was found for resting DBP response to training. Resting HR response to training was influenced by a major effect (accounting for 35% of the variance), with an ambiguous transmission from parents to offspring...
  22. pmc Evidence for at least two major loci influencing human fatness
    I B Borecki
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 63:831-8. 1998
    ....
  23. ncbi request reprint Familial resemblance for glucose and insulin metabolism indices derived from an intravenous glucose tolerance test in Blacks and Whites of the HERITAGE Family Study
    Y Hong
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Genet 60:22-30. 2001
    ..Interestingly, Blacks have higher heritability for overall glucose tolerance than Whites but there is no race difference in heritability estimates for insulin sensitivity or insulin secretion...
  24. ncbi request reprint Familial aggregation of resting blood pressure and heart rate in a sedentary population: the HERITAGE Family Study. Health, Risk Factors, Exercise Training, and Genetics
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Hypertens 12:264-70. 1999
    ....
  25. ncbi request reprint Segregation analysis of apolipoproteins A-1 and B-100 measured before and after an exercise training program: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Arterioscler Thromb Vasc Biol 20:807-14. 2000
    ..Baseline apo B-100 was influenced by a putative major recessive gene with a multifactorial component, but its response to training was influenced solely by a multifactorial component in these sedentary families...
  26. ncbi request reprint Genome-wide scan to identify quantitative trait loci for baseline resting heart rate and its response to endurance exercise training: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Sports Med 27:31-6. 2006
    ..In conclusion, among QTLs on 1 q, 2 p, 3 p, 4 q, and 11 p that replicated across subsamples and studies, 11 p is most promising for dense mapping and association studies in HERITAGE and other cohorts...
  27. ncbi request reprint Familial resemblance for free androgens and androgen glucuronides in sedentary black and white individuals: the HERITAGE Family Study. Health, Risk Factors, Exercise Training and Genetics
    Y Hong
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Endocrinol 170:485-92. 2001
    ..In conclusion, plasma levels of androgens and androgen glucuronides are highly heritable in both white individuals and black individuals. There are notable sex differences in the white individuals...
  28. ncbi request reprint Population differences in the pattern of familial aggregation for sex hormone-binding globulin and its response to exercise training: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Hum Biol 13:832-7. 2001
    ..Whereas modest familial effects were detected for the training response in Whites, the lack of similar effects in Blacks may be due to the smaller sample size...
  29. ncbi request reprint Evidence of pleiotropic loci for fasting insulin, total fat mass, and abdominal visceral fat in a sedentary population: the HERITAGE family study
    Y Hong
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obes Res 8:151-9. 2000
    ..To examine whether there is a major gene effect on fasting insulin and pleiotropic loci for fasting insulin, total fat mass (FM), and abdominal visceral fat (AVF)...
  30. ncbi request reprint Genome-wide linkage scans for prediabetes phenotypes in response to 20 weeks of endurance exercise training in non-diabetic whites and blacks: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 South Euclid Avenue, St Louis, MO, 63110, USA
    Diabetologia 48:1142-9. 2005
    ....
  31. ncbi request reprint Familial aggregation of stroke volume and cardiac output during submaximal exercise: the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Int J Sports Med 21:566-72. 2000
    ..Not only genetic determinants but also familial non-genetic factors might attribute to the observed patterns of familial aggregation of SV and Qc during submaximal exercise in the present study...
  32. ncbi request reprint Race differences in the pattern of familial aggregation for dehydroepiandrosterone sulfate and its responsiveness to training in the HERITAGE Family Study
    P An
    Division of Biostatistics, Washington University School of Medicine, S Louis, MO 63110-1093, USA
    Metabolism 50:916-20. 2001
    ..Genetic and nongenetic familial components influencing baseline DHEAS levels in both races may be different...
  33. ncbi request reprint Familiality of triglyceride and LPL response to exercise training: the HERITAGE study
    Y Hong
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Med Sci Sports Exerc 32:1438-44. 2000
    ..e., by baseline triglyceride (TG(B)) and deltaTG and by baseline postheparin lipoprotein lipase (PH-LPL(B)) and deltaPH-LPL activity)...
  34. ncbi request reprint Genomic scan of glucose and insulin metabolism phenotypes: the HERITAGE Family Study
    Ping An
    Division of Biostatistics, and the Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 52:246-53. 2003
    ..Fine mapping and association studies of candidate genes within these genomic regions are warranted...
  35. ncbi request reprint Common genetic and environmental effects on lipid phenotypes: the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Hum Hered 59:34-40. 2005
    ..Our aim is to investigate pair-wise polygenic and environmental correlations among lipid-lipoprotein levels at baseline and in response to regular exercise in Whites and Blacks...
  36. ncbi request reprint A genetic study of cortisol measured before and after endurance training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, and Department of Genetics, Washington University School of Medicine, Saint Louis, MO 63110 1093, USA
    Metabolism 51:360-5. 2002
    ..The putative major gene effects appear to explain most of the observed familial resemblance, this will motivate further linkage and association studies...
  37. ncbi request reprint Pleiotropic QTL on chromosome 12q23-q24 influences triglyceride and high-density lipoprotein cholesterol levels: the HERITAGE family study
    Mary E Feitosa
    Division of Statistical Genomics in the Center for Genome Sciences, Washington University School of Medicine, Saint Louis, MO, USA
    Hum Biol 78:317-27. 2006
    ..Further investigation should confirm whether IGF1 or another nearby gene is responsible for the concomitant variation in TG and HDL-C levels...
  38. ncbi request reprint Pleiotropic QTL on chromosome 19q13 for triglycerides and adiposity: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Campus Box 8067, 660 S Euclid, St Louis, MO 63110 1093, USA
    Atherosclerosis 185:426-32. 2006
    ..Polymorphisms in the APOE gene, and possibly LIPE gene, appear to be strong candidates for the source of this pleiotropic QTL...
  39. ncbi request reprint Evidence of QTLs on chromosomes 13q and 14q for triglycerides before and after 20 weeks of exercise training: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Campus Box 8067 Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110 1093, USA
    Atherosclerosis 182:349-60. 2005
    ..It is interesting that the strongest signals were found for the LDL-TG and HDL-TG subfractions, given their particular relationships with the atherogenic lipid profile including dense LDL and HDL particles...
  40. ncbi request reprint Meta-analysis of genome-wide scans for blood pressure in African American and Nigerian samples. The National Heart, Lung, and Blood Institute GeneLink Project
    Treva Rice
    Division of Biostatistics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Hypertens 19:270-4. 2006
    ..However, the combined linkage evidence across several studies can be synthesized using meta-analysis with the aim of providing more definitive support of linkage...
  41. ncbi request reprint Trends in metabolic syndrome and gene networks in human and rodent models
    Aldi T Kraja
    Division of Statistical Genomics, Washington University School of Medicine, 4444 Forest Park Blvd, Campus Box 8506, Saint Louis, MO 63110, USA
    Endocr Metab Immune Disord Drug Targets 8:198-207. 2008
    ..Our results justify the existence of MetS as a meaningful syndrome and suggest that a better understanding of its etiology can benefit the health of human kind...
  42. pmc Factor relationships of metabolic syndrome and echocardiographic phenotypes in the HyperGEN study
    Pinchia Huang
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Hypertens 26:1360-6. 2008
    ..Metabolic syndrome and its risk factors are predictors of cardiovascular events. Metabolic syndrome is also directly associated with echocardiographic phenotypes...
  43. ncbi request reprint Evidence of QTLs on chromosomes 1q42 and 8q24 for LDL-cholesterol and apoB levels in the HERITAGE family study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, MO, USA
    J Lipid Res 46:281-6. 2005
    ..As there are no known strong candidate genes in these regions for lipids, follow-up studies to determine the source of those signals are needed...
  44. ncbi request reprint Pleiotropic relationships between cortisol levels and adiposity: The HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Obes Res 10:1222-31. 2002
    ..To investigate familial basis for the relationship between cortisol adiposity at baseline and their training responses...
  45. ncbi request reprint Major gene effects on exercise ventilatory threshold: the HERITAGE Family Study
    Mary F Feitosa
    Division of Biostatistics, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Appl Physiol (1985) 93:1000-6. 2002
    ....
  46. ncbi request reprint Genetic variant characterization in intron 4 of the surfactant protein B gene
    Aaron Hamvas
    Division of Newborn Medicine, Edward Mallinckrodt Department of Pediatrics, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri, USA
    Hum Mutat 26:494-5. 2005
    ..7, 95% CI 1.0-7.2). Reliable characterization of genetic variants in intron 4 requires both a high fidelity polymerase and sequencing of variant alleles...
  47. ncbi request reprint Quantitative trait locus on chromosome 20q13 for plasma levels of C-reactive protein in healthy whites: the HERITAGE Family Study
    Timo A Lakka
    Pennington Biomedical Research Center, Baton Rouge, Louisiana, USA
    Physiol Genomics 27:103-7. 2006
    ..The present findings may be useful in the ongoing effort to search for genes contributing to inflammation and to identify individuals at an increased risk of chronic inflammatory diseases...
  48. ncbi request reprint Comprehensive linkage and linkage heterogeneity analysis of 4344 sibling pairs affected with hypertension from the Family Blood Pressure Program
    Tiffany A Greenwood
    Polymorphism Research Laboratory, Department of Psychiatry, University of California, San Diego, La Jolla, California 92093 0603, USA
    Genet Epidemiol 31:195-210. 2007
    ..Ultimately our results suggest that evidence for linkage heterogeneity can only be detected with large sample sizes, such as the FBPP, which is consistent with theoretical sample size calculations...
  49. ncbi request reprint Quantitative trait locus on 15q for a metabolic syndrome variable derived from factor analysis
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Sainte Foy, Quebec G1V 4G2, Canada
    Obesity (Silver Spring) 15:544-50. 2007
    ..75) was also observed on chromosomes 1p, 3p, 3q, 6q, 7p, 19q, and 21q. These quantitative trait loci may harbor genes contributing to the clustering of the metabolic syndrome-related phenotypes...
  50. ncbi request reprint CETP genotypes and HDL-cholesterol phenotypes in the HERITAGE Family Study
    Nadine Spielmann
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University System, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 31:25-31. 2007
    ..The CETP and APOE genotypes account for up to 9% of the variance in HDL-c phenotypes in the HERITAGE Family Study...
  51. ncbi request reprint Leptin and leptin receptor gene polymorphisms and changes in glucose homeostasis in response to regular exercise in nondiabetic individuals: the HERITAGE family study
    Timo A Lakka
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808 4124, USA
    Diabetes 53:1603-8. 2004
    ..Similar interaction was observed in blacks (P = 0.046). Variations in the LEP and LEPR genes are associated with the magnitude of the effects of regular exercise on glucose homeostasis in nondiabetic individuals...
  52. ncbi request reprint Cardiorespiratory fitness, BMI, and risk of hypertension: the HYPGENE study
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 39:1687-92. 2007
    ..Genetic factors contribute significantly to the interindividual differences in endurance training-induced changes in BP. However, similar data on the genotype-by-fitness interactions on the risk of hypertension are scarce...
  53. ncbi request reprint Genome-wide linkage scan for submaximal exercise heart rate in the HERITAGE family study
    Nadine Spielmann
    Pennington Biomedical Research Center, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Physiol Heart Circ Physiol 293:H3366-71. 2007
    ..The most promising regions for fine mapping in the HERITAGE Family Study were found on 2q33 for HR50 training response in whites, on 10q25-26 for baseline HR60 in blacks, and on 18q21-22 for both baseline HR50 and DeltaHR60 in whites...
  54. ncbi request reprint Effect of endothelin 1 genotype on blood pressure is dependent on physical activity or fitness levels
    Tuomo Rankinen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Hypertension 50:1120-5. 2007
    ..Our study provides an illustrative example of how physical activity and fitness level modifies the associations between a candidate gene and outcome phenotype...
  55. ncbi request reprint Genome-wide linkage scan for exercise stroke volume and cardiac output in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 10:57-62. 2002
    ..3, 3q13.3, 12q13.2) and one for baseline SV50 and Q50 (10p14). All these chromosomal regions include several potential candidate genes and therefore warrant further studies in the HERITAGE cohort and other studies...
  56. ncbi request reprint Familial resemblance of 7-year changes in body mass and adiposity
    Melanie S Hunt
    School of Kinesiology and Health Science, York University, Toronto, Ontario, Canada
    Obes Res 10:507-17. 2002
    ..To investigate the familial resemblance of 7-year changes in body mass and adiposity among Canadian families...
  57. ncbi request reprint G protein beta 3 polymorphism and hemodynamic and body composition phenotypes in the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 8:151-7. 2002
    ..The GNB3 genotype may play a minor role in HR and body fatness regulation in blacks and in responsiveness of resting BP to endurance training in black women...
  58. ncbi request reprint Uncoupling protein 3 gene is associated with body composition changes with training in HERITAGE study
    Christian Marc Lanouette
    Hôpital Laval and Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Laval University, Sainte Foy, Quebec, Canada G1K 7P4
    J Appl Physiol (1985) 92:1111-8. 2002
    ..0006), with a borderline result for body mass index (P = 0.06). We concluded that UCP3 could be involved in body composition changes after regular exercise...
  59. ncbi request reprint Titin is a candidate gene for stroke volume response to endurance training: the HERITAGE Family Study
    Tuomo Rankinen
    Pennington Biomedical Research Center, Human Genomics Laboratory, Baton Rouge, Louisiana 70808 4124, USA
    Physiol Genomics 15:27-33. 2003
    ..Since TTN is the largest gene in the human genome, the challenge is to identify the DNA sequence variants contributing to the interindividual differences in cardiac adaptation to endurance training...
  60. ncbi request reprint Genome-wide linkage scan for physical activity levels in the Quebec Family study
    Riitta L Simonen
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 35:1355-9. 2003
    ..Four physical activity level phenotypes were used...
  61. ncbi request reprint Compendium of genome-wide scans of lipid-related phenotypes: adding a new genome-wide search of apolipoprotein levels
    Yohan Bosse
    Lipid Research Center, Laval University Medical Research Center, Quebec, Canada
    J Lipid Res 45:2174-84. 2004
    ..However, concerns arise when displaying all data on the same map, because a large portion of the genome is now covered with loci supported by at least suggestive evidence of linkage...
  62. ncbi request reprint Linkage analysis of diabetes status among hypertensive families: the Hypertension Genetic Epidemiology Network study
    Christy L Avery
    Department of Epidemiology, University of North Carolina Chapel Hill, Chapel Hill, NC 27514, USA
    Diabetes 53:3307-12. 2004
    ..The identification and replication of type 2 diabetes QTLs will bring us closer to the detection of functional genes that influence diabetes susceptibility...
  63. ncbi request reprint A genome-wide linkage scan for dietary energy and nutrient intakes: the Health, Risk Factors, Exercise Training, and Genetics (HERITAGE) Family Study
    Agron Collaku
    Human Genomics Laboratory, Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, LA 70808 4124, USA
    Am J Clin Nutr 79:881-6. 2004
    ..A poor diet is a risk factor for chronic diseases such as obesity, cardiovascular disease, hypertension, and some cancers. Twin and family studies suggest that genetic factors potentially influence energy and nutrient intakes...
  64. ncbi request reprint Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity
    Luigi Bouchard
    Division of Kinesiology, Department of Social and Preventive Medicine, Faculty of Medicine, Lipid Research Centre, Canada
    Am J Clin Nutr 80:1478-86. 2004
    ..Obesity is frequently associated with eating disorders, and evidence indicates that both conditions are influenced by genetic factors. However, little is known about the genes influencing eating behaviors...
  65. ncbi request reprint Genome-wide linkage scan for the metabolic syndrome in the HERITAGE Family Study
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 88:5935-43. 2003
    ..Some of these chromosomal regions harbor promising potential candidate genes...
  66. pmc Acetylcholinesterase/paraoxonase genotype and expression predict anxiety scores in Health, Risk Factors, Exercise Training, and Genetics study
    Ella H Sklan
    Department of Biological Chemistry, Hebrew University of Jerusalem, Jerusalem 91904, Israel
    Proc Natl Acad Sci U S A 101:5512-7. 2004
    ....
  67. ncbi request reprint Hepatic lipase gene variant -514C>T is associated with lipoprotein and insulin sensitivity response to regular exercise: the HERITAGE Family Study
    Margarita Teran-Garcia
    Human Genomics Laboratory, Pennington Biomedical Research Center, 6400 Perkins Rd, Baton Rouge, LA 70808, USA
    Diabetes 54:2251-5. 2005
    ..The benefits from an exercise program on Si are likely to be substantial in the general population given the high frequency of the LIPC -514C allele, particularly in whites...
  68. ncbi request reprint Two ethnic-specific polymorphisms in the human Agouti-related protein gene are associated with macronutrient intake
    Ruth J F Loos
    Human Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Am J Clin Nutr 82:1097-101. 2005
    ..Exogenous administration of AGRP in rodents predisposes to high fat and high sugar intakes...
  69. ncbi request reprint Heritability of LDL peak particle diameter in the Quebec Family Study
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Quebec City, Quebec, Canada
    Genet Epidemiol 25:375-81. 2003
    ..These results suggest that LDL-PPD strongly aggregates in families, and that the familial resemblance appears to be primarily attributable to genetic factors. Genes responsible for this genetic contribution remain to be identified...
  70. ncbi request reprint The TNF-alpha G-308A polymorphism is associated with C-reactive protein levels: the HERITAGE Family Study
    Hanna Maaria Lakka
    Pennington Biomedical Research Center, Louisiana State University, 6400 Perkins Road, Baton Rouge, Louisiana 70808 4124, USA
    Vascul Pharmacol 44:377-83. 2006
    ..Pro-inflammatory cytokines, such as tumor necrosis factor alpha (TNF-alpha), stimulate the release of C-reactive protein (CRP). We investigated the association between the TNF-alpha G-308A polymorphism and plasma CRP levels...
  71. ncbi request reprint A polymorphism in the human agouti-related protein is associated with late-onset obesity
    George Argyropoulos
    Pennington Biomedical Research Center, Louisiana State University, Baton Rouge, Louisiana 70808, USA
    J Clin Endocrinol Metab 87:4198-202. 2002
    ..The c.199G-->A polymorphism in hAGRP could, therefore, play a role in the development of human obesity in an age-dependent fashion...
  72. pmc Association between blood pressure responses to the cold pressor test and dietary sodium intervention in a Chinese population
    Jing Chen
    Department of Medicine, Tulane University School of Medicine, 1443 Tulane Ave SL45, New Orleans, LA 70112, USA
    Arch Intern Med 168:1740-6. 2008
    ..We examined the association between BP responses to the CPT and to dietary sodium and potassium interventions...
  73. pmc Heritability of blood pressure responses to dietary sodium and potassium intake in a Chinese population
    Dongfeng Gu
    Cardiovascular Institute and Fu Wai Hospital, Beijing, China
    Hypertension 50:116-22. 2007
    ..In addition, the heritabilities of blood pressure responses to dietary sodium and potassium intake were moderate in this study population...
  74. ncbi request reprint Familial aggregation of physical activity levels in the Québec Family Study
    Riita L Simonen
    Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA
    Med Sci Sports Exerc 34:1137-42. 2002
    ..Familial aggregation of physical activity phenotypes was investigated in 696 subjects from 200 families of the Quebec Family Study. The mean age of offspring and parents was 27 and 53 yr, respectively...
  75. ncbi request reprint Familial resemblance in eating behaviors in men and women from the Quebec Family Study
    Véronique Provencher
    Department of Food Sciences and Nutrition, Laval University, Quebec, Canada
    Obes Res 13:1624-9. 2005
    ..The purpose of this study was to estimate the degree of familial resemblance in eating behavioral traits (cognitive dietary restraint, disinhibition, and susceptibility to hunger)...
  76. ncbi request reprint Evidence for a major quantitative trait locus on chromosome 17q21 affecting low-density lipoprotein peak particle diameter
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, Laval University, Sainte Foy, Quebec, G1V 4G2, Canada
    Circulation 107:2361-8. 2003
    ..However, association and linkage analyses have thus far been inconclusive in identifying the underlying gene(s)...
  77. ncbi request reprint Detection of a major gene effect for LDL peak particle diameter and association with apolipoprotein H gene haplotype
    Yohan Bosse
    Lipid Research Center, CHUL Research Center, TR 93, 2705 Laurier Blvd Sainte Foy, Que, Canada G1V 4G2
    Atherosclerosis 182:231-9. 2005
    ..Replication of the association between apolipoprotein H gene haplotype and LDL-PPD is required before reaching firm conclusion...