Affiliation: Washington University School of Medicine
Li G, Khandekar A, Yin T, Hicks S, Guo Q, Takahashi K, et al
. Differential Wnt-mediated programming and arrhythmogenesis in right versus left ventricles. J Mol Cell Cardiol. 2018;123:92-107 pubmed publisher
..These data show that embryonic perturbation of Wnt signaling in cardiomyocytes leads to right ventricular arrhythmia susceptibility in the adult heart through chamber-specific regulation of genes regulating cellular electrophysiology. ..
Meyers J, Jay P, Rentschler S. Reprogramming the conduction system: Onward toward a biological pacemaker. Trends Cardiovasc Med. 2016;26:14-20 pubmed publisher
..Here, we review experimental progress in animal models and discuss future directions, with a focus on reprogramming endogenous cells in the heart to treat defects of rhythm and conduction. ..
Lipovsky C, Brumback B, Khandekar A, Rentschler S. Multi-Scale Assessments of Cardiac Electrophysiology Reveal Regional Heterogeneity in Health and Disease. J Cardiovasc Dev Dis. 2018;5: pubmed publisher
Gillers B, Chiplunkar A, Aly H, Valenta T, Basler K, Christoffels V, et al
. Canonical wnt signaling regulates atrioventricular junction programming and electrophysiological properties. Circ Res. 2015;116:398-406 pubmed publisher
..Our data further suggest that ventricular pre-excitation may require both morphological patterning defects, as well as myocardial lineage reprogramming, to allow robust conduction across accessory pathway tissue. ..
Qiao Y, Lipovsky C, HICKS S, Bhatnagar S, Li G, Khandekar A, et al
. Transient Notch Activation Induces Long-Term Gene Expression Changes Leading to Sick Sinus Syndrome in Mice. Circ Res. 2017;121:549-563 pubmed publisher
..Notch reactivation induces electrical changes, resulting in sinus bradycardia, sinus pauses, and a susceptibility to atrial arrhythmias, which contribute to a phenotype resembling sick sinus syndrome. ..