Research Topics
Species | L RatnerSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Chemotherapy for human immunodeficiency virus-associated non-Hodgkin's lymphoma in combination with highly active antiretroviral therapyL Ratner
AIDS Malignancy Consortium Operation Center, University of Alabama, Birmingham, USA
J Clin Oncol 19:2171-8. 2001..In addition, the effects on viral load, CD4 counts, and opportunistic infections were examined with the use of combination chemotherapy combined with HAART...- Studies of the immortalizing activity of HTLV type 1 Tax, using an infectious molecular clone and transgenic miceL Ratner
Washington University School of Medicine, St Louis, Missouri 63110, USA
AIDS Res Hum Retroviruses 16:1647-51. 2000..A mutation disrupting Tax interaction with CREB-binding protein, CBP, did not affect lymphocyte immortalization by the infectious molecular clone. These models provide new insights into the molecular details of HTLV-1 leukemogenesis... - The contribution of NF-kappa B activity to spontaneous proliferation and resistance to apoptosis in human T-cell leukemia virus type 1 Tax-induced tumorsT Portis
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Blood 98:1200-8. 2001..These results strongly suggest that Tax-mediated induction of NF-kappa B activity contributes to tumorigenesis in vivo. (Blood. 2001;98:1200-1208).. 
Analysis of p53 inactivation in a human T-cell leukemia virus type 1 Tax transgenic mouse modelT Portis
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Virol 75:2185-93. 2001..These studies suggest that functional inactivation of p53 by HTLV-1 Tax, whether by mutation or another mechanism, is not critical for initial tumor formation, but contributes to late-stage tumor progression...- Dual regulation of silent and productive infection in monocytes by distinct human immunodeficiency virus type 1 determinantsP Westervelt
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110
J Virol 66:3925-31. 1992..These findings indicate a central role for the "accessory" genes vpu and vpr in productive human immunodeficiency virus type 1 replication in monocytes and indicate that vpu and vpr may be capable of functional complementation... - Sequence heterogeneity of Nef transcripts in HIV-1-infected subjects at different stages of diseaseL Ratner
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Virology 223:245-50. 1996..Functional analyses of a representative clone from each of the remaining 9 subjects showed that all nef alleles were capable of CD4 cell surface down-regulation, but only three nef alleles suppressed the induction of IL-2 transcription... - The HTLV receptor is a widely expressed proteinS R Trejo
Washington University School of Medicine, St Louis, Missouri, 63110, USA
Virology 268:41-8. 2000..Trypsin treatment of susceptible target lymphocytes reduced entry. Entry was partially resistant to ammonium chloride... - Viral protein U (Vpu)-mediated enhancement of human immunodeficiency virus type 1 particle release depends on the rate of cellular proliferationA Deora
Departments of Medicine, Pathology, and Molecular Microbiology, Washington University School of Medicine, 660 S. Euclid Ave, St. Louis, Missouri 63110, USA
J Virol 75:6714-8. 2001..In contrast, actively proliferating cells did not exhibit enhanced particle release with Vpu expression. This study demonstrates the necessity of Vpu for efficient viral particle release from quiescent cells... - A lymphoproliferative disorder caused by human T-lymphotropic virus type I. Demonstration of a continuum between acute and chronic adult T-cell leukemia/lymphomaL Ratner
Department of Medicine, Washington University, St Louis, Missouri 63110
Am J Med 83:953-8. 1987..A lymphoproliferative disorder developed that might be considered as a transition stage between acute and chronic adult T-cell leukemia/lymphoma. This suggests that HTLV-I-induced neoplasias represent a continuous disease spectrum... - Sensitivity of human immunodeficiency virus type 1 to fusion inhibitors targeted to the gp41 first heptad repeat involves distinct regions of gp41 and is consistently modulated by gp120 interactions with the coreceptorC A Derdeyn
Department of Microbiology, Birmingham, Alabama 35294, USA
J Virol 75:8605-14. 2001.... - Characterization of envelope glycoprotein mutants for human T-cell leukemia virus type 1 infectivity and immortalizationT Tsukahara
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Virol 75:9553-9. 2001..These results indicate that HTLV-1 spread is required for immortalization... - Phase I study of pegylated liposomal doxorubicin and the multidrug-resistance modulator, valspodarP M Fracasso
Alvin J Siteman Cancer Center and the Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Br J Cancer 93:46-53. 2005..009). Treatment with PEG-LD 25 mg m(-2) in combination with valspodar results in a moderate prolongation of total doxorubicin clearance and half-life but did not increase the toxicity of this agent...