Research Topics
| Ramakrishna U RaoSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
Endosymbiotic Wolbachia of parasitic filarial nematodes as drug targetsRamakrishna U Rao
Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
Indian J Med Res 122:199-204. 2005..In this review, the current knowledge of Wolbachia as a drug target and potential ways to reduce the infection through anti-Wolbachia treatments is discussed...
Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodesRamakrishna U Rao
Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
Exp Parasitol 121:38-45. 2009..Neither NTZ nor TZ cleared adult worms or microfilariae in infected gerbils. These results show that NTZ and TZ have potent effects on B. malayi nematodes in vitro. However, they were not effective in vivo...- Transglutaminases of lower organismsRamakrishna U Rao
Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St. Louis, MO 63110, USA
Prog Exp Tumor Res 38:209-22. 2005 - Effects of gamma radiation on Brugia malayi infective larvae and their intracellular Wolbachia bacteriaR Rao
Infectious Diseases Division, Department of Internal Medicine, School of Medicine, Washington University, Campus Box 8051, 660 S Euclid Ave, St Louis, MO 63110, USA
Parasitol Res 97:219-27. 2005..In contrast, jirds injected with irradiated L3 did not develop microfilaremia or antibodies to wsp. Additional studies are needed to test the hypothesis that irradiation retards growth and development of filarial L3 by killing Wolbachia... 
A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNARamakrishna U Rao
Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
Trans R Soc Trop Med Hyg 103:365-70. 2009..bancrofti and Plasmodium spp. in human populations and for assessing the impact of interventions aimed at controlling or eliminating these diseases...- Brugia malayi: effects of gamma radiation on adult worms and their intracellular Wolbachia bacteriaRamakrishna U Rao
Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
Exp Parasitol 109:87-93. 2005..These effects are essentially the same as those observed in adult worms treated with doxycycline. These studies suggest that effects of irradiation on reproduction in Brugia malayi may be caused by effects of irradiation on Wolbachia... - Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasisPeter Fischer
Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Trop Med Hyg 76:502-7. 2007.... - A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoesRamakrishna U Rao
Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Trop Med Hyg 74:826-32. 2006..We believe that real-time PCR has great potential as a tool for monitoring progress in large-scale filariasis elimination programs... - Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivoRamakrishna U Rao
Infectious Diseases Division, Department of Internal Medicine, St, Louis, Missouri, USA
J Biomed Sci 19:21. 2012..Most filarial nematodes contain Wolbachia symbionts. The purpose of this study was to examine the effects of doxycycline on gene expression in Wolbachia and adult female Brugia malayi... - Detection of Brugia parasite DNA in human blood by real-time PCRRamakrishna U Rao
Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8051, St Louis, MO 63110, USA
J Clin Microbiol 44:3887-93. 2006..timori endemicity on Alor Island, Indonesia, where microfilaria-positive individuals had low densities after mass treatment. Thus, the Eclipse MGB real-time PCR assay is a sensitive means of detecting Brugia parasite DNA in human blood... - Brugia malayi: effects of antibacterial agents on larval viability and development in vitroRamakrishna U Rao
Infectious Diseases Division, Internal Medicine Department, Barnes Jewish Hospital and Washington University, School of Medicine, St Louis, MO 63110, USA
Exp Parasitol 101:77-81. 2002..While it is possible that antibiotics directly affect filarial L3, we believe it is more likely that the effects seen are indirect effects related to bacterial killing... - In vitro effects of antibiotics on Brugia malayi worm survival and reproductionR Rao
Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, Missouri, USA
J Parasitol 88:605-11. 2002..These studies show that antibiotics active against Rickettsiaceae affect adult B. malayi worms and Mf in vitro. Additional studies will be needed to elucidate the mechanisms of action of these antibiotics on Wolbachia and filarial worms... - Transglutaminases, thioredoxins and protein disulphide isomerase: diverse enzymes with a common goal of cross-linking proteins in lower organismsRamakrishna U Rao
Washington University School of Medicine, St Louis, Missouri, USA
Indian J Exp Biol 42:235-43. 2004..Special reference is made to filarial nematode and bacterial TGases since they are the most well-characterized and studied enzymes among non-mammalian TGases...