Ramakrishna U Rao

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 121:38-45. 2009
  2. ncbi request reprint Endosymbiotic Wolbachia of parasitic filarial nematodes as drug targets
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Indian J Med Res 122:199-204. 2005
  3. ncbi request reprint Effects of gamma radiation on Brugia malayi infective larvae and their intracellular Wolbachia bacteria
    R Rao
    Infectious Diseases Division, Department of Internal Medicine, School of Medicine, Washington University, Campus Box 8051, 660 S Euclid Ave, St Louis, MO 63110, USA
    Parasitol Res 97:219-27. 2005
  4. ncbi request reprint Transglutaminases of lower organisms
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Prog Exp Tumor Res 38:209-22. 2005
  5. pmc A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Trans R Soc Trop Med Hyg 103:365-70. 2009
  6. ncbi request reprint Brugia malayi: effects of gamma radiation on adult worms and their intracellular Wolbachia bacteria
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 109:87-93. 2005
  7. pmc Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasis
    Peter Fischer
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 76:502-7. 2007
  8. pmc A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 74:826-32. 2006
  9. pmc Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, St, Louis, Missouri, USA
    J Biomed Sci 19:21. 2012
  10. ncbi request reprint Brugia malayi: effects of antibacterial agents on larval viability and development in vitro
    Ramakrishna U Rao
    Infectious Diseases Division, Internal Medicine Department, Barnes Jewish Hospital and Washington University, School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 101:77-81. 2002

Detail Information

Publications15

  1. doi request reprint Brugia malayi: Effects of nitazoxanide and tizoxanide on adult worms and microfilariae of filarial nematodes
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 121:38-45. 2009
    ..Neither NTZ nor TZ cleared adult worms or microfilariae in infected gerbils. These results show that NTZ and TZ have potent effects on B. malayi nematodes in vitro. However, they were not effective in vivo...
  2. ncbi request reprint Endosymbiotic Wolbachia of parasitic filarial nematodes as drug targets
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Indian J Med Res 122:199-204. 2005
    ..In this review, the current knowledge of Wolbachia as a drug target and potential ways to reduce the infection through anti-Wolbachia treatments is discussed...
  3. ncbi request reprint Effects of gamma radiation on Brugia malayi infective larvae and their intracellular Wolbachia bacteria
    R Rao
    Infectious Diseases Division, Department of Internal Medicine, School of Medicine, Washington University, Campus Box 8051, 660 S Euclid Ave, St Louis, MO 63110, USA
    Parasitol Res 97:219-27. 2005
    ..In contrast, jirds injected with irradiated L3 did not develop microfilaremia or antibodies to wsp. Additional studies are needed to test the hypothesis that irradiation retards growth and development of filarial L3 by killing Wolbachia...
  4. ncbi request reprint Transglutaminases of lower organisms
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Prog Exp Tumor Res 38:209-22. 2005
  5. pmc A qPCR-based multiplex assay for the detection of Wuchereria bancrofti, Plasmodium falciparum and Plasmodium vivax DNA
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Trans R Soc Trop Med Hyg 103:365-70. 2009
    ..bancrofti and Plasmodium spp. in human populations and for assessing the impact of interventions aimed at controlling or eliminating these diseases...
  6. ncbi request reprint Brugia malayi: effects of gamma radiation on adult worms and their intracellular Wolbachia bacteria
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 109:87-93. 2005
    ..These effects are essentially the same as those observed in adult worms treated with doxycycline. These studies suggest that effects of irradiation on reproduction in Brugia malayi may be caused by effects of irradiation on Wolbachia...
  7. pmc Persistence of Brugia malayi DNA in vector and non-vector mosquitoes: implications for xenomonitoring and transmission monitoring of lymphatic filariasis
    Peter Fischer
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 76:502-7. 2007
    ....
  8. pmc A real-time PCR-based assay for detection of Wuchereria bancrofti DNA in blood and mosquitoes
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Trop Med Hyg 74:826-32. 2006
    ..We believe that real-time PCR has great potential as a tool for monitoring progress in large-scale filariasis elimination programs...
  9. pmc Effects of doxycycline on gene expression in Wolbachia and Brugia malayi adult female worms in vivo
    Ramakrishna U Rao
    Infectious Diseases Division, Department of Internal Medicine, St, Louis, Missouri, USA
    J Biomed Sci 19:21. 2012
    ..Most filarial nematodes contain Wolbachia symbionts. The purpose of this study was to examine the effects of doxycycline on gene expression in Wolbachia and adult female Brugia malayi...
  10. ncbi request reprint Brugia malayi: effects of antibacterial agents on larval viability and development in vitro
    Ramakrishna U Rao
    Infectious Diseases Division, Internal Medicine Department, Barnes Jewish Hospital and Washington University, School of Medicine, St Louis, MO 63110, USA
    Exp Parasitol 101:77-81. 2002
    ..While it is possible that antibiotics directly affect filarial L3, we believe it is more likely that the effects seen are indirect effects related to bacterial killing...
  11. pmc Detection of Brugia parasite DNA in human blood by real-time PCR
    Ramakrishna U Rao
    Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8051, St Louis, MO 63110, USA
    J Clin Microbiol 44:3887-93. 2006
    ..timori endemicity on Alor Island, Indonesia, where microfilaria-positive individuals had low densities after mass treatment. Thus, the Eclipse MGB real-time PCR assay is a sensitive means of detecting Brugia parasite DNA in human blood...
  12. pmc Using existing drugs as leads for broad spectrum anthelmintics targeting protein kinases
    Christina M Taylor
    The Genome Institute, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Pathog 9:e1003149. 2013
    ..elegans, and six compounds also showed efficacy in at least one of the parasitic species. Hypotheses regarding the pathway the compounds may target and their molecular mechanism for activity are discussed...
  13. ncbi request reprint In vitro effects of antibiotics on Brugia malayi worm survival and reproduction
    R Rao
    Department of Internal Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, Missouri, USA
    J Parasitol 88:605-11. 2002
    ..These studies show that antibiotics active against Rickettsiaceae affect adult B. malayi worms and Mf in vitro. Additional studies will be needed to elucidate the mechanisms of action of these antibiotics on Wolbachia and filarial worms...
  14. ncbi request reprint Transglutaminases, thioredoxins and protein disulphide isomerase: diverse enzymes with a common goal of cross-linking proteins in lower organisms
    Ramakrishna U Rao
    Washington University School of Medicine, St Louis, Missouri, USA
    Indian J Exp Biol 42:235-43. 2004
    ..Special reference is made to filarial nematode and bacterial TGases since they are the most well-characterized and studied enzymes among non-mammalian TGases...
  15. pmc Integrated school-based surveillance for soil-transmitted helminth infections and lymphatic filariasis in Gampaha district, Sri Lanka
    Sharmini Gunawardena
    Department of Parasitology, Faculty of Medicine, University of Colombo, Sri Lanka Department of Parasitology, Faculty of Medicine, University of Kelaniya, Sri Lanka Anti Filariasis Campaign, Ministry of Health, Sri Lanka Department of Internal Medicine, Infectious Diseases Division, Washington University School of Medicine, St Louis, Missouri Centre for Neglected Tropical Diseases, Liverpool School of Tropical Medicine, United Kingdom
    Am J Trop Med Hyg 90:661-6. 2014
    ..The added cost of including STH testing was ∼$5,000 per EU. These results suggest that it is feasible to integrate school-based surveillance for STH and LF...