Marcus E Raichle

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Brain work and brain imaging
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 29:449-76. 2006
  2. ncbi request reprint Neuroscience. The brain's dark energy
    Marcus E Raichle
    Department of Radiology corrected, Washington University School of Medicine, St Louis, MO 63110, USA corrected
    Science 314:1249-50. 2006
  3. pmc The restless brain
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Brain Connect 1:3-12. 2011
  4. doi request reprint Two views of brain function
    Marcus E Raichle
    Departments of Radiology, Neurology, Neurobiology and Biomedical Engineering, Washington University School of Medicine, 4525 Scott Avenue, Room 2116, St Louis, MO 63110, USA
    Trends Cogn Sci 14:180-90. 2010
  5. doi request reprint Chapter 18: the origins of functional brain imaging in humans
    Marcus E Raichle
    Department of Radiology and Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Handb Clin Neurol 95:257-68. 2010
  6. pmc Appraising the brain's energy budget
    Marcus E Raichle
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:10237-9. 2002
  7. ncbi request reprint Functional brain imaging and human brain function
    Marcus E Raichle
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:3959-62. 2003
  8. ncbi request reprint Intrinsic brain activity sets the stage for expression of motivated behavior
    Marcus E Raichle
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Comp Neurol 493:167-76. 2005
  9. doi request reprint A brief history of human brain mapping
    Marcus E Raichle
    Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Trends Neurosci 32:118-26. 2009
  10. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001

Detail Information

Publications90

  1. ncbi request reprint Brain work and brain imaging
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 29:449-76. 2006
    ..Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity...
  2. ncbi request reprint Neuroscience. The brain's dark energy
    Marcus E Raichle
    Department of Radiology corrected, Washington University School of Medicine, St Louis, MO 63110, USA corrected
    Science 314:1249-50. 2006
  3. pmc The restless brain
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Brain Connect 1:3-12. 2011
    ..In this essay, some of the unique features of intrinsic activity are reviewed, as it relates to our understanding of brain organization...
  4. doi request reprint Two views of brain function
    Marcus E Raichle
    Departments of Radiology, Neurology, Neurobiology and Biomedical Engineering, Washington University School of Medicine, 4525 Scott Avenue, Room 2116, St Louis, MO 63110, USA
    Trends Cogn Sci 14:180-90. 2010
    ....
  5. doi request reprint Chapter 18: the origins of functional brain imaging in humans
    Marcus E Raichle
    Department of Radiology and Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Handb Clin Neurol 95:257-68. 2010
    ..While much of this work has transpired over the past couple of decades, its roots can be traced back more than a century...
  6. pmc Appraising the brain's energy budget
    Marcus E Raichle
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:10237-9. 2002
  7. ncbi request reprint Functional brain imaging and human brain function
    Marcus E Raichle
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 23:3959-62. 2003
  8. ncbi request reprint Intrinsic brain activity sets the stage for expression of motivated behavior
    Marcus E Raichle
    Department of Radiology, Washington University, St Louis, Missouri 63110, USA
    J Comp Neurol 493:167-76. 2005
    ..Distinguishing intrinsic from evoked activity in the context of functional brain imaging experiments is challenging, however. Here we review some evolving strategies for doing so...
  9. doi request reprint A brief history of human brain mapping
    Marcus E Raichle
    Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Trends Neurosci 32:118-26. 2009
    ..Although much of this work has transpired over the past couple of decades, its roots can be traced back more than a century...
  10. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors...
  11. ncbi request reprint A default mode of brain function: a brief history of an evolving idea
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 37:1083-90; discussion 1097-9. 2007
    ..Most critically, this work has called attention to the importance of intrinsic functional activity in assessing brain behavior relationships...
  12. pmc The neural correlates of consciousness: an analysis of cognitive skill learning
    M E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Philos Trans R Soc Lond B Biol Sci 353:1889-901. 1998
    ....
  13. doi request reprint Mapping the human brain at rest with diffuse optical tomography
    Brian R White
    Department of Physics, Washington University, St Louis, MO, USA
    Conf Proc IEEE Eng Med Biol Soc 2009:4070-2. 2009
    ....
  14. pmc Modulation of the brain's functional network architecture in the transition from wake to sleep
    Linda J Larson-Prior
    Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University in St Louis, St Louis, MO, USA
    Prog Brain Res 193:277-94. 2011
    ..These data clarify the complex and dynamic nature of the transitional period between wake and sleep and suggest the need for more studies investigating the dynamics of these processes...
  15. pmc Distinct brain networks for adaptive and stable task control in humans
    Nico U F Dosenbach
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:11073-8. 2007
    ..These two independent networks appear to operate on different time scales and affect downstream processing via dissociable mechanisms...
  16. ncbi request reprint Transient BOLD responses at block transitions
    Michael D Fox
    Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 28:956-66. 2005
    ..Relevance of the current findings to studies of exogenous attention, task shifting, and the BOLD overshoot is discussed...
  17. pmc Preoperative sensorimotor mapping in brain tumor patients using spontaneous fluctuations in neuronal activity imaged with functional magnetic resonance imaging: initial experience
    Dongyang Zhang
    Department of Radiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Neurosurgery 65:226-36. 2009
    ..To describe initial experience with resting-state correlation mapping as a potential aid for presurgical planning of brain tumor resection...
  18. pmc Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 67:584-7. 2010
    ....
  19. pmc The default mode network and self-referential processes in depression
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1942-7. 2009
    ..These findings provide a brain network framework within which to consider the pathophysiology of depression...
  20. pmc Loss of intranetwork and internetwork resting state functional connections with Alzheimer's disease progression
    Mathew R Brier
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 32:8890-9. 2012
    ..These results provide insight into AD pathophysiology and reinforce an integrative view of the brain's functional organization...
  21. ncbi request reprint Coherent spontaneous activity identifies a hippocampal-parietal memory network
    Justin L Vincent
    Mallinckrodt Institute of Radiology, and Department of Neurology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    J Neurophysiol 96:3517-31. 2006
    ..These regions showed greater activity to successfully recollected items as compared with other trial types. Together, these results associate specific regions of parietal cortex that are sensitive to successful recollection with the HF...
  22. pmc The global signal and observed anticorrelated resting state brain networks
    Michael D Fox
    Departments of Radiology, Washington University in St Louis, St Louis, Missouri, USA
    J Neurophysiol 101:3270-83. 2009
    ....
  23. pmc Noninvasive functional and structural connectivity mapping of the human thalamocortical system
    Dongyang Zhang
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Cereb Cortex 20:1187-94. 2010
    ..However, important differences between structural and functional mapping results are also manifest which suggests a more complex interpretation and emphasizes the unique contributions from structural and functional mapping...
  24. pmc The maturing architecture of the brain's default network
    Damien A Fair
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:4028-32. 2008
    ..We found that the default regions are only sparsely functionally connected at early school age (7-9 years old); over development, these regions integrate into a cohesive, interconnected network...
  25. ncbi request reprint Intrinsic fluctuations within cortical systems account for intertrial variability in human behavior
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Neuron 56:171-84. 2007
    ..In addition to establishing a functional and behavioral significance of intrinsic brain activity, these results lend new insight into the origins of variability in human behavior...
  26. pmc Regional variability of imaging biomarkers in autosomal dominant Alzheimer's disease
    Tammie L S Benzinger
    Departments of Radiology, Biostatistics, Neurology, Pathology and Immunology, and Psychiatry, Washington University School of Medicine, St Louis, MO, 63110
    Proc Natl Acad Sci U S A 110:E4502-9. 2013
    ..Additional analyses of individuals in which longitudinal data were available suggested that an accelerated appearance of volumetric declines approximately coincides with the onset of the symptomatic phase of the disease. ..
  27. pmc A method for using blocked and event-related fMRI data to study "resting state" functional connectivity
    Damien A Fair
    Department of Neurology, Washington University School of Medicine, Campus Box 8111, 660 S Euclid, St Louis, MO 63110, USA
    Neuroimage 35:396-405. 2007
    ..Although using event-related data residuals for resting state functional connectivity may still be useful, results should be interpreted with care...
  28. pmc Development of distinct control networks through segregation and integration
    Damien A Fair
    Departments of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:13507-12. 2007
    ..Delay/disruption in the developmental processes of segregation and integration may play a role in disorders of control, such as autism, attention deficit hyperactivity disorder, and Tourette's syndrome...
  29. pmc Intrinsic functional relations between human cerebral cortex and thalamus
    Dongyang Zhang
    Washington University, Department of Radiology, Campus Box 8225, 510 South Kingshighway Blvd, St Louis, MO 63110, USA
    J Neurophysiol 100:1740-8. 2008
    ..These results extend our understanding of the intrinsic network organization of the human brain to the thalamus and highlight the potential of resting-state fMRI BOLD imaging to elucidate thalamocortical relationships...
  30. pmc Spontaneous neuronal activity distinguishes human dorsal and ventral attention systems
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:10046-51. 2006
    ..These findings demonstrate that the neuroanatomical substrates of human attention persist in the absence of external events, reflected in the correlation structure of spontaneous activity...
  31. pmc Electrophysiological correlates of the brain's intrinsic large-scale functional architecture
    Biyu J He
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:16039-44. 2008
    ..Our results provide an important bridge between the large-scale brain networks readily revealed by spontaneous BOLD signals and their underlying neurophysiology...
  32. pmc Regional aerobic glycolysis in the human brain
    S Neil Vaishnavi
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17757-62. 2010
    ....
  33. pmc Resting-state functional connectivity in the human brain revealed with diffuse optical tomography
    Brian R White
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Neuroimage 47:148-56. 2009
    ..In addition, the comprehensive hemoglobin contrasts of fc-DOT enable innovative studies of the biophysical origin of the functional connectivity signal...
  34. pmc The fMRI signal, slow cortical potential and consciousness
    Biyu J He
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Trends Cogn Sci 13:302-9. 2009
    ..This hypothesis, unlike several previous theories of consciousness, is firmly rooted in physiology and as such is entirely amenable to empirical testing...
  35. pmc The temporal structures and functional significance of scale-free brain activity
    Biyu J He
    Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuron 66:353-69. 2010
    ..Our findings reveal robust temporal structures and behavioral significance of scale-free brain activity and should motivate future study on its physiological mechanisms and cognitive implications...
  36. pmc Dissociated mean and functional connectivity BOLD signals in visual cortex during eyes closed and fixation
    Mark McAvoy
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Neurophysiol 108:2363-72. 2012
    ..Science 279: 91-95, 1998), our results suggest that dissociated endogenous neural activity in primary and extrastriate cortex may represent a general aspect of brain function...
  37. pmc Bidirectional relationship between functional connectivity and amyloid-β deposition in mouse brain
    Adam W Bero
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci 32:4334-40. 2012
    ....
  38. pmc Premotor functional connectivity predicts impulsivity in juvenile offenders
    Benjamin J Shannon
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 108:11241-5. 2011
    ..This observation suggests that impulsivity in the offender population is a consequence of a delay in typical development, rather than a distinct abnormality...
  39. pmc Resting states affect spontaneous BOLD oscillations in sensory and paralimbic cortex
    Mark McAvoy
    Department of Radiology, Washington University School of Medicine, 4525 Scott Ave, Campus Box 8225, Rm 2110, St Louis, MO 63110, USA
    J Neurophysiol 100:922-31. 2008
    ..In conclusion, changes in resting state were associated with synchronous modulations of spontaneous BOLD oscillations in cortical sensory areas driven by two spatially overlapping, but temporally uncorrelated signals...
  40. pmc Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition
    Andrei G Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17763-7. 2010
    ....
  41. pmc Cortical network functional connectivity in the descent to sleep
    Linda J Larson-Prior
    Department of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:4489-94. 2009
    ..Rather, accumulating evidence supports the hypothesis that spontaneous BOLD fluctuations reflect processes that maintain the integrity of functional systems in the brain...
  42. pmc The human brain is intrinsically organized into dynamic, anticorrelated functional networks
    Michael D Fox
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 102:9673-8. 2005
    ..We suggest that both task-driven neuronal responses and behavior are reflections of this dynamic, ongoing, functional organization of the brain...
  43. ncbi request reprint Aerobic glycolysis in the human brain is associated with development and neotenous gene expression
    Manu S Goyal
    Neuroimaging Laboratories, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA Electronic address
    Cell Metab 19:49-57. 2014
    ..Our results suggest that brain AG supports developmental processes, particularly those required for synapse formation and growth...
  44. doi request reprint Disease and the brain's dark energy
    Dongyang Zhang
    Mallinckrodt Institute of Radiology, Washington University, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Nat Rev Neurol 6:15-28. 2010
    ..To end the article, we explore some of the basic science pursuits that have been undertaken to further understand the physiology behind intrinsic activity as imaged with BOLD fMRI...
  45. pmc Evidence for a frontoparietal control system revealed by intrinsic functional connectivity
    Justin L Vincent
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurophysiol 100:3328-42. 2008
    ..The frontoparietal control system is therefore anatomically positioned to integrate information from these two opposing brain systems...
  46. ncbi request reprint Symmetry of cortical folding abnormalities in Williams syndrome revealed by surface-based analyses
    David C Van Essen
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:5470-83. 2006
    ..These findings provide insights regarding possible developmental mechanisms that give rise to folding abnormalities and to the spectrum of behavioral characteristics associated with WS...
  47. pmc Emotion-induced changes in human medial prefrontal cortex: I. During cognitive task performance
    J R Simpson
    Mallinckrodt Institute of Radiology, and Departments of Anatomy and Neurobiology, Psychiatry, and Neurology, Washington University School of Medicine, St Louis, MO, 63110, USA
    Proc Natl Acad Sci U S A 98:683-7. 2001
    ..Taken together, these results suggest that the MPFC is part of a network, including the hypothalamus and brainstem, whose activity reflects a dynamic interplay between cognitive task performance and emotion...
  48. pmc Neuronal activity regulates the regional vulnerability to amyloid-β deposition
    Adam W Bero
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Neurosci 14:750-6. 2011
    ..Long-term unilateral vibrissal deprivation decreased amyloid plaque formation and growth. Our results suggest a mechanism to account for the vulnerability of specific brain regions to Aβ deposition in Alzheimer's disease...
  49. ncbi request reprint Effect of practice on reading performance and brain function
    Deborah L Kerr
    Department of Radiology, Campus Box 8225, 4525 Scott Street, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroreport 15:607-10. 2004
    ....
  50. ncbi request reprint Coherent spontaneous activity accounts for trial-to-trial variability in human evoked brain responses
    Michael D Fox
    Department of Radiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Nat Neurosci 9:23-5. 2006
    ....
  51. ncbi request reprint The BOLD onset transient: identification of novel functional differences in schizophrenia
    Michael D Fox
    Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 25:771-82. 2005
    ..Relevance of these findings to both an interpretation of the onset transient and the pathology of schizophrenia are discussed...
  52. pmc Noninvasive estimation of the arterial input function in positron emission tomography imaging of cerebral blood flow
    Yi Su
    Department of Radiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    J Cereb Blood Flow Metab 33:115-21. 2013
    ..The image-derived AIF (IDAIF) method was validated against conventional arterial sampling. The IDAIF generated highly reproducible CBF estimations, generally in good agreement with the conventional technique...
  53. pmc A brief history of the resting state: the Washington University perspective
    Abraham Z Snyder
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimage 62:902-10. 2012
    ..We then discuss resting state research performed in our laboratory since 2005 with an emphasis on papers of particular interest...
  54. pmc Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratio
    Andrei G Vlassenko
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:1964-9. 2006
    ....
  55. ncbi request reprint Spontaneous fluctuations in brain activity observed with functional magnetic resonance imaging
    Michael D Fox
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 8:700-11. 2007
    ..Although several challenges remain, these studies have provided insight into the intrinsic functional architecture of the brain, variability in behaviour and potential physiological correlates of neurological and psychiatric disease...
  56. pmc Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain
    Mark A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:659-64. 2004
    ..Our observations support the hypothesis that an increase in the NADH/NAD(+) ratio activates signaling pathways to selectively increase CBF in the physiologically stimulated brain regions...
  57. ncbi request reprint Searching for a baseline: functional imaging and the resting human brain
    D A Gusnard
    The Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri 63110, USA
    Nat Rev Neurosci 2:685-94. 2001
    ..We explore this possibility, including the manner in which we might define a baseline and the implications of such a baseline for our understanding of brain function...
  58. pmc Tracking neuronal fiber pathways in the living human brain
    T E Conturo
    Department of Radiology and Neuroimaging Laboratory, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 96:10422-7. 1999
    ..This approach enhances the power of modern imaging by enabling study of fiber connections among anatomically and functionally defined brain regions in individual human subjects...
  59. pmc Medial prefrontal cortex and self-referential mental activity: relation to a default mode of brain function
    D A Gusnard
    Mallinckrodt Institute of Radiology and Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:4259-64. 2001
    ..We suggest that a useful way to explore the neurobiology of the self is to explore the nature of default state activity...
  60. pmc Coupling between changes in human brain temperature and oxidative metabolism during prolonged visual stimulation
    D A Yablonskiy
    Mallinckrodt Institute of Radiology, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:7603-8. 2000
    ....
  61. ncbi request reprint Direct comparison of episodic encoding and retrieval of words: an event-related fMRI study
    K B McDermott
    Washington University School of Medicine, St Louis, MO, USA
    Memory 7:661-78. 1999
    ..Regions more active in retrieval than encoding included bilateral inferior parietal cortex, bilateral precuneus, right frontal polar cortex, right dorsolateral prefrontal cortex, and right inferior frontal/insular cortex...
  62. ncbi request reprint Tactile attention tasks enhance activation in somatosensory regions of parietal cortex: a positron emission tomography study
    H Burton
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cereb Cortex 9:662-74. 1999
    ..These non-sensory areas may constitute a network that provides a source of modulating influences on the earlier stage, sensory areas...
  63. pmc Preserved speech abilities and compensation following prefrontal damage
    R L Buckner
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 93:1249-53. 1996
    ..We used functional brain imaging with positron emission tomography (PET) as a basis for this study...
  64. pmc The effects of practice on the functional anatomy of task performance
    S E Petersen
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:853-60. 1998
    ..The specific regions used for scaffolding and storage appear to be task dependent...
  65. ncbi request reprint A common network of functional areas for attention and eye movements
    M Corbetta
    Department of Neurology, McDonnell Center for Higher Brain Functions, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuron 21:761-73. 1998
    ..This anatomical overlap is consistent with the hypothesis that attentional and oculomotor processes are tightly integrated at the neural level...
  66. ncbi request reprint Functional MRI studies of word-stem completion: reliability across laboratories and comparison to blood flow imaging with PET
    J G Ojemann
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110
    Hum Brain Mapp 6:203-15. 1998
    ..A further implication of the consistencies, which extended to both increases and decreases in signal, is that the underlying brain physiology leading to BOLD contrast may be more similar to blood flow than originally appreciated...
  67. pmc Adaptive changes in early and late blind: a fMRI study of Braille reading
    H Burton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurophysiol 87:589-607. 2002
    ..It is argued that these responses may represent critical language processing mechanisms normally present in visual cortex...
  68. pmc Default brain functionality in blind people
    H Burton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:15500-5. 2004
    ..More generally, these results support the notion that the brain largely operates intrinsically, with sensory information modulating rather than determining system operations...
  69. pmc Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data
    M A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:6859-64. 2001
    ..These findings strongly indicate that the increase in CBF associated with physiological activation is regulated by factors other than local requirements in oxygen...
  70. pmc Adaptive changes in early and late blind: a FMRI study of verb generation to heard nouns
    H Burton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurophysiol 88:3359-71. 2002
    ..It remains possible that these responses represent adaptations which initially are for processing either sound or touch, but which are later generalized to the other modality during acquisition of Braille reading skills...
  71. pmc Resting state functional connectivity in preclinical Alzheimer's disease
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 74:340-7. 2013
    ....
  72. pmc Disrupted modular organization of resting-state cortical functional connectivity in U.S. military personnel following concussive 'mild' blast-related traumatic brain injury
    Kihwan Han
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neuroimage 84:76-96. 2014
    ..The underlying biological mechanisms and consequences of disrupted between-module connectivity are unknown, thus further studies are required. ..
  73. pmc Gene expression-based modeling of human cortical synaptic density
    Manu S Goyal
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 110:6571-6. 2013
    ..Our approach provides a promising avenue for exploring how complex interactions among genes may contribute to neurobiological phenomena across the human lifespan...
  74. pmc Trends and properties of human cerebral cortex: correlations with cortical myelin content
    Matthew F Glasser
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA Electronic address
    Neuroimage 93:165-75. 2014
    ..Finally, we discuss the future of the in vivo myeloarchitectural field and cortical parcellation--"in vivo Brodmann mapping"--in general...
  75. doi request reprint Transmembrane dynamics of water exchange in human brain
    Xiang He
    Department of Radiology, Washington University in St Louis, One Brookings Drive, Saint Louis, Missouri, USA
    Magn Reson Med 67:562-71. 2012
    ..We estimated that the water transport time through the neuronal membranes is on the order of several tens of seconds; a finding consistent with older PET tracer kinetic studies using (15)O-water...
  76. pmc Loss of resting interhemispheric functional connectivity after complete section of the corpus callosum
    James M Johnston
    Department of Neurosurgery, Washington University, St Louis, Missouri 63110, USA
    J Neurosci 28:6453-8. 2008
    ..Such observations have the potential to increase our understanding of large-scale brain systems in health and disease as well as improve the treatment of neurologic disorders...
  77. pmc Detection of blast-related traumatic brain injury in U.S. military personnel
    Christine L Mac Donald
    Washington University School of Medicine, St Louis, MO 63110, USA
    N Engl J Med 364:2091-100. 2011
    ..Blast-related traumatic brain injuries have been common in the Iraq and Afghanistan wars, but fundamental questions about the nature of these injuries remain unanswered...
  78. pmc Persistence and brain circuitry
    Debra A Gusnard
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:3479-84. 2003
    ..These findings represent a fresh approach to linking normal individual differences in personality and behavior to specific neuronal structures and subsystems...
  79. pmc Emotion-induced changes in human medial prefrontal cortex: II. During anticipatory anxiety
    J R Simpson
    Mallinckrodt Institute of Radiology, and Departments of Anatomy and Neurobiology, Psychiatry and Neurology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:688-93. 2001
    ..The characterization of such relationships within the human brain enables new insights into the integration of cognition and emotion...
  80. ncbi request reprint Intrinsic functional architecture in the anaesthetized monkey brain
    J L Vincent
    Department of Radiology, Washington University in St Louis, Missouri 63110, USA
    Nature 447:83-6. 2007
    ..Our results indicate that coherent system fluctuations probably reflect an evolutionarily conserved aspect of brain functional organization that transcends levels of consciousness...
  81. ncbi request reprint Human brain activity time-locked to perceptual event boundaries
    J M Zacks
    Department of Psychology, Washington University, One Brookings Drive, Saint Louis, Missouri 63130, USA
    Nat Neurosci 4:651-5. 2001
    ..Activity within this network may provide a basis for parsing the temporally evolving environment into meaningful units...
  82. pmc Functional deactivations: change with age and dementia of the Alzheimer type
    Cindy Lustig
    Department of Psychology, Washington University, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 100:14504-9. 2003
    ....
  83. pmc Integration of emotion and cognition in the lateral prefrontal cortex
    Jeremy R Gray
    Department of Psychology, Washington University, One Brookings Drive, St Louis, MO 63130, USA
    Proc Natl Acad Sci U S A 99:4115-20. 2002
    ..Other regions in lateral PFC showed hemispheric specialization for emotion and for stimuli separately, consistent with a hierarchical and hemisphere-based mechanism of integration...
  84. ncbi request reprint Volumetric reduction in left subgenual prefrontal cortex in early onset depression
    Kelly N Botteron
    Department of Radiology, School of Medicine, Washington University, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110, USA
    Biol Psychiatry 51:342-4. 2002
    ..In this study, the authors test the hypothesis that SGPFC reduction is present in adolescent onset MD, and examine differences in the magnitude of reduction in younger versus older women...
  85. pmc Verbal memory deficit following traumatic brain injury: assessment using advanced MRI methods
    C L MacDonald
    Departments of Neurology, Washington University, St Louis, MO 63110, USA
    Neurology 71:1199-201. 2008
  86. pmc Detection of cortical activation during averaged single trials of a cognitive task using functional magnetic resonance imaging
    R L Buckner
    Department of Radiology, Massachusetts General Hospital Nuclear Magnetic Resonance Center, Charlestown 02129, USA
    Proc Natl Acad Sci U S A 93:14878-83. 1996
    ..Such paradigms will provide experimental flexibility and time-resolved data for individual brain regions on a trial-by-trial basis...
  87. pmc Disruption of large-scale brain systems in advanced aging
    Jessica R Andrews-Hanna
    Department of Psychology, Center for Brain Science, Harvard University, Cambridge, MA 02138, USA
    Neuron 56:924-35. 2007
    ..These results suggest that cognitive decline in normal aging arises from functional disruption in the coordination of large-scale brain systems that support cognition...
  88. ncbi request reprint A proposal for a Decade of the Mind initiative
    James S Albus
    Science 317:1321. 2007
  89. ncbi request reprint Functional anatomical correlates of antidepressant drug treatment assessed using PET measures of regional glucose metabolism
    Wayne C Drevets
    Neuroimaging in Mood and Anxiety Disorders Section, National Institutes of Health, NIMH MIB, Bethesda, MD 20892, USA
    Eur Neuropsychopharmacol 12:527-44. 2002
    ....
  90. ncbi request reprint Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levels
    Wayne C Drevets
    Section on Neuroimaging of Mood and Anxiety Disorders, Molecular Imaging Branch, NIH National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
    Pharmacol Biochem Behav 71:431-47. 2002
    ....