Janet S Rader

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint MLH3 mutation in endometrial cancer
    Nicholas P Taylor
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Cancer Res 66:7502-8. 2006
  2. pmc A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening
    Janet S Rader
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA Department of Genetics, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA
    Proteomics Clin Appl 2:1658-69. 2008
  3. ncbi request reprint CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer
    Zhengyan Zhang
    Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8064, St Louis, MO 63110, USA
    Cancer Res 67:11202-8. 2007
  4. doi request reprint Phase I study and preliminary pharmacology of the novel innate immune modulator rBBX-01 in gynecologic cancers
    Janet S Rader
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:3089-97. 2008
  5. doi request reprint Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis
    Elizabeth A Kidd
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Box 8224, St Louis, MO 63110, USA
    J Clin Oncol 28:2108-13. 2010
  6. ncbi request reprint Preoperative lymph node staging of early-stage cervical carcinoma by [18F]-fluoro-2-deoxy-D-glucose-positron emission tomography
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, Missouri 63110, USA
    Cancer 104:2484-91. 2005
  7. ncbi request reprint DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis
    Nicholas P Taylor
    Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Mod Pathol 19:1333-8. 2006
  8. ncbi request reprint Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 107:83-9. 2006
  9. ncbi request reprint Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 25:2042-8. 2007
  10. pmc Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Gynecol Oncol 130:64-8. 2013

Detail Information

Publications80

  1. ncbi request reprint MLH3 mutation in endometrial cancer
    Nicholas P Taylor
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Cancer Res 66:7502-8. 2006
    ..The identification of inherited missense variants, somatic missense mutations (present in 3 of 57 tumors), and LOH in the tumor from a patient with a germ line missense change suggest a role for MLH3 in endometrial tumorigenesis...
  2. pmc A unified sample preparation protocol for proteomic and genomic profiling of cervical swabs to identify biomarkers for cervical cancer screening
    Janet S Rader
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA Department of Genetics, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, MO, USA
    Proteomics Clin Appl 2:1658-69. 2008
    ..HNRPA2B1 was identified as a biomarker candidate with increased expression in cancer compared to normal cervix and validated by Western blot...
  3. ncbi request reprint CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer
    Zhengyan Zhang
    Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8064, St Louis, MO 63110, USA
    Cancer Res 67:11202-8. 2007
    ..None of seven nearby genes was differentially expressed in cervical cancer. The importance of CD83 in epithelial versus dendritic cells needs to be determined, as does its role in promoting cervical cancer...
  4. doi request reprint Phase I study and preliminary pharmacology of the novel innate immune modulator rBBX-01 in gynecologic cancers
    Janet S Rader
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:3089-97. 2008
    ..This phase I trial was done to determine the safety and basic pharmacology of rBBX-01...
  5. doi request reprint Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis
    Elizabeth A Kidd
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Box 8224, St Louis, MO 63110, USA
    J Clin Oncol 28:2108-13. 2010
    ..27 (95% CI 16.56 to 55.34). CONCLUSION Nodal involvement detected by FDG-PET in cervical cancer relates to clinical stage, is comparable to historical data, and stratifies patient recurrence and survival outcomes...
  6. ncbi request reprint Preoperative lymph node staging of early-stage cervical carcinoma by [18F]-fluoro-2-deoxy-D-glucose-positron emission tomography
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, Missouri 63110, USA
    Cancer 104:2484-91. 2005
    ..The objective of this study was to determine the sensitivity and specificity of PET in detecting lymph node metastasis in women with early-stage cervical carcinoma...
  7. ncbi request reprint DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis
    Nicholas P Taylor
    Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Mod Pathol 19:1333-8. 2006
    ..The high rate of concordance for these molecular defects between the carcinoma and sarcoma components adds to existing molecular evidence that carcinosarcomas are clonal malignancies...
  8. ncbi request reprint Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 107:83-9. 2006
    ..The study was undertaken to determine the safety and efficacy of the monoclonal, antivascular endothelial growth factor antibody bevacizumab in combination with cytotoxic chemotherapy for women with platinum-refractory ovarian cancer...
  9. ncbi request reprint Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 25:2042-8. 2007
    ..We sought to determine whether MSI and MLH1 methylation are associated with clinicopathologic variables and survival outcomes in a large series of patients with endometrial carcinomas of the endometrioid type...
  10. pmc Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Gynecol Oncol 130:64-8. 2013
    ..We evaluated the activity and safety of the combination of topotecan, cisplatin and bevacizumab in patients with recurrent or persistent carcinoma of the cervix...
  11. doi request reprint Clinical outcomes of definitive intensity-modulated radiation therapy with fluorodeoxyglucose-positron emission tomography simulation in patients with locally advanced cervical cancer
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 77:1085-91. 2010
    ..This study aimed to evaluate the toxicity and clinical outcomes for cervical cancer patients treated definitively with intensity-modulated radiation therapy (IMRT) compared with non-IMRT treatment...
  12. doi request reprint "Surgical Apgar Score" predicts postoperative complications after cytoreduction for advanced ovarian cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 116:370-3. 2010
    ..We sought to estimate the ability of this metric to predict major postoperative complications in women undergoing ovarian cancer cytoreductive procedures...
  13. doi request reprint Phase II evaluation of topotecan and navelbine in patients with recurrent ovarian, fallopian tube or primary peritoneal cancer
    Thomas J Herzog
    Division of Gynecologic Oncology, Columbia University, College of Physicians and Surgeons, Irving Cancer Center, New York, NY 10032, USA
    Gynecol Oncol 111:467-73. 2008
    ..To assess the efficacy and toxicity profile in patients with recurrent ovarian or primary peritoneal cancer treated with topotecan at 2.5 mg/m(2) days 1 and 8 plus vinorelbine at 25 mg/m(2) days 1 and 8 every 3 weeks...
  14. doi request reprint Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer
    Rebecca A Brooks
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 112:104-9. 2009
    ..To evaluate survival after detection of recurrent cervical cancer by FDG-PET in symptomatic versus asymptomatic patients...
  15. ncbi request reprint Human papillomavirus triage for young women with atypical squamous cells of undetermined significance
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 107:822-9. 2006
    ..We sought to estimate the usefulness of human papillomavirus testing for young women with atypical squamous cells of undetermined significance...
  16. ncbi request reprint Cervical dysplasia in adolescents
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 106:115-20. 2005
    ..We determined the natural history and outcome of adolescents with low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL)...
  17. ncbi request reprint FDG-PET evaluation of vaginal carcinoma
    Wayne T Lamoreaux
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 62:733-7. 2005
    ..To compare the results of CT and positron emission tomography (PET) and F-18 fluorodeoxyglucose (FDG) in the detection of the primary tumor and lymph node metastases in carcinoma of the vagina...
  18. ncbi request reprint Human papillomavirus type and tobacco use as predictors of survival in early stage cervical carcinoma
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 98:84-91. 2005
    ..The aim of this study was to define the prognostic significance of HPV 18 and its phylogenetically related viruses and smoking on survival in patients with early stage cervical cancer...
  19. pmc TP53, MDM2, NQO1, and susceptibility to cervical cancer
    Xiaoxia Hu
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Epidemiol Biomarkers Prev 19:755-61. 2010
    ..Our results indicate that functional polymorphisms in TP53 codon 72 and NQO1 SNP609 associate with the risk of cervical cancer especially in women infected with type 16- and/or type 18-related HPVs...
  20. ncbi request reprint Prospective evaluation of FDG-PET for detecting pelvic and para-aortic lymph node metastasis in uterine corpus cancer
    Neil S Horowitz
    Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 95:546-51. 2004
    ....
  21. doi request reprint Chemoradiation in locally advanced cervical carcinoma: an analysis of cisplatin dosing and other clinical prognostic factors
    Elizabeth K Nugent
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 4th Floor Maternity, St Louis, MO 63110, USA
    Gynecol Oncol 116:438-41. 2010
    ..The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer...
  22. ncbi request reprint Utility of parametrectomy for early stage cervical cancer treated with radical hysterectomy
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer 110:1281-6. 2007
    ..Parametrectomy results in significant morbidity. The objective of the study was to determine factors predictive of parametrial tumor spread and to define a subset of patients at low risk for parametrial disease...
  23. ncbi request reprint Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer
    Carolyn K McCourt
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO, USA
    Gynecol Oncol 104:535-9. 2007
    ....
  24. ncbi request reprint Fine mapping and evaluation of candidate genes for cervical cancer on 11q23
    Zhengyan Zhang
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Chromosomes Cancer 43:95-103. 2005
    ..6-Mb stretch of DNA on 11q23.3-q24.1 and that somatic mutations in RNF26, USP2, TRIM29, POU2F3, or PPP2R1B probably are not important for cervical carcinogenesis...
  25. pmc ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
    J Clin Oncol 27:3091-6. 2009
    ..Knowledge of ATR mutation status may hold promise for individualized treatment and targeted therapies in patients with endometrial cancer...
  26. ncbi request reprint CA-125 response in patients with recurrent ovarian or primary peritoneal cancer treated with pegylated liposomal doxorubicin or topotecan
    Gabrielle Gossner
    Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:212-8. 2006
    ..In this study, we sought to gain insight into response patterns regarding CA-125 in responders vs. non-responders and to determine whether specific "cut-off" values could help predict ultimate clinical response...
  27. ncbi request reprint Comparison of high-dose-rate and low-dose-rate brachytherapy in the treatment of endometrial carcinoma
    Alaa Fayed
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 67:480-4. 2007
    ..To compare the outcomes for endometrial carcinoma patients treated with either high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy...
  28. pmc Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history
    Barbara M Buttin
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 74:1262-9. 2004
    ..A combination of MSI and immunohistochemistry analyses may be helpful in screening for MSH6 mutation carriers...
  29. pmc The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy
    Nora T Kizer
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 117:948-56. 2011
    ..The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear...
  30. pmc A microRNA expression signature for cervical cancer prognosis
    Xiaoxia Hu
    Departments of Radiation Oncology, Pathology and Immunology, and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:1441-8. 2010
    ..In particular, miR-200a is likely to affect the metastatic potential of cervical cancer cells by coordinate suppression of multiple genes controlling cell motility...
  31. ncbi request reprint External radiotherapy versus vaginal brachytherapy for patients with intermediate risk endometrial cancer
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 106:215-20. 2007
    ..To determine if brachytherapy alone is adequate adjuvant local therapy in patients classified as intermediate risk after complete surgical staging for endometrioid adenocarcinoma...
  32. ncbi request reprint Effect of a T0 radical hysterectomy specimen on survival for early stage cervical cancer
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, 8th Floor, New York, NY 10032, USA
    Gynecol Oncol 107:280-4. 2007
    ..The goal of this study was to evaluate the outcome of patients with no residual tumor (T0) in their hysterectomy specimens...
  33. ncbi request reprint Cervical carcinoma in the elderly: an analysis of patterns of care and outcome
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 103:85-91. 2005
    ..Advanced age often is considered a poor prognostic factor for cervical carcinoma. The authors investigated the patterns of care and treatment outcomes of elderly women with cervical carcinoma...
  34. ncbi request reprint Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J Siteman Cancer Center, St Louis, MO, USA
    Radiat Med 24:625-30. 2006
    ..We sought to review outcomes in patients with stage IVB carcinoma of the cervix treated with irradiation in combination with chemotherapy...
  35. pmc Differential display identifies overexpression of the USP36 gene, encoding a deubiquitinating enzyme, in ovarian cancer
    Jianduan Li
    Department of Obstetrics, Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Med Sci 5:133-42. 2008
    ..To find potential diagnostic markers or therapeutic targets, we used differential display technique to identify genes that are over or under expressed in human ovarian cancer...
  36. ncbi request reprint Identification of chromosomal alterations important in the development of cervical intraepithelial neoplasia and invasive carcinoma using alignment of DNA microarray data
    Margaret A Fitzpatrick
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:458-62. 2006
    ..To use microarray data to reveal regions of potential chromosomal loss or gain important in cervical intraepithelial neoplasia (CIN) and invasive cervical cancer by identifying mRNA expression biases in contiguous chromosomal regions...
  37. ncbi request reprint Acute toxicity of postoperative IMRT and chemotherapy for endometrial cancer
    Ryan M Tierney
    Department of Radiation Oncology, Box 8224, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St Louis, MO 63110, USA
    Radiat Med 25:439-45. 2007
    ..The aim of this study was to determine the acute toxicity of postoperative intensity-modulated radiotherapy (IMRT) with and without chemotherapy in patients with endometrial cancer...
  38. ncbi request reprint Relationship of ovarian neoplasms and body mass index
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Reprod Med 50:595-602. 2005
    ..To describe the distribution of benign and malignant ovarian neoplasms among overweight and obese women...
  39. ncbi request reprint IGSF4 promoter methylation and expression silencing in human cervical cancer
    Jianduan Li
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 96:150-8. 2005
    ..We evaluated IGSF4, a putative TSG located in the region, for promoter methylation and gene silencing in CC cell lines and cervical tissues...
  40. ncbi request reprint Cervical cancer histology and tumor differentiation affect 18F-fluorodeoxyglucose uptake
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 115:3548-54. 2009
    ..This study aimed to evaluate the variation in cervical cancer glucose metabolism for different tumor histologies and levels of differentiation, as measured by the uptake of 18F-fluorodeoxyglucose (FDG) by positron emission tomography (PET)...
  41. ncbi request reprint Phase II evaluation of a 3-day infusion of topotecan in patients with recurrent ovarian or primary peritoneal cancer
    Thomas J Herzog
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:637-41. 2006
    ..To assess the efficacy and toxicity profile in patients treated with topotecan at 2.0 mg/m2/day x 3 days every 3 weeks...
  42. ncbi request reprint Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation
    Barbara M Buttin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 10:481-90. 2004
    ..The aim of this study was to evaluate number and types of synchronous and metachronous malignancies in patients with endometrial carcinoma with and without microsatellite instability (MSI)...
  43. ncbi request reprint Liquid-based cytology for the postirradiation surveillance of women with gynecologic malignancies
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 91:134-8. 2003
    ..To determine the performance of liquid-based cytology using ThinPrep in the postirradiation surveillance of women with gynecologic malignancies...
  44. ncbi request reprint Panniculectomy: improving lymph node yield in morbidly obese patients with endometrial neoplasms
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 94:436-41. 2004
    ..The goal of this study was to determine the effect of panniculectomy on staging adequacy and lymph node yield in obese women with endometrial carcinoma undergoing staging laparotomy...
  45. pmc Denaturing high-performance liquid chromatography for detecting and typing genital human papillomavirus
    Jianduan Li
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Microbiol 41:5563-71. 2003
    ..6% of the samples. Our results indicate that HPV typing by GP-dHPLC permits discrimination of common genital HPV types, detection of multiple HPV infections, and identification of HPV variants in clinical samples...
  46. pmc Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers
    Paul J Goodfellow
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:5908-13. 2003
    ..The minimum estimate of the prevalence of inherited MSH6 mutation in endometrial cancer is 1.6% (7 of 441), comparable with the predicted prevalence for patients with colorectal cancer...
  47. pmc Polymorphisms in MMP9 and SIPA1 are associated with increased risk of nodal metastases in early-stage cervical cancer
    Rebecca Brooks
    Washington University School of Medicine Barnes Jewish Hospital, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 4911 Barnes Jewish Hospital Plaza Box 8064, Saint Louis, MO 63110, USA
    Gynecol Oncol 116:539-43. 2010
    ..We investigated the association of these SNPs with nodal metastases in early-stage cervical cancer...
  48. ncbi request reprint Bevacizumab combination therapy in heavily pretreated, recurrent cervical cancer
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:489-93. 2006
    ..To report the utility of the monoclonal, anti-vascular endothelial growth factor antibody bevacizumab in combination with cytotoxic chemotherapy for women with recurrent cervical cancer...
  49. ncbi request reprint Bevacizumab therapy in patients with recurrent uterine neoplasms
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Anticancer Res 27:3525-8. 2007
    ..Angiogenesis plays an important role in endometrial carcinogenesis. We reviewed our experience with the anti-VEGF monoclonal antibody bevacizumab for the treatment of recurrent uterine neoplasms...
  50. doi request reprint The value of perioperative imaging in patients with uterine sarcomas
    Elizabeth K Nugent
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, USA
    Gynecol Oncol 115:37-40. 2009
    ..To explore the yield and impact of perioperative imaging on management among patients undergoing surgical resection and treatment of uterine sarcomas...
  51. ncbi request reprint Phase I study of docetaxel in combination with the P-glycoprotein inhibitor, zosuquidar, in resistant malignancies
    Paula M Fracasso
    Department of Medicine, Alvin J Siteman Cancer Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 10:7220-8. 2004
    ..To determine the maximum tolerated dose, dose-limiting toxicity, and pharmacokinetics of docetaxel infused over 1 hour when given in combination with oral zosuquidar to patients with resistant solid tumors...
  52. ncbi request reprint Epithelial ovarian tumors of low malignant potential: the role of microinvasion
    Barbara M Buttin
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Obstet Gynecol 99:11-7. 2002
    ..To identify prognostic factors that may be used to predict an aggressive disease course and poor outcome in patients with epithelial ovarian tumors of low malignant potential (borderline tumors)...
  53. ncbi request reprint Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma
    Bradford P Whitcomb
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 9:2277-87. 2003
    ..This study was designed to determine whether there is a methylator phenotype in stage I and II endometrioid endometrial adenocarcinoma, and if so, whether methylation correlates with recurrence...
  54. ncbi request reprint Double cervix with bilateral and synchronous HSIL associated with different high-risk HPV types. A case report
    Karen R Pinto
    Department of Pathology and Immunology, Washington University Medical Center, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Acta Cytol 48:273-7. 2004
    ..However, there is no information in the literature on the specific types of HPV causing the concomitant lesions in cases with a double cervix...
  55. doi request reprint Long-term assessment of bladder and bowel dysfunction after radical hysterectomy
    Rebecca A Brooks
    Washington University School of Medicine Barnes Jewish Hospital, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 4911 Barnes Jewish Hospital Plaza Box 8064, Saint Louis, MO 63110, USA
    Gynecol Oncol 114:75-9. 2009
    ..To determine the long-term effects of radical hysterectomy on bladder and bowel function...
  56. ncbi request reprint Colposcopic accuracy of obstetrics and gynecology residents
    Margaret E Baum
    Division of General Gynecology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Barnes Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 103:966-70. 2006
    ..The objective of our study was to determine the accuracy of gynecology residents' colposcopic impressions...
  57. ncbi request reprint Long-term outcome of women who undergo panniculectomy at the time of gynecologic surgery
    Jason D Wright
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 102:86-91. 2006
    ..The goal of this study was to determine the long-term outcomes and patient satisfaction of women who underwent panniculectomy at the time of pelvic surgery...
  58. ncbi request reprint Synchronous ovarian metastases at the time of laparotomy for colon cancer
    Jason D Wright
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 92:851-5. 2004
    ..The aim of the study was to identify clinical features, define prognostic factors and optimize treatment in patients with colorectal cancer with synchronous ovarian metastases at the time of initial diagnosis...
  59. ncbi request reprint Ribosomal DNA methylation in patients with endometrial carcinoma: an independent prognostic marker
    Matthew A Powell
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 94:2941-52. 2002
    ..The objective of this study was to investigate the prognostic significance of ribosomal DNA (rDNA) methylation in patients with endometrial carcinoma...
  60. ncbi request reprint Cervical sarcomas: an analysis of incidence and outcome
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 99:348-51. 2005
    ..Cervical sarcomas are exceedingly rare neoplasms associated with a poor prognosis. The objective of this study was to examine the treatment and outcome of women with cervical sarcomas...
  61. ncbi request reprint Resource utilization for ovarian cancer patients at the end of life: how much is too much?
    Sharyn N Lewin
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 99:261-6. 2005
    ..The goal of this study was to compare the total cost of hospital-based resources utilized in ovarian cancer patients during their last 60 days of life for those enrolled in hospice versus those not on hospice...
  62. ncbi request reprint Prospective evaluation of positron emission tomography for the detection of groin node metastases from vulvar cancer
    David E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Gynecol Oncol 85:179-84. 2002
    ..We set out to determine the ability of positron emission tomography with fluorodeoxyglucose to detect groin lymph node metastases from vulvar cancer...
  63. ncbi request reprint Cervix carcinoma, concurrent chemoradiotherapy, and salvage of isolated paraaortic lymph node recurrence
    Anurag K Singh
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:450-5. 2005
    ..To determine the effect of concurrent chemoradiotherapy on the outcome of invasive cervical carcinoma patients with disease recurrence isolated to the paraaortic lymph nodes...
  64. ncbi request reprint The significance of pneumatosis intestinalis or bowel perforation in patients with gynecologic malignancies
    Neil S Horowitz
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 86:79-84. 2002
    ..The objectives of this study were to evaluate the clinical significance and outcome of pneumatosis intestinalis or bowel perforation in patients with gynecologic malignancies...
  65. ncbi request reprint Primary peritoneal carcinoma presenting as adenocarcinoma on a Pap smear. A case report
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    J Reprod Med 47:933-5. 2002
    ..Primary peritoneal carcinoma is an uncommon malignancy that usually presents with gastrointestinal symptoms from abdominal carcinomatosis...
  66. pmc The accuracy of colposcopic grading for detection of high-grade cervical intraepithelial neoplasia
    L Stewart Massad
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Low Genit Tract Dis 13:137-44. 2009
    ..To relate aspects of online colposcopic image assessment to the diagnosis of grades 2 and 3 cervical intraepithelial neoplasia (CIN 2+)...
  67. ncbi request reprint Phase I dose and sequencing study of pegylated liposomal doxorubicin and docetaxel in patients with advanced malignancies
    Paula M Fracasso
    Alvin J Siteman Cancer Center, St Louis, Missouri 63110, USA
    Cancer 98:610-7. 2003
    ..The authors conducted a Phase I trial to evaluate the maximum tolerated dose (MTD), toxicities, and effect of dose sequencing of this combination in patients with advanced malignancies...
  68. doi request reprint Cardiac arrest during laparotomy with argon beam coagulation of metastatic ovarian cancer
    Nora Kizer
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Comprehensive Cancer Center, St Louis, MO, USA
    Int J Gynecol Cancer 19:237-8. 2009
    ..The argon beam coagulation (ABC) is a safe and effective tool for surgical cytoreduction of metastatic ovarian carcinomas...
  69. ncbi request reprint Acute abdominal pain with a calcified pelvic mass
    Jason D Wright
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Pediatr Adolesc Gynecol 16:237-41. 2003
    ..A case of a 15-year-old with a calcified pelvic mass is presented with a review of the differential diagnosis...
  70. ncbi request reprint Expression and localization of GRP75 in human epithelial tumors and normal tissues
    Tomasz Srokowski
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Appl Immunohistochem Mol Morphol 12:132-8. 2004
    ..The authors conclude that GRP75 is highly expressed in both benign and malignant epithelium, as well as cells of specialized function from a variety of tissues...
  71. ncbi request reprint Phase II trial of pyrazoloacridine in patients with persistent or recurrent endometrial carcinoma: a Gynecologic Oncology Group Study
    Steven C Plaxe
    Division of Gynecologic Oncology, University of California at San Diego, San Diego, California 92103, USA
    Gynecol Oncol 84:241-4. 2002
    ..The aims of this study were to determine the response rate of pyrazoloacridine (PZA) in patients with recurrent or persistent endometrial carcinoma and to describe the nature and degree of toxicity in this population...
  72. ncbi request reprint Randomized trial of cisplatin and ifosfamide with or without bleomycin in squamous carcinoma of the cervix: a gynecologic oncology group study
    Jeffrey D Bloss
    Division of Gynecologic Oncology, Ellis Fischel Cancer Center, University of Missouri Health Sciences Center, Columbia, USA
    J Clin Oncol 20:1832-7. 2002
    ..This study prospectively evaluates the combination of bleomycin to this regimen in women with histologically proven advanced recurrent or persistent squamous cell carcinoma of the cervix...
  73. ncbi request reprint Profiling microdissected epithelium and stroma to model genomic signatures for cervical carcinogenesis accommodating for covariates
    David Gius
    Radiation Oncology Branch, Center for Cancer Research, National Cancer Institute, NIH, Bethesda, Maryland 20892, USA
    Cancer Res 67:7113-23. 2007
    ....
  74. pmc Evaluation of candidate methylation markers to detect cervical neoplasia
    Narayan Shivapurkar
    Hamon Center for Therapeutic Oncology Research, Department of Pathology, UT Southwestern Medical Center, Dallas, TX 75930, USA
    Gynecol Oncol 107:549-53. 2007
    ..We used quantitative PCR assays to evaluate methylation in five candidate genes (TNFRSF10C, DAPK1, SOCS3, HS3ST2 and CDH1) previously demonstrated as methylated in cervical cancer...
  75. ncbi request reprint Surgical-pathological predictors of disease-free survival and risk groupings for IB2 cervical cancer: do the traditional models still apply?
    Scott A Kamelle
    Oklahoma Health Sciences Center, USA
    Gynecol Oncol 94:249-55. 2004
    ..To evaluate how the independent predictors of recurrence for stage IB2 cervical cancers treated with up-front radical hysterectomy apply to established risk models...
  76. ncbi request reprint A comparison of stages IB1 and IB2 cervical cancers treated with radical hysterectomy. Is size the real difference?
    Teresa L Rutledge
    University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Gynecol Oncol 95:70-6. 2004
    ..To compare stages IB1 and IB2 cervical cancers treated with radical hysterectomy (RH) and to define predictors of nodal status and recurrence...
  77. doi request reprint Identification of novel methylation markers in cervical cancer using restriction landmark genomic scanning
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD 20852 7234, USA
    Cancer Res 68:2489-97. 2008
    ..Inclusion of NOL4 and LHFPL4 in evaluating methylation panels for early detection, risk prediction, and etiologic research on cervical cancer is warranted...
  78. pmc Aberrant expression of oncogenic and tumor-suppressive microRNAs in cervical cancer is required for cancer cell growth
    Xiaohong Wang
    HIV and AIDS Malignancy Branch, Center for Cancer Research, Nation Cancer Institute National Institutes of Health, Bethesda, Maryland, United States of America
    PLoS ONE 3:e2557. 2008
    ..When introduced into cell lines, miR-146a was found to promote cell proliferation. Collectively, our data indicate that downregulation of miR-143 and miR-145 and upregulation of miR-146a play a role in cervical carcinogenesis...
  79. ncbi request reprint Cervical tissue collection methods for RNA preservation: comparison of snap-frozen, ethanol-fixed, and RNAlater-fixation
    Sophia S Wang
    Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD 20892, USA
    Diagn Mol Pathol 15:144-8. 2006
    ....
  80. ncbi request reprint Cervical cancer prevention in the era of prophylactic vaccines: a preview for gynecologic oncologists
    Yvonne Collins
    University of Illinois, Chicago, IL, USA
    Gynecol Oncol 102:552-62. 2006
    ..This article is intended to provide gynecologic oncologists with a comprehensive background in modern cervical cancer prevention strategies...