J S Rader

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Cancer among first-degree relatives of probands with invasive and borderline ovarian cancer
    J S Rader
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 92:589-95. 1998
  2. ncbi request reprint Cervical cancer suppressor gene is within 1 cM on 6p23
    J S Rader
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Chromosomes Cancer 27:373-9. 2000
  3. ncbi request reprint Atypical clustering of gynecologic malignancies: A family study including molecular analysis of candidate genes
    D E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 77:18-25. 2000
  4. ncbi request reprint A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer
    J D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Int J Gynecol Cancer 18:400-6. 2008
  5. doi request reprint Prognostic factors associated with response in platinum retreatment of platinum-resistant ovarian cancer
    T T Nguyen
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Gynecol Cancer 18:1194-9. 2008
  6. ncbi request reprint Loss of heterozygosity at 11q23.3 in vasculoinvasive and metastatic squamous cell carcinoma of the cervix
    J S Rader
    Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Obstetrics and Gynecology, Washington University Medical Center, St Louis, MO 63110, USA
    Hum Pathol 32:475-8. 2001
  7. ncbi request reprint Lack of effect of tumor size on the prognosis of carcinoma of the uterine cervix Stage IB and IIA treated with preoperative irradiation and surgery
    P W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 45:645-51. 1999
  8. ncbi request reprint Gene expression patterns in advanced human cervical cancer
    P W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Gynecol Cancer 16:562-7. 2006
  9. ncbi request reprint Absence of PTEN repeat tract mutation in endometrial cancers with microsatellite instability
    D E Cohn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 79:101-6. 2000
  10. ncbi request reprint Microsatellite instability, MLH1 promoter methylation, and loss of mismatch repair in endometrial cancer and concomitant atypical hyperplasia
    N Horowitz
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 86:62-8. 2002

Collaborators

Detail Information

Publications23

  1. ncbi request reprint Cancer among first-degree relatives of probands with invasive and borderline ovarian cancer
    J S Rader
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 92:589-95. 1998
    ..The familial clustering of ovarian, breast, endometrial, colon; and prostate cancer was compared in first-degree relatives of probands with invasive and borderline ovarian cancer to determine coaggregation...
  2. ncbi request reprint Cervical cancer suppressor gene is within 1 cM on 6p23
    J S Rader
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Genes Chromosomes Cancer 27:373-9. 2000
    ..Our data strongly suggest that a gene important in cervical cancer tumorigenesis is located within a 1-cM region of 6p23, and it is not imprinted...
  3. ncbi request reprint Atypical clustering of gynecologic malignancies: A family study including molecular analysis of candidate genes
    D E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 77:18-25. 2000
    ..We set out to determine whether hereditary nonpolyposis colorectal cancer (HNPCC) was responsible for cancer susceptibility in a family with gynecologic malignancies in three consecutive generations...
  4. ncbi request reprint A multi-institutional evaluation of factors predictive of toxicity and efficacy of bevacizumab for recurrent ovarian cancer
    J D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York, USA
    Int J Gynecol Cancer 18:400-6. 2008
    ..Gastrointestinal perforations occurred in 7%. The perforations occurred in heavily pretreated patients who were responding to therapy...
  5. doi request reprint Prognostic factors associated with response in platinum retreatment of platinum-resistant ovarian cancer
    T T Nguyen
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Gynecol Cancer 18:1194-9. 2008
    ..There was no association between the response to platinum retreatment and the number of intervening cytotoxic agents utilized. Further prospective study is warranted to define the optimal timing of platinum retreatment...
  6. ncbi request reprint Loss of heterozygosity at 11q23.3 in vasculoinvasive and metastatic squamous cell carcinoma of the cervix
    J S Rader
    Lauren V. Ackerman Laboratory of Surgical Pathology, Department of Obstetrics and Gynecology, Washington University Medical Center, St Louis, MO 63110, USA
    Hum Pathol 32:475-8. 2001
    ..3 appear to be important in tumor progression, facilitating lymphvascular space invasion and, by inference, spread to lymph nodes in squamous cell carcinoma of the cervix...
  7. ncbi request reprint Lack of effect of tumor size on the prognosis of carcinoma of the uterine cervix Stage IB and IIA treated with preoperative irradiation and surgery
    P W Grigsby
    Radiation Oncology Center, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 45:645-51. 1999
    ..The purpose of this analysis was to evaluate the prognostic significance of cervical tumor size in patients with Stages Ib and IIa carcinoma of the cervix treated with preoperative irradiation and radical or conservative hysterectomy...
  8. ncbi request reprint Gene expression patterns in advanced human cervical cancer
    P W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Int J Gynecol Cancer 16:562-7. 2006
    ..Both overall and cause-specific survivals were different between these two patient groups (P= 0.006). This limited data set identified candidate biomarkers of extent of lymph node metastases that correlated with poor survival outcome...
  9. ncbi request reprint Absence of PTEN repeat tract mutation in endometrial cancers with microsatellite instability
    D E Cohn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 79:101-6. 2000
    ..We set out to investigate the relationship between MSI and PTEN mutation in a large series of primary endometrial carcinomas...
  10. ncbi request reprint Microsatellite instability, MLH1 promoter methylation, and loss of mismatch repair in endometrial cancer and concomitant atypical hyperplasia
    N Horowitz
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 86:62-8. 2002
    ..Our objective was to determine if methylation is always present in MSI-positive atypical hyperplasia concomitant with MSI-positive, methylation-positive carcinoma...
  11. ncbi request reprint Radical hysterectomy for cervical cancer in obese women
    D E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Obstet Gynecol 96:727-31. 2000
    ..To estimate the morbidity, adequacy of surgery, and survival of obese women undergoing radical hysterectomy and pelvic lymphadenectomy...
  12. ncbi request reprint Association between DQB1 and cervical cancer in patients with human papillomavirus and family controls
    R J Neuman
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Obstet Gynecol 95:134-40. 2000
    ..To overcome problems of misleading causal inferences common in traditional case-control studies, a family-based test, the transmission/disequilibrium test, was used...
  13. ncbi request reprint Factors predicting subcutaneous implanted central venous port function: the relationship between catheter tip location and port failure in patients with gynecologic malignancies
    D E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, St. Louis, Missouri 63110, USA
    Gynecol Oncol 83:533-6. 2001
    ..Confirmation of the location of the catheter tip is imperative for the long-term function of a subcutaneous implanted central venous port...
  14. ncbi request reprint Prophylactic oophorectomy and ovarian cancer surveillance. Patient perceptions and satisfaction
    E M Swisher
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, and Department of Medicine and Genetics, Washington University School of Medicine, St Louis, Missouri, USA
    J Reprod Med 46:87-94. 2001
    ..To evaluate decision making, information gathering, satisfaction and regret in women at increased risk of ovarian cancer who had undergone prophylactic oophorectomy or ovarian cancer surveillance...
  15. ncbi request reprint Aberrant promoter methylation and silencing of the POU2F3 gene in cervical cancer
    Z Zhang
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 25:5436-45. 2006
    ..The results suggested that POU2F3 might be one of the CC-related tumor suppressor genes, which are disrupted by both epigenetic and genetic mechanisms...
  16. ncbi request reprint Phase I study of rubitecan and gemcitabine in patients with advanced malignancies
    P M Fracasso
    Departments of Medicine and Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Oncol 13:1819-25. 2002
    ..We conducted a phase I trial to evaluate the maximum tolerated dose (MTD) and toxicities of this combination in advanced malignancies...
  17. ncbi request reprint Role of the ultrasonic surgical aspirator in gynecology
    N S Horowitz
    Department of Obstetrics and Gynecology, Washington University Medical Center, St Louis, Missouri 63110, USA
    Obstet Gynecol Clin North Am 28:775-90. 2001
    ..Although the ultrasonic surgical aspirator has had favorable results to date and future applications seem promising, the ultimate role of this device needs to be established with clinical trials...
  18. ncbi request reprint A phase II study to determine the efficacy and tolerability of intravenous ZD9331 in heavily pretreated patients with ovarian cancer
    J S Rader
    Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 91:318-25. 2003
    ..This Phase II, multicenter, open-label study was conducted to assess the efficacy and tolerability of ZD9331, a novel direct-acting thymidylate synthase inhibitor, in heavily pretreated patients with ovarian cancer...
  19. ncbi request reprint Genotypic and phenotypic progression in endometrial tumorigenesis: determining when defects in DNA mismatch repair and KRAS2 occur
    D E Cohn
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Genes Chromosomes Cancer 32:295-301. 2001
    ..These discordant genotypes suggest genetic heterogeneity in endometrial hyperplasia and concomitant cancer...
  20. ncbi request reprint A relationship between methylenetetrahydrofolate reductase variants and the development of invasive cervical cancer
    D S Gerhard
    Department of Genetics, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 90:560-5. 2003
    ..Two common genetic polymorphisms, causing reduced MTHFR activity, have been identified. Therefore, the goal of this study was to evaluate these MTHFR variations as risk factors for invasive cervical cancer...
  21. pmc Microsatellite instability and mutational analysis of transforming growth factor beta receptor type II gene (TGFBR2) in sporadic ovarian cancer
    A J Alvi
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Mol Pathol 54:240-3. 2001
    ..The spurious TGFBR2 frameshift mutations detected by sequencing after conventional PCR underline the importance of confirming putative mutations in repetitive sequences by alternative methods...
  22. ncbi request reprint Cyclooxygenase-2 is overexpressed in human cervical cancer
    S Kulkarni
    Department of Medicine, New York Presbyterian Hospital-Cornell, New York 10021, USA
    Clin Cancer Res 7:429-34. 2001
    ..Taken together, these findings suggest that deregulation of the EGF receptor signaling pathway may lead to enhanced COX-2 expression in cervical cancer...
  23. pmc Mutation screening analysis of the retinoblastoma related gene RB2/p130 in sporadic ovarian cancer and head and neck squamous cell cancer
    A J Alvi
    Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, Birmingham B15 2TT, UK
    Mol Pathol 55:153-5. 2002
    ..To investigate the involvement of the RB2/p130 gene in the pathogenesis of sporadic ovarian cancer in addition to head and neck squamous cell carcinoma (HNSCC)...