Brad Racette

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Increased risk of parkinsonism associated with welding exposure
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurotoxicology 33:1356-61. 2012
  2. pmc Pathophysiology of manganese-associated neurotoxicity
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63131, USA
    Neurotoxicology 33:881-6. 2012
  3. pmc High-throughput mutational analysis of TOR1A in primary dystonia
    Jianfeng Xiao
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Med Genet 10:24. 2009
  4. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  5. pmc A population-based study of parkinsonism in an Amish community
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroepidemiology 33:225-30. 2009
  6. ncbi request reprint The impact of litigation on neurologic research
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Neurology 67:2124-8. 2006
  7. pmc [18F]FDOPA PET as an endophenotype for Parkinson's Disease linkage studies
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 141:245-9. 2006
  8. ncbi request reprint Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders
    B A Racette
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Neurology 64:230-5. 2005
  9. ncbi request reprint [18F]FDOPA PET and clinical features in parkinsonism due to manganism
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 20:492-6. 2005
  10. pmc Pathophysiology of parkinsonism due to hydrocephalus
    B A Racette
    Department of Neurology and Neurological Surgery Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    J Neurol Neurosurg Psychiatry 75:1617-9. 2004

Research Grants

  1. PARKINSON DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTER
    Brad Racette; Fiscal Year: 2002
  2. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2011
  3. Epidemilogy of Parkinsonism in Welders
    Brad Racette; Fiscal Year: 2009
  4. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2010
  5. Epidemilogy of Parkinsonism in Welders
    Brad Racette; Fiscal Year: 2009
  6. Epidemiology of Parkinsonism in Welders
    Brad Racette; Fiscal Year: 2007
  7. PARKINSON'S DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTER
    Brad Racette; Fiscal Year: 2007
  8. GENETICS OF PARKINSON DISEASE IN THE AMISH
    Brad Racette; Fiscal Year: 2006
  9. PARKINSON DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTER
    Brad Racette; Fiscal Year: 2004
  10. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2010

Detail Information

Publications42

  1. pmc Increased risk of parkinsonism associated with welding exposure
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurotoxicology 33:1356-61. 2012
    ..The neurological phenotype associated with welding exposures has not been well described. Prior epidemiologic evidence linking occupational welding to parkinsonism is mixed, and remains controversial...
  2. pmc Pathophysiology of manganese-associated neurotoxicity
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63131, USA
    Neurotoxicology 33:881-6. 2012
    ..This symposium provided some converging evidence of the potential neurotoxic impact of Mn on the dopaminergic system and challenged existing paradigms on the pathophysiology of Mn in the central nervous system...
  3. pmc High-throughput mutational analysis of TOR1A in primary dystonia
    Jianfeng Xiao
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Med Genet 10:24. 2009
    ..The aim of this study was to identify TOR1A Exon 5 mutations in a large cohort of subjects with mainly non-generalized primary dystonia...
  4. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  5. pmc A population-based study of parkinsonism in an Amish community
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroepidemiology 33:225-30. 2009
    ..Parkinson's disease (PD) is a neurodegenerative disorder with unknown cause. Genetic mutations account for a minority of cases but the role of environmental factors is unclear...
  6. ncbi request reprint The impact of litigation on neurologic research
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Neurology 67:2124-8. 2006
    ..Litigation and its peripheral effects may bias investigators, impede research efforts, and harm research participants, thereby undermining efforts to understand the cause of neurologic disease...
  7. pmc [18F]FDOPA PET as an endophenotype for Parkinson's Disease linkage studies
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 141:245-9. 2006
    ..36 +/- 1.23. The [18F]FDOPA PET endophenotype permits phenoconversion in multi-incident PD families and may increase LOD score accuracy and power of an informative pedigree...
  8. ncbi request reprint Prevalence of parkinsonism and relationship to exposure in a large sample of Alabama welders
    B A Racette
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Neurology 64:230-5. 2005
    ..To estimate the prevalence of parkinsonism in welders in Alabama and to compare this prevalence with that in a general population sample...
  9. ncbi request reprint [18F]FDOPA PET and clinical features in parkinsonism due to manganism
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 20:492-6. 2005
    ..This case suggests that the clinical and pathophysiological features of manganese-associated parkinsonism may overlap with that of PD...
  10. pmc Pathophysiology of parkinsonism due to hydrocephalus
    B A Racette
    Department of Neurology and Neurological Surgery Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    J Neurol Neurosurg Psychiatry 75:1617-9. 2004
    ..Hydrocephalus associated with shunt malfunction can cause a distinct parkinsonian syndrome with greater dysfunction of projections from the medial substantia nigra to anterior striatum than in idiopathic Parkinson's disease...
  11. pmc Metal emissions and urban incident Parkinson disease: a community health study of Medicare beneficiaries by using geographic information systems
    Allison W Willis
    Department of Neurology, School of Medicine, Washington University, 660 South Euclid Avenue, Campus Box 8111, St Louis, MO 63110, USA
    Am J Epidemiol 172:1357-63. 2010
    ..1, 95% CI: 0.94, 1.31). Urban Parkinson disease incidence is greater in counties with high reported industrial release of copper or manganese. Environmental exposure to metals may be a risk factor for Parkinson disease in urban areas...
  12. ncbi request reprint A rapid method for mass screening for parkinsonism
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, United States
    Neurotoxicology 27:357-61. 2006
    ..Parkinsonism as diagnosed by our criteria was common in this group of welders...
  13. pmc Pregnancy in multiple system atrophy: a case report
    Lirong Zhu
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Med Case Reports 5:599. 2011
    ..abstract:..
  14. ncbi request reprint Convergence insufficiency in idiopathic Parkinson's disease responsive to levodopa
    B A Racette
    Washington University School of Medicine Department of Neurology and Neurologic Surgery Neurology Missouri, St Louis 63110, USA
    Strabismus 7:169-74. 1999
    ..This is the first reported case of convergence insufficiency in IPD responsive to levodopa...
  15. ncbi request reprint Welding-related parkinsonism: clinical features, treatment, and pathophysiology
    B A Racette
    Departments of Neurology and Neurological Surgery Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 56:8-13. 2001
    ..To determine whether welding-related parkinsonism differs from idiopathic PD...
  16. ncbi request reprint Thalamic stimulation for primary writing tremor
    B A Racette
    Department of Neurology and Neurologic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurol 248:380-2. 2001
    ..We conclude that nucleus ventralis intermedius thalamic stimulation is safe and effective for primary writing tremor...
  17. ncbi request reprint Late-onset neurodegeneration with brain iron accumulation type 1: expanding the clinical spectrum
    B A Racette
    Department of Neurology and Neurologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 16:1148-52. 2001
    ..We conclude that NBIA-1 pathology can develop at any age, and that the phenotype should be expanded to include late-onset parkinsonism. The relationship to hemiballismus and adult-onset dementia is less clear...
  18. ncbi request reprint Evaluation of a screening questionnaire for genetic studies of Parkinson's disease
    B A Racette
    Department of Neurology and Neurologic Surgery Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Med Genet 88:539-43. 1999
    ..However, we conclude that this screening questionnaire has inadequate sensitivity for detection of mild parkinsonism and direct examination is still critical for accurate classification for genetic studies...
  19. ncbi request reprint A multi-incident, Old-Order Amish family with PD
    B A Racette
    Department of Neurology and Neurological, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 58:568-74. 2002
    ..PD is largely a sporadic condition of unknown etiology, but specific inherited mutations are a cause of PD...
  20. ncbi request reprint Ipsilateral thalamic stimulation after thalamotomy for essential tremor. A case report
    B A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stereotact Funct Neurosurg 75:155-9. 2000
    ..Vim thalamic stimulation is an effective treatment option for recurrent tremor in patients who have undergone ipsilateral thalamotomy...
  21. ncbi request reprint Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024)
    Brad A Racette
    Department of Neurology and Neurological Surgery Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 17:1098-100. 2002
    ..Subsequent injections with botulinum toxin B provided substantial reduction of blepharospasm. This is the first reported case of secondary resistance to the new preparation of botulinum toxin A...
  22. ncbi request reprint Botulinum toxin B reduces sialorrhea in parkinsonism
    Brad A Racette
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 18:1059-61. 2003
    ..Mean peak benefit from injections lasted 14 weeks. We conclude that denervation of salivary glands with botulinum toxin B produces excellent reduction of excessive salivation associated with parkinsonism...
  23. ncbi request reprint Ptosis as a remote effect of therapeutic botulinum toxin B injection
    B A Racette
    Department of Neurology and Neurological Surgery, Washington University Sxhool of Medicine, St Louis, MO 63110, USA
    Neurology 59:1445-7. 2002
    ..The authors conclude that systemic spread of BTX-B can cause symptomatic involvement of autonomic neurons...
  24. ncbi request reprint Clinical features and comorbidity of mood fluctuations in Parkinson's disease
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    J Neuropsychiatry Clin Neurosci 14:438-42. 2002
    ..This association remained after removing effects of age and disease duration...
  25. doi request reprint Cancer incidence in a trial of an antiapoptotic agent for Parkinson's disease
    Steven R Schwid
    Department of Neurology, University of Rochester, Rochester, New York, USA
    Mov Disord 25:1801-8. 2010
    ..Melanoma occurrence in our PD patients was greater than predicted compared with the general population and was unrelated to dopaminergic therapy. Clinical surveillance of PD patients for melanoma may be warranted...
  26. pmc Geographic and ethnic variation in Parkinson disease: a population-based study of US Medicare beneficiaries
    Allison Wright Willis
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8111, St Louis, MO 63110, USA
    Neuroepidemiology 34:143-51. 2010
    ..Parkinson disease is a common neurodegenerative disease. The racial, sex, age, and geographic distributions of Parkinson disease in the US are unknown...
  27. doi request reprint Prospective study examining remote effects of botulinum toxin a in children with cerebral palsy
    Beth E Crowner
    Program in Physical Therapy, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Pediatr Neurol 39:253-8. 2008
    ..This information can help guide dosages of botulinum toxin A in the management of spasticity in children with cerebral palsy...
  28. pmc Conjugal Parkinsonism and Parkinson disease: a case series with environmental risk factor analysis
    Allison W Willis
    Department of Neurology, Washington University School of Medicine, Saint Louis, MO 63110, United States
    Parkinsonism Relat Disord 16:163-6. 2010
    ..Larger conjugal PD studies may permit stratification of concordant environmental exposures to determine dose responsiveness and relative contributions to PD risk...
  29. pmc High dose botulinum toxin A for the treatment of lower extremity hypertonicity in children with cerebral palsy
    Allison W Willis
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Dev Med Child Neurol 49:818-22. 2007
    ..All doses were associated with a significant increase in passive range of motion using the Tardieu scale. We conclude that higher dose BTX-A is safe in children with a spectrum of CP phenotypes and are well tolerated over time...
  30. pmc Sensitivity and specificity of the finger tapping task for the detection of psychogenic movement disorders
    Susan Criswell
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Parkinsonism Relat Disord 16:197-201. 2010
    ..ROC analysis identified a cutoff FTT ratio of 0.670 or less was 89.1% specific and 76.9% sensitive for the diagnosis of PMD. We conclude the FTT can provide supportive evidence for the diagnosis of PMD...
  31. ncbi request reprint Relative risk of spread of symptoms among the focal onset primary dystonias
    Elliott M Weiss
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Mov Disord 21:1175-81. 2006
    ..Different sites of onset of PTD confer different risks of spread, important for clinical prognosis. Different risks of spread may provide clues about underlying pathogenesis of adult-onset primary dystonias...
  32. pmc Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study
    Christopher F McNicoll
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Mov Disord 23:1596-601. 2008
    ..No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD...
  33. ncbi request reprint The use of botulinum toxin therapy for lower-extremity spasticity in children with cerebral palsy
    Susan R Criswell
    American Parkinson Disease Association Advanced Center for Parkinson Research, St Louis, Missouri, USA
    Neurosurg Focus 21:e1. 2006
    ..With a multidisciplinary approach, children with lower-extremity hypertonicity due to CP can experience improvements in muscle tone and function...
  34. pmc Impact of belief in neuroprotection on therapeutic intervention in Parkinson's disease
    Rodger J Elble
    Department of Neurology, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Mov Disord 25:1082-6. 2010
    ..We found the investigators' level of confidence in these agents had no effect on the time to symptomatic therapy or on the change in UPDRS during 12 months of treatment...
  35. ncbi request reprint Levodopa with carbidopa diminishes glycogen concentration, glycogen synthase activity, and insulin-stimulated glucose transport in rat skeletal muscle
    Jill L Smith
    Dept of Biology, St Louis University, 3507 Laclede Ave, St Louis, MO 63103, USA
    J Appl Physiol (1985) 97:2339-46. 2004
    ..The data demonstrate beta-adrenergic-dependent inhibition of insulin action by levodopa-carbidopa and suggest that unrecognized insulin resistance may exist in chronically treated patients with Parkinson's disease...
  36. ncbi request reprint Iatrogenic botulism due to therapeutic botulinum toxin a injection in a pediatric patient
    Beth E Crowner
    Program in Physical Therapy, Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Clin Neuropharmacol 30:310-3. 2007
    ..This case highlights the importance of physicians having adequate knowledge of primate and human literature on the lethal dose, 50% of botulinum toxin A before injecting children...
  37. ncbi request reprint Dystonia in a patient with ring chromosome 21
    Craig E Hou
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 18:1547-9. 2003
    ..We describe a patient with ring chromosome 21, with karyotype 46XX,r(21)(p11.2q22.3); 46,XX,dic r(21)(p11.2q22.3); 45, XX, -21, who developed childhood onset cervical dystonia...
  38. pmc Validity and reliability of an occupational exposure questionnaire for parkinsonism in welders
    Angela J Hobson
    Division of Environmental and Occupational Health, Saint Louis University School of Public Health, St Louis, Missouri, USA
    J Occup Environ Hyg 6:324-31. 2009
    ....
  39. ncbi request reprint Novel haplotypes in 17q21 are associated with progressive supranuclear palsy
    Pau Pastor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 56:249-58. 2004
    ..The identification of these specific subhaplotypes that modify risk for PSP/CBD supports the hypothesis that a pathogenic allele exists in a subgroup of PSP patients...
  40. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  41. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
  42. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...

Research Grants13

  1. PARKINSON DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTER
    Brad Racette; Fiscal Year: 2002
    ..The MDC at Washington University School of Medicine provides the breadth of clinical and basic research experience required to be a productive site in this large, multi-center neuroprotective trial in PD. ..
  2. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2011
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  3. Epidemilogy of Parkinsonism in Welders
    Brad Racette; Fiscal Year: 2009
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  4. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2010
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  5. Epidemilogy of Parkinsonism in Welders
    Brad Racette; Fiscal Year: 2009
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  6. Epidemiology of Parkinsonism in Welders
    Brad Racette; Fiscal Year: 2007
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..
  7. PARKINSON'S DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTER
    Brad Racette; Fiscal Year: 2007
    ..The MDC at Washington University School of Medicine provides the breadth of clinical and basic research experience required to be a productive site in this large, multi-center neuroprotective trial in PD. ..
  8. GENETICS OF PARKINSON DISEASE IN THE AMISH
    Brad Racette; Fiscal Year: 2006
    ..abstract_text> ..
  9. PARKINSON DISEASE NEUROPROTECTIVE TRIAL:CLINICAL CENTER
    Brad Racette; Fiscal Year: 2004
    ..The MDC at Washington University School of Medicine provides the breadth of clinical and basic research experience required to be a productive site in this large, multi-center neuroprotective trial in PD. ..
  10. Epidemilogy of Parkinsonism in Welders
    Brad A Racette; Fiscal Year: 2010
    ..The cohort assembled will provide unique opportunities for future research projects into gene-environment interactions and exposure related neuroimaging changes. ..