Research Topics
| Joseph PriceSummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Axo-axonic synapses formed by somatostatin-expressing GABAergic neurons in rat and monkey visual cortexYuri Gonchar
Department of Anatomy and Neurobiology, 8108, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 443:1-14. 2002..Thus, SOM neurons may influence synaptic excitation of pyramidal neurons at the level of synaptic inputs to dendrites as well as at the initiation site of action potential output...- Synaptic relationships between axon terminals from the mediodorsal thalamic nucleus and gamma-aminobutyric acidergic cortical cells in the prelimbic cortex of the ratMasaru Kuroda
Department of Anatomy, Toho University School of Medicine, Ohta ku, Tokyo 143 8540, Japan
J Comp Neurol 477:220-34. 2004..The anatomical findings indicate that GABAergic interneurons have a modulatory influence on excitatory reverberation between MD and the prefrontal cortex... - Midline and intralaminar thalamic connections with the orbital and medial prefrontal networks in macaque monkeysDavid T Hsu
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 504:89-111. 2007..The strong connections between the subgenual cortex and the Pa provide a pathway through which stress signals from the Pa may influence these prefrontal circuits... 
Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factorsYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Psychiatry 165:524-32. 2008..Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined...- Neural circuits underlying the pathophysiology of mood disordersJoseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
Trends Cogn Sci 16:61-71. 2012.... 
Neurocircuitry of mood disordersJoseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
Neuropsychopharmacology 35:192-216. 2010..A large body of human data from functional and structural imaging, as well as analysis of lesions and histological material indicates that this system is centrally involved in mood disorders...- What does it take to stay healthy past 100?: Commentary on "No disease in the brain of a 115-year-old woman"Joseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, United States
Neurobiol Aging 29:1140-2. 2008..Critical questions raised by the present report include what genetic or other factors allowed healthy survival to age 115 year, and whether anti-amyloid therapies will allow more general survival in good mental health beyond age 100?.. - Definition of the orbital cortex in relation to specific connections with limbic and visceral structures and other cortical regionsJoseph L Price
Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
Ann N Y Acad Sci 1121:54-71. 2007.... - Free will versus survival: brain systems that underlie intrinsic constraints on behaviorJoseph L Price
Department of Anatomy and Neurobiology, Washington University, School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 493:132-9. 2005..The overall function of this circuit is unclear, but may be involved in introspective monitoring of the individual... - Differential connections of the temporal pole with the orbital and medial prefrontal networks in macaque monkeysHideki Kondo
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Comp Neurol 465:499-523. 2003.... - Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer diseaseJoseph L Price
Department of Anatomy and Neurobiology, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO, USA
Neurobiol Aging 30:1026-36. 2009..To determine the frequency and possible cognitive effect of histological Alzheimer's disease (AD) in autopsied older nondemented individuals... - Differential connections of the perirhinal and parahippocampal cortex with the orbital and medial prefrontal networks in macaque monkeysHideki Kondo
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Comp Neurol 493:479-509. 2005..In contrast, the parahippocampal cortex and the medial prefrontal network are connected with the dorsal TG, the rostral superior temporal gyrus (STG) and dorsal bank of STS, and the retrosplenial cortex... - Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexusYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:11020-5. 2010.... - The default mode network and self-referential processes in depressionYvette I Sheline
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:1942-7. 2009..These findings provide a brain network framework within which to consider the pathophysiology of depression... - APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42Yvette I Sheline
Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 30:17035-40. 2010.... - Complementary circuits connecting the orbital and medial prefrontal networks with the temporal, insular, and opercular cortex in the macaque monkeyKadharbatcha S Saleem
Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Comp Neurol 506:659-93. 2008..This system, which is also connected with the entorhinal, parahippocampal, and cingulate/retrosplenial cortex, may be involved in emotion and other self-referential processes... - Cytoarchitectonic and chemoarchitectonic subdivisions of the perirhinal and parahippocampal cortices in macaque monkeysKadharbatcha S Saleem
RIKEN Brain Science Institute, Saitama 351 0198, Japan
J Comp Neurol 500:973-1006. 2007..quot; This area closely resembles the laterally adjacent area TE and the caudally adjacent area V4 but is clearly different from the more rostral area TF. These areas are likely to have distinct functions... - High-dimensional mapping of the hippocampus in depressionJoel A Posener
Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 South Euclid Ave, St Louis, MO 63110, USA
Am J Psychiatry 160:83-9. 2003..In this study, high-dimensional brain mapping was used to evaluate hippocampal shape and volume in patients with major depressive disorder and healthy comparison subjects... - A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonistKevin J Black
Departments of Psychiatry, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:17113-8. 2002.... - Correlations between antemortem hippocampal volume and postmortem neuropathology in AD subjectsJohn G Csernansky
Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
Alzheimer Dis Assoc Disord 18:190-5. 2004..The data suggest that hippocampal volume assessed in living subjects with probable AD is both a good marker of dementia severity and of an underlying element of the AD disease process... - Neuropathologic criteria for diagnosing Alzheimer disease in persons with pure dementia of Alzheimer typeDaniel W McKeel
Dept of Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
J Neuropathol Exp Neurol 63:1028-37. 2004..Thus cut-points based on both diffuse and neuritic SP in neocortical regions distinguished nondemented and AD subjects with high sensitivity and specificity... - Persistence and brain circuitryDebra A Gusnard
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 100:3479-84. 2003..These findings represent a fresh approach to linking normal individual differences in personality and behavior to specific neuronal structures and subsystems... - Comparative aspects of amygdala connectivityJoseph L Price
Department of Anatomy Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Ann N Y Acad Sci 985:50-8. 2003..All of these systems are present in all mammals studied; the major differences lie in the greater elaboration of the cerebral cortex in primates... - Aging, preclinical Alzheimer disease, and early detectionJoseph L Price
Department of Anatony and Neurobiology, Washington University School of Medicine, St Louis Missouri, USA
Alzheimer Dis Assoc Disord 17:S60-2. 2003 - Glial reduction in amygdala in major depressive disorder is due to oligodendrocytesMassihullah Hamidi
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Biol Psychiatry 55:563-9. 2004..There was no significant decrease in astrocyte or microglia density in MDD or BD subjects. CONCLUSIONS: The glial cell reduction previously found in the amygdala in MDD is primarily due to oligodendrocytes... - Low glial numbers in the amygdala in major depressive disorderMichael P Bowley
Department of Anatomy and Neurobiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Biol Psychiatry 52:404-12. 2002..CONCLUSIONS: Glia are reduced in the amygdala in major depressive disorder, especially on the left side. The results suggest that lithium and valproate may moderate the glial reduction... - Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failureAna Maria Arbelaez
Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
Diabetes 57:470-5. 2008..We investigated the role of cerebral mechanisms in HAAF by measuring regional brain activation during recurrent hypoglycemia with attenuated counterregulatory responses and comparing it with initial hypoglycemia in healthy individuals... - Architectonic subdivision of the human orbital and medial prefrontal cortexDost Ongur
Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Comp Neurol 460:425-49. 2003..The parallel organization of the OMPFC in monkeys and humans allows experimental data from monkeys to be applied to studies of the human cortex... - MRI measures of entorhinal cortex versus hippocampus in preclinical ADJohn C Morris
Neurology 59:1474; author reply 1474-5. 2002 - Glucose metabolism in the amygdala in depression: relationship to diagnostic subtype and plasma cortisol levelsWayne C Drevets
Section on Neuroimaging of Mood and Anxiety Disorders, Molecular Imaging Branch, NIH National Institute of Mental Health, Building 1, Room B3 10, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Pharmacol Biochem Behav 71:431-47. 2002.... - Cortical abnormalities in bipolar disorder investigated with MRI and voxel-based morphometryAllison C Nugent
Section on Neuroimaging in Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, 1 Center Drive, MSC 0135, Bethesda, MD 20892 0135, USA
Neuroimage 30:485-97. 2006....
Research Grants
- OLFACTORY CORTEXJoseph Price; Fiscal Year: 2002..By correlating the PET and MRI images, levels of metabolic and synaptic activity can be determined within the defined architectonic areas as a function of unipolar or bipolar depression. ..
- STUDIES ON THE OLFACTORY CORTEXJoseph Price; Fiscal Year: 2007..Drevets), to determine which specific areas and networks are affected in these disorders. ..
- STUDIES ON THE OLFACTORY CORTEXJoseph Price; Fiscal Year: 1993..In addition, electrophysiological recording of responses to olfactory bulb stimulation will be used to map the olfactory related area of the orbital cortex, and to guide the placement of microinjection of the axonal tracers...