W J Powers

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint The use of positron emission tomography in cerebrovascular disease
    William J Powers
    Department of Neurology, Neurological Surgery, and Radiology, East Building Imaging Center, Room 2218F, Campus Box 8225, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimaging Clin N Am 13:741-58. 2003
  2. pmc Selective defect of in vivo glycolysis in early Huntington's disease striatum
    William J Powers
    Department of Neurology, Program in Physical Therapy, and Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:2945-9. 2007
  3. ncbi request reprint Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage
    W J Powers
    Department of Neurology and Neurological Surgery, Lillian Strauss Institute for Neuroscience, Washington University School of Medicine, St Louis, MO 631101, USA
    Neurology 57:18-24. 2001
  4. ncbi request reprint Intra-arterial thrombolysis for basilar artery thrombosis: trial it
    William J Powers
    Department of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 38:704-6. 2007
  5. ncbi request reprint Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage
    A R Zazulia
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Cereb Blood Flow Metab 21:804-10. 2001
  6. ncbi request reprint No reduction in cerebral metabolism as a result of early moderate hyperventilation following severe traumatic brain injury
    M N Diringer
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 92:7-13. 2000
  7. ncbi request reprint Compensatory mechanisms for chronic cerebral hypoperfusion in patients with carotid occlusion
    C P Derdeyn
    Mallinckrodt Institute of Radiology, Department of Neurology, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Stroke 30:1019-24. 1999
  8. ncbi request reprint Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion
    C P Derdeyn
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 29:754-8. 1998
  9. ncbi request reprint Lack of correlation between pattern of collateralization and misery perfusion in patients with carotid occlusion
    C P Derdeyn
    Mallinckrodt Institute of Radiology, Department of Neurology, Institute of the Jewish Hospital of St Louis, Washington University School of Medicine, St Louis, MO, USA
    Stroke 30:1025-32. 1999
  10. ncbi request reprint Severe hemodynamic impairment and border zone--region infarction
    C P Derdeyn
    Neuroradiology Section, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Radiology 220:195-201. 2001

Detail Information

Publications49

  1. ncbi request reprint The use of positron emission tomography in cerebrovascular disease
    William J Powers
    Department of Neurology, Neurological Surgery, and Radiology, East Building Imaging Center, Room 2218F, Campus Box 8225, Washington University School of Medicine, 4525 Scott Avenue, St Louis, MO 63110, USA
    Neuroimaging Clin N Am 13:741-58. 2003
    ..Whether the role of PET expands to impact the management of individual patients will depend on the results of investigations like the Carotid Occlusion Surgery Study that directly assess the ability of PET to influence patient outcome...
  2. pmc Selective defect of in vivo glycolysis in early Huntington's disease striatum
    William J Powers
    Department of Neurology, Program in Physical Therapy, and Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:2945-9. 2007
    ..Because glycolytic metabolism is predominantly astrocytic, the selective reduction in striatal CMRglc raises the possibility that astrocyte dysfunction may be involved in the pathogenesis of HD...
  3. ncbi request reprint Autoregulation of cerebral blood flow surrounding acute (6 to 22 hours) intracerebral hemorrhage
    W J Powers
    Department of Neurology and Neurological Surgery, Lillian Strauss Institute for Neuroscience, Washington University School of Medicine, St Louis, MO 631101, USA
    Neurology 57:18-24. 2001
    ..The authors undertook this study to provide further information on the changes in whole-brain and periclot regional CBF that occur with pharmacologic reductions in mean arterial pressure (MAP) in patients with acute ICH...
  4. ncbi request reprint Intra-arterial thrombolysis for basilar artery thrombosis: trial it
    William J Powers
    Department of Neurology and Neurological Surgery, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 38:704-6. 2007
    ....
  5. ncbi request reprint Hypoperfusion without ischemia surrounding acute intracerebral hemorrhage
    A R Zazulia
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Cereb Blood Flow Metab 21:804-10. 2001
    ..Thus, the authors found no evidence for ischemia in the periclot zone of hypoperfusion in acute ICH patients studied 5 to 22 hours after hemorrhage onset...
  6. ncbi request reprint No reduction in cerebral metabolism as a result of early moderate hyperventilation following severe traumatic brain injury
    M N Diringer
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 92:7-13. 2000
    ..The authors tested the hypothesis that moderate hyperventilation induced early after TBI would not produce a reduction in CBF severe enough to cause cerebral energy failure (CBF that is insufficient to meet metabolic needs)...
  7. ncbi request reprint Compensatory mechanisms for chronic cerebral hypoperfusion in patients with carotid occlusion
    C P Derdeyn
    Mallinckrodt Institute of Radiology, Department of Neurology, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Stroke 30:1019-24. 1999
    ..Regional measurements of the cerebral rate of glucose metabolism (CMRGlc) were made on follow-up in 5 patients. Statistical significance (P<0.05) was measured with t tests and linear regression analysis...
  8. ncbi request reprint Increased oxygen extraction fraction is associated with prior ischemic events in patients with carotid occlusion
    C P Derdeyn
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 29:754-8. 1998
    ..The purpose of our study was to investigate the relationship between misery perfusion (increased oxygen extraction fraction, OEF) and baseline risk factors in patients with carotid occlusion...
  9. ncbi request reprint Lack of correlation between pattern of collateralization and misery perfusion in patients with carotid occlusion
    C P Derdeyn
    Mallinckrodt Institute of Radiology, Department of Neurology, Institute of the Jewish Hospital of St Louis, Washington University School of Medicine, St Louis, MO, USA
    Stroke 30:1025-32. 1999
    ..The purpose of this investigation was to determine the relationship of angiographic findings to increased OEF in these patients...
  10. ncbi request reprint Severe hemodynamic impairment and border zone--region infarction
    C P Derdeyn
    Neuroradiology Section, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Radiology 220:195-201. 2001
    ....
  11. ncbi request reprint Count-based PET method for predicting ischemic stroke in patients with symptomatic carotid arterial occlusion
    C P Derdeyn
    Section of Neuroradiology, Mallinckrodt Institute, St Louis, MO, USA
    Radiology 212:499-506. 1999
    ....
  12. ncbi request reprint Mannitol bolus preferentially shrinks non-infarcted brain in patients with ischemic stroke
    T O Videen
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO, USA
    Neurology 57:2120-2. 2001
    ..1 +/- 2.8 mL (0.6%, p < 0.005). Brain in the noninfarcted hemisphere shrank more (0.8 +/- 0.4%) than in the infarcted hemisphere (0.0 +/- 0.5%, p < 0.05)...
  13. pmc A default mode of brain function
    M E Raichle
    Mallinckrodt Institute of Radiology and Departments of Neurology and Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:676-82. 2001
    ..These decreases suggest the existence of an organized, baseline default mode of brain function that is suspended during specific goal-directed behaviors...
  14. ncbi request reprint Comparison of PET oxygen extraction fraction methods for the prediction of stroke risk
    C P Derdeyn
    Neuroradiology Section, Division of Radiologic Services, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    J Nucl Med 42:1195-7. 2001
    ..737 (ratios of absolute). CONCLUSION: All 3 methods are predictive of stroke risk in patients with unilateral carotid artery occlusion. ROC curve analysis is useful for selecting optimal thresholds for maximal sensitivity and specificity...
  15. ncbi request reprint Measurement of cerebral blood flow in chronic carotid occlusive disease: comparison of dynamic susceptibility contrast perfusion MR imaging with positron emission tomography
    Pratik Mukherjee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJNR Am J Neuroradiol 24:862-71. 2003
    ....
  16. pmc Cerebral mitochondrial metabolism in early Parkinson's disease
    William J Powers
    Department of Neurology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7025, USA
    J Cereb Blood Flow Metab 28:1754-60. 2008
    ..Whether this is the case in early PD and whether it is important in the pathogenesis of PD will require further study...
  17. ncbi request reprint Preview of a new trial of extracranial-to-intracranial arterial anastomosis: the carotid occlusion surgery study
    H P Adams
    Division of Cerebrovascular Diseases, Department of Neurology, University of Iowa College of Medicine, Iowa City, Iowa 52242, USA
    Neurosurg Clin N Am 12:613-24, ix-x. 2001
    ..Several issues that are being addressed in this new trial are described in this article...
  18. ncbi request reprint Progression of mass effect after intracerebral hemorrhage
    A R Zazulia
    Departments of Neurology and Neurological Surgery, Lillian Strauss Institute for Neuroscience of the Jewish Hospital of St Louis, MO, USA
    Stroke 30:1167-73. 1999
    ..Our goal was to determine the time course and cause for progression of mass effect after ICH...
  19. ncbi request reprint Cost-effectiveness of screening for asymptomatic carotid atherosclerotic disease
    C P Derdeyn
    Department of Radiology, University of Wisconsin Hospitals and Clinics, Madison, USA
    Stroke 27:1944-50. 1996
    ..The purpose of this study is to evaluate the cost-effectiveness of using Doppler ultrasound as a screening tool to select subjects for arteriography and subsequent surgery...
  20. ncbi request reprint Regional cerebrovascular and metabolic effects of hyperventilation after severe traumatic brain injury
    Michael N Diringer
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 96:103-8. 2002
    ..In the present study they sought to determine if hyperventilation lowers CBF below the ischemic threshold of 18 to 20 ml/100 g/ min in any brain region and if those reductions cause energy failure (defined as a fall in CMRO2)...
  21. pmc No effect of low-dose statins treatment on cerebral blood flow in humans with atherosclerotic cerebrovascular disease
    Colin P Derdeyn
    Department of Neurology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 27:1643-8. 2007
    ..9+/-13.5 and 44.2+/-13.3 mL/100 g min for the statin and nonstatin groups, respectively. We conclude that the stroke risk reduction observed with statin therapy in humans likely involves mechanisms other than an increased basal CBF...
  22. doi request reprint PET studies of cerebral metabolism in Parkinson disease
    William J Powers
    Department of Neurology, School of Medicine, University of North Carolina at Chapel Hill, 170 Manning Drive, Rm 2131, CB 7025, Chapel Hill, NC 27599 7025, USA
    J Bioenerg Biomembr 41:505-8. 2009
    ..Which is the case in early PD and whether these metabolic abnormalities are important in the pathogenesis of PD will require further study...
  23. ncbi request reprint 10 most commonly asked questions about carotid artery occlusion
    William J Powers
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Neurologist 9:167-9. 2003
  24. ncbi request reprint Patterns of infarction in hemodynamic failure
    Colin P Derdeyn
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cerebrovasc Dis 24:11-9. 2007
    ..The purpose of this study was to investigate the clinical and imaging features of stroke in these patients...
  25. doi request reprint Transient focal increase in perihematomal glucose metabolism after acute human intracerebral hemorrhage
    Allyson R Zazulia
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Stroke 40:1638-43. 2009
    ....
  26. ncbi request reprint The Carotid Occlusion Surgery Study
    Robert L Grubb
    Department of Neurological Surgery, Washington University School of Medicine, Washington University Medical Center, St Louis, Missouri 63110 1093, USA
    Neurosurg Focus 14:e9. 2003
    ..It is estimated that 186 patients will be required in each group. Assuming that 40% of PET scans will demonstrate increased OEF, this will require enrolling 930 clinically eligible individuals...
  27. ncbi request reprint Effect of hyperoxia on cerebral metabolic rate for oxygen measured using positron emission tomography in patients with acute severe head injury
    Michael N Diringer
    Department of Neurology, Neurology Neurosurgery Intensive Care Unit, Barnes Jewish Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 106:526-9. 2007
    ....
  28. pmc Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease
    Allyson R Zazulia
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 30:1883-9. 2010
    ..30, 95% CI=-7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD...
  29. ncbi request reprint Symptomatic autoregulatory failure in acute ischemic stroke
    Allyson R Zazulia
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 68:389-90. 2007
  30. ncbi request reprint Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited
    Colin P Derdeyn
    Neuroradiology Section, Division of Radiological Sciences, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    Brain 125:595-607. 2002
    ..The physiological explanation for the measurement of normal CBV in patients with increased OEF is less certain and may reflect preserved autoregulatory capacity...
  31. ncbi request reprint Mirror movements complicate interpretation of cerebral activation changes during recovery from subcortical infarction
    G F Wittenberg
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA
    Neurorehabil Neural Repair 14:213-21. 2000
    ..However, the common occurrence of mirror movements, particularly with effortful tasks, complicates interpretation of data regarding the role of the ipsilateral hemisphere in recovery...
  32. ncbi request reprint Risks of stroke and current indications for cerebral revascularization in patients with carotid occlusion
    R L Grubb
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Neurosurg Clin N Am 12:473-87, vii. 2001
    ....
  33. pmc Attenuation of counterregulatory responses to recurrent hypoglycemia by active thalamic inhibition: a mechanism for hypoglycemia-associated autonomic failure
    Ana Maria Arbelaez
    Campus Box 8127, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Diabetes 57:470-5. 2008
    ..We investigated the role of cerebral mechanisms in HAAF by measuring regional brain activation during recurrent hypoglycemia with attenuated counterregulatory responses and comparing it with initial hypoglycemia in healthy individuals...
  34. doi request reprint Imaging preventable infarction in patients with acute ischemic stroke
    W J Powers
    Department of Neurology, University of North Carolina School of Medicine, 170 Manning Dr, Rm 2131, CB 7025, Chapel Hill, NC 27599 7025, USA
    AJNR Am J Neuroradiol 29:1823-5. 2008
    ..This article will discuss the design, analysis, and interpretation of clinical research studies carried out to establish the accuracy and clinical value of neuroimaging to select such patients...
  35. ncbi request reprint Blood-to-brain glucose transport, cerebral glucose metabolism, and cerebral blood flow are not increased after hypoglycemia
    S A Segel
    Division of Endocrinology, Diabetes and Metabolism, Department of Medicine, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Diabetes 50:1911-7. 2001
    ..They do not exclude regional increments in blood-to-brain glucose transport. Alternatively, the fundamental alteration might lie beyond the blood-brain barrier...
  36. pmc Cerebellum as the normal reference for the detection of increased cerebral oxygen extraction
    Thomas T Jiang
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 30:1767-76. 2010
    ..0001). These methods may be useful for categorizing the hemodynamic status of patients with bilateral cerebral occlusive diseases, including atherosclerosis and moyamoya, to determine the association with the risk of subsequent stroke...
  37. ncbi request reprint Effect of normal saline bolus on cerebral blood flow in regions with low baseline flow in patients with vasospasm following subarachnoid hemorrhage
    Sarah C Jost
    Department of Neurology, Neurological Surgery, and Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 103:25-30. 2005
    ..The purpose of this study was to examine the effects of volume expansion on regional (r)CBF in patients with DIND following SAH...
  38. pmc Normal platelet mitochondrial complex I activity in Huntington's disease
    William J Powers
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 27:99-101. 2007
    ..Reductions > 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present...
  39. pmc Autoregulation after ischaemic stroke
    William J Powers
    Department of Neurology, University of North Carolina School of Medicine, North Carolina 27599 7025, USA
    J Hypertens 27:2218-22. 2009
    ..Data from human participants have failed to resolve the question whether cerebral blood flow (CBF) in the peri-infarct region will decrease due to impaired autoregulation when systemic mean arterial pressure (MAP) is rapidly reduced...
  40. ncbi request reprint Primary angiitis of the central nervous system at conventional angiography
    Yasha Kadkhodayan
    Neuroimaging Laboratory, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Radiology 233:878-82. 2004
    ..To retrospectively determine the sensitivity and specificity of cerebral angiography for the diagnosis of primary angiitis of the central nervous system (CNS)...
  41. pmc Intracerebral hemorrhage and head trauma: common effects and common mechanisms of injury
    William J Powers
    Department of Neurology, University of North Carolina, Chapel Hill, NC 27599 7025, USA
    Stroke 41:S107-10. 2010
    ..Recent data demonstrating contralateral hemispheric damage in patients with acute ICH provide further support for this theory of common injury mechanisms...
  42. pmc Activation of human medial prefrontal cortex during autonomic responses to hypoglycemia
    Denise Teves
    Division of Endocrinology, Metabolism, and Lipid Research of the Department of Internal Medicine, Washington University School of Medicine, Campus Box 8127, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:6217-21. 2004
    ..These results provide evidence that the MPFC participates in the autonomic responses to simple physiological stimuli in humans...
  43. pmc Dynamic susceptibility contrast MRI with localized arterial input functions
    John J Lee
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Magn Reson Med 63:1305-14. 2010
    ..Regression analysis for localized arterial input function gave estimates of a scaling factor for quantitation that described perfusion accurately in patients with substantial variability in hemodynamic impairment...
  44. doi request reprint Acute stroke imaging research roadmap
    Max Wintermark
    University of California, San Francisco, Department of Radiology, Neuroradiology Section, 505 Parnassus Avenue, Box 0628, San Francisco, CA 94143 0628, USA
    Stroke 39:1621-8. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...
  45. ncbi request reprint Re: Stages and thresholds of hemodynamic failure
    Colin P Derdeyn
    Stroke 34:589. 2003
  46. ncbi request reprint Emergency craniotomy for intracerebral hemorrhage: when doesn't it help and does it ever help?
    James M Gebel
    Neurology 58:1325-6. 2002
  47. ncbi request reprint Carotid arteriography: still golden after all these years?
    William J Powers
    Neurology 62:1246-7. 2004
  48. ncbi request reprint National Institute of Neurological Disorders and Stroke-Canadian Stroke Network vascular cognitive impairment harmonization standards
    Vladimir Hachinski
    London Health Sciences Centre, University Campus, London, Ontario, Canada
    Stroke 37:2220-41. 2006
    ....
  49. pmc Acute stroke imaging research roadmap
    Max Wintermark
    Department of Radiology, University of California, San Francisco, CA 94143 0628, USA
    AJNR Am J Neuroradiol 29:e23-30. 2008
    ..The present article summarizes these recommendations and examines practical steps to achieve them...