Research Topics
Genomes and Genes | Simon N PowellSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Therapeutic exploitation of tumor cell defects in homologous recombinationSimon N Powell
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Anticancer Agents Med Chem 8:448-60. 2008..Thus, functional assays of homologous recombination could become a useful technique to determine phenotype of human breast cancer, which in turn will influence the choice of therapy...
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repairRaj K Pandita
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
Mol Cell Biol 26:1850-64. 2006..Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...- Accelerated partial-breast irradiation using proton beams: initial clinical experienceKevin R Kozak
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 66:691-8. 2006..Because of the dosimetric advantages of proton 3D-CPBI, technique modifications are being explored to improve acute skin tolerance... - Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repairArun Gupta
Washington University School of Medicine, St Louis, MO, USA
Cell Cycle 8:2198-210. 2009.... 
Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsiesHenning Willers
Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA
Mol Cancer Res 7:1304-9. 2009....- Tubular carcinoma of the breast: a retrospective analysis and review of the literatureTimothy Sullivan
Department of Radiation Oncology, Harvard Medical School, Boston, MA 02114, USA
Breast Cancer Res Treat 93:199-205. 2005..Adjuvant RT reduces the incidence of local failure following CS for tubular carcinoma, however, elderly women treated by CS may have a very low risk of local recurrence without adjuvant RT... - Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and largerScott R Floyd
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 66:358-64. 2006..LVI was significantly associated with LRF in our series, indicating that patients with this risk factor require careful consideration with regard to further local therapy... - Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cellsJames W Evans
Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305 5152, USA
Cancer Res 68:257-65. 2008.... - Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joiningJing Zhuang
Department of Radiation Oncology, Vanderbilt University Medical Centre, 1301 22nd Avenue South, Nashville, TN 37232, USA
Cancer Res 66:1401-8. 2006..We suggest that the differential control of NHEJ subprocesses by BRCA1, in concert with Chk2, reduces the mutagenic potential of NHEJ, thereby contributing to the prevention of familial breast cancers... - Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repairJunran Zhang
Department of Radiation Oncology, Massachusetts General Hospital Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
Mol Cell Biol 24:708-18. 2004..We propose a dual regulatory role for BRCA1 in maintaining genome integrity, whereby BRCA1 phosphorylation status controls the selectivity of repair events dictated by HR and error-prone NHR... - Quantifying the impact of immediate reconstruction in postmastectomy radiation: a large, dose-volume histogram-based analysisNisha Ohri
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
Int J Radiat Oncol Biol Phys 84:e153-9. 2012..To assess the impact of immediate breast reconstruction on postmastectomy radiation (PMRT) using dose-volume histogram (DVH) data... - MDC1 interacts with Rad51 and facilitates homologous recombinationJunran Zhang
Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
Nat Struct Mol Biol 12:902-9. 2005..Together, our findings suggest that MDC1 functions in Rad51-mediated homologous recombination by retaining Rad51 in chromatin... - The role of RPA2 phosphorylation in homologous recombination in response to replication arrestWei Shi
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Carcinogenesis 31:994-1002. 2010..Thus, our data suggest that RPA2 hyperphosphorylation plays a critical role in maintenance of genomic stability and cell survival after a DNA replication block via promotion of HR... - DNA damage induces p53-dependent BRCA1 nuclear exportZhihui Feng
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
J Biol Chem 279:28574-84. 2004..These results imply that, in addition to ATM-, ATR-, and Chk2-dependent phosphorylations, cytoplasmic relocalization of BRCA1 protein is a mechanism whereby BRCA1 function is regulated in response to DNA damage... - Negative Regulation of AKT Activation by BRCA1Tao Xiang
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
Cancer Res 68:10040-4. 2008..Our results show that BRCA1 is a negative regulator of the AKT pathway and imply the significance of the BRCA1/AKT pathway in tumorigenesis... - Helical tomotherapy planning for left-sided breast cancer patients with positive lymph nodes: comparison to conventional multiport breast techniqueS Murty Goddu
Washington University School of Medicine, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 73:1243-51. 2009..To evaluate the feasibility of using helical tomotherapy for locally advanced left-sided breast cancer... - Use of tamoxifen with postsurgical irradiation may improve survival in estrogen and progesterone receptor-positive male breast cancerShannon Fogh
Department of Radiation Oncology, Boston University Medical Center, USA
Clin Breast Cancer 11:39-45. 2011..The purpose of this study is to assess the impact of adjuvant therapy on survival in males with non-metastatic breast cancer... - Locoregional recurrence rates and prognostic factors for failure in node-negative patients treated with mastectomy: implications for postmastectomy radiationReshma Jagsi
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 62:1035-9. 2005..Because the chest wall is the most common site of failure, treating the chest wall alone in these patients to minimize toxicity is reasonable... - Lung dose-volume parameters and the risk of pneumonitis for patients treated with accelerated partial-breast irradiation using three-dimensional conformal radiotherapyAbram Recht
Beth Israel Deaconess Medical Center, Department of Radiation Oncology, Boston MA 02215, USA
J Clin Oncol 27:3887-93. 2009..We therefore examined the risk of pneumonitis in relation to lung dose-volume parameters... - Rad52 inactivation is synthetically lethal with BRCA2 deficiencyZhihui Feng
Department of Radiation Oncology, Washington University, St Louis, MO 63108, USA
Proc Natl Acad Sci U S A 108:686-91. 2011..Rad52 thus is an independent and alternative repair pathway of homologous recombination and a target for therapy in BRCA2-deficient cells... - Accelerated partial breast irradiation using proton beams: Initial dosimetric experienceAlphonse G Taghian
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
Int J Radiat Oncol Biol Phys 65:1404-10. 2006..We present our initial experience with protons for three-dimensional, conformal, external-beam accelerated partial breast irradiation (3D-CPBI)... - Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?Alphonse G Taghian
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 62:386-91. 2005..To evaluate and quantify the effect of irradiated lung volume, radiation dose, and paclitaxel chemotherapy on the development of radiation pneumonitis (RP) in breast cancer patients with positive lymph nodes... - BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase IIAlejandro D Treszezamsky
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
Cancer Res 67:7078-81. 2007..Overall, these results suggest that etoposide is a potentially useful drug in the treatment of BRCA-deficient human cancers... - The effect of delaying radiation therapy for systemic chemotherapy on local-regional control in breast cancerTorunn I Yock
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Breast Cancer Res Treat 84:161-71. 2004..It remains controversial as to whether the administration of chemotherapy prior to radiation following the surgical treatment for localized breast cancer compromises local control... - Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiationAlphonse G Taghian
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 64:1092-9. 2006..Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT)... - The role of the BRCA1 tumor suppressor in DNA double-strand break repairJunran Zhang
Department of Radiation Oncology, Washington University in St. Louis, 4511 Forest Park Boulevard, St. Louis, Missouri 63108, USA
Mol Cancer Res 3:531-9. 2005..Finally, we will explore the idea that tumor suppression by BRCA1 depends on its control of DNA DSB repair, resulting in the promotion of error-free and the inhibition of error-prone recombinational repair... - BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?Simon N Powell
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
Mol Cell 10:1262-3. 2002..The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA... - Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implicationsAlphonse G Taghian
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
J Clin Oncol 23:1951-61. 2005..Our aim is to evaluate the IFP and pO(2) before and after neoadjuvant CT using sequential paclitaxel and doxorubicin in patients with breast cancer tumors of >/= 3 cm... - The interaction of p53 with replication protein A mediates suppression of homologous recombinationLarisa Y Romanova
Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
Oncogene 23:9025-33. 2004..We hypothesize that sequestration of RPA by p53 at the sites of recombination is one means by which p53 can inhibit HR processes. Our data support and extend the previously formulated 'dual model' of p53's role as guardian of the genome... - Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guidelineBenjamin D Smith
Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
Int J Radiat Oncol Biol Phys 81:59-68. 2011..However, it remains controversial whether these results apply to all subgroups of patients. We therefore developed an evidence-based guideline to provide direction for clinical practice... - Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-dose-rate interstitial implantBrian D Lawenda
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 56:671-80. 2003..Only the long-term follow-up of this and other implant studies will allow an understanding of the total radiation dose necessary for tumor control and the volume of breast that requires treatment... - ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joiningHongyan Wang
Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
Cancer Res 64:7139-43. 2004..These results indicate that the effects of ATR on cell radiosensitivity are independent of NHEJ but are linked to HRR that may be affected by the deficient S and G(2) checkpoints... - Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiationSimon N Powell
Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Oncogene 22:5784-91. 2003..The unsolved mystery is the other genetic changes that must occur to turn a BRCA-deficient cell from a nonviable cell into a tumor cell capable of endless growth... - Biomarkers and mechanisms of FANCD2 functionHenning Willers
Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital, Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
J Biomed Biotechnol 2008:821529. 2008..Our data emphasize the need for multiple biomarkers, such as gammaH2AX, FANCD2, and RAD51, to capture all pathway activities... - Risk of lymphedema after regional nodal irradiation with breast conservation therapyJohn J Coen
Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 55:1209-15. 2003..To evaluate the risk factors for lymphedema in patients receiving breast conservation therapy for early-stage breast cancer... - Favorable prognosis in patients with T1a/T1bN0 triple-negative breast cancers treated with multimodality therapyAlice Y Ho
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
Cancer 118:4944-52. 2012..The authors evaluated the clinical characteristics, natural history, and outcomes of patients who had ≤1 cm, lymph node-negative, triple-negative breast cancer (TNBC)... - Enhancing radiotherapy through a greater understanding of homologous recombinationChristopher A Barker
Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
Semin Radiat Oncol 20:267-273.e3. 2010..We conclude that the field of radiation oncology has only scratched the surface of a potentially highly efficacious therapeutic strategy... - A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancerXiaoxia Hu
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
Gynecol Oncol 114:457-64. 2009..A reliable method that could predict disease outcome would improve care of patients with this disease. The main aim of this study is to identify novel prognostic biomarkers for advanced ovarian cancer... - Radiotherapy and breast reconstruction: complications and cosmesis with TRAM versus tissue expander/implantAshish K Chawla
Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
Int J Radiat Oncol Biol Phys 54:520-6. 2002..CONCLUSION: The tolerance and cosmetic outcome of breast reconstruction for breast cancer patients in irradiated sites depends significantly on the type of reconstruction used... - The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancerFen Xia
Harvard Medical School, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
Semin Radiat Oncol 12:296-304. 2002..The focus of our investigation is on those genetic alterations in tumors that affect the response to therapy, which will ultimately allow strategies to achieve therapeutic gain... - Fhit and CHK1 have opposing effects on homologous recombination repairBaocheng Hu
Beijing Institute of Biotechnology, Beijing, China
Cancer Res 65:8613-6. 2005.... - The roles of BRCA1 and BRCA2 in the cellular response to ionizing radiationSimon N Powell
Massachusetts General Hospital and Harvard Medical School, Boston, USA
Radiat Res 163:699-700. 2005 - BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damageMegan Fabbro
Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
J Biol Chem 279:31251-8. 2004..These findings suggest that BRCA1-BARD1 complexes act as an adaptor to mediate ATM/ATR-directed phosphorylation of p53, influencing G(1)/S cell cycle progression after DNA damage... - Model-based predictions of BRCA1/2 mutation status in breast carcinoma patients treated at an academic medical centerKristen M Shannon
Division of Hematology/Oncology, Massachusetts General Hospital, Boston 02114, USA
Cancer 94:305-13. 2002..The actual number of patients eligible to receive BRCA1/2 genetic testing outweighs the number of patients seen for genetic counseling at the study institution. Finally, limited correlation was found between current predictive models... - Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53Jochen Dahm-Daphi
Laboratory of Experimental Radiation Oncology, Department of Radiotherapy and Radiation Oncology, University Hospital Eppendorf, University of Hamburg, 20246 Hamburg, Germany
Oncogene 24:1663-72. 2005..In conclusion, our data suggest that p53 restricts the mutagenic effects of NHEJ without compromising repair proficiency or cell survival, thereby maintaining genomic stability... - Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patientsChristoph Bert
Abteilung Biophysik, Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
Int J Radiat Oncol Biol Phys 64:1265-74. 2006..To assess the utility of surface imaging on patient setup for accelerated partial-breast irradiation (APBI)... - Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancerHarold J Burstein
Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
Int J Radiat Oncol Biol Phys 64:496-504. 2006..To evaluate the safety and feasibility of concurrent radiation therapy and paclitaxel-based adjuvant chemotherapy, given either weekly or every 3 weeks, after adjuvant doxorubicin and cyclophosphamide (AC)... - Can ICAM modulation prevent lung injury from ionizing radiation?Lisa A Kachnic
J Natl Cancer Inst 94:704-5. 2002
Research Grants
- DNA Recombinational Repair: Role of the p53 Tumor Suppressor ProteinSimon Powell; Fiscal Year: 2007....