Simon N Powell

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Therapeutic exploitation of tumor cell defects in homologous recombination
    Simon N Powell
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Anticancer Agents Med Chem 8:448-60. 2008
  2. pmc Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair
    Raj K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
    Mol Cell Biol 26:1850-64. 2006
  3. ncbi request reprint Accelerated partial-breast irradiation using proton beams: initial clinical experience
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:691-8. 2006
  4. ncbi request reprint Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair
    Arun Gupta
    Washington University School of Medicine, St Louis, MO, USA
    Cell Cycle 8:2198-210. 2009
  5. doi request reprint Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies
    Henning Willers
    Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA
    Mol Cancer Res 7:1304-9. 2009
  6. doi request reprint Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells
    James W Evans
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 68:257-65. 2008
  7. pmc Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair
    Junran Zhang
    Department of Radiation Oncology, Massachusetts General Hospital Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Biol 24:708-18. 2004
  8. ncbi request reprint Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining
    Jing Zhuang
    Department of Radiation Oncology, Vanderbilt University Medical Centre, 1301 22nd Avenue South, Nashville, TN 37232, USA
    Cancer Res 66:1401-8. 2006
  9. ncbi request reprint Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger
    Scott R Floyd
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:358-64. 2006
  10. ncbi request reprint Tubular carcinoma of the breast: a retrospective analysis and review of the literature
    Timothy Sullivan
    Department of Radiation Oncology, Harvard Medical School, Boston, MA 02114, USA
    Breast Cancer Res Treat 93:199-205. 2005

Research Grants

Collaborators

Detail Information

Publications51

  1. ncbi request reprint Therapeutic exploitation of tumor cell defects in homologous recombination
    Simon N Powell
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Anticancer Agents Med Chem 8:448-60. 2008
    ..Thus, functional assays of homologous recombination could become a useful technique to determine phenotype of human breast cancer, which in turn will influence the choice of therapy...
  2. pmc Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair
    Raj K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
    Mol Cell Biol 26:1850-64. 2006
    ..Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...
  3. ncbi request reprint Accelerated partial-breast irradiation using proton beams: initial clinical experience
    Kevin R Kozak
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:691-8. 2006
    ..We present our initial clinical experience with proton, three-dimensional, conformal, external beam, partial-breast irradiation (3D-CPBI)...
  4. ncbi request reprint Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair
    Arun Gupta
    Washington University School of Medicine, St Louis, MO, USA
    Cell Cycle 8:2198-210. 2009
    ....
  5. doi request reprint Utility of DNA repair protein foci for the detection of putative BRCA1 pathway defects in breast cancer biopsies
    Henning Willers
    Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital Cancer Center, Harvard Medical School, Charlestown, Massachusetts, USA
    Mol Cancer Res 7:1304-9. 2009
    ....
  6. doi request reprint Homologous recombination is the principal pathway for the repair of DNA damage induced by tirapazamine in mammalian cells
    James W Evans
    Department of Radiation Oncology, Division of Radiation and Cancer Biology, Stanford University, Stanford, California 94305 5152, USA
    Cancer Res 68:257-65. 2008
    ....
  7. pmc Chk2 phosphorylation of BRCA1 regulates DNA double-strand break repair
    Junran Zhang
    Department of Radiation Oncology, Massachusetts General Hospital Harvard Medical School, 149 13th Street, Charlestown, MA 02129, USA
    Mol Cell Biol 24:708-18. 2004
    ..We propose a dual regulatory role for BRCA1 in maintaining genome integrity, whereby BRCA1 phosphorylation status controls the selectivity of repair events dictated by HR and error-prone NHR...
  8. ncbi request reprint Checkpoint kinase 2-mediated phosphorylation of BRCA1 regulates the fidelity of nonhomologous end-joining
    Jing Zhuang
    Department of Radiation Oncology, Vanderbilt University Medical Centre, 1301 22nd Avenue South, Nashville, TN 37232, USA
    Cancer Res 66:1401-8. 2006
    ..We suggest that the differential control of NHEJ subprocesses by BRCA1, in concert with Chk2, reduces the mutagenic potential of NHEJ, thereby contributing to the prevention of familial breast cancers...
  9. ncbi request reprint Low local recurrence rate without postmastectomy radiation in node-negative breast cancer patients with tumors 5 cm and larger
    Scott R Floyd
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 66:358-64. 2006
    ..To assess the need for adjuvant radiotherapy following mastectomy for patients with node-negative breast tumors 5 cm or larger...
  10. ncbi request reprint Tubular carcinoma of the breast: a retrospective analysis and review of the literature
    Timothy Sullivan
    Department of Radiation Oncology, Harvard Medical School, Boston, MA 02114, USA
    Breast Cancer Res Treat 93:199-205. 2005
    ..The favorable prognosis associated with tubular carcinoma of the breast has led some studies to propose less aggressive treatments for patients with this disease. This study aims to address the extent of therapy needed for tubular patients...
  11. doi request reprint Quantifying the impact of immediate reconstruction in postmastectomy radiation: a large, dose-volume histogram-based analysis
    Nisha Ohri
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, New York 10065, USA
    Int J Radiat Oncol Biol Phys 84:e153-9. 2012
    ..To assess the impact of immediate breast reconstruction on postmastectomy radiation (PMRT) using dose-volume histogram (DVH) data...
  12. ncbi request reprint MDC1 interacts with Rad51 and facilitates homologous recombination
    Junran Zhang
    Department of Radiation Oncology, MGH Cancer Center, Massachusetts General Hospital and Harvard Medical School, 149 13th Street, Charlestown, Massachusetts 02129, USA
    Nat Struct Mol Biol 12:902-9. 2005
    ..Together, our findings suggest that MDC1 functions in Rad51-mediated homologous recombination by retaining Rad51 in chromatin...
  13. pmc Negative Regulation of AKT Activation by BRCA1
    Tao Xiang
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Cancer Res 68:10040-4. 2008
    ..Our results show that BRCA1 is a negative regulator of the AKT pathway and imply the significance of the BRCA1/AKT pathway in tumorigenesis...
  14. ncbi request reprint DNA damage induces p53-dependent BRCA1 nuclear export
    Zhihui Feng
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Charlestown, MA 02129, USA
    J Biol Chem 279:28574-84. 2004
    ..These results imply that, in addition to ATM-, ATR-, and Chk2-dependent phosphorylations, cytoplasmic relocalization of BRCA1 protein is a mechanism whereby BRCA1 function is regulated in response to DNA damage...
  15. doi request reprint The role of RPA2 phosphorylation in homologous recombination in response to replication arrest
    Wei Shi
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Carcinogenesis 31:994-1002. 2010
    ..Thus, our data suggest that RPA2 hyperphosphorylation plays a critical role in maintenance of genomic stability and cell survival after a DNA replication block via promotion of HR...
  16. pmc Lamin A/C depletion enhances DNA damage-induced stalled replication fork arrest
    Mayank Singh
    Department of Radiation Oncology, UT Southwestern Medical Center, Dallas, Texas, USA
    Mol Cell Biol 33:1210-22. 2013
    ..We propose that lamin A/C is required for maintaining genomic stability following replication fork stalling, induced by either ICL damage or replicative stress, in order to facilitate fork regression prior to DNA damage repair...
  17. doi request reprint Helical tomotherapy planning for left-sided breast cancer patients with positive lymph nodes: comparison to conventional multiport breast technique
    S Murty Goddu
    Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 73:1243-51. 2009
    ..To evaluate the feasibility of using helical tomotherapy for locally advanced left-sided breast cancer...
  18. doi request reprint Lung dose-volume parameters and the risk of pneumonitis for patients treated with accelerated partial-breast irradiation using three-dimensional conformal radiotherapy
    Abram Recht
    Beth Israel Deaconess Medical Center, Department of Radiation Oncology, Boston MA 02215, USA
    J Clin Oncol 27:3887-93. 2009
    ..We therefore examined the risk of pneumonitis in relation to lung dose-volume parameters...
  19. pmc Rad52 inactivation is synthetically lethal with BRCA2 deficiency
    Zhihui Feng
    Department of Radiation Oncology, Washington University, St Louis, MO 63108, USA
    Proc Natl Acad Sci U S A 108:686-91. 2011
    ..Rad52 thus is an independent and alternative repair pathway of homologous recombination and a target for therapy in BRCA2-deficient cells...
  20. doi request reprint Use of tamoxifen with postsurgical irradiation may improve survival in estrogen and progesterone receptor-positive male breast cancer
    Shannon Fogh
    Department of Radiation Oncology, Boston University Medical Center, USA
    Clin Breast Cancer 11:39-45. 2011
    ..The purpose of this study is to assess the impact of adjuvant therapy on survival in males with non-metastatic breast cancer...
  21. ncbi request reprint Locoregional recurrence rates and prognostic factors for failure in node-negative patients treated with mastectomy: implications for postmastectomy radiation
    Reshma Jagsi
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, 100 Blossom Street, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 62:1035-9. 2005
    ..Survival appears improved in patients at higher risk for LRR. This study addresses whether subsets of node-negative patients with sufficiently high risk of LRR might benefit from PMRT...
  22. ncbi request reprint Accelerated partial breast irradiation using proton beams: Initial dosimetric experience
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA
    Int J Radiat Oncol Biol Phys 65:1404-10. 2006
    ..We present our initial experience with protons for three-dimensional, conformal, external-beam accelerated partial breast irradiation (3D-CPBI)...
  23. ncbi request reprint Is a reduction in radiation lung volume and dose necessary with paclitaxel chemotherapy for node-positive breast cancer?
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 62:386-91. 2005
    ..To evaluate and quantify the effect of irradiated lung volume, radiation dose, and paclitaxel chemotherapy on the development of radiation pneumonitis (RP) in breast cancer patients with positive lymph nodes...
  24. ncbi request reprint BRCA1- and BRCA2-deficient cells are sensitive to etoposide-induced DNA double-strand breaks via topoisomerase II
    Alejandro D Treszezamsky
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA, USA
    Cancer Res 67:7078-81. 2007
    ..Overall, these results suggest that etoposide is a potentially useful drug in the treatment of BRCA-deficient human cancers...
  25. ncbi request reprint The effect of delaying radiation therapy for systemic chemotherapy on local-regional control in breast cancer
    Torunn I Yock
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Breast Cancer Res Treat 84:161-71. 2004
    ..It remains controversial as to whether the administration of chemotherapy prior to radiation following the surgical treatment for localized breast cancer compromises local control...
  26. ncbi request reprint Initial dosimetric experience using simple three-dimensional conformal external-beam accelerated partial-breast irradiation
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 64:1092-9. 2006
    ..Several accelerated partial-breast irradiation (APBI) techniques are being investigated in patients with early-stage breast cancer. We present our initial experience using three-dimensional conformal radiation therapy (3D-CRT)...
  27. ncbi request reprint The role of the BRCA1 tumor suppressor in DNA double-strand break repair
    Junran Zhang
    Department of Radiation Oncology, Washington University in St Louis, 4511 Forest Park Boulevard, St Louis, Missouri 63108, USA
    Mol Cancer Res 3:531-9. 2005
    ..Finally, we will explore the idea that tumor suppression by BRCA1 depends on its control of DNA DSB repair, resulting in the promotion of error-free and the inhibition of error-prone recombinational repair...
  28. ncbi request reprint BRCA2 keeps Rad51 in line. High-fidelity homologous recombination prevents breast and ovarian cancer?
    Simon N Powell
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Building 149, 13th Street, Charlestown, MA 02129, USA
    Mol Cell 10:1262-3. 2002
    ..The mechanistic link between the BRCA2 protein, homologous recombination, and genomic instability has become clearer as a result of recent work describing the structures of different BRCA2 domains bound to Rad51 and to single-stranded DNA...
  29. ncbi request reprint Paclitaxel decreases the interstitial fluid pressure and improves oxygenation in breast cancers in patients treated with neoadjuvant chemotherapy: clinical implications
    Alphonse G Taghian
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    J Clin Oncol 23:1951-61. 2005
    ..Our aim is to evaluate the IFP and pO(2) before and after neoadjuvant CT using sequential paclitaxel and doxorubicin in patients with breast cancer tumors of >/= 3 cm...
  30. ncbi request reprint The interaction of p53 with replication protein A mediates suppression of homologous recombination
    Larisa Y Romanova
    Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Charlestown, MA 02129, USA
    Oncogene 23:9025-33. 2004
    ..We hypothesize that sequestration of RPA by p53 at the sites of recombination is one means by which p53 can inhibit HR processes. Our data support and extend the previously formulated 'dual model' of p53's role as guardian of the genome...
  31. ncbi request reprint Dose-volume analysis of radiotherapy for T1N0 invasive breast cancer treated by local excision and partial breast irradiation by low-dose-rate interstitial implant
    Brian D Lawenda
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 56:671-80. 2003
    ..Thus, the tolerance of escalating doses of partial breast RT should be determined, because this approach may become a standard treatment for patients with early-stage breast cancer...
  32. doi request reprint Fractionation for whole breast irradiation: an American Society for Radiation Oncology (ASTRO) evidence-based guideline
    Benjamin D Smith
    Department of Radiation Oncology, University of Texas M D Anderson Cancer Center, Houston, TX 77030, USA
    Int J Radiat Oncol Biol Phys 81:59-68. 2011
    ..However, it remains controversial whether these results apply to all subgroups of patients. We therefore developed an evidence-based guideline to provide direction for clinical practice...
  33. ncbi request reprint ATR affecting cell radiosensitivity is dependent on homologous recombination repair but independent of nonhomologous end joining
    Hongyan Wang
    Department of Radiation Oncology, Kimmel Cancer Center of Jefferson Medical College, Thomas Jefferson University, Philadelphia, Pennsylvania 19107, USA
    Cancer Res 64:7139-43. 2004
    ..These results indicate that the effects of ATR on cell radiosensitivity are independent of NHEJ but are linked to HRR that may be affected by the deficient S and G(2) checkpoints...
  34. doi request reprint Black race as a prognostic factor in triple-negative breast cancer patients treated with breast-conserving therapy: a large, single-institution retrospective analysis
    Carmen A Perez
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Breast Cancer Res Treat 139:497-506. 2013
    ..Black women with TNBC had equivalent local control, but higher risk of regional nodal failure, compared with non-black counterparts. The routine use of comprehensive nodal irradiation may be beneficial for black women with TNBC...
  35. pmc Biomarkers and mechanisms of FANCD2 function
    Henning Willers
    Laboratory of Cellular and Molecular Radiation Oncology, Department of Radiation Oncology, Massachusetts General Hospital, Cancer Center and Harvard Medical School, Charlestown, MA 02129, USA
    J Biomed Biotechnol 2008:821529. 2008
    ..Our data emphasize the need for multiple biomarkers, such as gammaH2AX, FANCD2, and RAD51, to capture all pathway activities...
  36. ncbi request reprint Risk of lymphedema after regional nodal irradiation with breast conservation therapy
    John J Coen
    Department of Radiation Oncology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 55:1209-15. 2003
    ..To evaluate the risk factors for lymphedema in patients receiving breast conservation therapy for early-stage breast cancer...
  37. ncbi request reprint Roles of BRCA1 and BRCA2 in homologous recombination, DNA replication fidelity and the cellular response to ionizing radiation
    Simon N Powell
    Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Oncogene 22:5784-91. 2003
    ..The unsolved mystery is the other genetic changes that must occur to turn a BRCA-deficient cell from a nonviable cell into a tumor cell capable of endless growth...
  38. doi request reprint Favorable prognosis in patients with T1a/T1bN0 triple-negative breast cancers treated with multimodality therapy
    Alice Y Ho
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Cancer 118:4944-52. 2012
    ..The authors evaluated the clinical characteristics, natural history, and outcomes of patients who had ≤1 cm, lymph node-negative, triple-negative breast cancer (TNBC)...
  39. doi request reprint A miR-200 microRNA cluster as prognostic marker in advanced ovarian cancer
    Xiaoxia Hu
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 114:457-64. 2009
    ..A reliable method that could predict disease outcome would improve care of patients with this disease. The main aim of this study is to identify novel prognostic biomarkers for advanced ovarian cancer...
  40. doi request reprint Enhancing radiotherapy through a greater understanding of homologous recombination
    Christopher A Barker
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY, USA
    Semin Radiat Oncol 20:267-273.e3. 2010
    ..We conclude that the field of radiation oncology has only scratched the surface of a potentially highly efficacious therapeutic strategy...
  41. pmc Development of an assay to measure mutagenic non-homologous end-joining repair activity in mammalian cells
    Ranjit S Bindra
    Department of Radiation Oncology, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA
    Nucleic Acids Res 41:e115. 2013
    ..Collectively, the novel DSB repair assay and inducible I-SceI will be useful tools to further elucidate the complexities of NHEJ and HR repair...
  42. ncbi request reprint The molecular basis of radiosensitivity and chemosensitivity in the treatment of breast cancer
    Fen Xia
    Harvard Medical School, Department of Radiation Oncology, Massachusetts General Hospital, Boston, MA 02114, USA
    Semin Radiat Oncol 12:296-304. 2002
    ..The focus of our investigation is on those genetic alterations in tumors that affect the response to therapy, which will ultimately allow strategies to achieve therapeutic gain...
  43. ncbi request reprint Radiotherapy and breast reconstruction: complications and cosmesis with TRAM versus tissue expander/implant
    Ashish K Chawla
    Department of Radiation Oncology, Massachusetts General Hospital, Harvard Medical School, Boston, MA 02114, USA
    Int J Radiat Oncol Biol Phys 54:520-6. 2002
    ..Many of these patients also undergo breast reconstruction. We reviewed our institutions' experience to determine the outcome of patients treated with breast reconstruction and RT...
  44. ncbi request reprint BRCA1-BARD1 complexes are required for p53Ser-15 phosphorylation and a G1/S arrest following ionizing radiation-induced DNA damage
    Megan Fabbro
    Queensland Institute of Medical Research, Post Office Royal Brisbane Hospital, Brisbane, Queensland 4029, Australia
    J Biol Chem 279:31251-8. 2004
    ..These findings suggest that BRCA1-BARD1 complexes act as an adaptor to mediate ATM/ATR-directed phosphorylation of p53, influencing G(1)/S cell cycle progression after DNA damage...
  45. ncbi request reprint Model-based predictions of BRCA1/2 mutation status in breast carcinoma patients treated at an academic medical center
    Kristen M Shannon
    Division of Hematology Oncology, Massachusetts General Hospital, Boston 02114, USA
    Cancer 94:305-13. 2002
    ....
  46. ncbi request reprint Nonhomologous end-joining of site-specific but not of radiation-induced DNA double-strand breaks is reduced in the presence of wild-type p53
    Jochen Dahm-Daphi
    Laboratory of Experimental Radiation Oncology, Department of Radiotherapy and Radiation Oncology, University Hospital Eppendorf, University of Hamburg, 20246 Hamburg, Germany
    Oncogene 24:1663-72. 2005
    ..In conclusion, our data suggest that p53 restricts the mutagenic effects of NHEJ without compromising repair proficiency or cell survival, thereby maintaining genomic stability...
  47. ncbi request reprint Fhit and CHK1 have opposing effects on homologous recombination repair
    Baocheng Hu
    Beijing Institute of Biotechnology, Beijing, China
    Cancer Res 65:8613-6. 2005
    ....
  48. ncbi request reprint The roles of BRCA1 and BRCA2 in the cellular response to ionizing radiation
    Simon N Powell
    Massachusetts General Hospital and Harvard Medical School, Boston, USA
    Radiat Res 163:699-700. 2005
  49. ncbi request reprint Clinical experience with a 3D surface patient setup system for alignment of partial-breast irradiation patients
    Christoph Bert
    Abteilung Biophysik, Gesellschaft fur Schwerionenforschung, Darmstadt, Germany
    Int J Radiat Oncol Biol Phys 64:1265-74. 2006
    ..To assess the utility of surface imaging on patient setup for accelerated partial-breast irradiation (APBI)...
  50. ncbi request reprint Can ICAM modulation prevent lung injury from ionizing radiation?
    Lisa A Kachnic
    J Natl Cancer Inst 94:704-5. 2002
  51. ncbi request reprint Prospective evaluation of concurrent paclitaxel and radiation therapy after adjuvant doxorubicin and cyclophosphamide chemotherapy for Stage II or III breast cancer
    Harold J Burstein
    Department of Medical Oncology, Dana Farber Cancer Institute and Brigham and Women s Hospital, and Harvard Medical School, Boston, MA 02115, USA
    Int J Radiat Oncol Biol Phys 64:496-504. 2006
    ..To evaluate the safety and feasibility of concurrent radiation therapy and paclitaxel-based adjuvant chemotherapy, given either weekly or every 3 weeks, after adjuvant doxorubicin and cyclophosphamide (AC)...

Research Grants4