David Piwnica-Worms

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems
    Robin S Dothager
    BRIGHT Institute, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e13300. 2010
  2. ncbi request reprint Probing multidrug resistance P-glycoprotein transporter activity with SPECT radiopharmaceuticals
    David Piwnica-Worms
    Molecular Imaging Center, Washington University Medical School, St Louis, MO, USA
    Curr Top Med Chem 10:1834-45. 2010
  3. ncbi request reprint Introduction to molecular imaging
    David R Piwnica-Worms
    Mallinckrodt Institute of Radiology, Washington University, Saint Louis, MO 63110, USA
    J Am Coll Radiol 1:2-3. 2004
  4. ncbi request reprint Molecular imaging of host-pathogen interactions in intact small animals
    David Piwnica-Worms
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Box 8225, Washington University, St Louis, MO 63110, USA
    Cell Microbiol 6:319-31. 2004
  5. ncbi request reprint Current state of imaging protein-protein interactions in vivo with genetically encoded reporters
    Victor Villalobos
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Biomed Eng 9:321-49. 2007
  6. ncbi request reprint Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease
    David Piwnica-Worms
    Washington University Medical School, 510 South Kingshighway Boulevard, Box 8225, St Louis, MO 63110, USA
    Neuroimaging Clin N Am 16:575-89, viii. 2006
  7. ncbi request reprint CXCR4 regulates growth of both primary and metastatic breast cancer
    Matthew C P Smith
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 64:8604-12. 2004
  8. ncbi request reprint Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis
    Kristin E Bullok
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Biochemistry 46:4055-65. 2007
  9. ncbi request reprint Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging
    Aparna H Kesarwala
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 5:465-74. 2006
  10. pmc Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone
    Angela C Hirbe
    Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:14062-7. 2007

Research Grants

  1. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 1999
  2. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2007
  3. Soc for Molecular Imaging 3rd Annual International Mtg
    David Piwnica Worms; Fiscal Year: 2004
  4. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2004
  5. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2002
  6. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2002
  7. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2001
  8. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2001
  9. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2000
  10. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2009

Collaborators

Detail Information

Publications104 found, 100 shown here

  1. pmc Cerenkov radiation energy transfer (CRET) imaging: a novel method for optical imaging of PET isotopes in biological systems
    Robin S Dothager
    BRIGHT Institute, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e13300. 2010
    ..Upon β(+) decay, the initial velocity of high-energy β(+) particles can momentarily exceed the speed of light in tissue, producing Cerenkov radiation that is detectable by optical imaging, but is highly absorbed in living organisms...
  2. ncbi request reprint Probing multidrug resistance P-glycoprotein transporter activity with SPECT radiopharmaceuticals
    David Piwnica-Worms
    Molecular Imaging Center, Washington University Medical School, St Louis, MO, USA
    Curr Top Med Chem 10:1834-45. 2010
    ....
  3. ncbi request reprint Introduction to molecular imaging
    David R Piwnica-Worms
    Mallinckrodt Institute of Radiology, Washington University, Saint Louis, MO 63110, USA
    J Am Coll Radiol 1:2-3. 2004
  4. ncbi request reprint Molecular imaging of host-pathogen interactions in intact small animals
    David Piwnica-Worms
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, 510 S Kingshighway Blvd, Box 8225, Washington University, St Louis, MO 63110, USA
    Cell Microbiol 6:319-31. 2004
    ....
  5. ncbi request reprint Current state of imaging protein-protein interactions in vivo with genetically encoded reporters
    Victor Villalobos
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Biomed Eng 9:321-49. 2007
    ....
  6. ncbi request reprint Single photon emission computed tomography and positron emission tomography imaging of multi-drug resistant P-glycoprotein--monitoring a transport activity important in cancer, blood-brain barrier function and Alzheimer's disease
    David Piwnica-Worms
    Washington University Medical School, 510 South Kingshighway Boulevard, Box 8225, St Louis, MO 63110, USA
    Neuroimaging Clin N Am 16:575-89, viii. 2006
    ....
  7. ncbi request reprint CXCR4 regulates growth of both primary and metastatic breast cancer
    Matthew C P Smith
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 64:8604-12. 2004
    ..These data indicate that CXCR4 is required to initiate proliferation and/or promote survival of breast cancer cells in vivo and suggest that CXCR4 inhibitors will improve treatment of patients with primary and metastatic breast cancer...
  8. ncbi request reprint Biochemical and in vivo characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis
    Kristin E Bullok
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University Medical School, St Louis, Missouri 63110, USA
    Biochemistry 46:4055-65. 2007
    ..Thus, TcapQ647 represents a sensitive, effector caspase-specific far-red "smart" probe to noninvasively monitor apoptosis in vivo...
  9. ncbi request reprint Second-generation triple reporter for bioluminescence, micro-positron emission tomography, and fluorescence imaging
    Aparna H Kesarwala
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 5:465-74. 2006
    ..This second-generation triple reporter incorporating enhanced components enables bioluminescence, PET, and fluorescence imaging of cells and living animals...
  10. pmc Disruption of CXCR4 enhances osteoclastogenesis and tumor growth in bone
    Angela C Hirbe
    Department of Medicine, Division of Oncology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:14062-7. 2007
    ..These data demonstrate that disruption of CXCR4 enhances osteoclastogenesis and suggest that inhibition of CXCR4 may enhance established skeletal tumor burden by increasing OC activity...
  11. pmc Antagonism of inhibitor of apoptosis proteins increases bone metastasis via unexpected osteoclast activation
    Chang Yang
    Division of Bone and Mineral Diseases, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Discov 3:212-23. 2013
    ..Thus, IAP antagonist-based cancer treatment may be compromised by osteoporosis and enhanced skeletal metastasis, which may be prevented by antiresorptive agents...
  12. pmc The ADP receptor P2RY12 regulates osteoclast function and pathologic bone remodeling
    Xinming Su
    Department of Medicine, Division of Oncology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:3579-92. 2012
    ..These results demonstrate that P2RY12 is the primary ADP receptor in OCs and suggest that P2RY12 inhibition is a potential therapeutic target for pathologic bone loss...
  13. ncbi request reprint In vitro and in vivo characterization of a dual-function green fluorescent protein--HSV1-thymidine kinase reporter gene driven by the human elongation factor 1 alpha promoter
    Gary D Luker
    Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Mol Imaging 1:65-73. 2002
    ..These data extend previous reports by showing that a human promoter can be detected in vitro and in vivo with a dual-function reporter exploiting optical and radiotracer techniques...
  14. ncbi request reprint Molecular imaging of protein-protein interactions: controlled expression of p53 and large T-antigen fusion proteins in vivo
    Gary D Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 63:1780-8. 2003
    ..These data demonstrate that the imaging two-hybrid system responds in a proportional fashion to increasing amounts of interacting proteins in vivo...
  15. pmc Kinetics of regulated protein-protein interactions revealed with firefly luciferase complementation imaging in cells and living animals
    Kathryn E Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:12288-93. 2004
    ....
  16. pmc Granulocyte colony-stimulating factor enhances bone tumor growth in mice in an osteoclast-dependent manner
    Angela C Hirbe
    Department of Medicine and Division of Oncology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Blood 109:3424-31. 2007
    ..These data demonstrate a G-CSF-induced stimulation of tumor growth in bone that is OC dependent...
  17. ncbi request reprint Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo
    Lihua Yang
    Department of Pediatrics, and Neurology and Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cancer Res 67:651-8. 2007
    ..These data indicate that the clinical evaluation of phosphodiesterase inhibitors in the treatment of patients with brain tumors is warranted...
  18. pmc Valosin-containing protein (VCP) is required for autophagy and is disrupted in VCP disease
    Jeong Sun Ju
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 187:875-88. 2009
    ..These data implicate VCP in autophagy and suggest that impaired autophagy explains the pathology seen in IBMPFD muscle, including TDP-43 accumulation...
  19. ncbi request reprint Characterization of a 67Ga/68Ga radiopharmaceutical for SPECT and PET of MDR1 P-glycoprotein transport activity in vivo: validation in multidrug-resistant tumors and at the blood-brain barrier
    Vijay Sharma
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, St Louis, Missouri, USA
    J Nucl Med 46:354-64. 2005
    ....
  20. doi request reprint Proteasome inhibition blocks ligand-induced dynamic processing and internalization of epidermal growth factor receptor via altered receptor ubiquitination and phosphorylation
    Aparna H Kesarwala
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:976-83. 2009
    ..These observations point to a potential mechanism for the synergistic therapeutic effects of combination EGFR- and proteasome-targeted therapies...
  21. pmc A bioluminescent transposon reporter-trap identifies tumor-specific microenvironment-induced promoters in Salmonella for conditional bacterial-based tumor therapy
    Kelly Flentie
    BRIGHT Institute, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Discov 2:624-37. 2012
    ..Furthermore, Salmonella expressing Shiga toxin from the STM1787 promoter provided potent and selective antitumor activity in vitro and in vivo, showing the potential for a conditional bacterial-based tumor-specific therapeutic...
  22. pmc T-cell activation promotes tumorigenesis in inflammation-associated cancer
    Dan Rauch
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Retrovirology 6:116. 2009
    ....
  23. pmc Loss of Par-1a/MARK3/C-TAK1 kinase leads to reduced adiposity, resistance to hepatic steatosis, and defective gluconeogenesis
    Jochen K Lennerz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cell Biol 30:5043-56. 2010
    ..Thus, although Par-1a and Par-1b can compensate for one another during embryogenesis, their individual disruption gives rise to distinct metabolic phenotypes in adult mice...
  24. pmc Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit
    Elizabeth A Morgan
    Department of Medicine, Mallinkrodt Institute of Radiology, St Louis, Missouri, USA
    FASEB J 24:1117-27. 2010
    ..Hurchla, M. A., Deng, H., Floyd, D., Berdy, A., Prior, J. L., Piwnica-Worms, D., Teitelbaum, S. L., Ross, F. P., Weilbaecher, K. N. Dissection of platelet and myeloid cell defects by conditional targeting of the beta3-integrin subunit...
  25. ncbi request reprint Quantitation of pulmonary transgene expression with PET imaging
    Jean Christophe Richard
    Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 45:644-54. 2004
    ....
  26. pmc Fluorophore-conjugated iron oxide nanoparticle labeling and analysis of engrafting human hematopoietic stem cells
    Dustin J Maxwell
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri, USA
    Stem Cells 26:517-24. 2008
    ..The use of fluorophore-labeled iron oxide nanoparticles for fluorescence imaging in combination with flow cytometry allows evaluation of labeling efficiencies and homing capabilities of defined human HSC subsets...
  27. pmc An improved cell-penetrating, caspase-activatable, near-infrared fluorescent peptide for apoptosis imaging
    Dustin Maxwell
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Ophthalmology and Visual Sciences, Washington University Medical School, St Louis, Missouri 63110, USA
    Bioconjug Chem 20:702-9. 2009
    ..Thus, KcapQ represents an improved effector caspase-activatable NIRF probe for enhanced noninvasive analysis of apoptosis in whole cells and live animals...
  28. ncbi request reprint Characterization of a novel 99mTc-carbonyl complex as a functional probe of MDR1 P-glycoprotein transport activity
    Mary Dyszlewski
    Washington University School of Medicine, St Louis, MO, USA
    Mol Imaging 1:24-35. 2002
    ....
  29. pmc 18F-AFETP, 18F-FET, and 18F-FDG imaging of mouse DBT gliomas
    Kiran Kumar Solingapuram Sai
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 54:1120-6. 2013
    ..The tracer (18)F-AFETP is a structural analog of histidine and is a lead compound for imaging cationic amino acid transport, a relatively unexplored target for oncologic imaging...
  30. pmc Dual-color click beetle luciferase heteroprotein fragment complementation assays
    Victor Villalobos
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Developmental Biology, Washington University, St Louis, MO 63110, USA
    Chem Biol 17:1018-29. 2010
    ..These dual-color protein interaction switches may enable directed dynamic analysis of a variety of protein interactions in living cells...
  31. ncbi request reprint In vivo RNA interference-mediated ablation of MDR1 P-glycoprotein
    Andrea Pichler
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 11:4487-94. 2005
    ..Our results show that shRNAi effectively inhibited MDR1 expression and function in cultured cells, tumor implants and mammalian liver, documenting the feasibility of a knockdown approach to reversing MDR in vivo...
  32. pmc Generation of a highly inducible Gal4-->Fluc universal reporter mouse for in vivo bioluminescence imaging
    Andrea Pichler
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:15932-7. 2008
    ..Thus, this highly inducible Gal4-->Fluc conditional reporter strain should facilitate imaging studies of protein interactions, signaling cascades, viral dissemination, and therapy within the physiological context of the whole animal...
  33. pmc Imaging spontaneous tumorigenesis: inflammation precedes development of peripheral NK tumors
    Dan Rauch
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 113:1493-500. 2009
    ..The use of BLI expands our ability to interrogate the role of Tax in tumorigenesis in vivo and has made the association of inflammation with tumor initiation amenable for study...
  34. pmc Cyclic AMP suppression is sufficient to induce gliomagenesis in a mouse model of neurofibromatosis-1
    Nicole M Warrington
    Department of Pediatrics, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Developmental Biology, and Anatomy and Neurobiology, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cancer Res 70:5717-27. 2010
    ..Together, these results indicate that low levels of cAMP in a susceptible Nf1 mouse strain are sufficient to promote gliomagenesis, and justify the implementation of cAMP-based stroma-targeted therapies for glioma...
  35. pmc CXCL12 mediates trophic interactions between endothelial and tumor cells in glioblastoma
    Shyam Rao
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e33005. 2012
    ..Therapeutic disruption of endothelial cell trophic functions could complement the structural disruption of anti-angiogenic regimens and, in combination, might also improve the efficacy of radiation and chemotherapy in treating GBMs...
  36. pmc APT102, a novel adpase, cooperates with aspirin to disrupt bone metastasis in mice
    Ozge Uluçkan
    Department of Medicine, Division of Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biochem 104:1311-23. 2008
    ..Anti-platelet drugs such as ASA + APT102 could be valuable experimental tools for studying the role of platelet activation in metastasis as well as a therapeutic option for the prevention of bone metastases...
  37. ncbi request reprint TAT-BH4 and TAT-Bcl-xL peptides protect against sepsis-induced lymphocyte apoptosis in vivo
    Richard S Hotchkiss
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 176:5471-7. 2006
    ..In conclusion, TAT-conjugated antiapoptotic Bcl-2-like peptides may offer a novel therapy to prevent apoptosis in sepsis and improve survival...
  38. pmc Identification of a ligand-induced transient refractory period in nuclear factor-kappaB signaling
    Britney L Moss
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 283:8687-98. 2008
    ..Overall, the data suggested that nuclear export of NF-kappaB.IkappaBalpha complexes represented another rate-limiting step that may impact this refractory period, thereby providing an additional regulatory mechanism...
  39. pmc Imaging reversal of multidrug resistance in living mice with bioluminescence: MDR1 P-glycoprotein transports coelenterazine
    Andrea Pichler
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:1702-7. 2004
    ....
  40. pmc Breast cancer cell targeting by prenylation inhibitors elucidated in living animals with a bioluminescence reporter
    Sharon L Chinault
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 18:4136-44. 2012
    ..Determining whether prenylation inhibitors directly or indirectly target tumor and/or host cells is key to understanding therapeutic mechanisms...
  41. pmc Mechanics of EGF receptor/ErbB2 kinase activation revealed by luciferase fragment complementation imaging
    Jennifer L Macdonald-Obermann
    Department of Biochemistry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 109:137-42. 2012
    ..Thus, activation of the kinases in the EGFR/ErbB2 asymmetric dimer occurs in a specific sequence and depends on the kinase activity of the EGF receptor...
  42. pmc Stably integrated luxCDABE for assessment of Salmonella invasion kinetics
    Kelly N Flentie
    Department of Molecular Microbiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 7:222-33. 2008
    ..In each case, Salmonella invasion of eukaryotic cells was invC dependent...
  43. ncbi request reprint Continuous delivery of D-luciferin by implanted micro-osmotic pumps enables true real-time bioluminescence imaging of luciferase activity in vivo
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Molecular Biology and Pharmacology, Washington University in St Louis, St Louis, MO 63110, USA
    Mol Imaging 6:121-30. 2007
    ..We conclude that implanted pumps provide reliable, prolonged substrate delivery for high temporal resolution BLI, traversing complications of repetitive substrate injections...
  44. pmc Asp-960/Glu-961 controls the movement of the C-terminal tail of the epidermal growth factor receptor to regulate asymmetric dimer formation
    Katherine S Yang
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 285:24014-22. 2010
    ..Mutation of these residues destabilizes this hinge, facilitating the formation of the activating asymmetric dimer and leading to enhanced receptor signaling...
  45. pmc Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
    Patricia Goldhoff
    Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:7717-25. 2008
    ..Previously, we identified the cyclic AMP phosphodiesterase-4 (PDE4) inhibitor Rolipram as a potent antitumor agent. Here, we investigate the role of PDE4 in brain tumors and examine the utility of PDE4 as a therapeutic target...
  46. pmc CD47 regulates bone mass and tumor metastasis to bone
    Ozge Uluçkan
    Division of Oncology, Department of Medicine and Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:3196-204. 2009
    ..CD47 is a novel therapeutic target to strengthen bone mass and diminish metastatic tumor growth in bone...
  47. ncbi request reprint Bioluminescence imaging of period1 gene expression in utero
    Meera T Saxena
    Department of Biology, Washington University, St Louis, MO 63110, USA
    Mol Imaging 6:68-72. 2007
    ..We conclude that luciferase-based reporters can provide a sensitive, noninvasive measure of in utero gene expression...
  48. pmc Bioluminescence imaging captures the expression and dynamics of endogenous p21 promoter activity in living mice and intact cells
    Kelsey L Tinkum
    Department of Cell Biology and Physiology, Washington University, St Louis, Missouri 63130, USA
    Mol Cell Biol 31:3759-72. 2011
    ..This inducible p21(FLuc) knock-in reporter strain will facilitate imaging studies of p53-dependent and -independent stress responses within the physiological context of the whole animal...
  49. pmc Spectral unmixing of multicolored bioluminescence emitted from heterogeneous biological sources
    Seth T Gammon
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anal Chem 78:1520-7. 2006
    ..Thus, our software provided a rapid, simple, and accurate method for simultaneously measuring multiple bioluminescent reporters in living cells...
  50. ncbi request reprint Permeation peptide conjugates for in vivo molecular imaging applications
    Kristin E Bullok
    Washington University Medical School, St Louis, MO 63110, USA
    Mol Imaging 5:1-15. 2006
    ..These novel permeation peptide conjugates maintain rapid translocation across cell membranes into intracellular compartments and have the potential for targeted in vivo applications in molecular imaging and combination therapy...
  51. ncbi request reprint Imaging 26S proteasome activity and inhibition in living mice
    Gary D Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Med 9:969-73. 2003
    ....
  52. pmc Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis
    Jonathan E McDunn
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, 63110, USA
    FASEB J 22:561-8. 2008
    ..Molecular approaches to activate the antiapoptotic Akt and ERK signaling pathways may provide a novel tool to study these signaling pathways, as well as a new antiapoptotic strategy for the treatment of sepsis and other acute injuries...
  53. ncbi request reprint Imaging pulmonary gene expression with positron emission tomography
    Jean Cristophe Richard
    Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 167:1257-63. 2003
    ..48, p < 0.001) and fluorescent protein (r(2) = 0.46, p < 0.001). We conclude that positron emission tomographic imaging is a sensitive and quantitative method for detecting pulmonary reporter gene expression noninvasively...
  54. pmc Immunodeficient mouse strains display marked variability in growth of human melanoma lung metastases
    Beatriz M Carreno
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Cancer Res 15:3277-86. 2009
    ....
  55. pmc CD8+ T cells regulate bone tumor burden independent of osteoclast resorption
    Kaihua Zhang
    Department of Orthopedics, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 71:4799-808. 2011
    ..Our findings show the important contribution of CD8(+) T cells in the regulation of bone metastases regardless of OC status, thus including T cells as critical regulators of tumor growth in bone...
  56. pmc Noninvasive bioluminescence imaging of herpes simplex virus type 1 infection and therapy in living mice
    Gary D Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Virol 76:12149-61. 2002
    ..These data demonstrate that bioluminescence imaging can be used for noninvasive, real-time monitoring of HSV-1 infection and therapy in living mice...
  57. ncbi request reprint Synthesis and characterization of a Gd-DOTA-D-permeation peptide for magnetic resonance relaxation enhancement of intracellular targets
    Andrew M Prantner
    Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Imaging 2:333-41. 2003
    ....
  58. ncbi request reprint Strain-specific susceptibility for pulmonary metastasis of sarcoma 180 cells in inbred mice
    Haris G Vikis
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 70:4859-67. 2010
    ..One possible mechanism of resistance to pulmonary metastasis in BTBRT+tf/J mice may require T-cell function. Our experiments present a new mouse model for further characterization of the genetics and mechanisms of pulmonary metastasis...
  59. pmc LRP6 overexpression defines a class of breast cancer subtype and is a target for therapy
    Chia Chen Liu
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:5136-41. 2010
    ..Together, our studies highlight LRP6 as a potential therapeutic target in breast cancer, and introduce Mesd as a promising antitumor agent for treating breast cancer subtypes with Wnt activation at the cell surface...
  60. ncbi request reprint Characterization of novel histidine-tagged Tat-peptide complexes dual-labeled with (99m)Tc-tricarbonyl and fluorescein for scintigraphy and fluorescence microscopy
    Kristin E Bullok
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Bioconjug Chem 13:1226-37. 2002
    ....
  61. pmc Quantitation of selective autophagic protein aggregate degradation in vitro and in vivo using luciferase reporters
    Jeong Sun Ju
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue Saint Louis, MO 63110, USA
    Autophagy 5:511-9. 2009
    ..Our study demonstrates a method to quantify the autophagic flux of an expanded polyglutamine via luciferase reporters in vitro and in vivo...
  62. ncbi request reprint Synthesis and characterization of a small, membrane-permeant, caspase-activatable far-red fluorescent peptide for imaging apoptosis
    Kristin Bullok
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, St Louis, Missouri 63110, USA
    J Med Chem 48:5404-7. 2005
    ..Upon exposure to executioner caspases, TcapQ(647) was specifically cleaved, thereby releasing the fluorophore from the quencher and enabling imaging of apoptosis...
  63. pmc Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100
    Bruno Nervi
    Division of Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Blood 113:6206-14. 2009
    ..These studies provide a proof-of-principle for directing therapy to the critical tethers that promote AML-niche interactions...
  64. pmc Factors affecting human T cell engraftment, trafficking, and associated xenogeneic graft-vs-host disease in NOD/SCID beta2mnull mice
    Bruno Nervi
    Division of Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Saint Louis, MO, USA
    Exp Hematol 35:1823-38. 2007
    ..Models of immunodeficient mice that consistently and efficiently reconstitute with xenoreactive human T cells would be a valuable tool for the in vivo study of GVHD, as well as other human immune responses...
  65. ncbi request reprint TAT-Bim induces extensive apoptosis in cancer cells
    Hiroyuki Kashiwagi
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Surg Oncol 14:1763-71. 2007
    ..Since apoptosis is executed by intracellular proteins, molecular approaches must incorporate a method to deliver the treatment into the tumor cells...
  66. pmc The collagen receptor discoidin domain receptor 2 stabilizes SNAIL1 to facilitate breast cancer metastasis
    Kun Zhang
    BRIGHT Institute, Washington University, St Louis, Missouri 63110, USA
    Nat Cell Biol 15:677-87. 2013
    ..As such, DDR2 could be an RTK (receptor tyrosine kinase) target for the treatment of breast cancer metastasis...
  67. pmc Quantitation of the effect of ErbB2 on epidermal growth factor receptor binding and dimerization
    Yu Li
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:31116-25. 2012
    ....
  68. pmc Suppression of G-protein-coupled receptor kinase 3 expression is a feature of classical GBM that is required for maximal growth
    B Mark Woerner
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Mol Cancer Res 10:156-66. 2012
    ..Together, these experiments show that GRK3 is a negative regulator of cell growth whose expression is preferentially reduced in GBM of the classical subtype as a consequence of activity in primary gliomagenic pathways...
  69. pmc Real-time imaging of notch activation with a luciferase complementation-based reporter
    Ma Xenia G Ilagan
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Sci Signal 4:rs7. 2011
    ..These experiments showed that Notch-LCI is an effective approach for characterizing modulators that target Notch signaling and for studying pathway dynamics in normal and disease contexts...
  70. pmc The ARF tumor suppressor regulates bone remodeling and osteosarcoma development in mice
    Daniel A Rauch
    Division of Molecular Oncology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 5:e15755. 2010
    ..Finally, these data underscore the potential of targeting bone remodeling as adjuvant therapy or in patients with genetic predispositions to prevent the development of OS...
  71. pmc Measuring brain tumor growth: combined bioluminescence imaging-magnetic resonance imaging strategy
    Sarah C Jost
    Department of Neurosurgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Imaging 8:245-53. 2009
    ....
  72. ncbi request reprint Selective cell uptake of modified Tat peptide-fluorophore conjugates in rat retina in ex vivo and in vivo models
    Edward M Barnett
    Department of Ophthalmology, Mallinckrodt Institute of Radiology, Washington University in St Louis School of Medicine, MO 63110 1093, USA
    Invest Ophthalmol Vis Sci 47:2589-95. 2006
    ..To determine the pattern of retinal uptake of modified Tat peptide-fluorophore conjugates in the rat after ex vivo application and intravitreal injection...
  73. ncbi request reprint Real-time imaging of ligand-induced IKK activation in intact cells and in living mice
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, Box 8225, St Louis, Missouri 63110, USA
    Nat Methods 2:607-14. 2005
    ....
  74. pmc P-glycoprotein deficiency at the blood-brain barrier increases amyloid-beta deposition in an Alzheimer disease mouse model
    John R Cirrito
    Department of Neurology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Clin Invest 115:3285-90. 2005
    ..These data establish a direct link between Pgp and Abeta metabolism in vivo and suggest that Pgp activity at the BBB could affect risk for developing AD as well as provide a novel diagnostic and therapeutic target...
  75. pmc Bioluminescence imaging of myeloperoxidase activity in vivo
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Med 15:455-61. 2009
    ..Thus, luminol-BLI provides a noninvasive, specific and highly sensitive optical readout of phagocyte-mediated MPO activity in vivo and may enable new diagnostic applications in a wide range of acute and chronic inflammatory conditions...
  76. doi request reprint Detection of protein-protein interactions in live cells and animals with split firefly luciferase protein fragment complementation
    Victor Villalobos
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, St Louis, MO, USA
    Methods Mol Biol 439:339-52. 2008
    ..The split luciferase fusion constructs described here are inducible by addition of ligands, small molecules or drugs, in this example, rapamycin, and have been shown to work in vivo...
  77. pmc Senescent stromal-derived osteopontin promotes preneoplastic cell growth
    Ermira Pazolli
    Department of Cell Biology and Physiology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 69:1230-9. 2009
    ....
  78. ncbi request reprint Recent advances in imaging the lungs of intact small animals
    Daniel P Schuster
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Cell Mol Biol 30:129-38. 2004
    ..These new instruments, part of an emerging suite of techniques collectively known as "molecular imaging," provide an enormous potential for elucidating lung biology in intact animal models and systems...
  79. pmc Noninvasive imaging of protein-protein interactions in living animals
    Gary D Luker
    Molecular Imaging Center, Mallinckrodt Institute of Radiology and Department of Molecular Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:6961-6. 2002
    ..Imaging protein-binding partners in vivo will enable functional proteomics in whole animals and provide a tool for screening compounds targeted to specific protein-protein interactions in living animals...
  80. pmc Structure-activity relationships, kinetics, selectivity, and mechanistic studies of synthetic hydraphile channels in bacterial and mammalian cells
    W Matthew Leevy
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Org Biomol Chem 3:3544-50. 2005
    ..Whole cell patch clamping with mammalian cells confirms a channel mechanism in living cells suggesting that this family may comprise novel and flexible pharmacological agents...
  81. pmc Advances in bioluminescence imaging of live animal models
    Robin S Dothager
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Curr Opin Biotechnol 20:45-53. 2009
    ..New approaches to bioluminescence imaging of cell migration, signaling pathways, drug action, and interacting protein partners in vivo allow the study of biology and disease within the context of living animals...
  82. pmc An anti-apoptotic peptide improves survival in lethal total body irradiation
    Jonathan E McDunn
    Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Biochem Biophys Res Commun 382:657-62. 2009
    ....
  83. ncbi request reprint Spying on cancer: molecular imaging in vivo with genetically encoded reporters
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Cancer Cell 7:5-15. 2005
    ..Spying on cancer with genetically encoded imaging reporters provides insight into cancer-specific molecular machinery within the context of the whole animal...
  84. ncbi request reprint Kinetics of in vivo elimination of suicide gene-expressing T cells affects engraftment, graft-versus-host disease, and graft-versus-leukemia after allogeneic bone marrow transplantation
    Michael P Rettig
    Division of Oncology, Siteman Cancer Center, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 173:3620-30. 2004
    ..This murine model demonstrates the potential usefulness of DeltaCD34-tk-expressing T cells to control GVHD, promote alloengraftment, and provide a graft-vs-leukemia effect in man...
  85. ncbi request reprint Quantitative analysis of permeation peptide complexes labeled with Technetium-99m: chiral and sequence-specific effects on net cell uptake
    Seth T Gammon
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University Medical School, Staint Louis, Missouri 63110, USA
    Bioconjug Chem 14:368-76. 2003
    ..The best of these peptide sequences could be employed as in vivo imaging and drug delivery agents to translocate substrates into cells...
  86. pmc The bisphosphonate zoledronic acid decreases tumor growth in bone in mice with defective osteoclasts
    Angela C Hirbe
    Department of Medicine, Division of Molecular Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bone 44:908-16. 2009
    ..OC-defective mice treated with ZA demonstrated a significant 88% decrease in tumor growth in bone compared to vehicle-treated OC-defective mice. These data support an osteoclast-independent role for N-BP therapy in bone metastasis...
  87. ncbi request reprint Visualizing protein-protein interactions in living animals
    Gary D Luker
    Department of Molecular Biology, Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University Medical School, 510 South Kingshighway Boulevard, 63110, St Louis, MO, USA
    Methods 29:110-22. 2003
    ....
  88. ncbi request reprint Evidence for a plasma membrane-mediated permeability barrier to Tat basic domain in well-differentiated epithelial cells: lack of correlation with heparan sulfate
    Stefania Violini
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biochemistry 41:12652-61. 2002
    ..The unanticipated presence of a permeation barrier to Tat-peptides in well-differentiated epithelial cells suggests the existence of cell-specific mechanisms for mediated translocation of these permeation peptides...
  89. ncbi request reprint Molecular imaging of gene expression and protein function in vivo with PET and SPECT
    Vijay Sharma
    Molecular Imaging Center, Mallinckrodt Institute of Radiology and Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Magn Reson Imaging 16:336-51. 2002
    ....
  90. pmc Molecular imaging of pulmonary disease in vivo
    Robin S Dothager
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Department of Developmental Biology, Washington University Medical School, 510 S Kingshighway Blvd, Box 8225 St Louis, MO 63110, USA
    Proc Am Thorac Soc 6:403-10. 2009
    ..Molecular imaging" holds enormous potential for elucidating the molecular mechanisms of pulmonary disease and therapeutic response in intact animal models and humans...
  91. pmc Loss of the Par-1b/MARK2 polarity kinase leads to increased metabolic rate, decreased adiposity, and insulin hypersensitivity in vivo
    Jonathan B Hurov
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Proc Natl Acad Sci U S A 104:5680-5. 2007
    ..Taken together, these data indicate that Par-1b is a regulator of glucose metabolism and adiposity in the whole animal and may be a valuable drug target for the treatment of both type 2 diabetes and obesity...
  92. pmc Luciferase fragment complementation imaging of conformational changes in the epidermal growth factor receptor
    Katherine S Yang
    Department of Biochemistry and Molecular Biophysics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 284:7474-82. 2009
    ..Our data demonstrate the utility of the luciferase system for in vivo imaging changes in EGF receptor dimerization and conformation. They also identify two sequential ligand-induced conformational changes in the EGF receptor...
  93. ncbi request reprint Molecular imaging strategies for drug discovery and development
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, and Department of Molecular Biology and Pharmacology, Washington University Medical School, Saint Louis, MO 63110, USA
    Curr Opin Chem Biol 10:334-42. 2006
    ....
  94. ncbi request reprint Optimizing luciferase protein fragment complementation for bioluminescent imaging of protein-protein interactions in live cells and animals
    Kathryn E Luker
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Methods Enzymol 385:349-60. 2004
  95. ncbi request reprint Monitoring proteasome activity in cellulo and in living animals by bioluminescent imaging: technical considerations for design and use of genetically encoded reporters
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Methods Enzymol 399:512-30. 2005
    ..Such technology enables repetitive, temporally resolved, and regionally targeted assessment of proteasomal activity in vivo...
  96. pmc Revascularization of ischemic limbs after transplantation of human bone marrow cells with high aldehyde dehydrogenase activity
    Benjamin J Capoccia
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Blood 113:5340-51. 2009
    ..These clinically relevant cells may prove useful in the treatment of critical ischemia in humans...
  97. pmc Single-cell imaging of retinal ganglion cell apoptosis with a cell-penetrating, activatable peptide probe in an in vivo glaucoma model
    Edward M Barnett
    Department of Ophthalmology and Visual Sciences, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:9391-6. 2009
    ..Stereospecificity was also exhibited by the lack of intracellular fluorescence upon administration of the noncleavable isomer, dTcapQ. TcapQ has potential utility in detecting and monitoring single-cell apoptosis in glaucoma in vivo...
  98. pmc Real-time imaging of beta-catenin dynamics in cells and living mice
    Snehal Naik
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:17465-70. 2007
    ..These beta-cat reporters represent a powerful new strategy for identifying in cellulo and in vivo dynamic regulators and mechanism-based therapeutics of signaling pathways mediated by beta-cat stabilization...
  99. ncbi request reprint Veni, vidi, vici: in vivo molecular imaging of immune response
    Shimon Gross
    Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 27:533-8. 2007
    ..Continuing the "From the Field" series (see Editorial [2007] 26, 131), Gross et al. summarize how modern molecular imaging techniques can successfully dissect the complexities of immune response in vivo...
  100. pmc CXCL12 alone is insufficient for gliomagenesis in Nf1 mutant mice
    Tao Sun
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuroimmunol 224:108-13. 2010
    ..Forced CXCL12 expression induced glioma at a low frequency. Further, treatment of Nf1 OPG mice with AMD3100, a CXCR4 antagonist, did not attenuate glioma growth. Thus, it appears, CXCL12 alone cannot promote gliomagenesis in NF1 mice...
  101. pmc Rational design of novel red-shifted BRET pairs: Platforms for real-time single-chain protease biosensors
    Seth T Gammon
    Dept of Molecular Biology and Pharmacology, and Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Biotechnol Prog 25:559-69. 2009
    ..Thus, we illustrate a general methodology for the rational design of new BRET systems and provide a novel single-chain BRET protease biosensor that is long lived, red-shifted, and utilizes D-luciferin...

Research Grants20

  1. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 1999
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new therapies, including gene therapy and new molecular targeted chemotherapy in cancer. ..
  2. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2007
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new molecular targeted therapies in cancer. ..
  3. Soc for Molecular Imaging 3rd Annual International Mtg
    David Piwnica Worms; Fiscal Year: 2004
    ..This proposal requests funds to provide partial support for travel and subsistence expenses for invited participants, minority faculty and young investigators from North America and overseas. ..
  4. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2004
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new molecular targeted therapies in cancer. ..
  5. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2002
    ..abstract_text> ..
  6. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2002
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new therapies, including gene therapy and new molecular targeted chemotherapy in cancer. ..
  7. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2001
    ..abstract_text> ..
  8. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2001
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new therapies, including gene therapy and new molecular targeted chemotherapy in cancer. ..
  9. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 2000
    ..abstract_text> ..
  10. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2009
    ..These activities benefit from the combination expertise of this applicant team in chemistry, molecular imaging, biochemistry, and vision biology. ..
  11. IMAGING MULTIDRUG RESISTANCE AND MODULATION IN BREAST CA
    David Piwnica Worms; Fiscal Year: 1999
    ..abstract_text> ..
  12. Washington University Molecular Imaging Center
    David Piwnica Worms; Fiscal Year: 2007
    ....
  13. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2000
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new therapies, including gene therapy and new molecular targeted chemotherapy in cancer. ..
  14. Washington University Molecular Imaging Center
    David Piwnica Worms; Fiscal Year: 2007
    ..The P50 Center grant will now promote excellence in molecular imaging in cancer research by providing a formal conduit for interdisciplinary multi-modality collaborations. ..
  15. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2006
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new molecular targeted therapies in cancer. ..
  16. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2005
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new molecular targeted therapies in cancer. ..
  17. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David Piwnica Worms; Fiscal Year: 2003
    ..Studies with these novel imaging tools will assist interrogation of the efficacy of new therapies, including gene therapy and new molecular targeted chemotherapy in cancer. ..
  18. MEMBRANE PERMEANT PEPTIDES FOR IMAGING CELL FUNCTION
    David R Piwnica Worms; Fiscal Year: 2010
    ..These activities benefit from the combination expertise of this applicant team in chemistry, molecular imaging, biochemistry, and vision biology. ..