Affiliation: Washington University School of Medicine
Tufariello J, Chapman J, Kerantzas C, Wong K, VilchÃ¨ze C, Jones C, et al. Separable roles for Mycobacterium tuberculosis ESX-3 effectors in iron acquisition and virulence. Proc Natl Acad Sci U S A. 2016;113:E348-57 pubmed publisher
..Further, we demonstrate that the ESX-3 T7SS secretes certain effectors that are important for iron uptake while additional secreted effectors modulate virulence in an iron-independent fashion. ..
Tinaztepe E, Wei J, Raynowska J, Portal Celhay C, Thompson V, Philips J. Role of Metal-Dependent Regulation of ESX-3 Secretion in Intracellular Survival of Mycobacterium tuberculosis. Infect Immun. 2016;84:2255-2263 pubmed publisher
..tuberculosis survival. Our findings detail the regulatory differences of esx-3 in M. tuberculosis and M. smegmatis and demonstrate the importance of metal-dependent regulation of ESX-3 for virulence in M. tuberculosis. ..