Arie Perry

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma
    Arie Perry
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Cancer 101:2318-26. 2004
  2. ncbi INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
    Mod Pathol 18:951-8. 2005
  3. doi Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Brain Pathol 19:81-90. 2009
  4. ncbi Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature
    Arie Perry
    Division of Neuropathology, Washington University, St Louis, MO 63110 1093, USA
    Brain Pathol 15:55-65. 2005
  5. pmc Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall
    Arie Perry
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Acta Neuropathol 120:237-52. 2010
  6. ncbi Meningothelial hyperplasia: a detailed clinicopathologic, immunohistochemical and genetic study of 11 cases
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Brain Pathol 15:109-15. 2005
  7. ncbi Cancer therapy-associated CNS neuropathology: an update and review of the literature
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Acta Neuropathol 111:197-212. 2006
  8. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features
    Christine E Fuller
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 62:1118-28. 2003
  9. ncbi Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1
    Nicole M Warrington
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:8588-95. 2007
  10. ncbi Alterations of protein 4.1 family members in ependymomas: a study of 84 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 18:991-7. 2005

Collaborators

Detail Information

Publications101 found, 100 shown here

  1. ncbi Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma
    Arie Perry
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Cancer 101:2318-26. 2004
    ..Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma...
  2. ncbi INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
    Mod Pathol 18:951-8. 2005
    ..Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor...
  3. doi Malignant gliomas with primitive neuroectodermal tumor-like components: a clinicopathologic and genetic study of 53 cases
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Brain Pathol 19:81-90. 2009
    ....
  4. ncbi Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature
    Arie Perry
    Division of Neuropathology, Washington University, St Louis, MO 63110 1093, USA
    Brain Pathol 15:55-65. 2005
    ..In contrast, most perivascular spindled cells of pure MA are genetically and immunohistochemically similar to non-neoplastic meningothelial cells, consistent with current histogenetic theories...
  5. pmc Oligodendroglial neoplasms with ganglioglioma-like maturation: a diagnostic pitfall
    Arie Perry
    Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Acta Neuropathol 120:237-52. 2010
    ..We conclude that GGLF represents yet another form of neuronal differentiation in oligodendroglial neoplasms. Recognition of this pattern will prevent a misdiagnosis of ganglioglioma with its potential for under-treatment...
  6. ncbi Meningothelial hyperplasia: a detailed clinicopathologic, immunohistochemical and genetic study of 11 cases
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Brain Pathol 15:109-15. 2005
    ..It may be preneoplastic in some, though further studies are needed to test this hypothesis...
  7. ncbi Cancer therapy-associated CNS neuropathology: an update and review of the literature
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Acta Neuropathol 111:197-212. 2006
    ..Therefore, it is critical to recognize the full spectrum of cancer therapy-associated neuropathology, the topic of the current review...
  8. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features
    Christine E Fuller
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 62:1118-28. 2003
    ..We conclude that 1) distinct genetic subsets are identifiable by FISH in morphologically ambiguous gliomas, and 2) both histological grading and molecular analysis yield prognostically useful information...
  9. ncbi Spatiotemporal differences in CXCL12 expression and cyclic AMP underlie the unique pattern of optic glioma growth in neurofibromatosis type 1
    Nicole M Warrington
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:8588-95. 2007
    ..Collectively, these studies provide a mechanism for the unique pattern of NF1-associated glioma growth...
  10. ncbi Alterations of protein 4.1 family members in ependymomas: a study of 84 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 18:991-7. 2005
    ..009). We conclude that alterations of Protein 4.1 family members are common in ependymal tumors and that specific alterations are associated with distinct clinicopathologic subsets...
  11. pmc Targeted inhibition of cyclic AMP phosphodiesterase-4 promotes brain tumor regression
    Patricia Goldhoff
    Department of Pediatrics, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:7717-25. 2008
    ..Previously, we identified the cyclic AMP phosphodiesterase-4 (PDE4) inhibitor Rolipram as a potent antitumor agent. Here, we investigate the role of PDE4 in brain tumors and examine the utility of PDE4 as a therapeutic target...
  12. pmc Immunohistochemical analysis supports a role for INI1/SMARCB1 in hereditary forms of schwannomas, but not in solitary, sporadic schwannomas
    Sushama Patil
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO, USA
    Brain Pathol 18:517-9. 2008
    ..These results confirm a role for INI1/SMARCB1 in multiple schwannoma syndromes and suggest that a different pathway of tumorigenesis occurs in solitary, sporadic tumors...
  13. ncbi Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma
    Eriks A Lusis
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:7121-6. 2005
    ....
  14. ncbi Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas
    Sergei I Bannykh
    Department of Pathology, Yale University School of Medicine, New Haven, CT 65210, USA
    J Neurooncol 76:115-27. 2006
    ..Our data raise a possibility that histogenesis of gliomas have more common features than previously anticipated...
  15. doi Postoperative imaging surveillance in pediatric pilocytic astrocytomas
    Ian G Dorward
    Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 6:346-52. 2010
    ..Whereas several reports recommend no postoperative imaging, one study proposed surveillance MR imaging studies to detect delayed recurrences...
  16. pmc PDGFRA amplification is common in pediatric and adult high-grade astrocytomas and identifies a poor prognostic group in IDH1 mutant glioblastoma
    Joanna J Phillips
    Department of Pathology, University of California San Francisco, San Francisco, CA, USA
    Brain Pathol 23:565-73. 2013
    ..To our knowledge, this is the largest survey of PDGFRA status in adult and pediatric HGAs and suggests PDGFRA amplification increases with grade and is associated with a less favorable prognosis in IDH1 mutant de novo GBMs. ..
  17. doi Diagnostic implications of IDH1-R132H and OLIG2 expression patterns in rare and challenging glioblastoma variants
    Nancy M Joseph
    Department of Pathology, University of California San Francisco, San Francisco, CA 94143, USA
    Mod Pathol 26:315-26. 2013
    ..Therefore, in one of the most challenging differential diagnoses, IDH1 positivity could provide strong support for glioblastoma with oligodendroglial component, while essentially excluding small cell glioblastoma...
  18. doi Disseminated oligodendroglial-like leptomeningeal tumor of childhood: a distinctive clinicopathologic entity
    Fausto J Rodriguez
    Department of Pathology, Division of Neuropathology, Johns Hopkins Hospital, Johns Hopkins University, Baltimore, MD, 21231, USA
    Acta Neuropathol 124:627-41. 2012
    ..We report a series of a neoplasm with distinct clinicopathologic and molecular features. Although most progress slowly, a significant fraction develop aggressive features...
  19. doi Preclinical cancer therapy in a mouse model of neurofibromatosis-1 optic glioma
    Balazs Hegedus
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 68:1520-8. 2008
    ..Collectively, these findings suggest that this Nf1 optic glioma model may be a potential preclinical benchmark for identifying novel therapies that have a high likelihood of success in human clinical trials...
  20. ncbi INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma
    Alexander R Judkins
    Department of Pathology, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Neuropathol Exp Neurol 64:391-7. 2005
    ..This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone...
  21. ncbi Molecular diagnostics in central nervous system tumors
    Christine E Fuller
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, and Division of Neuropathology, Washington University School of Medicine, St Louis, MO, USA
    Adv Anat Pathol 12:180-94. 2005
    ....
  22. ncbi Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin
    Mukesh K Sharma
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:890-900. 2007
    ..These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated...
  23. doi Mucoepidermoid carcinoma of the cervix: another tumor with the t(11;19)-associated CRTC1-MAML2 gene fusion
    Jochen K M Lennerz
    Divisions of Anatomic and Molecular Pathology, Washington University Medical Center, St Louis, MO, USA
    Am J Surg Pathol 33:835-43. 2009
    ....
  24. ncbi Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Front Biosci 8:a1-9. 2003
    ....
  25. pmc Identification of transcriptional regulatory networks specific to pilocytic astrocytoma
    Hrishikesh Deshmukh
    Department of Pathology and Immunology, Washington University School of Medicine, 660, S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Med Genomics 4:57. 2011
    ....
  26. ncbi Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults
    Jack Raisanen
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
    Brain Pathol 15:23-8. 2005
    ..These molecular findings confirm the occurrence of AT/RTs in adults. Although rare, AT/RT should be considered in the differential diagnosis of poorly differentiated intracranial tumors in adults...
  27. ncbi 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 17:9-14. 2004
    ....
  28. ncbi Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature
    Elena L Zarovnaya
    Department of Pathology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    J Neurooncol 84:49-55. 2007
    ..An unrestricted autopsy was performed. To our knowledge, this is the first case of a spinal atypical teratoid/rhabdoid tumor in an adult fully documented with molecular, immunohistochemical, cytogenetic and autopsy findings...
  29. pmc Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Pathol 161:665-72. 2002
    ..This report represents the first gene expression profiling studies of meningiomas and identifies some initial candidate genes that may provide further insights into the genetic basis for meningioma pathogenesis...
  30. doi Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes
    Christopher Dunham
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 32:478-84. 2008
    ..Genetic analyses revealed a t(12;22)(q13;q12) and a unique underlying clear cell sarcomalike type 1 EWS/ATF-1 gene fusion...
  31. ncbi Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    Biplab Dasgupta
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 65:236-45. 2005
    ....
  32. ncbi High-throughput molecular profiling of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH)
    Christine E Fuller
    Division of Neuropathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 61:1078-84. 2002
    ..The overall concordance rate between paired tumor core samples was 93%. We conclude that TMA-FISH is an efficient and reliable method for detecting molecular alterations in high-grade astrocytomas...
  33. doi Array-based comparative genomic hybridization identifies CDK4 and FOXM1 alterations as independent predictors of survival in malignant peripheral nerve sheath tumor
    Jinsheng Yu
    Department of Pathology and Immunology, Washington University School of Medicine, Saint Louis, Missouri, USA
    Clin Cancer Res 17:1924-34. 2011
    ..To identify survival-associated genomic biomarkers, we performed high-resolution array-based comparative genomic hybridization (aCGH) on a large set of MPNSTs...
  34. doi Spectrum of pilomyxoid astrocytomas: intermediate pilomyxoid tumors
    Michael W Johnson
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Am J Surg Pathol 34:1783-91. 2010
    ..Further follow-up is needed to more accurately determine the prognosis of intermediate tumors...
  35. ncbi Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis
    Victoria A Robb
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 13:191-202. 2003
    ..1B interactors including CD44 and betaII-spectrin. Collectively, these results suggest that Protein 4.1R functions as an important tumor suppressor in the molecular pathogenesis of meningioma...
  36. pmc A novel murine model for localized radiation necrosis and its characterization using advanced magnetic resonance imaging
    Sarah C Jost
    Department of Neurosurgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 75:527-33. 2009
    ..To develop a murine model of radiation necrosis using fractionated, subtotal cranial irradiation; and to investigate the imaging signature of radiation-induced tissue damage using advanced magnetic resonance imaging techniques...
  37. ncbi Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 14:297-303. 2004
    ..We conclude that distinct molecular classes of MPNST exist and that the ability to stratify these tumors based on unique and biologically relevant gene expression profiles may be important for future targeted therapeutics...
  38. ncbi Natural history of neurofibromatosis 1-associated optic nerve glioma in mice
    M Livia Bajenaru
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Ann Neurol 57:119-27. 2005
    ..Last, we observed neovascularization and microglial cell infiltration by 3 weeks of age before overt neoplastic transformation, suggesting that these cellular changes participate in the early stages of tumor formation...
  39. ncbi Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    Xing Fan
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:7787-93. 2004
    ..Our data indicate that Notch1 and Notch2 can have opposite effects on the growth of a single tumor type, and show that Notch2 can be overexpressed after gene amplification in human tumors...
  40. ncbi Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival
    Ezequiel I Surace
    partment of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuropathol Exp Neurol 63:1015-27. 2004
    ..Moreover, TSLC1 loss was associated with decreased patient survival, within the overall group, and in the atypical meningiomas. Collectively, these results suggest that TSLC1 plays an important role in meningioma pathogenesis...
  41. ncbi The alternative lengthening of telomere phenotype is significantly associated with loss of ATRX expression in high-grade pediatric and adult astrocytomas: a multi-institutional study of 214 astrocytomas
    Malak Abedalthagafi
    1 Division of Neuropathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA 2 Division of Surgical Pathology, Department of Pathology, University of California, San Francisco, San Francisco, CA, USA
    Mod Pathol 26:1425-32. 2013
    ..03 for each). In summary, our data show that the ALT and ATRX protein alterations are common in both pediatric and adult high-grade astrocytomas, often with associated PDGFRA gene amplification. ..
  42. ncbi Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma
    Pang Hsien Tu
    Division of Neuropathology and Section of Hematopathology, Campus Box 8118, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Clin Oncol 23:5718-27. 2005
    ..Although rare overall, marginal zone B-cell lymphoma (MZBCL) is the most common primary low-grade CNS lymphoma reported in the literature. The aim of this study is to elucidate the biology and genetic features of this unusual tumor...
  43. doi Rosette-forming glioneuronal tumors of the posterior fossa
    Manish N Shah
    Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 5:98-103. 2010
    ..These cases expand the known clinical and histological spectrum of this rare tumor type. Given the lack of fourth ventricle involvement in most of these cases, the authors suggest revising the name to RGNT of the posterior fossa...
  44. ncbi Primary Ewing sarcoma of the brain: a case report and literature review
    Syed Ali Jaffar Kazmi
    Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Diagn Mol Pathol 16:108-11. 2007
    ..Demonstration of characteristic translocations by molecular studies differentiates CNS-EES from cPNET and help clinicians make informed decisions regarding therapy...
  45. ncbi Blocking CXCR4-mediated cyclic AMP suppression inhibits brain tumor growth in vivo
    Lihua Yang
    Department of Pediatrics, and Neurology and Molecular Imaging Center, Mallinckrodt Institute of Radiology, Washington University School of Medicine and St Louis Children s Hospital, St Louis, Missouri 63110, USA
    Cancer Res 67:651-8. 2007
    ..These data indicate that the clinical evaluation of phosphodiesterase inhibitors in the treatment of patients with brain tumors is warranted...
  46. ncbi Cytologic diagnosis of Ewing sarcoma/peripheral neuroectodermal tumor with paired prospective molecular genetic analysis
    Souzan Sanati
    Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish and Saint Louis Children s Hospitals, Washington University Medical Center, St Louis, MO 63110 1093, USA
    Cancer 111:192-9. 2007
    ....
  47. pmc Identification of gene markers associated with aggressive meningioma by filtering across multiple sets of gene expression arrays
    Jourdan E Stuart
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 70:1-12. 2011
    ....
  48. ncbi Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 35:1413-8. 2004
    ..3) The characteristic FXIIIa staining pattern reported for HPC also is encountered frequently in anaplastic meningiomas and therefore is nonspecific in this diagnostic setting...
  49. ncbi Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas
    Kenneth B Fallon
    Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    J Neuropathol Exp Neurol 63:314-22. 2004
    ....
  50. ncbi The differential diagnosis of pilocytic astrocytoma with atypical features and malignant glioma: an analysis of 16 cases with emphasis on distinguishing molecular features
    Matthew D Cykowski
    Department of Pathology, University of Oklahoma Health Sciences Center, Oklahoma City, OK, USA
    J Neurooncol 115:477-86. 2013
    ....
  51. ncbi The efficacy of radiation therapy in the management of grade I astrocytomas
    Elizabeth A Kidd
    Department of Radiation Oncology and Mallinckrodt Institute of Radiology, St Louis, MO, USA
    J Neurooncol 76:55-8. 2006
    ....
  52. doi Gliosarcoma arising from an oligodendroglioma (oligosarcoma)
    Annie Hiniker
    Department of Pathology, University of California San Francisco, CA, USA
    Clin Neuropathol 32:165-70. 2013
    ..Here we present a case with detailed genetic evidence that suggests that mesenchymal metaplasia sarcomatous transformation is possible in classic oligodendrogliomas with 1p19q codeletions...
  53. doi Meningiomas in pregnancy: a clinicopathologic study of 17 cases
    Eriks A Lusis
    Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri, USA
    Neurosurgery 71:951-61. 2012
    ..Dramatic growth of meningiomas is occasionally encountered during pregnancy. While cell proliferation is often assumed, hemodynamic changes have also been touted as a cause...
  54. pmc Early recurrence in standard-risk medulloblastoma patients with the common idic(17)(p11.2) rearrangement
    Gabriel A Bien-Willner
    Washington University, Department of Pathology, St Louis, MO, USA
    Neuro Oncol 14:831-40. 2012
    ..FISH detection of idic(17)(p11.2) may be useful for risk stratification in standard-risk patients. The presence of this abnormal chromosome is associated with early recurrence of medulloblastoma...
  55. ncbi Ependymomas with neuronal differentiation: a morphologic and immunohistochemical spectrum
    Fausto J Rodriguez
    Department of Pathology, Mayo Clinic, Rochester, MN, USA
    Acta Neuropathol 113:313-24. 2007
    ..The clinical significance of these observations is unknown but deserves further exploration...
  56. doi Glioblastomas with giant cell and sarcomatous features in patients with Turcot syndrome type 1: a clinicopathological study of 3 cases
    Eriks A Lusis
    Department of Neurosurgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurosurgery 67:811-7; discussion 817. 2010
    ..Turcot syndrome (TS) is a rare genetic disorder of DNA mismatch repair predisposing to glioblastoma (GBM) in the type 1 variant...
  57. doi Brainstem glioma presenting as pruritus in children with neurofibromatosis-1
    Rachel S Darken
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63119, USA
    J Pediatr Hematol Oncol 31:972-6. 2009
    ..This unusual presentation emphasizes the importance of appreciating subtle, often hard to localize, symptoms in this high-risk population...
  58. doi Central nervous system primitive neuroectodermal tumors: a clinicopathologic and genetic study of 33 cases
    Amir Behdad
    Department of Pathology, Cedar Sinai Medical Center, Los Angeles, Calif, USA
    Brain Pathol 20:441-50. 2010
    ....
  59. ncbi DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation
    Veena Rajaram
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63132, USA
    Genes Chromosomes Cancer 46:508-13. 2007
    ....
  60. ncbi The in vivo antitumoral effects of lipopolysaccharide against glioblastoma multiforme are mediated in part by Toll-like receptor 4
    Michael R Chicoine
    Department of Neurosurgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Neurosurgery 60:372-80; discussion 381. 2007
    ..However, the precise role of Tlr-4 in these antitumoral effects remains unknown...
  61. ncbi Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors
    Robert S Bridge
    Department of Pathology and Immunology, Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO 63110 1093, USA
    Mod Pathol 19:1-8. 2006
    ..The commercial break apart probe set is both readily available and easy to interpret, making it particularly attractive. Nonetheless, complex round cell tumors often benefit from molecular testing with multiple methods...
  62. ncbi Significance of necrosis in grading of oligodendroglial neoplasms: a clinicopathologic and genetic study of newly diagnosed high-grade gliomas
    C Ryan Miller
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 24:5419-26. 2006
    ..WHO 2000 grading criteria for high-grade oligodendroglial neoplasms [anaplastic oligoastrocytoma (AOA) and anaplastic oligodendroglioma (AO)] remain subjective, and the existence of grade 4 variants is controversial...
  63. ncbi Differential involvement of protein 4.1 family members DAL-1 and NF2 in intracranial and intraspinal ependymomas
    Pratima K Singh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 10963, USA
    Mod Pathol 15:526-31. 2002
    ....
  64. pmc Isocitrate dehydrogenase 1 analysis differentiates gangliogliomas from infiltrative gliomas
    Craig Horbinski
    Department of Pathology, University of Kentucky, Lexington, KY 40536, USA
    Brain Pathol 21:564-74. 2011
    ..5 vs. 46.1 years, P=0.0033). IDH1/2 testing of tumors suspected of being gangliogliomas may therefore be advisable, particularly in the adult population...
  65. ncbi Status of the NF1 tumor suppressor locus in uveal melanoma
    William J Foster
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Ophthalmol 121:1311-5. 2003
    ..A clinical association has been observed between uveal melanoma and neurofibromatosis type 1 (NF1). This study aims to determine whether the NF1 tumor suppressor gene is mutated in uveal melanoma...
  66. doi Oligodendrogliomas in children
    Kimberly M Creach
    Department of Radiation Oncology and Mallinckrodt Institute of Radiology, Washington University School of Medicine, 660 South Euclid Avenue, Saint Louis, MO 63110, USA
    J Neurooncol 106:377-82. 2012
    ..Our data demonstrate that patients with less than GTR and <3 years at diagnosis are at increased risk for progression and may benefit from more aggressive therapy...
  67. ncbi Malignant rhabdoid meningioma arising in the setting of preexisting ganglioglioma: a diagnosis supported by fluorescence in situ hybridization. Case report
    Sergei I Bannykh
    Department of Pathology, University of California at San Diego, La Jolla, California 92093 0612, USA
    J Neurosurg 97:1450-5. 2002
    ....
  68. ncbi Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Neuropathol Exp Neurol 61:702-9. 2002
    ..001). Thus, FISH analysis identifies relatively specific genetic patterns that may be useful in selected cases, for which the differential diagnosis includes low- or high-grade MPNST...
  69. ncbi A role for chromosome 9p21 deletions in the malignant progression of meningiomas and the prognosis of anaplastic meningiomas
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Pathol 12:183-90. 2002
    ..We conclude that chromosome 9p21 deletions are associated with malignant progression of meningiomas and poor prognosis in anaplastic meningiomas...
  70. ncbi Receptor tyrosine kinases in sinonasal undifferentiated carcinomas--evaluation for EGFR, c-KIT, and HER2/neu expression
    Rebecca D Chernock
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Head Neck 31:919-27. 2009
    ..Our objective was to identify the expression of epidermal growth factor receptor (EGFR), c-KIT (CD117), and HER2/neu in sinonasal undifferentiated carcinoma (SNUC)...
  71. ncbi EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma
    Michael Covinsky
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 36:74-81. 2005
    ....
  72. ncbi Glioblastoma
    C Ryan Miller
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Arch Pathol Lab Med 131:397-406. 2007
    ....
  73. pmc Pathology of low-grade gliomas: an update of emerging concepts
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Neuro Oncol 5:168-78. 2003
    ..Also discussed are current controversies of classification/grading and the role of ancillary testing via immunohistochemical and genetic techniques...
  74. pmc Rituximab-associated progressive multifocal leukoencephalopathy in rheumatoid arthritis
    David B Clifford
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Arch Neurol 68:1156-64. 2011
    ..To describe the development of progressive multifocal leukoencephalopathy (PML) in patients with rheumatoid arthritis (RA) treated with rituximab...
  75. ncbi Medulloblastomas with favorable versus unfavorable histology: how many small blue cell tumor types are there in the brain?
    Arie Perry
    Division of Neuropathology, Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Adv Anat Pathol 9:345-50. 2002
    ..Medulloblastoma grading based on anaplasia demonstrated a statistically stronger association with patient outcome than clinical staging. Therefore, histologic grading of medulloblastomas seems warranted as a routine diagnostic aid...
  76. ncbi Meningeal tumors of childhood and infancy. An update and literature review
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Pathol 13:386-408. 2003
    ..As in other areas of pediatric pathology, there are significant differences between this patient cohort and adults, differences which will be emphasized in this review...
  77. ncbi Molecular pathogenesis of meningiomas
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Neurooncol 70:183-202. 2004
    ....
  78. ncbi Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas
    David H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 62:2085-91. 2002
    ..We conclude that PAs are genetically unique gliomas with gene expression profiles that resemble those of fetal astrocytes and, to a lesser extent, oligodendroglial precursors...
  79. ncbi Postoperative radiation therapy for grade II and III intracranial ependymoma
    David B Mansur
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:387-91. 2005
    ..To retrospectively determine the long-term outcome of intracranial ependymoma patients treated with surgery and postoperative radiation therapy...
  80. doi Clinicopathologic features of recurrent dysembryoplastic neuroepithelial tumor and rare malignant transformation: a report of 5 cases and review of the literature
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, 660 S Euclid Avenue, Campus Box 8057, St Louis, MO 63110, USA
    J Neurooncol 94:283-92. 2009
    ..These findings suggest that these patients may need closer follow-up than initially suggested, lending further support to the notion that this tumor behaves more like a benign neoplasm, rather than a dysplastic or hamartomatous lesion...
  81. pmc Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma
    Melissa Frei-Jones
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 2:125-9. 2008
    ..The authors present the case of an infant born with a life-threatening, unresectable intracranial hemangioma in which treatment with thalidomide resulted in a good clinical outcome...
  82. ncbi Mantel statistics to correlate gene expression levels from microarrays with clinical covariates
    William D Shannon
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 23:87-96. 2002
    ..We also show how the Mantel statistics can be used to rank subsets of genes, found using standard clustering methods, in terms of differential expression across samples...
  83. ncbi Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
    Lori A Worley
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:1466-71. 2007
    ..To compare a gene expression-based classifier versus the standard genetic prognostic marker, monosomy 3, for predicting metastasis in uveal melanoma...
  84. ncbi Embryonal tumor with abundant neuropil and true rosettes (ETANTR): report of a case with prominent neurocytic differentiation
    Christopher Dunham
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, Campus Box, 8118, St Louis, MO 63110, USA
    J Neurooncol 84:91-8. 2007
    ..The lack of common PNET-associated FISH abnormalities in this case adds to the limited cytogenetic genetic data on this rare pediatric embryonal neoplasm...
  85. ncbi Gliosarcoma with primitive neuroectodermal differentiation: case report and review of the literature
    Keith J Kaplan
    Department of Pathology, Evanston Hospital, 2650 Ridge Ave, Evanston, IL 60201, USA
    J Neurooncol 83:313-8. 2007
    ..The clinical and pathological features of a gliosarcoma with a primitive neuroectodermal component in a 52-year-old male are presented. To our knowledge, only three other cases of such an entity have been reported in the English literature...
  86. ncbi Unmasking the secrets of meningioma: a slow but rewarding journey
    Arie Perry
    Washington University School of Medicine, St Louis, Missouri, USA
    Surg Neurol 61:171-3. 2004
  87. ncbi Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies
    B Mark Woerner
    Department of Pediatrics, Division of Pediatric Hematology Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 65:11392-9. 2005
    ....
  88. ncbi Expression and function of somatostatin receptors in peripheral nerve sheath tumors
    Christian Mawrin
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    J Neuropathol Exp Neurol 64:1080-8. 2005
    ..Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs...
  89. ncbi 1p/19q chromosome deletions in metastatic oligodendroglioma
    Ryan Merrell
    Department of Neurology, University of Alabama at Birmingham, AL 35294, USA
    J Neurooncol 80:203-7. 2006
    ..Genetic analysis serves a valuable ancillary role in the diagnostic workup of such cases...
  90. ncbi Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma
    Kenneth Aldape
    M D Anderson Cancer Center, Department of Pathology and Brain Tumor Center, 1515 Holcombe Blvd, Houston, TX 60153, USA
    Arch Pathol Lab Med 131:242-51. 2007
    ..These findings raise questions as to the role of 1p/19q testing in clinical practice, both as a prognostic marker and as a potential diagnostic marker among infiltrating glial neoplasms...
  91. ncbi Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma
    Geeta Chacko
    Division of Neuropathology, Department of Neurological Sciences, Christian Medical College, Vellore, India
    J Neurooncol 84:217-22. 2007
    ..We speculate that the PXA was a quiescent tumor and that the secondary genetic alterations, including inactivation of the INI1 gene led to clinical progression...
  92. ncbi Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Cancer 101:1445-54. 2004
    ..Medullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components...
  93. doi Ependymal tumors with sarcomatous change ("ependymosarcoma"): a clinicopathologic and molecular cytogenetic study
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 32:699-709. 2008
    ..Although rare, ependymal neoplasms must be included among the gliomas prone to undergo sarcomatous change and we propose the term "ependymosarcoma" for these tumors...
  94. ncbi Glioneuronal tumours in neurofibromatosis type 1: MRI-pathological study
    Marco Fedi
    Department of Medicine Neurology, Austin and Repatriation Medical Centre, University of Melborne, Heidelberg, Vic, Australia
    J Clin Neurosci 11:745-7. 2004
    ..Because of the excellent prognosis following the resection of these tumours, it is important to distinguish them from other NF1-associated tumours...
  95. pmc Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from Radiation Therapy Oncology Group trials
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuro Oncol 6:96-103. 2004
    ..Long-term and short-term survival groups of high-grade astrocytomas appear to have dissimilar frequencies of 19q, 9p, and 10q deletions. TMA-FISH is a rapid and efficient way of evaluating genetic alterations in such tumors...
  96. pmc Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neuropathol Exp Neurol 67:240-9. 2008
    ..Classic PA and LGSI are the most common, and most have favorable prognoses. By contrast, DAs are more aggressive, similar to those that arise sporadically...
  97. ncbi Gray zones in brain tumor classification: evolving concepts
    Dimitri Trembath
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Adv Anat Pathol 15:287-97. 2008
    ..In the current review, we discuss these issues and offer some practical guidelines for dealing with problematic cases...
  98. ncbi Malignant rhabdoid tumor mimicking hepatoblastoma: a case report and literature review
    Lars M Wagner
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 10:409-15. 2007
    ..Important similarities and differences between hepatoblastoma and rhabdoid tumors are reviewed, and suggestions are offered to help distinguish these 2 tumor types...
  99. ncbi Genetic and expression profiles of cerebellar liponeurocytomas
    Sonja Horstmann
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 14:281-9. 2004
    ..Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different...
  100. ncbi Pediatric oligodendrogliomas: a study of molecular alterations on 1p and 19q using fluorescence in situ hybridization
    Ravi Raghavan
    Neuropathology Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neuropathol Exp Neurol 62:530-7. 2003
    ..Genomic screening on a larger series is clearly indicated to delineate the unique molecular characteristics of these rare pediatric tumors...
  101. ncbi Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues
    Shyra J Miller
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 66:2584-91. 2006
    ....