A Perry

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Identification of transcriptional regulatory networks specific to pilocytic astrocytoma
    Hrishikesh Deshmukh
    Department of Pathology and Immunology, Washington University School of Medicine, 660, S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Med Genomics 4:57. 2011
  2. pmc NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors
    A Perry
    Departments of Pathology and Neurology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Pathol 159:57-61. 2001
  3. ncbi Oligodendroglial neoplasms: current concepts, misconceptions, and folklore
    A Perry
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Adv Anat Pathol 8:183-99. 2001
  4. ncbi Clinicopathologic assessment and grading of embolized meningiomas: a correlative study of 64 patients
    A Perry
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110 1093, USA
    Cancer 92:701-11. 2001
  5. ncbi Meningeal tumors of childhood and infancy. An update and literature review
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Pathol 13:386-408. 2003
  6. pmc Pathology of low-grade gliomas: an update of emerging concepts
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Neuro Oncol 5:168-78. 2003
  7. ncbi Molecular pathogenesis of meningiomas
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Neurooncol 70:183-202. 2004
  8. ncbi "Rhabdoid" meningioma: an aggressive variant
    A Perry
    Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 22:1482-90. 1998
  9. ncbi Combined oligodendroglioma/pleomorphic xanthoastrocytoma: a probable collision tumor: case report
    A Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Neurosurgery 48:1358-61. 2001
  10. ncbi Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas
    D H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuropathol Appl Neurobiol 26:361-7. 2000

Detail Information

Publications92

  1. pmc Identification of transcriptional regulatory networks specific to pilocytic astrocytoma
    Hrishikesh Deshmukh
    Department of Pathology and Immunology, Washington University School of Medicine, 660, S, Euclid Ave, St, Louis, MO 63110, USA
    BMC Med Genomics 4:57. 2011
    ....
  2. pmc NF1 deletions in S-100 protein-positive and negative cells of sporadic and neurofibromatosis 1 (NF1)-associated plexiform neurofibromas and malignant peripheral nerve sheath tumors
    A Perry
    Departments of Pathology and Neurology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Pathol 159:57-61. 2001
    ....
  3. ncbi Oligodendroglial neoplasms: current concepts, misconceptions, and folklore
    A Perry
    Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Adv Anat Pathol 8:183-99. 2001
    ..This paper reviews the morphologic and genetic spectrum of oligodendroglial neoplasms, recent diagnostic and prognostic developments, and potential future directions...
  4. ncbi Clinicopathologic assessment and grading of embolized meningiomas: a correlative study of 64 patients
    A Perry
    Department of Pathology and Immunology, Division of Neuropathology, Washington University School of Medicine, Barnes Jewish Hospital, St Louis, MO 63110 1093, USA
    Cancer 92:701-11. 2001
    ..However, the resulting necrosis and compensatory proliferation reportedly have hampered subsequent histologic grading...
  5. ncbi Meningeal tumors of childhood and infancy. An update and literature review
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Pathol 13:386-408. 2003
    ..As in other areas of pediatric pathology, there are significant differences between this patient cohort and adults, differences which will be emphasized in this review...
  6. pmc Pathology of low-grade gliomas: an update of emerging concepts
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Neuro Oncol 5:168-78. 2003
    ..Also discussed are current controversies of classification/grading and the role of ancillary testing via immunohistochemical and genetic techniques...
  7. ncbi Molecular pathogenesis of meningiomas
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Neurooncol 70:183-202. 2004
    ....
  8. ncbi "Rhabdoid" meningioma: an aggressive variant
    A Perry
    Department of Laboratory Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA
    Am J Surg Pathol 22:1482-90. 1998
    ..Report of four cases. Am J Surg Pathol 1998;22:231-8). They further suggest that rhabdoid meningiomas are highly aggressive tumors and that the rhabdoid phenotype represents a marker of malignant transformation in meningiomas...
  9. ncbi Combined oligodendroglioma/pleomorphic xanthoastrocytoma: a probable collision tumor: case report
    A Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Neurosurgery 48:1358-61. 2001
    ..We report the first case of combined oligodendroglioma and pleomorphic xanthoastrocytoma...
  10. ncbi Loss of neurofibromatosis 1 (NF1) gene expression in NF1-associated pilocytic astrocytomas
    D H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neuropathol Appl Neurobiol 26:361-7. 2000
    ..These results demonstrate that, in contrast to sporadic astrocytomas, loss of NF1 expression is an important primary genetic event in the pathogenesis of NF1-associated pilocytic astrocytomas...
  11. doi High-resolution, dual-platform aCGH analysis reveals frequent HIPK2 amplification and increased expression in pilocytic astrocytomas
    H Deshmukh
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Oncogene 27:4745-51. 2008
    ....
  12. ncbi A role for fluorescence in situ hybridization detection of chromosome 22q dosage in distinguishing atypical teratoid/rhabdoid tumors from medulloblastoma/central primitive neuroectodermal tumors
    L A Bruch
    Department of Pathology (Neuropathology) and Anatomic Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 32:156-62. 2001
    ....
  13. ncbi PS6K amplification characterizes a small subset of anaplastic meningiomas
    D X Cai
    Department of Pathology, Washington University School of Medicine, 660 S Euclid Ave, Box 8118, St Louis, MO 63110, USA
    Am J Clin Pathol 115:213-8. 2001
    ..Further studies are needed to map the 17q23 amplicon to determine whether additional genes in this region are amplified in high-grade meningiomas...
  14. ncbi Molecular analysis of astrocytomas presenting after age 10 in individuals with NF1
    D H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 61:1397-400. 2003
    ..Although brain tumors are less common in teenagers and adults with NF1, recent studies have suggested that patients with NF1 are at a significantly increased risk of developing astrocytomas...
  15. ncbi Aggressive phenotypic and genotypic features in pediatric and NF2-associated meningiomas: a clinicopathologic study of 53 cases
    A Perry
    Divisions of Neuropathology, Washington University School of Medicine, St. Louis, Missouri 63110-1093, USA
    J Neuropathol Exp Neurol 60:994-1003. 2001
    ..Given the high frequency of undiagnosed NF2 in the pediatric cases, a careful search for other features of this disease is warranted in any child presenting with a meningioma...
  16. ncbi Gene expression profiling with oligonucleotide microarrays distinguishes World Health Organization grade of oligodendrogliomas
    M A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Cancer Res 61:1825-9. 2001
    ....
  17. ncbi The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1
    J R Leonard
    Department of Neurology, St Louis Children s Hospital and Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neurology 67:1509-12. 2006
    ..Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations...
  18. ncbi Matrilin-2 expression distinguishes clinically relevant subsets of pilocytic astrocytoma
    M K Sharma
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 66:127-30. 2006
    ..These results suggest that matrilin-2 may be a specific and clinically useful biomarker for discriminating between indolent and clinically aggressive PA...
  19. ncbi Neuropathology for the neuroradiologist: palisades and pseudopalisades
    F J Wippold
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJNR Am J Neuroradiol 27:2037-41. 2006
    ..The purpose of this report is to review the significance of palisades and pseudopalisades in the context of such tumors as schwannomas and glioblastomas...
  20. ncbi Cancer-related gene expression profiles in NF1-associated pilocytic astrocytomas
    J Li
    Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
    Neurology 56:885-90. 2001
    ....
  21. ncbi Large cell/anaplastic medulloblastomas and medullomyoblastomas: clinicopathological and genetic features
    J R Leonard
    Department of Neurosurgery, Washington University School of Medicine, St. Louis Children's Hospital, Missouri 63110, USA
    J Neurosurg 95:82-8. 2001
    ..These findings indicate that LC/A morphological characteristics reflect a more advanced tumor stage than that found in pure medulloblastomas or in typical medullomyoblastomas...
  22. ncbi Chromosome 22q dosage in composite extrarenal rhabdoid tumors: clonal evolution or a phenotypic mimic?
    C E Fuller
    Division of Neuropathology, Department of Pathology and Immunology, Barnes Jewish and St Louis Children s Hospitals, Washington University Medical Center, St Louis, MO 63110, USA
    Hum Pathol 32:1102-8. 2001
    ....
  23. ncbi Neuropathology for the neuroradiologist: Antoni A and Antoni B tissue patterns
    F J Wippold
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    AJNR Am J Neuroradiol 28:1633-8. 2007
    ..Distinctive histologic patterns seen within the peripheral nerve sheath tumor schwannoma include the Antoni A and Antoni B regions. The purpose of this report is to review the significance of Antoni regions in the context of schwannomas...
  24. ncbi Neuropathology for the neuroradiologist: fluorescence in situ hybridization
    F J Wippold
    Neuroradiology Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    AJNR Am J Neuroradiol 28:406-10. 2007
    ..The technique has proved useful in typing a variety of tumors such as oligodendrogliomas and in understanding the genetic forces driving oncogenesis...
  25. ncbi Metastatic adenocarcinoma to the brain: an immunohistochemical approach
    A Perry
    Department of Anatomic Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Hum Pathol 28:938-43. 1997
    ..GCDFP-15 and ER are relatively specific, but insensitive markers, and PR is nonspecific and difficult to interpret...
  26. doi CRTC1 rearrangements in the absence of t(11;19) in primary cutaneous mucoepidermoid carcinoma
    J K M Lennerz
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA
    Br J Dermatol 161:925-9. 2009
    ..The latter has been shown to harbour an oncogenic translocation resulting in a fusion gene consisting of exon 1 of CRTC1/MECT1/TORC1 at 19p and exons 2-5 of MAML2 at 11q...
  27. ncbi Pathology of low- and intermediate-grade gliomas
    C E Fuller
    Division of Neuropathology, Washington University School of Medicine, St. Louis, MO, USA
    Semin Radiat Oncol 11:95-102. 2001
    ..This article reviews the pathology of low- and intermediate-grade gliomas, highlighting practical diagnostic and prognostic issues...
  28. ncbi Familial dementia with Lewy bodies: clinicopathologic analysis of two kindreds
    J E Galvin
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 59:1079-82. 2002
    ..Familial DLB is clinically heterogeneous and occurs with or without coexistent AD, suggesting the relevance of LB pathology for the developing dementia...
  29. ncbi Fibrous meningioma with tyrosine-rich crystals
    M E Couce
    Department of Pathology, Mayo Clinic, Rochester, Minnesota 55905, USA
    Ultrastruct Pathol 23:341-5. 1999
    ..By morphology, histochemistry, and ultrastructure, the crystals resembled tyrosine-rich crystals occurring in salivary gland tumors. This is the first report of a fibrous meningioma containing tyrosine-rich crystals...
  30. ncbi Neuropathology for the neuroradiologist: Rosenthal fibers
    F J Wippold
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    AJNR Am J Neuroradiol 27:958-61. 2006
    ..This report reviews the neuropathologically observed intracellular inclusions known as Rosenthal fibers in the context of Alexander disease and slow-growing tumors such as pilocytic astrocytoma...
  31. ncbi Loss of DAL-1, a protein 4.1-related tumor suppressor, is an important early event in the pathogenesis of meningiomas
    D H Gutmann
    Departments of Neurology and Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Mol Genet 9:1495-500. 2000
    ....
  32. ncbi Late-onset neurodegeneration with brain iron accumulation type 1: expanding the clinical spectrum
    B A Racette
    Department of Neurology and Neurologic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 16:1148-52. 2001
    ..We conclude that NBIA-1 pathology can develop at any age, and that the phenotype should be expanded to include late-onset parkinsonism. The relationship to hemiballismus and adult-onset dementia is less clear...
  33. ncbi Neuropathology for the neuroradiologist: rosettes and pseudorosettes
    F J Wippold
    Neuroradiology Section, Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    AJNR Am J Neuroradiol 27:488-92. 2006
    ....
  34. ncbi Large-scale molecular comparison of human schwann cells to malignant peripheral nerve sheath tumor cell lines and tissues
    Shyra J Miller
    Division of Experimental Hematology, Cincinnati Children s Hospital Research Foundation, University of Cincinnati College of Medicine, Cincinnati, Ohio 45229, USA
    Cancer Res 66:2584-91. 2006
    ....
  35. ncbi Molecular diagnostics in central nervous system tumors
    Christine E Fuller
    Department of Pathology, St Jude Children s Research Hospital, Memphis, TN 38105, and Division of Neuropathology, Washington University School of Medicine, St Louis, MO, USA
    Adv Anat Pathol 12:180-94. 2005
    ....
  36. ncbi Cancer therapy-associated CNS neuropathology: an update and review of the literature
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Acta Neuropathol 111:197-212. 2006
    ..Therefore, it is critical to recognize the full spectrum of cancer therapy-associated neuropathology, the topic of the current review...
  37. pmc Use of thalidomide to diminish growth velocity in a life-threatening congenital intracranial hemangioma
    Melissa Frei-Jones
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg Pediatr 2:125-9. 2008
    ..The authors present the case of an infant born with a life-threatening, unresectable intracranial hemangioma in which treatment with thalidomide resulted in a good clinical outcome...
  38. ncbi Expression and function of somatostatin receptors in peripheral nerve sheath tumors
    Christian Mawrin
    Department of Neuropathology, Otto von Guericke University, Magdeburg, Germany
    J Neuropathol Exp Neurol 64:1080-8. 2005
    ..Furthermore, our findings suggest a potential clinical role for somatostatin receptor agonists in tumor imaging and/or treatment of schwannomas and MPNSTs...
  39. ncbi Molecular diagnosis of Ewing sarcoma/primitive neuroectodermal tumor in routinely processed tissue: a comparison of two FISH strategies and RT-PCR in malignant round cell tumors
    Robert S Bridge
    Department of Pathology and Immunology, Lauren V Ackerman Laboratory of Surgical Pathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, MO 63110 1093, USA
    Mod Pathol 19:1-8. 2006
    ..The commercial break apart probe set is both readily available and easy to interpret, making it particularly attractive. Nonetheless, complex round cell tumors often benefit from molecular testing with multiple methods...
  40. ncbi Oligodendroglial-specific transcriptional factor SOX10 is ubiquitously expressed in human gliomas
    Sergei I Bannykh
    Department of Pathology, Yale University School of Medicine, New Haven, CT 65210, USA
    J Neurooncol 76:115-27. 2006
    ..Our data raise a possibility that histogenesis of gliomas have more common features than previously anticipated...
  41. ncbi Integrative genomic analysis identifies NDRG2 as a candidate tumor suppressor gene frequently inactivated in clinically aggressive meningioma
    Eriks A Lusis
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 65:7121-6. 2005
    ....
  42. ncbi Significance of necrosis in grading of oligodendroglial neoplasms: a clinicopathologic and genetic study of newly diagnosed high-grade gliomas
    C Ryan Miller
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 24:5419-26. 2006
    ..WHO 2000 grading criteria for high-grade oligodendroglial neoplasms [anaplastic oligoastrocytoma (AOA) and anaplastic oligodendroglioma (AO)] remain subjective, and the existence of grade 4 variants is controversial...
  43. ncbi Distinct genetic signatures among pilocytic astrocytomas relate to their brain region origin
    Mukesh K Sharma
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Cancer Res 67:890-900. 2007
    ..These results suggest that glial tumors share an intrinsic, lineage-specific molecular signature that reflects the brain region in which their nonmalignant predecessors originated...
  44. doi Gray zones in brain tumor classification: evolving concepts
    Dimitri Trembath
    Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC, USA
    Adv Anat Pathol 15:287-97. 2008
    ..In the current review, we discuss these issues and offer some practical guidelines for dealing with problematic cases...
  45. ncbi 1p/19q chromosome deletions in metastatic oligodendroglioma
    Ryan Merrell
    Department of Neurology, University of Alabama at Birmingham, AL 35294, USA
    J Neurooncol 80:203-7. 2006
    ..Genetic analysis serves a valuable ancillary role in the diagnostic workup of such cases...
  46. doi Ependymal tumors with sarcomatous change ("ependymosarcoma"): a clinicopathologic and molecular cytogenetic study
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Am J Surg Pathol 32:699-709. 2008
    ..Although rare, ependymal neoplasms must be included among the gliomas prone to undergo sarcomatous change and we propose the term "ependymosarcoma" for these tumors...
  47. pmc Gliomas in neurofibromatosis type 1: a clinicopathologic study of 100 patients
    Fausto J Rodriguez
    Department of Laboratory Medicine and Pathology, Mayo Clinic College of Medicine, Rochester, MN 55905, USA
    J Neuropathol Exp Neurol 67:240-9. 2008
    ..Classic PA and LGSI are the most common, and most have favorable prognoses. By contrast, DAs are more aggressive, similar to those that arise sporadically...
  48. doi Primary intracerebral angiomatoid fibrous histiocytoma: report of a case with a t(12;22)(q13;q12) causing type 1 fusion of the EWS and ATF-1 genes
    Christopher Dunham
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Surg Pathol 32:478-84. 2008
    ..Genetic analyses revealed a t(12;22)(q13;q12) and a unique underlying clear cell sarcomalike type 1 EWS/ATF-1 gene fusion...
  49. ncbi Malignant rhabdoid tumor mimicking hepatoblastoma: a case report and literature review
    Lars M Wagner
    Division of Hematology Oncology, Cincinnati Children s Hospital Medical Center, Cincinnati, OH 45229, USA
    Pediatr Dev Pathol 10:409-15. 2007
    ..Important similarities and differences between hepatoblastoma and rhabdoid tumors are reviewed, and suggestions are offered to help distinguish these 2 tumor types...
  50. ncbi Primary Ewing sarcoma of the brain: a case report and literature review
    Syed Ali Jaffar Kazmi
    Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    Diagn Mol Pathol 16:108-11. 2007
    ..Demonstration of characteristic translocations by molecular studies differentiates CNS-EES from cPNET and help clinicians make informed decisions regarding therapy...
  51. ncbi Glioblastoma
    C Ryan Miller
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Arch Pathol Lab Med 131:397-406. 2007
    ....
  52. ncbi Atypical teratoid/rhabdoid tumor arising in the setting of a pleomorphic xanthoastrocytoma
    Geeta Chacko
    Division of Neuropathology, Department of Neurological Sciences, Christian Medical College, Vellore, India
    J Neurooncol 84:217-22. 2007
    ..We speculate that the PXA was a quiescent tumor and that the secondary genetic alterations, including inactivation of the INI1 gene led to clinical progression...
  53. ncbi Atypical teratoid/rhabdoid tumor of the spine in an adult: case report and review of the literature
    Elena L Zarovnaya
    Department of Pathology, Dartmouth Hitchcock Medical Center, One Medical Center Drive, Lebanon, NH 03756, USA
    J Neurooncol 84:49-55. 2007
    ..An unrestricted autopsy was performed. To our knowledge, this is the first case of a spinal atypical teratoid/rhabdoid tumor in an adult fully documented with molecular, immunohistochemical, cytogenetic and autopsy findings...
  54. ncbi Transcriptomic versus chromosomal prognostic markers and clinical outcome in uveal melanoma
    Lori A Worley
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:1466-71. 2007
    ..To compare a gene expression-based classifier versus the standard genetic prognostic marker, monosomy 3, for predicting metastasis in uveal melanoma...
  55. ncbi DNA sequence of the translocation breakpoints in undifferentiated embryonal sarcoma arising in mesenchymal hamartoma of the liver harboring the t(11;19)(q11;q13.4) translocation
    Veena Rajaram
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63132, USA
    Genes Chromosomes Cancer 46:508-13. 2007
    ....
  56. ncbi Clinicopathologic aspects of 1p/19q loss and the diagnosis of oligodendroglioma
    Kenneth Aldape
    M D Anderson Cancer Center, Department of Pathology and Brain Tumor Center, 1515 Holcombe Blvd, Houston, TX 60153, USA
    Arch Pathol Lab Med 131:242-51. 2007
    ..These findings raise questions as to the role of 1p/19q testing in clinical practice, both as a prognostic marker and as a potential diagnostic marker among infiltrating glial neoplasms...
  57. ncbi Clinicopathologic and genetic profile of intracranial marginal zone lymphoma: a primary low-grade CNS lymphoma that mimics meningioma
    Pang Hsien Tu
    Division of Neuropathology and Section of Hematopathology, Campus Box 8118, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    J Clin Oncol 23:5718-27. 2005
    ..Although rare overall, marginal zone B-cell lymphoma (MZBCL) is the most common primary low-grade CNS lymphoma reported in the literature. The aim of this study is to elucidate the biology and genetic features of this unusual tumor...
  58. ncbi Meningothelial hyperplasia: a detailed clinicopathologic, immunohistochemical and genetic study of 11 cases
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, Campus Box 8118, 660 South Euclid Ave, St Louis, MO 63110, USA
    Brain Pathol 15:109-15. 2005
    ..It may be preneoplastic in some, though further studies are needed to test this hypothesis...
  59. ncbi INI1 protein expression distinguishes atypical teratoid/rhabdoid tumor from choroid plexus carcinoma
    Alexander R Judkins
    Department of Pathology, University of Pennsylvania School of Medicine and Children s Hospital of Philadelphia, 3615 Civic Center Blvd, Philadelphia, PA 19104, USA
    J Neuropathol Exp Neurol 64:391-7. 2005
    ..This expression pattern seems to better define the 2 groups of tumors than does light or electron microscopy, routine immunohistochemistry, or cytogenetic analysis alone...
  60. ncbi Prognostic value of 1p, 19q, 9p, 10q, and EGFR-FISH analyses in recurrent oligodendrogliomas
    Kenneth B Fallon
    Division of Neuropathology, University of Alabama at Birmingham, Birmingham, Alabama 35294 0007, USA
    J Neuropathol Exp Neurol 63:314-22. 2004
    ....
  61. ncbi Unmasking the secrets of meningioma: a slow but rewarding journey
    Arie Perry
    Washington University School of Medicine, St Louis, Missouri, USA
    Surg Neurol 61:171-3. 2004
  62. ncbi Clinical utility of fluorescence in situ hybridization (FISH) in morphologically ambiguous gliomas with hybrid oligodendroglial/astrocytic features
    Christine E Fuller
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropathol Exp Neurol 62:1118-28. 2003
    ..We conclude that 1) distinct genetic subsets are identifiable by FISH in morphologically ambiguous gliomas, and 2) both histological grading and molecular analysis yield prognostically useful information...
  63. ncbi 9p21 and 13q14 dosages in ependymomas. A clinicopathologic study of 101 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 17:9-14. 2004
    ....
  64. ncbi Identification of a third Protein 4.1 tumor suppressor, Protein 4.1R, in meningioma pathogenesis
    Victoria A Robb
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 13:191-202. 2003
    ..1B interactors including CD44 and betaII-spectrin. Collectively, these results suggest that Protein 4.1R functions as an important tumor suppressor in the molecular pathogenesis of meningioma...
  65. ncbi Pediatric oligodendrogliomas: a study of molecular alterations on 1p and 19q using fluorescence in situ hybridization
    Ravi Raghavan
    Neuropathology Laboratory, University of Texas Southwestern Medical Center, Dallas, Texas 75390 9073, USA
    J Neuropathol Exp Neurol 62:530-7. 2003
    ..Genomic screening on a larger series is clearly indicated to delineate the unique molecular characteristics of these rare pediatric tumors...
  66. ncbi Malignant rhabdoid meningioma arising in the setting of preexisting ganglioglioma: a diagnosis supported by fluorescence in situ hybridization. Case report
    Sergei I Bannykh
    Department of Pathology, University of California at San Diego, La Jolla, California 92093 0612, USA
    J Neurosurg 97:1450-5. 2002
    ....
  67. ncbi High-throughput molecular profiling of high-grade astrocytomas: the utility of fluorescence in situ hybridization on tissue microarrays (TMA-FISH)
    Christine E Fuller
    Division of Neuropathology, Barnes Jewish Hospital, Washington University Medical Center, St Louis, Missouri 63110, USA
    J Neuropathol Exp Neurol 61:1078-84. 2002
    ..The overall concordance rate between paired tumor core samples was 93%. We conclude that TMA-FISH is an efficient and reliable method for detecting molecular alterations in high-grade astrocytomas...
  68. ncbi Ancillary FISH analysis for 1p and 19q status: preliminary observations in 287 gliomas and oligodendroglioma mimics
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Front Biosci 8:a1-9. 2003
    ....
  69. ncbi Medulloblastomas with favorable versus unfavorable histology: how many small blue cell tumor types are there in the brain?
    Arie Perry
    Division of Neuropathology, Box 8118, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Adv Anat Pathol 9:345-50. 2002
    ..Medulloblastoma grading based on anaplasia demonstrated a statistically stronger association with patient outcome than clinical staging. Therefore, histologic grading of medulloblastomas seems warranted as a routine diagnostic aid...
  70. pmc Molecular characterization of human meningiomas by gene expression profiling using high-density oligonucleotide microarrays
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Am J Pathol 161:665-72. 2002
    ..This report represents the first gene expression profiling studies of meningiomas and identifies some initial candidate genes that may provide further insights into the genetic basis for meningioma pathogenesis...
  71. ncbi Differential NF1, p16, and EGFR patterns by interphase cytogenetics (FISH) in malignant peripheral nerve sheath tumor (MPNST) and morphologically similar spindle cell neoplasms
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    J Neuropathol Exp Neurol 61:702-9. 2002
    ..001). Thus, FISH analysis identifies relatively specific genetic patterns that may be useful in selected cases, for which the differential diagnosis includes low- or high-grade MPNST...
  72. ncbi Mantel statistics to correlate gene expression levels from microarrays with clinical covariates
    William D Shannon
    Department of Medicine, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Genet Epidemiol 23:87-96. 2002
    ..We also show how the Mantel statistics can be used to rank subsets of genes, found using standard clustering methods, in terms of differential expression across samples...
  73. ncbi Differential involvement of protein 4.1 family members DAL-1 and NF2 in intracranial and intraspinal ependymomas
    Pratima K Singh
    Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110 10963, USA
    Mod Pathol 15:526-31. 2002
    ....
  74. ncbi A role for chromosome 9p21 deletions in the malignant progression of meningiomas and the prognosis of anaplastic meningiomas
    Arie Perry
    Division of Neuropathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Brain Pathol 12:183-90. 2002
    ..We conclude that chromosome 9p21 deletions are associated with malignant progression of meningiomas and poor prognosis in anaplastic meningiomas...
  75. pmc Analysis of 1p, 19q, 9p, and 10q as prognostic markers for high-grade astrocytomas using fluorescence in situ hybridization on tissue microarrays from Radiation Therapy Oncology Group trials
    Daniel J Brat
    Departments of Pathology and Laboratory Medicine, Emory University School of Medicine, Atlanta, GA 30322, USA
    Neuro Oncol 6:96-103. 2004
    ..Long-term and short-term survival groups of high-grade astrocytomas appear to have dissimilar frequencies of 19q, 9p, and 10q deletions. TMA-FISH is a rapid and efficient way of evaluating genetic alterations in such tumors...
  76. ncbi Glioneuronal tumours in neurofibromatosis type 1: MRI-pathological study
    Marco Fedi
    Department of Medicine Neurology, Austin and Repatriation Medical Centre, University of Melborne, Heidelberg, Vic, Australia
    J Clin Neurosci 11:745-7. 2004
    ..Because of the excellent prognosis following the resection of these tumours, it is important to distinguish them from other NF1-associated tumours...
  77. ncbi Insights into meningioangiomatosis with and without meningioma: a clinicopathologic and genetic series of 24 cases with review of the literature
    Arie Perry
    Division of Neuropathology, Washington University, St Louis, MO 63110 1093, USA
    Brain Pathol 15:55-65. 2005
    ..In contrast, most perivascular spindled cells of pure MA are genetically and immunohistochemically similar to non-neoplastic meningothelial cells, consistent with current histogenetic theories...
  78. ncbi Chromosome 22q deletions in atypical teratoid/rhabdoid tumors in adults
    Jack Raisanen
    Department of Pathology, University of Texas Southwestern Medical Center, 5323 Harry Hines Blvd, Dallas, TX 75390 9073, USA
    Brain Pathol 15:23-8. 2005
    ..These molecular findings confirm the occurrence of AT/RTs in adults. Although rare, AT/RT should be considered in the differential diagnosis of poorly differentiated intracranial tumors in adults...
  79. ncbi INI1 expression is retained in composite rhabdoid tumors, including rhabdoid meningiomas
    Arie Perry
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63001 1093, USA
    Mod Pathol 18:951-8. 2005
    ..Therefore, we conclude that INI1 immunohistochemistry is a relatively simple, sensitive, and specific technique for distinguishing malignant rhabdoid tumor and atypical teratoid/rhabdoid tumor from composite rhabdoid tumor...
  80. ncbi Alterations of protein 4.1 family members in ependymomas: a study of 84 cases
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Mod Pathol 18:991-7. 2005
    ..009). We conclude that alterations of Protein 4.1 family members are common in ependymal tumors and that specific alterations are associated with distinct clinicopathologic subsets...
  81. ncbi EWS-ATF1 fusion transcripts in gastrointestinal tumors previously diagnosed as malignant melanoma
    Michael Covinsky
    Lauren V Ackerman Laboratory of Surgical Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 36:74-81. 2005
    ....
  82. ncbi Anaplastic meningioma versus meningeal hemangiopericytoma: immunohistochemical and genetic markers
    Veena Rajaram
    Department of Pathology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Hum Pathol 35:1413-8. 2004
    ..3) The characteristic FXIIIa staining pattern reported for HPC also is encountered frequently in anaplastic meningiomas and therefore is nonspecific in this diagnostic setting...
  83. ncbi Postoperative radiation therapy for grade II and III intracranial ependymoma
    David B Mansur
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:387-91. 2005
    ..To retrospectively determine the long-term outcome of intracranial ependymoma patients treated with surgery and postoperative radiation therapy...
  84. ncbi Glioma formation in neurofibromatosis 1 reflects preferential activation of K-RAS in astrocytes
    Biplab Dasgupta
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Cancer Res 65:236-45. 2005
    ....
  85. ncbi Natural history of neurofibromatosis 1-associated optic nerve glioma in mice
    M Livia Bajenaru
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Ann Neurol 57:119-27. 2005
    ..Last, we observed neovascularization and microglial cell infiltration by 3 weeks of age before overt neoplastic transformation, suggesting that these cellular changes participate in the early stages of tumor formation...
  86. ncbi Loss of tumor suppressor in lung cancer-1 (TSLC1) expression in meningioma correlates with increased malignancy grade and reduced patient survival
    Ezequiel I Surace
    partment of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neuropathol Exp Neurol 63:1015-27. 2004
    ..Moreover, TSLC1 loss was associated with decreased patient survival, within the overall group, and in the atypical meningiomas. Collectively, these results suggest that TSLC1 plays an important role in meningioma pathogenesis...
  87. ncbi Notch1 and notch2 have opposite effects on embryonal brain tumor growth
    Xing Fan
    Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    Cancer Res 64:7787-93. 2004
    ..Our data indicate that Notch1 and Notch2 can have opposite effects on the growth of a single tumor type, and show that Notch2 can be overexpressed after gene amplification in human tumors...
  88. ncbi Small cell astrocytoma: an aggressive variant that is clinicopathologically and genetically distinct from anaplastic oligodendroglioma
    Arie Perry
    Division of Neuropathology, Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110 1093, USA
    Cancer 101:2318-26. 2004
    ..Small cell glioblastoma (GBM) is a variant with monomorphous, deceptively bland nuclei that often is misdiagnosed as anaplastic oligodendroglioma...
  89. ncbi Gene expression profiling reveals unique molecular subtypes of Neurofibromatosis Type I-associated and sporadic malignant peripheral nerve sheath tumors
    Mark A Watson
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 14:297-303. 2004
    ..We conclude that distinct molecular classes of MPNST exist and that the ability to stratify these tumors based on unique and biologically relevant gene expression profiles may be important for future targeted therapeutics...
  90. ncbi Genetic and expression profiles of cerebellar liponeurocytomas
    Sonja Horstmann
    International Agency for Research on Cancer, Lyon, France
    Brain Pathol 14:281-9. 2004
    ..Furthermore, the cDNA expression array data suggest a relationship to central neurocytomas, but the presence of TP53 mutations, which are absent in central neurocytomas, suggests that their genetic pathways are different...
  91. ncbi Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature
    Kathleen J Helton
    Department of Radiological Sciences, St Jude Children s Research Hospital, Memphis, TN 38105 2794, USA
    Cancer 101:1445-54. 2004
    ..Medullomyoblastoma (MMB) is a rare cerebellar embryonal neoplasm that occurs almost exclusively in children. It is biphasic by microscopy, containing myoblastic and primitive neuroectodermal components...
  92. ncbi Comparative gene expression profile analysis of neurofibromatosis 1-associated and sporadic pilocytic astrocytomas
    David H Gutmann
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 62:2085-91. 2002
    ..We conclude that PAs are genetically unique gliomas with gene expression profiles that resemble those of fetal astrocytes and, to a lesser extent, oligodendroglial precursors...