JOEL SYNES PERLMUTTER

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Vocal exercise versus voice rest following botulinum toxin injections: a randomized crossover trial
    Randal C Paniello
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, MO 63110, USA
    Ann Otol Rhinol Laryngol 118:759-63. 2009
  2. pmc Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Behav Brain Funct 7:45. 2011
  3. pmc High-throughput mutational analysis of TOR1A in primary dystonia
    Jianfeng Xiao
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Med Genet 10:24. 2009
  4. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
  5. ncbi request reprint Blood flow responses to deep brain stimulation of thalamus
    J S Perlmutter
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 58:1388-94. 2002
  6. ncbi request reprint Deep brain stimulation
    Joel S Perlmutter
    Department of Neurology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 29:229-57. 2006
  7. ncbi request reprint Dysfunction of dopaminergic pathways in dystonia
    Joel S Perlmutter
    Departments of Neurology, Radiology, and Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Neurol 94:163-70. 2004
  8. pmc Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson disease
    Samer D Tabbal
    Department of Neurology, Washington University in St Louis, 4525 Scott Avenue, St Louis, MO 63130, USA
    Exp Neurol 211:234-42. 2008
  9. ncbi request reprint The impact of litigation on neurologic research
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Neurology 67:2124-8. 2006
  10. pmc Selective defect of in vivo glycolysis in early Huntington's disease striatum
    William J Powers
    Department of Neurology, Program in Physical Therapy, and Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:2945-9. 2007

Research Grants

  1. MECHANISM OF DEEP BRAIN STIMULATION
    Joel Perlmutter; Fiscal Year: 2007
  2. VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONS
    JOEL SYNES PERLMUTTER; Fiscal Year: 2010
  3. Mechanisms of Deep Brain Stimulation
    JOEL SYNES PERLMUTTER; Fiscal Year: 2010
  4. CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISM
    Joel Perlmutter; Fiscal Year: 2007
  5. CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISM
    Joel Perlmutter; Fiscal Year: 2009
  6. VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONS
    Joel Perlmutter; Fiscal Year: 2009
  7. RESCUE FROM NIGROSTRIATAL INJURY
    Joel Perlmutter; Fiscal Year: 2003
  8. MECHANISM OF DEEP BRAIN STIMULATION
    Joel Perlmutter; Fiscal Year: 2003

Detail Information

Publications65

  1. pmc Vocal exercise versus voice rest following botulinum toxin injections: a randomized crossover trial
    Randal C Paniello
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, Missouri, MO 63110, USA
    Ann Otol Rhinol Laryngol 118:759-63. 2009
    ..We tested this effect in patients who underwent botulinum toxin injections for adductor spasmodic dysphonia...
  2. pmc Correlation of CAG repeat length between the maternal and paternal allele of the Huntingtin gene: evidence for assortative mating
    Peg Nopoulos
    Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, Iowa, USA
    Behav Brain Funct 7:45. 2011
    ..The current study shows a significant correlation between the CAG repeat length of the maternal and paternal allele in the Huntingtin gene among healthy subjects, suggesting assortative mating...
  3. pmc High-throughput mutational analysis of TOR1A in primary dystonia
    Jianfeng Xiao
    Department of Neurology, University of Tennessee Health Science Center, Memphis, TN, USA
    BMC Med Genet 10:24. 2009
    ..The aim of this study was to identify TOR1A Exon 5 mutations in a large cohort of subjects with mainly non-generalized primary dystonia...
  4. pmc The Gly2019Ser mutation in LRRK2 is not fully penetrant in familial Parkinson's disease: the GenePD study
    Jeanne C Latourelle
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, MA, USA
    BMC Med 6:32. 2008
    ..Studies of the penetrance of LRRK2 mutations have produced a wide range of estimates, possibly due to differences in study design and recruitment, including in particular differences between samples of familial PD versus sporadic PD...
  5. ncbi request reprint Blood flow responses to deep brain stimulation of thalamus
    J S Perlmutter
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 58:1388-94. 2002
    ..Despite this clinical benefit, the mechanism of action of DBS remains unknown. In this investigation, we sought to determine the effects of VIM DBS on neuronal function...
  6. ncbi request reprint Deep brain stimulation
    Joel S Perlmutter
    Department of Neurology, Washington University School of Medicine, Washington University, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 29:229-57. 2006
    ..Although we review relevant clinical issues, we emphasize the importance of current and future investigations on these topics...
  7. ncbi request reprint Dysfunction of dopaminergic pathways in dystonia
    Joel S Perlmutter
    Departments of Neurology, Radiology, and Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    Adv Neurol 94:163-70. 2004
  8. pmc Unilateral subthalamic nucleus stimulation has a measurable ipsilateral effect on rigidity and bradykinesia in Parkinson disease
    Samer D Tabbal
    Department of Neurology, Washington University in St Louis, 4525 Scott Avenue, St Louis, MO 63130, USA
    Exp Neurol 211:234-42. 2008
    ..Bilateral deep brain stimulation (DBS) of the subthalamic nucleus (STN) improves motor function in Parkinson disease (PD). However, little is known about the quantitative effects on motor behavior of unilateral STN DBS...
  9. ncbi request reprint The impact of litigation on neurologic research
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Neurology 67:2124-8. 2006
    ..Litigation and its peripheral effects may bias investigators, impede research efforts, and harm research participants, thereby undermining efforts to understand the cause of neurologic disease...
  10. pmc Selective defect of in vivo glycolysis in early Huntington's disease striatum
    William J Powers
    Department of Neurology, Program in Physical Therapy, and Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus Box 8225, 4525 Scott Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:2945-9. 2007
    ..Because glycolytic metabolism is predominantly astrocytic, the selective reduction in striatal CMRglc raises the possibility that astrocyte dysfunction may be involved in the pathogenesis of HD...
  11. pmc Podokinetic after-rotation in Parkinson disease
    Minna Hong
    Movement Science Program, Washington University School of Medicine, St Louis, MO 63108, USA
    Brain Res 1128:99-106. 2007
    ..Future studies are needed to determine whether the rotating platform may act as a rehabilitative tool to reinforce motor patterns for turning and alleviate turning difficulties in people with PD...
  12. ncbi request reprint Perception of active and passive turning in Parkinson disease
    Gammon M Earhart
    Program in Physical Therapy, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurorehabil Neural Repair 21:116-22. 2007
    ..Many individuals with Parkinson disease (PD) experience difficulty with turning, yet little is known about the reasons for this difficulty...
  13. ncbi request reprint Safety and efficacy of subthalamic nucleus deep brain stimulation performed with limited intraoperative mapping for treatment of Parkinson's disease
    Samer D Tabbal
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurosurgery 61:119-27; discussion 127-9. 2007
    ....
  14. pmc [18F]FDOPA PET as an endophenotype for Parkinson's Disease linkage studies
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 141:245-9. 2006
    ..36 +/- 1.23. The [18F]FDOPA PET endophenotype permits phenoconversion in multi-incident PD families and may increase LOD score accuracy and power of an informative pedigree...
  15. pmc Effects of thalamic stimulation frequency on intention and postural tremor
    Gammon M Earhart
    Program in Physical Therapy, Washington University, St Louis, MO, USA
    Exp Neurol 208:257-63. 2007
    ....
  16. pmc Validation of a fiducial-based atlas localization method for deep brain stimulation contacts in the area of the subthalamic nucleus
    Tom O Videen
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosci Methods 168:275-81. 2008
    ..This method provides an accurate and reliable means for STN DBS contact localization...
  17. pmc Decreased striatal dopamine receptor binding in primary focal dystonia: a D2 or D3 defect?
    Morvarid Karimi
    Department of Neurology, Washington University School of Medicine, Saint Louis, Missouri 63110 1093, USA
    Mov Disord 26:100-6. 2011
    ..These findings when coupled with other literature suggest that a defect in D3, rather than D2, receptor expression may be associated with primary focal dystonia...
  18. pmc Validation of the reference tissue model for estimation of dopaminergic D2-like receptor binding with [18F](N-methyl)benperidol in humans
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO, USA
    Nucl Med Biol 35:335-41. 2008
    ....
  19. pmc A kinematic and electromyographic analysis of turning in people with Parkinson disease
    Minna Hong
    Movement Science Program, Washington University School of Medicine, St Louis, Missouri, USA
    Neurorehabil Neural Repair 23:166-76. 2009
    ..Turning in tight spaces, which may be particularly impaired in Parkinson disease, is an essential part of our daily lives, yet a comprehensive analysis of in-place turning has not been published...
  20. pmc Gait and balance in essential tremor: variable effects of bilateral thalamic stimulation
    Gammon M Earhart
    Program in Physical Therapy, Washington University, St Louis, Missouri 63108, USA
    Mov Disord 24:386-91. 2009
    ..A better understanding of the mechanisms underlying gait and balance impairments in those with bilateral DBS is critical to reduce falls and fractures in this group...
  21. pmc A population-based study of parkinsonism in an Amish community
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroepidemiology 33:225-30. 2009
    ..Parkinson's disease (PD) is a neurodegenerative disorder with unknown cause. Genetic mutations account for a minority of cases but the role of environmental factors is unclear...
  22. pmc Mapping Go-No-Go performance within the subthalamic nucleus region
    Tamara Hershey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain 133:3625-34. 2010
    ....
  23. pmc Amyloid imaging of Lewy body-associated disorders
    Erin R Foster
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Mov Disord 25:2516-23. 2010
    ..Amyloid-β may modify the severity of global cognitive impairment in individuals with Lewy body-associated dementia...
  24. ncbi request reprint A rapid method for mass screening for parkinsonism
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, United States
    Neurotoxicology 27:357-61. 2006
    ..Parkinsonism as diagnosed by our criteria was common in this group of welders...
  25. ncbi request reprint Levodopa challenge neuroimaging of levodopa-related mood fluctuations in Parkinson's disease
    Kevin J Black
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Neuropsychopharmacology 30:590-601. 2005
    ..The findings require confirmation in larger and better-matched groups...
  26. ncbi request reprint Clinical features and comorbidity of mood fluctuations in Parkinson's disease
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, MO 63110, USA
    J Neuropsychiatry Clin Neurosci 14:438-42. 2002
    ..This association remained after removing effects of age and disease duration...
  27. pmc A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist
    Kevin J Black
    Departments of Psychiatry, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:17113-8. 2002
    ....
  28. ncbi request reprint Botulinum toxin B reduces sialorrhea in parkinsonism
    Brad A Racette
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 18:1059-61. 2003
    ..Mean peak benefit from injections lasted 14 weeks. We conclude that denervation of salivary glands with botulinum toxin B produces excellent reduction of excessive salivation associated with parkinsonism...
  29. ncbi request reprint Rapid intravenous loading of levodopa for human research: clinical results
    Kevin J Black
    Department of Psychiatry and APDA Advanced Research Center for Parkinson Disease, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Neurosci Methods 127:19-29. 2003
    ..D.), and produced statistically significant antiparkinsonian benefit (16% mean reduction in a standard rating of parkinsonian motor signs, P<0.0005)...
  30. ncbi request reprint Secondary nonresponsiveness to new bulk botulinum toxin A (BCB2024)
    Brad A Racette
    Department of Neurology and Neurological Surgery Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 17:1098-100. 2002
    ..Subsequent injections with botulinum toxin B provided substantial reduction of blepharospasm. This is the first reported case of secondary resistance to the new preparation of botulinum toxin A...
  31. ncbi request reprint Dopaminergic modulation of response inhibition: an fMRI study
    Tamara Hershey
    Psychiatry Department, Washington University School of Medicine, USA
    Brain Res Cogn Brain Res 20:438-48. 2004
    ..In summary, right parietal and cerebellar regions important in mediating specific aspects of the GNG task were modulated by levodopa, suggesting a region-specific role for dopamine in response inhibition...
  32. ncbi request reprint Asymmetric regional cerebral blood flow in sedated baboons measured by positron emission tomography (PET)
    Jason A Kaufman
    Department of Anthropology, Washington University, St Louis, Missouri 63130, USA
    Am J Phys Anthropol 121:369-77. 2003
    ..Cerebral blood flow itself was uncorrelated with age, and differences between males and females were not significant...
  33. ncbi request reprint [18F]FDOPA PET and clinical features in parkinsonism due to manganism
    Brad A Racette
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mov Disord 20:492-6. 2005
    ..This case suggests that the clinical and pathophysiological features of manganese-associated parkinsonism may overlap with that of PD...
  34. pmc Cerebral mitochondrial metabolism in early Parkinson's disease
    William J Powers
    Department of Neurology, University of North Carolina Chapel Hill, Chapel Hill, North Carolina 27599 7025, USA
    J Cereb Blood Flow Metab 28:1754-60. 2008
    ..Whether this is the case in early PD and whether it is important in the pathogenesis of PD will require further study...
  35. ncbi request reprint Cognitive-pharmacologic functional magnetic resonance imaging in tourette syndrome: a pilot study
    Tamara Hershey
    Department of Psychiatry, Washington University, St Louis, Missouri, USA
    Biol Psychiatry 55:916-25. 2004
    ....
  36. pmc Huntington CAG repeat size does not modify onset age in familial Parkinson's disease: the GenePD study
    Christopher F McNicoll
    Department of Neurology, Boston University School of Medicine, Boston University, Boston, Massachusetts 02118, USA
    Mov Disord 23:1596-601. 2008
    ..No relation between the HD CAG repeat size and the age at onset for PD was found in this sample of familial PD...
  37. ncbi request reprint Postural tremor suppression is dependent on thalamic stimulation frequency
    Mwiza Ushe
    Department of Neurology, Washington University, St Louis, Missouri, USA
    Mov Disord 21:1290-2. 2006
    ....
  38. pmc Assessment of Parkinson disease manifestations
    Joel S Perlmutter
    Washington University School of Medicine in St Louis, St Louis, Missouri, USA
    Curr Protoc Neurosci . 2009
    ..Finally, some common applications of these scales are described...
  39. pmc Radiation dosimetry of N-([11C]methyl)benperidol as determined by whole-body PET imaging of primates
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 35:771-8. 2008
    ..We report the absorbed radiation dosimetry of i.v.-administered (11)C-NMB, a critical step before applying this radioligand to imaging studies in humans...
  40. ncbi request reprint Modified high-performance liquid chromatography with electrochemical detection method for plasma measurement of levodopa, 3-O-methyldopa, dopamine, carbidopa and 3,4-dihydroxyphenyl acetic acid
    Morvarid Karimi
    Department of Neurology, Washington University in St Louis, St Louis, MO, USA
    J Chromatogr B Analyt Technol Biomed Life Sci 836:120-3. 2006
    ....
  41. pmc Motor asymmetry and substantia nigra volume are related to spatial delayed response performance in Parkinson disease
    Erin R Foster
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Cogn 67:1-10. 2008
    ..In conclusion, left motor dysfunction and smaller right SN volume are associated with poorer spatial memory...
  42. ncbi request reprint Effect of stimulation frequency on tremor suppression in essential tremor
    Mwiza Ushe
    Department of Neurology, Washington University in St Louis, St Louis, Missouri, USA
    Mov Disord 19:1163-8. 2004
    ..Second, thalamic DBS provides tremor benefit in a graded manner and is not an all-or-nothing phenomenon...
  43. pmc Task-specific dystonias: a review
    Diego Torres-Russotto
    Department of Neurology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 1142:179-99. 2008
    ..Prognosis may vary depending upon body part involved and specific type of task affected. Further research may reveal new insights into the etiology, pathophysiology, natural history, and improved treatment of these conditions...
  44. pmc Normal platelet mitochondrial complex I activity in Huntington's disease
    William J Powers
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 27:99-101. 2007
    ..Reductions > 10% were excluded with 80% confidence. A systemic defect in complex I activity is not present in early HD when striatal neuronal degeneration is already present...
  45. ncbi request reprint Novel haplotypes in 17q21 are associated with progressive supranuclear palsy
    Pau Pastor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 56:249-58. 2004
    ..The identification of these specific subhaplotypes that modify risk for PSP/CBD supports the hypothesis that a pathogenic allele exists in a subgroup of PSP patients...
  46. pmc [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization
    Jinbin Xu
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Synapse 63:717-28. 2009
    ..In vitro autoradiography studies of rat and monkey brains show that [(3)H]WC-10 labeled D(3) sites in the striatal region...
  47. ncbi request reprint Atlas template images for nonhuman primate neuroimaging: baboon and macaque
    Kevin J Black
    Departments of Psychiatry, Neurology, and Radiology, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Methods Enzymol 385:91-102. 2004
  48. pmc [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen
    Jinbin Xu
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Synapse 64:449-59. 2010
    ..A mathematical model for calculating the absolute densities of dopamine D(2) and D(3) receptors based on the in vitro receptor binding data of [3H]WC-10 and [3H]raclopride was developed...
  49. pmc Cervical carotid and circle of willis arterial anatomy of macaque monkeys: a comparative anatomy study
    Nishant Kumar
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anat Rec (Hoboken) 292:976-84. 2009
    ..Knowledge of these differences and similarities between human and macaque anatomy is important in developing endovascular macaque models of human diseases, such as ischemic stroke...
  50. ncbi request reprint Enhancement of rigidity in Parkinson's disease with activation
    Minna Hong
    Movement Science Program, Washington University School of Medicine, St Louis, MO 63108, USA
    Mov Disord 22:1164-8. 2007
    ..Further, activation did not enhance muscle tone in controls suggesting that this procedure may help distinguish people with PD from controls...
  51. ncbi request reprint Different effects of unilateral versus bilateral subthalamic nucleus stimulation on walking and reaching in Parkinson's disease
    Amy J Bastian
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Mov Disord 18:1000-7. 2003
    ..Our findings also suggest that maximal improvement of walking requires bilateral rather than unilateral STN stimulation...
  52. ncbi request reprint Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study
    Mei Sun
    Molecular Neurogenetics Unit, Center for Human Genetic Research, Massachusetts General Hospital, Harvard Medical School, Boston 02114, USA
    Arch Neurol 63:826-32. 2006
    ..The PARK2 gene at 6q26 encodes parkin, whose inactivation is implicated in an early-onset autosomal recessive form of Parkinson disease (PD)...
  53. ncbi request reprint Functional changes in brain activity during acquisition and practice of movement sequences
    Hanneke I van Mier
    University of Maastricht, Faculty of Psychology, Neurocognition, Maastricht, The Netherlands
    Motor Control 8:500-20. 2004
    ..These results suggest that different neural structures (involving a premotor-parietal-cerebellar circuit) play a role in a sequential maze learning task...
  54. ncbi request reprint Effects of pallidotomy and levodopa on walking and reaching movements in Parkinson's disease
    Amy J Bastian
    Kennedy Krieger Institute, Baltimore, Maryland 21205, USA
    Mov Disord 18:1008-17. 2003
    ....
  55. ncbi request reprint Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline
    Clifford W Shults
    Department of Neurosciences, Mail Code 0662, University of California San Diego, 9500 Gilman Dr, La Jolla, CA 92093 0662, USA
    Arch Neurol 59:1541-50. 2002
    ..Parkinson disease (PD) is a degenerative neurological disorder for which no treatment has been shown to slow the progression...
  56. ncbi request reprint Parkinson's disease and apolipoprotein E: possible association with dementia but not age at onset
    Abbas Parsian
    University of Louisville Birth Defects Center, University of Louisville Health Sciences Center, Louisville, Kentucky 40202, USA
    Genomics 79:458-61. 2002
    ..05 level. We conclude that APOE does not play an important role in susceptibility to PD or age at onset of PD, but may play a role in dementia associated with PD in our sample...
  57. ncbi request reprint Prevalence of parkin gene mutations and variations in idiopathic Parkinson's disease
    Rashmi Sinha
    Department of Pediatrics, UMAS College of Medicine, Little Rock, AR, USA
    Parkinsonism Relat Disord 11:341-7. 2005
    ..We concluded that no new mutation, nor the previously described parkin polymorphisms or known mutations, are playing any direct role in the development of PD in this group of PD patients...
  58. ncbi request reprint Writer's cramp: questions of causation
    Joel S Perlmutter
    Neurology 69:331-2. 2007
  59. ncbi request reprint Association of a variation in the promoter region of the brain-derived neurotrophic factor gene with familial Parkinson's disease
    Abbas Parsian
    Birth Defects Center, University of Louisville Health Sciences Center, Department of Molecular and Cellular Biology, 501 S Preston Street, Room 301, Louisville, KY 40202, USA
    Parkinsonism Relat Disord 10:213-9. 2004
    ..Our data indicate the possibility of linkage disequilibrium between the C270T variation and a mutation in coding region of the BDNF gene and suggest that this gene may play a role in the development of familial PD...
  60. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...
  61. ncbi request reprint Blind men and blinking elephants
    Craig Evinger
    Neurology 60:1732-3. 2003
  62. ncbi request reprint Predictors of deterioration in health-related quality of life in Parkinson's disease: results from the DATATOP trial
    Connie Marras
    Division of Neurology, Toronto Western Hospital, University Health Network, University of Toronto, Toronto, Ontario, Canada
    Mov Disord 23:653-9; quiz 776. 2008
    ..Our focus in clinical care needs to be broadened beyond assessing and treating Parkinsonism, recognizing the impact of mood, cognition and function on HRQOL...
  63. pmc Replication of association between ELAVL4 and Parkinson disease: the GenePD study
    Anita L Destefano
    Department of Biostatistics, Boston University School of Public Health, 715 Albany Street, Crosstown Center, 3rd Floor, Boston, MA 02118, USA
    Hum Genet 124:95-9. 2008
    ..This replication of association with rs967582 in a third cohort further implicates ELAVL4 as a PD susceptibility gene...
  64. pmc Research priorities in spasmodic dysphonia
    Christy L Ludlow
    Laryngeal and Speech Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, 10 Center Drive, Bethesda, MD 20892, USA
    Otolaryngol Head Neck Surg 139:495-505. 2008
    ..To identify research priorities to increase understanding of the pathogenesis, diagnosis, and improved treatment of spasmodic dysphonia...
  65. pmc Update on blepharospasm: report from the BEBRF International Workshop
    Mark Hallett
    Human Motor Control Section, NINDS, NIH, 10 Center Drive MSC 1428, Bethesda, MD 20892 1428, USA
    Neurology 71:1275-82. 2008
    ..Physiologic studies indicate increased plasticity and trigeminal sensitization. While botulinum neurotoxin injections are the mainstay of therapy, other therapies are on the horizon...

Research Grants20

  1. MECHANISM OF DEEP BRAIN STIMULATION
    Joel Perlmutter; Fiscal Year: 2007
    ..This innovative study brings together rigorous, carefully controlled PET investigations with quantified motor and cognitive behavioral measures. ..
  2. VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONS
    JOEL SYNES PERLMUTTER; Fiscal Year: 2010
    ..This application proposes to develop and validate a neuroimaging biomarker to measure PD progression;a critical step needed to determine the efficacy of any newly proposed intervention. ..
  3. Mechanisms of Deep Brain Stimulation
    JOEL SYNES PERLMUTTER; Fiscal Year: 2010
    ..Such basic observations have importance for understanding normal function as well as how impairments lead to disabilities in other basal ganglia related disorders with motor or cognitive dysfunction. ..
  4. CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISM
    Joel Perlmutter; Fiscal Year: 2007
    ..These studies will provide a solid foundation for a clinical trial in humans with C3 and can potentially reduce the suffering and economic burden of PD. ..
  5. CARBOXYFULLERENE TREATMENT OF MPTP-INDUCED PARKINSONISM
    Joel Perlmutter; Fiscal Year: 2009
    ..These studies will provide a solid foundation for a clinical trial in humans with C3 and can potentially reduce the suffering and economic burden of PD. ..
  6. VALIDATION OF NEUROIMAGING BIOMARKERS FOR NIGROSTRIATAL NEURONS
    Joel Perlmutter; Fiscal Year: 2009
    ..This application proposes to develop and validate a neuroimaging biomarker to measure PD progression; a critical step needed to determine the efficacy of any newly proposed intervention. ..
  7. RESCUE FROM NIGROSTRIATAL INJURY
    Joel Perlmutter; Fiscal Year: 2003
    ..If this strategy works, these results will provide the preliminary data for a proper trial of these promising drugs in humans. ..
  8. MECHANISM OF DEEP BRAIN STIMULATION
    Joel Perlmutter; Fiscal Year: 2003
    ..Such information may help to optimize treatment with this new modality and potentially suggest alternate approaches to provide additional clinical benefit. ..