T K Pandita

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint ATM function and telomere stability
    Tej K Pandita
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York, NY 10032, USA
    Oncogene 21:611-8. 2002
  2. ncbi request reprint ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
    Andrea L Bredemeyer
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 442:466-70. 2006
  3. pmc Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair
    Raj K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
    Mol Cell Biol 26:1850-64. 2006
  4. pmc The cellular control of DNA double-strand breaks
    Shaun P Scott
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    J Cell Biochem 99:1463-75. 2006
  5. ncbi request reprint Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status
    Clayton R Hunt
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 67:3010-7. 2007
  6. ncbi request reprint Role of mammalian Rad9 in genomic stability and ionizing radiation response
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine 4511 Forest Park Ave, St Louis, Missouri 63108, USA
    Cell Cycle 5:1289-91. 2006
  7. ncbi request reprint Regulation of telomere movement by telomere chromatin structure
    T K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Mol Life Sci 64:131-8. 2007
  8. pmc Molecular parameters of hyperthermia for radiosensitization
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Crit Rev Eukaryot Gene Expr 19:235-51. 2009
  9. pmc Chromatin remodeling finds its place in the DNA double-strand break response
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Nucleic Acids Res 37:1363-77. 2009
  10. ncbi request reprint HSP70 and genomic stability
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Cell Cycle 3:591-2. 2004

Collaborators

Detail Information

Publications41

  1. ncbi request reprint ATM function and telomere stability
    Tej K Pandita
    Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York, NY 10032, USA
    Oncogene 21:611-8. 2002
    ..While ATM has both nuclear and cytoplasmic functions, this review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage...
  2. ncbi request reprint ATM stabilizes DNA double-strand-break complexes during V(D)J recombination
    Andrea L Bredemeyer
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 442:466-70. 2006
    ....
  3. pmc Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repair
    Raj K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
    Mol Cell Biol 26:1850-64. 2006
    ..Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...
  4. pmc The cellular control of DNA double-strand breaks
    Shaun P Scott
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    J Cell Biochem 99:1463-75. 2006
    ..This review will address the control of DSBs in damaged eukaryotic cells, the physiological processes that require the introduction of a DSB into the genome, and the maintenance of DSBs in non-damaged cells...
  5. ncbi request reprint Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 status
    Clayton R Hunt
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Cancer Res 67:3010-7. 2007
    ....
  6. ncbi request reprint Role of mammalian Rad9 in genomic stability and ionizing radiation response
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine 4511 Forest Park Ave, St Louis, Missouri 63108, USA
    Cell Cycle 5:1289-91. 2006
    ..These newly defined functions of mammalian Rad9 are discussed in relation to telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...
  7. ncbi request reprint Regulation of telomere movement by telomere chromatin structure
    T K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cell Mol Life Sci 64:131-8. 2007
    ..This review will summarize recent studies on telomere interactions with the nuclear matrix, telomere chromatin structure and factors that modify telomere chromatin structure as related to regulation of telomere movement...
  8. pmc Molecular parameters of hyperthermia for radiosensitization
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Crit Rev Eukaryot Gene Expr 19:235-51. 2009
    ..Thus, hyperthermia influences several molecular parameters involved in sensitizing tumor cells to radiation and can enhance the potential of targeted radiotherapy...
  9. pmc Chromatin remodeling finds its place in the DNA double-strand break response
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Nucleic Acids Res 37:1363-77. 2009
    ..This review summarizes recently identified factors that influence this complex process and the repair of DNA DSBs in eukaryotic cells...
  10. ncbi request reprint HSP70 and genomic stability
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Cell Cycle 3:591-2. 2004
    ..A recent study revealed that cells with inactivated HSP70 displayed telomere instability and high frequency of spontaneous chromosomal aberrations, indicating a possible role for HSP70 proteins in the maintenance of genomic stability...
  11. pmc Telomeres, histone code, and DNA damage response
    S Misri
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cytogenet Genome Res 122:297-307. 2008
    ..This review will summarize the role of DNA damage repair proteins specifically ataxia-telangiectasia mutated (ATM) and its effectors and the telomere complex in maintaining genome stability...
  12. pmc Involvement of human MOF in ATM function
    Arun Gupta
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Mol Cell Biol 25:5292-305. 2005
    ..The overexpression of wild-type hMOF yielded the opposite results, i.e., a modest increase in cell survival and enhanced DNA repair after IR exposure. These results suggest that hMOF influences the function of ATM...
  13. ncbi request reprint Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repair
    Arun Gupta
    Washington University School of Medicine, St Louis, MO, USA
    Cell Cycle 8:2198-210. 2009
    ....
  14. pmc MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repair
    Girdhar G Sharma
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Mol Cell Biol 30:3582-95. 2010
    ..We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair...
  15. pmc Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpoint
    Han Liu
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 467:343-6. 2010
    ....
  16. pmc Telomere recombination requires the MUS81 endonuclease
    Sicong Zeng
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Nat Cell Biol 11:616-23. 2009
    ..Thus, our results suggest that MUS81 is involved in the maintenance of ALT cell survival at least in part by homologous recombination of telomeres...
  17. pmc MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaks
    Beth A Helmink
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 206:669-79. 2009
    ....
  18. doi request reprint Detecting ATM-dependent chromatin modification in DNA damage and heat shock response
    Sandeep Misri
    Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 523:395-410. 2009
    ..This review summarizes the multiple approaches used to discern the role of ATM in chromatin modification in response to DNA damage as well as heat shock...
  19. pmc Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient mice
    Clayton R Hunt
    Department of Oncology, Radiation, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Mol Cell Biol 24:899-911. 2004
    ..1/3(-/-) cells in comparison to Hsp70.1/3(+/+) cells. Both in vivo and in vitro studies demonstrate for the first time that Hsp70.1 and Hsp70.3 have an essential role in maintaining genomic stability under stress conditions...
  20. pmc Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiation
    Girdhar G Sharma
    Radiation and Cancer Biology Division, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Mol Cell Biol 23:8363-76. 2003
    ..In addition, the isoform-specific effects on telomeres reinforce the notion that telomeres are in a heterochromatinized state...
  21. ncbi request reprint hTERT associates with human telomeres and enhances genomic stability and DNA repair
    Girdhar G Sharma
    Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
    Oncogene 22:131-46. 2003
    ..These novel functions of telomerase are distinct from its known effect on telomere length and have potentially important biological consequences...
  22. pmc Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytes
    Ching Yu Huang
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Exp Med 204:1371-81. 2007
    ....
  23. doi request reprint Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization
    Manjula Agarwal
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Cancer Res 68:3370-8. 2008
    ..These results suggest that inactivation of telomerase before combined hyperthermia and radiotherapy could improve tumor killing...
  24. ncbi request reprint Telomere stability correlates with longevity of human beings exposed to ionizing radiations
    Girdhar G Sharma
    Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
    Oncol Rep 10:1733-6. 2003
    ....
  25. ncbi request reprint Role of telomerase in radiocurability (review)
    Tej K Pandita
    Washington University School of Medicine, Saint Louis, MO 63108, USA
    Oncol Rep 10:263-70. 2003
    ....
  26. ncbi request reprint Detecting the influence of cell cycle regulatory proteins on human telomeres
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA
    Methods Mol Biol 241:329-39. 2004
  27. ncbi request reprint A multifaceted role for ATM in genome maintenance
    Tej K Pandita
    Department of Radiation Oncology, Radiation and Cancer Biology Division, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Expert Rev Mol Med 5:1-21. 2003
    ..This review focuses on the critical roles that ATM appears to play in cell-cycle checkpoints, DNA repair, telomere metabolism and oxidative stress, indicating how defects in these processes might lead to ataxia-telangiectasia...
  28. ncbi request reprint Role of HSPs and telomerase in radiotherapy
    Tej K Pandita
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
    Int J Hyperthermia 21:689-94. 2005
    ..This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy...
  29. ncbi request reprint Enrichment of cells in different phases of the cell cycle by centrifugal elutriation
    Tej K Pandita
    Department of Radiation Oncology, Washington State University School of Medicine, Saint Louis, MO, USA
    Methods Mol Biol 241:17-21. 2004
  30. pmc The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesis
    Arun Gupta
    Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
    Mol Cell Biol 28:397-409. 2008
    ....
  31. ncbi request reprint Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblasts
    Ehab H Sarsour
    Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa 52242, USA
    J Biol Chem 280:18033-41. 2005
    ..These results support the hypothesis that a redox-sensitive checkpoint regulated the progression of fibroblasts from G(0)/G(1) to S-phase...
  32. pmc Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stability
    Jennifer Blickwedehl
    Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
    Proc Natl Acad Sci U S A 105:16165-70. 2008
    ..Together, these data suggest a unique role for PA200 in genomic stability that is likely mediated through its ability to enhance postglutamyl cleavage by proteasomes...
  33. ncbi request reprint The role of the DNA double-strand break response network in meiosis
    Christine Richardson
    College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
    DNA Repair (Amst) 3:1149-64. 2004
    ..Numerous studies have identified both the genomic loci of the initiating DSBs and the proteins involved in their formation. This review will summarize the activation and signaling networks required for the DSB response in meiosis...
  34. ncbi request reprint Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1
    Limor Shahrabani-Gargir
    Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
    Endocrinology 145:5679-87. 2004
    ..Deregulated expression of the IGF-IR gene after ionizing radiation may be linked to genomic instability and enhanced transforming capacity...
  35. doi request reprint Single-stranded DNA-binding protein hSSB1 is critical for genomic stability
    Derek J Richard
    Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
    Nature 453:677-81. 2008
    ..These findings establish that hSSB1 influences diverse endpoints in the cellular DNA damage response...
  36. ncbi request reprint Lack of PTEN sequesters CHK1 and initiates genetic instability
    Janusz Puc
    Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
    Cancer Cell 7:193-204. 2005
    ..005). We conclude that loss of PTEN and subsequent activation of AKT impair CHK1 through phosphorylation, ubiquitination, and reduced nuclear localization to promote genomic instability in tumor cells...
  37. ncbi request reprint Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasia
    Shelly Ziv
    Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Hum Mol Genet 14:2929-43. 2005
    ....
  38. ncbi request reprint Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53
    Junghee Seo
    Department of Pathology and Immunology, Washington University School of Medicine, Suwon, Korea
    Oncogene 24:8176-86. 2005
    ..Collectively, our studies suggest that Cdt1 overexpression most likely contributes to tumorigenecity by causing genomic instability...
  39. ncbi request reprint Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cells
    Devanand Sarkar
    Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
    J Biol Chem 278:24542-51. 2003
    ..Inhibition of hPNPaseold-35 by an antisense approach provided partial but significant protection against interferon-beta-mediated growth inhibition, thus demonstrating the biological significance of hPNPaseold-35 in interferon action...
  40. ncbi request reprint c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instability
    Omid Vafa
    The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
    Mol Cell 9:1031-44. 2002
    ..We propose that oncogene activation can induce DNA damage and override damage controls, thereby accelerating tumor progression via genetic instability...
  41. ncbi request reprint A role for the HOXB7 homeodomain protein in DNA repair
    Ethel Rubin
    Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
    Cancer Res 67:1527-35. 2007
    ..This is the first mechanistic study providing definitive evidence for the involvement of any HOX protein in DNA double-strand break repair...