Research Topics
| T K PanditaSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Detail Information
Publications
ATM function and telomere stabilityTej K Pandita
Center for Radiological Research, College of Physicians and Surgeons, Columbia University, New York, New York, NY 10032, USA
Oncogene 21:611-8. 2002..While ATM has both nuclear and cytoplasmic functions, this review will focus on its roles in telomere metabolism and how ATM and telomeres serve as controllers of cellular responses to DNA damage...- ATM stabilizes DNA double-strand-break complexes during V(D)J recombinationAndrea L Bredemeyer
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 442:466-70. 2006.... 
Mammalian Rad9 plays a role in telomere stability, S- and G2-phase-specific cell survival, and homologous recombinational repairRaj K Pandita
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park Ave, St Louis, MO 63108, USA
Mol Cell Biol 26:1850-64. 2006..Together, these findings provide evidence of roles for mammalian Rad9 in telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure...- The cellular control of DNA double-strand breaksShaun P Scott
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St. Louis, MO 63108, USA
J Cell Biochem 99:1463-75. 2006..This review will address the control of DSBs in damaged eukaryotic cells, the physiological processes that require the introduction of a DSB into the genome, and the maintenance of DSBs in non-damaged cells... - Hyperthermia activates a subset of ataxia-telangiectasia mutated effectors independent of DNA strand breaks and heat shock protein 70 statusClayton R Hunt
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri, USA
Cancer Res 67:3010-7. 2007.... - Role of mammalian Rad9 in genomic stability and ionizing radiation responseTej K Pandita
Department of Radiation Oncology, Washington University School of Medicine 4511 Forest Park Ave, St Louis, Missouri 63108, USA
Cell Cycle 5:1289-91. 2006..These newly defined functions of mammalian Rad9 are discussed in relation to telomere stability and HR repair as a mechanism for promoting cell survival after IR exposure... - Regulation of telomere movement by telomere chromatin structureT K Pandita
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Cell Mol Life Sci 64:131-8. 2007..This review will summarize recent studies on telomere interactions with the nuclear matrix, telomere chromatin structure and factors that modify telomere chromatin structure as related to regulation of telomere movement... - Molecular parameters of hyperthermia for radiosensitizationTej K Pandita
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
Crit Rev Eukaryot Gene Expr 19:235-51. 2009..Thus, hyperthermia influences several molecular parameters involved in sensitizing tumor cells to radiation and can enhance the potential of targeted radiotherapy... - Chromatin remodeling finds its place in the DNA double-strand break responseTej K Pandita
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Nucleic Acids Res 37:1363-77. 2009..This review summarizes recently identified factors that influence this complex process and the repair of DNA DSBs in eukaryotic cells... - HSP70 and genomic stabilityTej K Pandita
Department of Radiation Oncology, Washington University School of Medicine, St Louis, Missouri 63108, USA
Cell Cycle 3:591-2. 2004..A recent study revealed that cells with inactivated HSP70 displayed telomere instability and high frequency of spontaneous chromosomal aberrations, indicating a possible role for HSP70 proteins in the maintenance of genomic stability... - Telomeres, histone code, and DNA damage responseS Misri
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Cytogenet Genome Res 122:297-307. 2008..This review will summarize the role of DNA damage repair proteins specifically ataxia-telangiectasia mutated (ATM) and its effectors and the telomere complex in maintaining genome stability... - Involvement of human MOF in ATM functionArun Gupta
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Mol Cell Biol 25:5292-305. 2005..The overexpression of wild-type hMOF yielded the opposite results, i.e., a modest increase in cell survival and enhanced DNA repair after IR exposure. These results suggest that hMOF influences the function of ATM... - Cell cycle checkpoint defects contribute to genomic instability in PTEN deficient cells independent of DNA DSB repairArun Gupta
Washington University School of Medicine, St Louis, MO, USA
Cell Cycle 8:2198-210. 2009.... - MOF and histone H4 acetylation at lysine 16 are critical for DNA damage response and double-strand break repairGirdhar G Sharma
Washington University School of Medicine, St Louis, Missouri 63108, USA
Mol Cell Biol 30:3582-95. 2010..We propose that MOF, through H4K16ac (histone code), has a critical role at multiple stages in the cellular DNA damage response and DSB repair... - Phosphorylation of MLL by ATR is required for execution of mammalian S-phase checkpointHan Liu
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 467:343-6. 2010.... - Telomere recombination requires the MUS81 endonucleaseSicong Zeng
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Nat Cell Biol 11:616-23. 2009..Thus, our results suggest that MUS81 is involved in the maintenance of ALT cell survival at least in part by homologous recombination of telomeres... - MRN complex function in the repair of chromosomal Rag-mediated DNA double-strand breaksBeth A Helmink
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Exp Med 206:669-79. 2009.... 
Detecting ATM-dependent chromatin modification in DNA damage and heat shock responseSandeep Misri
Washington University School of Medicine, St Louis, MO, USA
Methods Mol Biol 523:395-410. 2009..This review summarizes the multiple approaches used to discern the role of ATM in chromatin modification in response to DNA damage as well as heat shock...- Genomic instability and enhanced radiosensitivity in Hsp70.1- and Hsp70.3-deficient miceClayton R Hunt
Department of Oncology, Radiation, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Mol Cell Biol 24:899-911. 2004..1/3(-/-) cells in comparison to Hsp70.1/3(+/+) cells. Both in vivo and in vitro studies demonstrate for the first time that Hsp70.1 and Hsp70.3 have an essential role in maintaining genomic stability under stress conditions... - Human heterochromatin protein 1 isoforms HP1(Hsalpha) and HP1(Hsbeta) interfere with hTERT-telomere interactions and correlate with changes in cell growth and response to ionizing radiationGirdhar G Sharma
Radiation and Cancer Biology Division, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Mol Cell Biol 23:8363-76. 2003..In addition, the isoform-specific effects on telomeres reinforce the notion that telomeres are in a heterochromatinized state... - hTERT associates with human telomeres and enhances genomic stability and DNA repairGirdhar G Sharma
Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
Oncogene 22:131-46. 2003..These novel functions of telomerase are distinct from its known effect on telomere length and have potentially important biological consequences... - Defects in coding joint formation in vivo in developing ATM-deficient B and T lymphocytesChing Yu Huang
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
J Exp Med 204:1371-81. 2007.... - Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitizationManjula Agarwal
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Cancer Res 68:3370-8. 2008..These results suggest that inactivation of telomerase before combined hyperthermia and radiotherapy could improve tumor killing... - Telomere stability correlates with longevity of human beings exposed to ionizing radiationsGirdhar G Sharma
Radiation and Cancer Biology Division, Washington University School of Medicine, St Louis, MO 63108, USA
Oncol Rep 10:1733-6. 2003.... - Role of telomerase in radiocurability (review)Tej K Pandita
Washington University School of Medicine, Saint Louis, MO 63108, USA
Oncol Rep 10:263-70. 2003.... - Detecting the influence of cell cycle regulatory proteins on human telomeresTej K Pandita
Department of Radiation Oncology, Washington University School of Medicine, Saint Louis, MO, USA
Methods Mol Biol 241:329-39. 2004 - A multifaceted role for ATM in genome maintenanceTej K Pandita
Department of Radiation Oncology, Radiation and Cancer Biology Division, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Expert Rev Mol Med 5:1-21. 2003..This review focuses on the critical roles that ATM appears to play in cell-cycle checkpoints, DNA repair, telomere metabolism and oxidative stress, indicating how defects in these processes might lead to ataxia-telangiectasia... - Role of HSPs and telomerase in radiotherapyTej K Pandita
Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63108, USA
Int J Hyperthermia 21:689-94. 2005..This review will focus on the possible role of HSPs and telomerase in sensitizing tumour cells and, thus, enhancing the potential of targeted radiotherapy... - Enrichment of cells in different phases of the cell cycle by centrifugal elutriationTej K Pandita
Department of Radiation Oncology, Washington State University School of Medicine, Saint Louis, MO, USA
Methods Mol Biol 241:17-21. 2004 - The mammalian ortholog of Drosophila MOF that acetylates histone H4 lysine 16 is essential for embryogenesis and oncogenesisArun Gupta
Department of Radiation Oncology, Washington University School of Medicine, 4511 Forest Park, St Louis, MO 63108, USA
Mol Cell Biol 28:397-409. 2008.... - Manganese superoxide dismutase protects the proliferative capacity of confluent normal human fibroblastsEhab H Sarsour
Free Radical and Radiation Biology Program, Department of Radiation Oncology, The University of Iowa, Iowa City, Iowa 52242, USA
J Biol Chem 280:18033-41. 2005..These results support the hypothesis that a redox-sensitive checkpoint regulated the progression of fibroblasts from G(0)/G(1) to S-phase... - Role for proteasome activator PA200 and postglutamyl proteasome activity in genomic stabilityJennifer Blickwedehl
Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY 14263
Proc Natl Acad Sci U S A 105:16165-70. 2008..Together, these data suggest a unique role for PA200 in genomic stability that is likely mediated through its ability to enhance postglutamyl cleavage by proteasomes... - The role of the DNA double-strand break response network in meiosisChristine Richardson
College of Physicians and Surgeons, Columbia University, New York, NY 10032, USA
DNA Repair (Amst) 3:1149-64. 2004..Numerous studies have identified both the genomic loci of the initiating DSBs and the proteins involved in their formation. This review will summarize the activation and signaling networks required for the DSB response in meiosis... - Ataxia-telangiectasia mutated gene controls insulin-like growth factor I receptor gene expression in a deoxyribonucleic acid damage response pathway via mechanisms involving zinc-finger transcription factors Sp1 and WT1Limor Shahrabani-Gargir
Department of Clinical Biochemistry, Sackler School of Medicine, Tel Aviv University, Tel Aviv 69978, Israel
Endocrinology 145:5679-87. 2004..Deregulated expression of the IGF-IR gene after ionizing radiation may be linked to genomic instability and enhanced transforming capacity... - Single-stranded DNA-binding protein hSSB1 is critical for genomic stabilityDerek J Richard
Signal Transduction Laboratory, Queensland Institute of Medical Research, Brisbane, Queensland 4029, Australia
Nature 453:677-81. 2008..These findings establish that hSSB1 influences diverse endpoints in the cellular DNA damage response... - Lack of PTEN sequesters CHK1 and initiates genetic instabilityJanusz Puc
Institute for Cancer Genetics, Columbia University, New York, New York 10032, USA
Cancer Cell 7:193-204. 2005..005). We conclude that loss of PTEN and subsequent activation of AKT impair CHK1 through phosphorylation, ubiquitination, and reduced nuclear localization to promote genomic instability in tumor cells... - Impaired genomic stability and increased oxidative stress exacerbate different features of Ataxia-telangiectasiaShelly Ziv
Department of Neurobiochemistry, George S Wise Faculty of Life Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Hum Mol Genet 14:2929-43. 2005.... - Cdt1 transgenic mice develop lymphoblastic lymphoma in the absence of p53Junghee Seo
Department of Pathology and Immunology, Washington University School of Medicine, Suwon, Korea
Oncogene 24:8176-86. 2005..Collectively, our studies suggest that Cdt1 overexpression most likely contributes to tumorigenecity by causing genomic instability... - Down-regulation of Myc as a potential target for growth arrest induced by human polynucleotide phosphorylase (hPNPaseold-35) in human melanoma cellsDevanand Sarkar
Department of Pathology, Herbert Irving Comprehensive Cancer Center, Columbia University, College of Physicians and Surgeons, New York, New York 10032, USA
J Biol Chem 278:24542-51. 2003..Inhibition of hPNPaseold-35 by an antisense approach provided partial but significant protection against interferon-beta-mediated growth inhibition, thus demonstrating the biological significance of hPNPaseold-35 in interferon action... - c-Myc can induce DNA damage, increase reactive oxygen species, and mitigate p53 function: a mechanism for oncogene-induced genetic instabilityOmid Vafa
The Salk Institute for Biological Studies, La Jolla, CA 92037, USA
Mol Cell 9:1031-44. 2002..We propose that oncogene activation can induce DNA damage and override damage controls, thereby accelerating tumor progression via genetic instability... - A role for the HOXB7 homeodomain protein in DNA repairEthel Rubin
Department of Oncology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA
Cancer Res 67:1527-35. 2007..This is the first mechanistic study providing definitive evidence for the involvement of any HOX protein in DNA double-strand break repair...