Katherine I O'Rourke

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. pmc Transmissibility of caprine scrapie in ovine transgenic mice
    Katherine I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Pullman, WA 99164, USA
    BMC Vet Res 8:42. 2012
  2. ncbi request reprint PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States
    K I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Washington State University, Pullman 99164 7030, USA
    J Gen Virol 78:975-8. 1997
  3. pmc Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein
    K I O'Rourke
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 7030, USA
    J Clin Microbiol 36:1750-5. 1998
  4. ncbi request reprint PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease
    K I O'Rourke
    USDA, Agricultural Research Service, Animal Disease Research Unit, Pullman, WA 99164 7030, USA
    J Gen Virol 80:2765-9. 1999
  5. ncbi request reprint Ovine scrapie. New tools for control of an old disease
    K I O'Rourke
    US Department of Agriculture, Animal Disease Research Unit, Pullman, Washington, USA
    Vet Clin North Am Food Anim Pract 17:283-300, vi. 2001
  6. pmc Sparse PrP(Sc) accumulation in the placentas of goats with naturally acquired scrapie
    Katherine I O'Rourke
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, WA 99164, USA
    BMC Vet Res 7:7. 2011
  7. ncbi request reprint Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer
    Katherine I O'Rourke
    US Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, 3003 ADBF, Pullman, WA 99164, USA
    J Gen Virol 85:1339-46. 2004
  8. doi request reprint Cell-surface expression of PrPC and the presence of scrapie prions in the blood of goats
    Rohana P Dassanayake
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    J Gen Virol 93:1127-31. 2012
  9. pmc Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep
    Rohana P Dassanayake
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    BMC Vet Res 9:82. 2013
  10. ncbi request reprint Elk with a long incubation prion disease phenotype have a unique PrPd profile
    Katherine I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, Washington 99164, USA
    Neuroreport 18:1935-8. 2007

Detail Information

Publications31

  1. pmc Transmissibility of caprine scrapie in ovine transgenic mice
    Katherine I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Pullman, WA 99164, USA
    BMC Vet Res 8:42. 2012
    ....
  2. ncbi request reprint PrP genotypes and experimental scrapie in orally inoculated Suffolk sheep in the United States
    K I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Washington State University, Pullman 99164 7030, USA
    J Gen Virol 78:975-8. 1997
    ..Twelve 171-QQ sheep failed to develop disease. All 5 sheep homozygous for arginine (171-RR) and all 23 heterozygous (171-QR) sheep remained free of scrapie...
  3. pmc Monoclonal antibody F89/160.1.5 defines a conserved epitope on the ruminant prion protein
    K I O'Rourke
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 7030, USA
    J Clin Microbiol 36:1750-5. 1998
    ..MAb F89/160.1.5 will be useful in diagnostic and pathogenesis studies of the transmissible spongiform encephalopathies in these ruminant species...
  4. ncbi request reprint PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease
    K I O'Rourke
    USDA, Agricultural Research Service, Animal Disease Research Unit, Pullman, WA 99164 7030, USA
    J Gen Virol 80:2765-9. 1999
    ..In this study, Rocky Mountain elk homozygous for PrP codon 1 32 Met were over-represented in both free-ranging and farm-raised CWD-affected elk when compared to unaffected control groups...
  5. ncbi request reprint Ovine scrapie. New tools for control of an old disease
    K I O'Rourke
    US Department of Agriculture, Animal Disease Research Unit, Pullman, Washington, USA
    Vet Clin North Am Food Anim Pract 17:283-300, vi. 2001
    ....
  6. pmc Sparse PrP(Sc) accumulation in the placentas of goats with naturally acquired scrapie
    Katherine I O'Rourke
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, WA 99164, USA
    BMC Vet Res 7:7. 2011
    ..We describe the sparse accumulation of PrPSc in the placentas of goats with naturally acquired classical scrapie in comparison to field cases of classical ovine scrapie...
  7. ncbi request reprint Polymorphisms in the prion precursor functional gene but not the pseudogene are associated with susceptibility to chronic wasting disease in white-tailed deer
    Katherine I O'Rourke
    US Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, 3003 ADBF, Pullman, WA 99164, USA
    J Gen Virol 85:1339-46. 2004
    ....
  8. doi request reprint Cell-surface expression of PrPC and the presence of scrapie prions in the blood of goats
    Rohana P Dassanayake
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    J Gen Virol 93:1127-31. 2012
    ..Thus, similar to sheep, goat blood may be a suitable diagnostic target for the detection of scrapie infection...
  9. pmc Accumulation profiles of PrP(Sc) in hemal nodes of naturally and experimentally scrapie-infected sheep
    Rohana P Dassanayake
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    BMC Vet Res 9:82. 2013
    ..Therefore, the objective of this study was to compare the follicular accumulation of PrP(Sc) within hemal nodes and lymph nodes by prion epitope mapping and western blot studies...
  10. ncbi request reprint Elk with a long incubation prion disease phenotype have a unique PrPd profile
    Katherine I O'Rourke
    United States Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, Washington 99164, USA
    Neuroreport 18:1935-8. 2007
    ..We now report that elk lacking the predisposing 132-methionine allele develop chronic wasting disease after a long incubation period and display a novel PrP folding pattern...
  11. ncbi request reprint Abundant PrP(CWD) in tonsil from mule deer with preclinical chronic wasting disease
    Katherine I O'Rourke
    Agricultural Research Service, U S Department of Agriculture, Animal Disease Research Unit, Pullman, WA 99164, USA
    J Vet Diagn Invest 15:320-3. 2003
    ..5 mg starting wet weight of tissue. The abundant PrP(CWD) in mule deer tonsil will facilitate development and validation of high-throughput screening tests for CWD in large populations of free-ranging deer...
  12. pmc Classical scrapie prions in ovine blood are associated with B lymphocytes and platelet-rich plasma
    Rohana P Dassanayake
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    BMC Vet Res 7:75. 2011
    ..Therefore, the objective of this study was to determine whether circulating PBMCs, B lymphocytes and platelets from classical scrapie infected sheep harbor prion infectivity using a sheep bioassay...
  13. doi request reprint Differential immunoreactivity of goat derived scrapie following in vitro misfolding versus mouse bioassay
    Sally A Madsen-Bouterse
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Biochem Biophys Res Commun 423:770-4. 2012
    ..These observations suggest that concurrent PMCA and bioassay with tg338 could improve characterization of goat derived scrapie...
  14. doi request reprint Extended scrapie incubation time in goats singly heterozygous for PRNP S146 or K222
    Stephen N White
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, PO Box 646630, Pullman, WA 99164, USA
    Gene 501:49-51. 2012
    ....
  15. ncbi request reprint A processed pseudogene contributes to apparent mule deer prion gene heterogeneity
    Kelly A Brayton
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Gene 326:167-73. 2004
    ..Therefore, selection of a genotyping method specific for the functional gene is critical for large-scale studies to identify the role of the PRNP gene in susceptibility to CWD in mule deer...
  16. pmc Ovine progressive pneumonia provirus levels are unaffected by the prion 171R allele in an Idaho sheep flock
    Robert D Harrington
    Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, Pullman, WA 99164 6630, USA
    Genet Sel Evol 41:17. 2009
    ..This study provides further support to the adoption of PRNP 171R selection as a scrapie control measure...
  17. pmc Pregnancy status and fetal prion genetics determine PrPSc accumulation in placentomes of scrapie-infected sheep
    Wenbin Tuo
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, WA 99164, USA
    Proc Natl Acad Sci U S A 99:6310-5. 2002
    ..These results indicate that accumulation of PrP(Sc) is eliminated or reduced to undetectable levels in reproductive and placental tissues if infected ewes are not pregnant or conceive conceptuses with a resistant PrP genotype...
  18. ncbi request reprint Preliminary observations of genetic susceptibility of elk (Cervus elaphus nelsoni) to chronic wasting disease by experimental oral inoculation
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, Ames, IA 50010, USA
    J Vet Diagn Invest 18:110-4. 2006
    ..All 4 LL elk are alive at PI year 4 and are clinically normal, which suggests that 132LL elk may have reduced susceptibility to oral infection with CWD-infected material or may have prolonged incubation time...
  19. doi request reprint Diagnostic accuracy of rectal mucosa biopsy testing for chronic wasting disease within white-tailed deer (Odocoileus virginianus) herds in North America: effects of age, sex, polymorphism at PRNP codon 96, and disease progression
    Bruce V Thomsen
    National Veterinary Services Laboratories, U S Department of Agriculture, 1920 Dayton Avenue, Ames, IA 50010, USA
    J Vet Diagn Invest 24:878-87. 2012
    ..The overall diagnostic specificity was 99.8%. Selective use of antemortem rectal biopsy sample testing would provide valuable information during disease investigations of CWD-suspect deer herds...
  20. ncbi request reprint PrPSc accumulation in fetal cotyledons of scrapie-resistant lambs is influenced by fetus location in the uterus
    Janet Alverson
    USDA, ARS, Animal Disease Research Unit, 3003 ADBF, Washington State University, Pullman, WA 99164, USA
    J Gen Virol 87:1035-41. 2006
    ..This indicates that some sharing of fetal blood occurs between placentomes and fetuses residing in the same uterine horn, which can result in PrPSc accumulation in cotyledons with resistant genotypes...
  21. pmc Increased risk of chronic wasting disease in Rocky Mountain elk associated with decreased magnesium and increased manganese in brain tissue
    Stephen N White
    U S Department of Agriculture Agricultural Research Service, Animal Disease Unit, Pullman, Washington, USA
    Can J Vet Res 74:50-3. 2010
    ..This study demonstrated that mineral analysis may provide an additional disease correlate for assessing CWD risk, particularly in conjunction with genotype...
  22. ncbi request reprint Experimental transmission of chronic wasting disease agent from mule deer to cattle by the intracerebral route
    Amir N Hamir
    National Animal Disease Center, ARS, USDA, 2300 Dayton Avenue, PO Box 70, Ames, IA 50010, USA
    J Vet Diagn Invest 17:276-81. 2005
    ....
  23. pmc Small-ruminant lentivirus enhances PrPSc accumulation in cultured sheep microglial cells
    James B Stanton
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Virol 82:9839-47. 2008
    ....
  24. doi request reprint Myenteric neurons of the ileum that express somatostatin are a target of prion neuroinvasion in an alimentary model of sheep scrapie
    David A Schneider
    Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, 3003 ADBF, WSU, PO Box 646630, Pullman, WA 99164 6630, USA
    Acta Neuropathol 115:651-61. 2008
    ....
  25. pmc CD21-positive follicular dendritic cells: A possible source of PrPSc in lymph node macrophages of scrapie-infected sheep
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, WA 99164 7030, USA
    Am J Pathol 162:1075-81. 2003
    ..The results also suggest that follicular macrophages have proteases that process full-length PrP(Sc) to N-terminally truncated PrP(Sc)...
  26. ncbi request reprint Fewer PrPc myeloid-based cells in sheep with the prion-resistant genotype
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, US Department of Agriculture, USA
    Neuroreport 17:125-9. 2006
    ..05). One possibility for the lack of PrP(Sc) accumulation in brains and lymph nodes of scrapie-exposed sheep with 171RR PRNP genetics is because of fewer PrPc-positive myeloid-derived cells available for conversion of PrPc to PrP(Sc)...
  27. ncbi request reprint Immunohistochemical detection and distribution of prion protein in a goat with natural scrapie
    Reginald A Valdez
    Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Pullman, WA 99164 6630, USA
    J Vet Diagn Invest 15:157-62. 2003
    ..As with ovine scrapie, prion protein is widely distributed in the central and peripheral nervous systems, gastrointestinal tract, and lymphoid tissues in natural caprine scrapie...
  28. ncbi request reprint Blood chimerism confounds genetic relative susceptibility testing for classical scrapie in sheep
    David A Schneider
    Department of Agriculture, Agricultural Research Service, Animal Disease Research Unit, Pullman, WA 99164 6630, USA
    J Vet Diagn Invest 21:295-305. 2009
    ..The results demonstrate that naturally occurring blood chimerism can confound current testing efforts. The potential impacts of undetected chimeras on current scrapie eradication efforts are discussed...
  29. ncbi request reprint Failure of fallow deer (Dama dama) to develop chronic wasting disease when exposed to a contaminated environment and infected mule deer (Odocoileus hemionus)
    Jack C Rhyan
    National Wildlife Research Center, US Department of Agriculture, Animal and Plant Health Inspection Service, Veterinary Services, Fort Collins, Colorado 80521, USA
    J Wildl Dis 47:739-44. 2011
    ....
  30. pmc Active surveillance for scrapie by third eyelid biopsy and genetic susceptibility testing of flocks of sheep in Wyoming
    Katherine I O'Rourke
    Animal Disease Research Unit, Agricultural Research Service, Pullman, Washington 99164, USA
    Clin Diagn Lab Immunol 9:966-71. 2002
    ..Third-eyelid testing is a useful adjunct to flock monitoring programs, slaughter surveillance, and mandatory disease reporting in a comprehensive scrapie eradication and research program...
  31. pmc Association analysis of PRNP gene region with chronic wasting disease in Rocky Mountain elk
    Stephen N White
    Animal Disease Research Unit, Agricultural Research Service, U, S, Department of Agriculture, Pullman, WA 99164, USA
    BMC Res Notes 3:314. 2010
    ..Thus, additional genetic variants might provide increased protection, either alone or in combination with 132L...