David M Ornitz

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Fibroblast growth factors
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genome Biol 2:REVIEWS3005. 2001
  2. pmc FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    Irene H Hung
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 307:300-13. 2007
  3. doi Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 135:3161-71. 2008
  4. ncbi FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 302:80-91. 2007
  5. pmc Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation
    Anne L Jacob
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:315-28. 2006
  6. pmc Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:3169-77. 2011
  7. doi Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 237:713-24. 2008
  8. ncbi FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Development 133:1507-17. 2006
  9. pmc An FGF-WNT gene regulatory network controls lung mesenchyme development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 319:426-36. 2008
  10. pmc FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
    Mónica Vega-Hernández
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:3331-40. 2011

Collaborators

Detail Information

Publications56

  1. pmc Fibroblast growth factors
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genome Biol 2:REVIEWS3005. 2001
    ..When inappropriately expressed, some FGFs can contribute to the pathogenesis of cancer. A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems...
  2. pmc FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    Irene H Hung
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 307:300-13. 2007
    ..In developing stylopod elements, FGF9 promotes chondrocyte hypertrophy at early stages and regulates vascularization of the growth plate and osteogenesis at later stages of skeletal development...
  3. doi Hedgehog signaling to distinct cell types differentially regulates coronary artery and vein development
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 135:3161-71. 2008
    ..Finally, we present evidence suggesting that coronary arteries and veins may be derived from distinct lineages...
  4. ncbi FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 302:80-91. 2007
    ..FGF18 thus coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation...
  5. pmc Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation
    Anne L Jacob
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:315-28. 2006
    ..These data demonstrate that signaling through FGFR1 in osteoblasts is necessary to maintain the balance between bone formation and remodeling through a direct effect on osteoblast maturation...
  6. pmc Mesothelial- and epithelial-derived FGF9 have distinct functions in the regulation of lung development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:3169-77. 2011
    ..We show that FGF signaling is primarily responsible for regulating mesenchymal proliferation, whereas β-catenin signaling is a required permissive factor for mesenchymal FGF signaling...
  7. doi Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 237:713-24. 2008
    ..Together, these studies strongly suggest that myocardial cell proliferation and coronary development are genetically separable programs exemplifying one of the many potential uses of this genetic tool...
  8. ncbi FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Development 133:1507-17. 2006
    ....
  9. pmc An FGF-WNT gene regulatory network controls lung mesenchyme development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 319:426-36. 2008
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development...
  10. pmc FGF10/FGFR2b signaling is essential for cardiac fibroblast development and growth of the myocardium
    Mónica Vega-Hernández
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 138:3331-40. 2011
    ..Inactivation of this signaling pathway results in fewer epicardial derived cells within the compact myocardium, decreased myocardial proliferation and a resulting smaller thin-walled heart...
  11. pmc FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 134:3743-52. 2007
    ..These data suggest a molecular mechanism through which FGF9 and SHH signaling coordinately control the growth and patterning of the lung capillary plexus, and regulate the temporal and spatial expression of Vegfa...
  12. ncbi The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability
    Fernanda Laezza
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 27:12033-44. 2007
    ....
  13. pmc Fgf9 signaling regulates small intestinal elongation and mesenchymal development
    Michael J Geske
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 135:2959-68. 2008
    ..Taken together, the interaction of FGF and TGFbeta signaling pathways in the intestinal mesenchyme could represent novel targets for future short bowel syndrome therapies...
  14. pmc Missense mutations in Otopetrin 1 affect subcellular localization and inhibition of purinergic signaling in vestibular supporting cells
    Euysoo Kim
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Cell Neurosci 46:655-61. 2011
    ..These data suggest that the tlt and mlh mutations primarily affect the localization of Otop1, which interferes with its ability to interact with other proteins that are important for its cellular and biochemical function...
  15. pmc Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 118:2404-14. 2008
    ..Together, these data demonstrate that HH signaling is essential for cardiac function at the level of the coronary vasculature and caution against the use of HH antagonists in patients with prior or ongoing heart disease...
  16. pmc Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 20:1651-66. 2006
    ..Consistent with this, activation of HH signaling in the adult heart leads to an increase in coronary vessel density...
  17. pmc FGF14 regulates the intrinsic excitability of cerebellar Purkinje neurons
    Vikram G Shakkottai
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 33:81-8. 2009
    ..6 expression in Purkinje neurons, and that the loss of FGF14 impairs spontaneous and repetitive firing in Purkinje neurons by altering the expression of Nav1.6 channels...
  18. ncbi Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Dev Cell 8:85-95. 2005
    ..FGFs thus constitute all or part of the epicardial signal regulating myocardial growth and differentiation...
  19. pmc Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:15694-700. 2006
    ..This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity...
  20. pmc Fgf20 governs formation of primary and secondary dermal condensations in developing hair follicles
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Genes Dev 27:450-8. 2013
    ....
  21. pmc Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14
    David F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 26:14-26. 2007
    ..Impaired theta burst initiated long-term synaptic potentiation was also found in hippocampal slices from Fgf14(-/-) mice. These results suggest a role for FGF14 in certain spatial learning functions and synaptic plasticity...
  22. pmc FGF14 N-terminal splice variants differentially modulate Nav1.2 and Nav1.6-encoded sodium channels
    Fernanda Laezza
    Department of Developmental Biology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Cell Neurosci 42:90-101. 2009
    ..Thus, the FGF14 N-terminus is required for targeting and functional regulation of Nav channels, suggesting an important function for FGF14 alternative splicing in regulating neuronal excitability...
  23. pmc Beta-catenin deficiency causes DiGeorge syndrome-like phenotypes through regulation of Tbx1
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO, USA
    Development 137:1137-47. 2010
    ..These findings identify Wnt-beta-catenin signaling as a crucial upstream regulator of a Tbx1-Fgf8 signaling pathway and suggest that factors that affect Wnt-beta-catenin signaling could modify the incidence and severity of DGS...
  24. ncbi Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    Hongliang Hu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:49-60. 2005
    ..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development...
  25. pmc Analysis of a gain-of-function FGFR2 Crouzon mutation provides evidence of loss of function activity in the etiology of cleft palate
    Alison K Snyder-Warwick
    Division of Plastic Surgery, Departments of Developmental Biology and Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:2515-20. 2010
    ..Knowledge of how mesenchymal FGF signaling regulates palatal shelf development may ultimately lead to pharmacological approaches to reduce cleft palate incidence in genetically predisposed humans...
  26. pmc Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 133:173-80. 2006
    ..Thus, these data add to our understanding of FGF-mediated reciprocal epithelial-mesenchymal signaling...
  27. pmc Differentiation of the lateral compartment of the cochlea requires a temporally restricted FGF20 signal
    Sung Ho Huh
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Biol 10:e1001231. 2012
    ..The viability and hearing loss in Fgf20 knockout mice suggest that FGF20 may also be a deafness-associated gene in humans...
  28. pmc In vitro effects of recombinant otoconin 90 upon calcite crystal growth. Significance of tertiary structure
    Wenfu Lu
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 268:172-83. 2010
    ....
  29. pmc Regulation of cellular calcium in vestibular supporting cells by otopetrin 1
    Euysoo Kim
    Washington University School of Medicine, Department of Developmental Biology, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Neurophysiol 104:3439-50. 2010
    ..These data support a model in which OTOP1 acts as a sensor of the extracellular calcium concentration near supporting cells and responds to ATP in the endolymph to increase intracellular calcium levels during otoconia mineralization...
  30. pmc Shared circuitry: developmental signaling cascades regulate both embryonic and adult coronary vasculature
    Kory J Lavine
    Washington University School of Medicine, Department of Developmental Biology, St Louis, MO 63110, USA
    Circ Res 104:159-69. 2009
    ..We further describe the mechanism by which many of these same pathways also regulate the adult coronary vasculature and their potential use in the treatment of ischemic heart disease...
  31. pmc FGF9 and FGF20 maintain the stemness of nephron progenitors in mice and man
    Hila Barak
    Department of Developmental Biology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8103, St Louis, MO 63110, USA
    Dev Cell 22:1191-207. 2012
    ..These findings identify a long-sought-after critical component of the nephron stem cell niche and hold promise for long-term culture and utilization of these progenitors in vitro...
  32. pmc Development of the endochondral skeleton
    Fanxin Long
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cold Spring Harb Perspect Biol 5:a008334. 2013
    ..This review aims to integrate the known functions of extracellular signals and transcription factors that regulate development of the endochondral skeleton...
  33. pmc Delineating a conserved genetic cassette promoting outgrowth of body appendages
    Congxing Lin
    Division of Dermatology, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS Genet 9:e1003231. 2013
    ..These observations indicate that a conserved WNT-SP8-FGF8 genetic cassette is employed by both appendages for promoting outgrowth, and suggest a deep homology shared by the limb and external genitalia...
  34. pmc Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 276:391-402. 2004
    ..These studies demonstrate that Otop1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith...
  35. ncbi Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation
    Claudia M Garcia
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Dev Dyn 233:516-27. 2005
    ..It also contributes to the normal elongation of primary lens fiber cells and to the survival of lens epithelial cells...
  36. pmc FGF signaling in the developing endochondral skeleton
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Ave, St Louis, MO 63110, USA
    Cytokine Growth Factor Rev 16:205-13. 2005
    ..In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone...
  37. pmc Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Rm 3902 South Building Campus Box 8103, Washington University in St Louis, School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res 1091:58-74. 2006
    ....
  38. ncbi Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14
    Maolei Xiao
    Department of Molecular Biology and Pharmacology, Campus Box 8103, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Cell Neurosci 34:366-77. 2007
    ..These findings suggest a novel role for FGF14 in regulating synaptic plasticity via presynaptic mechanisms by affecting the mobilization, trafficking, or docking of synaptic vesicles to presynaptic active zones...
  39. ncbi Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice
    Elena G Ignatova
    Department of Otolaryngology, Washington University School of Medicine, 660 S Euclid Avenue, P O Box 8115, St Louis, MO 63110, USA
    Hear Res 194:65-72. 2004
    ....
  40. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    ..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected...
  41. pmc Healing of non-displaced fractures produced by fatigue loading of the mouse ulna
    Mario D Martinez
    Department of Orthopaedic Surgery, Washington University, St Louis, Missouri, USA
    Bone 46:1604-12. 2010
    ..In the future, the fatigue loading approach can be used create non-displaced bone fractures in transgenic and knockout mice to study the mechanisms by which the skeleton rapidly repairs damage...
  42. ncbi FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain
    Hisashi Umemori
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    Cell 118:257-70. 2004
    ..Inactivation of FGFR2 has similar effects. These results indicate that FGF22 and its relatives are presynaptic organizing molecules in the mammalian brain and suggest new functions for this family of signaling molecules...
  43. pmc Fibroblast growth factor expression during skeletal fracture healing in mice
    Gregory J Schmid
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 238:766-74. 2009
    ..These studies identify distinct groups of FGFs that are differentially expressed and suggest active stage-specific roles for FGF signaling during the fracture repair process...
  44. ncbi Bone morphogenetic protein receptor 1A signaling is dispensable for hematopoietic development but essential for vessel and atrioventricular endocardial cushion formation
    Changwon Park
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Development 133:3473-84. 2006
    ..Collectively, our studies indicate a crucial role for ALK3 in vessel remodeling, vessel integrity and endocardial cushion formation during the development of the circulation system...
  45. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
    ..These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear...
  46. ncbi Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Genet 24:33-40. 2008
    ..We focus on two key growth factor pathways: fibroblast growth factor and Hedgehog signaling...
  47. ncbi Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans
    Lynda M McDowell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 281:6924-30. 2006
    ..These studies demonstrated that specific glycosaminoglycans could be useful in treating ligand-dependent FGFR signaling-related diseases, such as Apert syndrome and cancer...
  48. pmc Identification of the Otopetrin Domain, a conserved domain in vertebrate otopetrins and invertebrate otopetrin-like family members
    Inna Hughes
    Department of Developmental Biology, Washington University School of Medicine, St, Louis, MO 63110, USA
    BMC Evol Biol 8:41. 2008
    ..Vertebrate Otop1 and its paralogues Otop2 and Otop3 define a new gene family with homology to the invertebrate Domain of Unknown Function 270 genes (DUF270; pfam03189)...
  49. pmc A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3
    Wenlin Yuan
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:5217-22. 2003
    ..This study establishes the first genetic model for CDH and identifies a previously unsuspected role for Slit3 in regulating the development of the diaphragm...
  50. pmc Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Cardiovasc Med 17:77-83. 2007
    ....
  51. ncbi Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1
    Belen Hurle
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Hum Mol Genet 12:777-89. 2003
    ..Otop1 and Otop1-like paralogues, Otop2 and Otop3, define a new gene family with homology to the C. elegans and D. melanoganster DUF270 genes...
  52. pmc Otopetrin 1 activation by purinergic nucleotides regulates intracellular calcium
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 104:12023-8. 2007
    ..In a physiologic setting, these activities could direct the formation and growth of otoconia and regulate other biomineralization processes...
  53. pmc A model for the pharmacological treatment of crouzon syndrome
    Chad A Perlyn
    Division of Plastic Surgery and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurosurgery 59:210-5; discussion 210-5. 2006
    ..The purpose of this study was to develop a pharmacological strategy using tyrosine kinase inhibition as a novel treatment for craniosynostotic syndromes caused by constitutive FGFR activation...
  54. pmc Histomorphological study of palatal shelf elevation during murine secondary palate formation
    Kai Yu
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, USA
    Dev Dyn 240:1737-44. 2011
    ..Our study provides a framework that recognizes variation in timing of palatal morphogenesis along the AP axis that will aid in the investigation of the mechanisms regulating palatal shelf elevation...
  55. ncbi FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:1446-65. 2002
  56. pmc Fibroblast growth factor 14 is an intracellular modulator of voltage-gated sodium channels
    Jun Yang Lou
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Physiol 569:179-93. 2005
    ..Together, these findings implicate FGF14 as a unique modulator of Nav channel activity in the CNS and provide a possible mechanism to explain the neurological phenotypes observed in mice and humans with mutations in Fgf14...