D M Ornitz

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bioessays 22:108-12. 2000
  2. ncbi FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:1446-65. 2002
  3. ncbi Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
    J Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 127:1833-43. 2000
  4. ncbi Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity
    A Chellaiah
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:34785-94. 1999
  5. ncbi The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
    W Yuan
    Department of Molecular Biology and Pharmacology, Department of Anatomy and Neurobiology, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 212:290-306. 1999
  6. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
  7. ncbi Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains
    Q Wang
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:3867-76. 2001
  8. ncbi Genomic structure, mapping, activity and expression of fibroblast growth factor 17
    J Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 83:165-78. 1999
  9. ncbi Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 216:72-88. 1999
  10. ncbi High-resolution mapping of tlt, a mouse mutant lacking otoconia
    H C Ying
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mamm Genome 10:544-8. 1999

Collaborators

Detail Information

Publications89

  1. ncbi FGFs, heparan sulfate and FGFRs: complex interactions essential for development
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Bioessays 22:108-12. 2000
    ..The establishment of a role for heparan sulfate in FGFR activation in vivo suggests that tissue-specific differences in the structure of heparan may modulate the activity of FGF. BioEssays 22:108-112, 2000...
  2. ncbi FGF signaling pathways in endochondral and intramembranous bone development and human genetic disease
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:1446-65. 2002
  3. ncbi Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures
    J Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 127:1833-43. 2000
    ..Finally, this developmental defect results in an ataxic gait in some mice...
  4. ncbi Mapping ligand binding domains in chimeric fibroblast growth factor receptor molecules. Multiple regions determine ligand binding specificity
    A Chellaiah
    Department of Molecular Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 274:34785-94. 1999
    ..These data demonstrate that multiple regions of the FGFR regulate ligand binding specificity and that these regions are distinct with respect to different members of the FGF family...
  5. ncbi The mouse SLIT family: secreted ligands for ROBO expressed in patterns that suggest a role in morphogenesis and axon guidance
    W Yuan
    Department of Molecular Biology and Pharmacology, Department of Anatomy and Neurobiology, Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 212:290-306. 1999
    ..The unique expression pattern in limb and other organs indicates additional potential functions of the Slit gene family...
  6. ncbi Receptor specificity of the fibroblast growth factor family
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:15292-7. 1996
    ..These data should serve as a biochemical foundation for determining developmental, physiological, and pathophysiological processes that involve FGF signaling pathways...
  7. ncbi Differential regulation of endochondral bone growth and joint development by FGFR1 and FGFR3 tyrosine kinase domains
    Q Wang
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:3867-76. 2001
    ....
  8. ncbi Genomic structure, mapping, activity and expression of fibroblast growth factor 17
    J Xu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 83:165-78. 1999
    ..In the developing great vessels Fgfl7 is preferentially expressed, suggesting that it may have a more prominent role in vascular growth...
  9. ncbi Genomic organization and embryonic expression of the mouse fibroblast growth factor 9 gene
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 216:72-88. 1999
    ..Fgf9 is coexpressed with other Fgf genes in some skeletal myoblasts, in limb apical ectoderm, in craniofacial ectoderm, and in the retina, inner ear, and tooth bud. Dev Dyn 1999;216:72-88...
  10. ncbi High-resolution mapping of tlt, a mouse mutant lacking otoconia
    H C Ying
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mamm Genome 10:544-8. 1999
    ..3 centiMorgans (cM) from the tilted locus. This study excludes both Fgfr3 and Hdh as candidate genes for tlt and identifies closely linked microsatellite markers that will be useful for the positional cloning of tlt...
  11. pmc Otoconin-90, the mammalian otoconial matrix protein, contains two domains of homology to secretory phospholipase A2
    Y Wang
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 95:15345-50. 1998
    ..The cloning of Oc90 will allow an examination of the role of this protein in otoconial biosynthesis and in diseases that affect the vestibular system...
  12. ncbi Repression of hedgehog signaling and BMP4 expression in growth plate cartilage by fibroblast growth factor receptor 3
    M C Naski
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, St Louis, MO 63110, USA
    Development 125:4977-88. 1998
    ....
  13. ncbi Mapping the mouse otoconin-90 (Oc90) gene to chromosome 15
    Y Wang
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri, 63110, USA
    Genomics 58:214-5. 1999
  14. ncbi Regulation of chondrocyte growth and differentiation by fibroblast growth factor receptor 3
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Novartis Found Symp 232:63-76; discussion 76-80, 272-82. 2001
    ..Analysis of these phenotypes and the biochemical consequences of the mutations in FGFR3 demonstrate that FGFR3-mediated signalling is an essential negative regulator of endochondral ossification...
  15. ncbi Overlapping expression and redundant activation of mesenchymal fibroblast growth factor (FGF) receptors by alternatively spliced FGF-8 ligands
    A G Blunt
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 272:3733-8. 1997
    ..These findings are consistent with the hypothesis that the multiple FGF-8 isoforms are functionally redundant and function to signal in paracrine (epithelial to mesenchymal) contexts...
  16. pmc Fibroblast growth factors
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genome Biol 2:REVIEWS3005. 2001
    ..When inappropriately expressed, some FGFs can contribute to the pathogenesis of cancer. A subset of the FGF family, expressed in adult tissue, is important for neuronal signal transduction in the central and peripheral nervous systems...
  17. ncbi Graded activation of fibroblast growth factor receptor 3 by mutations causing achondroplasia and thanatophoric dysplasia
    M C Naski
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 13:233-7. 1996
    ..Moreover, the mutations that are responsible for TD were more strongly activating than the mutation causing ACH, providing a biochemical explanation for the observation that the phenotype of TD is more severe than that of ACH...
  18. ncbi Lung hypoplasia and neonatal death in Fgf9-null mice identify this gene as an essential regulator of lung mesenchyme
    J S Colvin
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 128:2095-106. 2001
    ..We suggest a model whereby FGF9 signaling from the epithelium and reciprocal FGF10 signaling from the mesenchyme coordinately regulate epithelial airway branching and organ size during lung embryogenesis...
  19. ncbi Development and maintenance of otoconia: biochemical considerations
    R Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann N Y Acad Sci 942:162-78. 2001
    ....
  20. ncbi Subcellular and developmental expression of alternatively spliced forms of fibroblast growth factor 14
    Q Wang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 90:283-7. 2000
    ..The developmental expression pattern of Fgf14 in the cerebellum is complementary to that of Math1, a marker for proliferating granule cells in the external germinal layer...
  21. ncbi FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development
    C A MacArthur
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 121:3603-13. 1995
    ..FGF-8b and FGF-8c may therefore provide a mitogenic signal to the underlying mesenchyme during limb and craniofacial development...
  22. ncbi Physical mapping of the mouse tilted locus identifies an association between human deafness loci DFNA6/14 and vestibular system development
    B Hurle
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, Missouri 63110, USA
    Genomics 77:189-99. 2001
    ..3-p15 region. This analysis identified an inversion between the mouse and human genomes that places tlt and DFNA6/14 in close proximity...
  23. ncbi Male-to-female sex reversal in mice lacking fibroblast growth factor 9
    J S Colvin
    Department of Molecular Biology and, Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Cell 104:875-89. 2001
    ..While Sry is found only in some mammals, Fgfs are highly conserved. Thus, Fgfs may function in sex determination and reproductive system development in many species...
  24. ncbi MMTV-Fgf8 transgenic mice develop mammary and salivary gland neoplasia and ovarian stromal hyperplasia
    D Daphna-Iken
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Oncogene 17:2711-7. 1998
    ..These results demonstrate that production of FGF8b, and possibly other FGF8 isoforms, in the mammary and salivary glands contributes to oncogenesis, and that ovarian expression results in stromal hyperplasia...
  25. ncbi Identification and characterization of a novel member of the fibroblast growth factor family
    J M Greene
    Department of Molecular Biology and Pharmacology, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Eur J Neurosci 10:1911-25. 1998
    ..We have identified a novel member of the FGF family that is expressed in the central nervous system (CNS) and increases the number as well as the level of phenotypic differentiation of cortical neurons in vitro...
  26. ncbi Skeletal overgrowth and deafness in mice lacking fibroblast growth factor receptor 3
    J S Colvin
    Deparment of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 12:390-7. 1996
    ..Our results demonstrate that Fgfr3 is essential for normal endochondral ossification and inner ear development...
  27. ncbi Otoconial agenesis in tilted mutant mice
    D M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hear Res 122:60-70. 1998
    ..We further demonstrate that protein expression in the macular sensory epithelium is qualitatively unaltered in tilted mutant mice...
  28. ncbi Expression and biological activity of mouse fibroblast growth factor-9
    S Santos-Ocampo
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Biol Chem 271:1726-31. 1996
    ..Significantly, FGF-9 also binds to and activates the "b" splice form of FGFR3, thus becoming the first FGF ligand besides FGF-1 to activate this highly specific member of the FGF receptor family...
  29. ncbi Vertebrate slit, a secreted ligand for the transmembrane protein roundabout, is a repellent for olfactory bulb axons
    H S Li
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell 96:807-18. 1999
    ..These results establish a ligand-receptor relationship between two molecules important for neural development, suggest a role for Slit in olfactory bulb axon guidance, and reveal the existence of a new family of axon guidance molecules...
  30. ncbi FGF signalling generates ventral telencephalic cells independently of SHH
    Grigoriy Gutin
    Departments of Neuroscience and Molecular Genetics, Albert Einstein College of Medicine, 1410 Pelham Parkway South, Bronx, NY 10461, USA
    Development 133:2937-46. 2006
    ..Moreover, the Fgfr1;Fgfr2 phenotype, unlike the Shh phenotype, is not rescued by loss of Gli3, further indicating that FGFs act downstream of Shh and Gli3 to generate ventral telencephalic cell types...
  31. pmc A model for the pharmacological treatment of crouzon syndrome
    Chad A Perlyn
    Division of Plastic Surgery and Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurosurgery 59:210-5; discussion 210-5. 2006
    ..The purpose of this study was to develop a pharmacological strategy using tyrosine kinase inhibition as a novel treatment for craniosynostotic syndromes caused by constitutive FGFR activation...
  32. ncbi FGF18 is required for early chondrocyte proliferation, hypertrophy and vascular invasion of the growth plate
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 302:80-91. 2007
    ..FGF18 thus coordinates neovascularization of the growth plate with chondrocyte and osteoblast growth and differentiation...
  33. pmc Runx2 inhibits chondrocyte proliferation and hypertrophy through its expression in the perichondrium
    Eiichi Hinoi
    Department of Genetics and Development, Columbia University, College of Physicians and Surgeons, New York, NY 10032, USA
    Genes Dev 20:2937-42. 2006
    ..This study identifies a transcriptional basis for the inhibition of chondrocyte maturation by perichondrium and reveals that Runx2 fulfills antagonistic functions during chondrogenesis...
  34. pmc Fibroblast growth factor receptor 1 signaling in the osteo-chondrogenic cell lineage regulates sequential steps of osteoblast maturation
    Anne L Jacob
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:315-28. 2006
    ..These data demonstrate that signaling through FGFR1 in osteoblasts is necessary to maintain the balance between bone formation and remodeling through a direct effect on osteoblast maturation...
  35. pmc Fibroblast growth factor signals regulate a wave of Hedgehog activation that is essential for coronary vascular development
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 20:1651-66. 2006
    ..Consistent with this, activation of HH signaling in the adult heart leads to an increase in coronary vessel density...
  36. pmc Microscale analysis of proteins in inner ear tissues and fluids with emphasis on endolymphatic sac, otoconia, and organ of Corti
    Isolde Thalmann
    Department of Otolaryngology, Washington University School of Medicine, St Louis, MO 63110, USA
    Electrophoresis 27:1598-608. 2006
    ..These studies demonstrate how advanced preparatory and analytical techniques can be applied to studies of the inner ear...
  37. ncbi FGF9 and SHH signaling coordinate lung growth and development through regulation of distinct mesenchymal domains
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Development 133:1507-17. 2006
    ....
  38. ncbi Inhibition or activation of Apert syndrome FGFR2 (S252W) signaling by specific glycosaminoglycans
    Lynda M McDowell
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Biol Chem 281:6924-30. 2006
    ..These studies demonstrated that specific glycosaminoglycans could be useful in treating ligand-dependent FGFR signaling-related diseases, such as Apert syndrome and cancer...
  39. pmc Reciprocal epithelial-mesenchymal FGF signaling is required for cecal development
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 133:173-80. 2006
    ..Thus, these data add to our understanding of FGF-mediated reciprocal epithelial-mesenchymal signaling...
  40. ncbi Analysis of the biochemical mechanisms for the endocrine actions of fibroblast growth factor-23
    Xijie Yu
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, Indiana 46202, USA
    Endocrinology 146:4647-56. 2005
    ..Our biochemical findings provide important insights into the molecular mechanisms by which dysregulated FGF23 signaling leads to disorders of hyper- and hypophosphatemia...
  41. ncbi Fibroblast growth factor receptor 2 tyrosine kinase is required for prostatic morphogenesis and the acquisition of strict androgen dependency for adult tissue homeostasis
    Yongshun Lin
    Center for Cancer Biology and Nutrition, Institute of Biosciences and Technology, Texas A and M Health Science Center, 2121 W Holcombe Blvd, Houston, TX 77030 3303, USA
    Development 134:723-34. 2007
    ....
  42. pmc Rebuilding the coronary vasculature: hedgehog as a new candidate for pharmacologic revascularization
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Cardiovasc Med 17:77-83. 2007
    ....
  43. pmc Fgf9 signaling regulates small intestinal elongation and mesenchymal development
    Michael J Geske
    Department of Pathology and Immunology, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 135:2959-68. 2008
    ..Taken together, the interaction of FGF and TGFbeta signaling pathways in the intestinal mesenchyme could represent novel targets for future short bowel syndrome therapies...
  44. pmc Hedgehog signaling is critical for maintenance of the adult coronary vasculature in mice
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 118:2404-14. 2008
    ..Together, these data demonstrate that HH signaling is essential for cardiac function at the level of the coronary vasculature and caution against the use of HH antagonists in patients with prior or ongoing heart disease...
  45. pmc An FGF-WNT gene regulatory network controls lung mesenchyme development
    Yongjun Yin
    Department of Developmental Biology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 319:426-36. 2008
    ..Together, both FGF and WNT signaling pathways function to sustain mesenchymal growth and coordinate epithelial morphogenesis during the pseudoglandular stage of lung development...
  46. pmc Fibroblast growth factor receptor signaling is essential for lens fiber cell differentiation
    Haotian Zhao
    Graduate Program in Molecular, Cellular and Developmental Biology, College of Biological Sciences, The Ohio State University, Columbus, OH 43210, USA
    Dev Biol 318:276-88. 2008
    ..Therefore, while signaling by FGF receptors is essential for lens fiber differentiation, different FGF receptors function redundantly...
  47. doi Role of Fgf receptor 2c in adipocyte hypertrophy in mesenteric white adipose tissue
    Morichika Konishi
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Mol Cell Endocrinol 287:13-9. 2008
    ....
  48. doi Novel tool to suppress cell proliferation in vivo demonstrates that myocardial and coronary vascular growth represent distinct developmental programs
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 237:713-24. 2008
    ..Together, these studies strongly suggest that myocardial cell proliferation and coronary development are genetically separable programs exemplifying one of the many potential uses of this genetic tool...
  49. ncbi FGF signaling regulates mesenchymal differentiation and skeletal patterning along the limb bud proximodistal axis
    Kai Yu
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110 USA
    Development 135:483-91. 2008
    ....
  50. ncbi Fibroblast growth factors and Hedgehogs: at the heart of the epicardial signaling center
    Kory J Lavine
    Department of Developmental Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Trends Genet 24:33-40. 2008
    ..We focus on two key growth factor pathways: fibroblast growth factor and Hedgehog signaling...
  51. pmc FGF9 and SHH regulate mesenchymal Vegfa expression and development of the pulmonary capillary network
    Andrew C White
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Development 134:3743-52. 2007
    ..These data suggest a molecular mechanism through which FGF9 and SHH signaling coordinately control the growth and patterning of the lung capillary plexus, and regulate the temporal and spatial expression of Vegfa...
  52. ncbi Fibroblast growth factor receptors cooperate to regulate neural progenitor properties in the developing midbrain and hindbrain
    Jonna Saarimäki-Vire
    Institute of Biotechnology, Viikki Biocenter, University of Helsinki, 00014 Helsinki, Finland
    J Neurosci 27:8581-92. 2007
    ..We propose a model for regulation of progenitor cell self-renewal and neuronal differentiation by combinatorial intercellular signals in the ventral midbrain...
  53. pmc FGF9 regulates early hypertrophic chondrocyte differentiation and skeletal vascularization in the developing stylopod
    Irene H Hung
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Campus Box 8103, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 307:300-13. 2007
    ..In developing stylopod elements, FGF9 promotes chondrocyte hypertrophy at early stages and regulates vascularization of the growth plate and osteogenesis at later stages of skeletal development...
  54. ncbi Abnormalities in cartilage and bone development in the Apert syndrome FGFR2(+/S252W) mouse
    Yingli Wang
    Institute of Genetic Medicine, Department of Pediatrics, The Johns Hopkins University School of Medicine, 733 North Broadway, Baltimore, MD 21205, USA
    Development 132:3537-48. 2005
    ..Our results suggest that altered cartilage and bone development play a significant role in the pathogenesis of the Apert syndrome phenotype...
  55. ncbi Signaling through FGF receptor-2 is required for lens cell survival and for withdrawal from the cell cycle during lens fiber cell differentiation
    Claudia M Garcia
    Department of Ophthalmology and Visual Sciences, Washington University, St Louis, Missouri 63110, USA
    Dev Dyn 233:516-27. 2005
    ..It also contributes to the normal elongation of primary lens fiber cells and to the survival of lens epithelial cells...
  56. pmc Coordination of chondrogenesis and osteogenesis by fibroblast growth factor 18
    Zhonghao Liu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    Genes Dev 16:859-69. 2002
    ..These data demonstrate that FGF18 signals through another FGFR to regulate osteoblast growth. Signaling to multiple FGFRs positions FGF18 to coordinate chondrogenesis in the growth plate with osteogenesis in cortical and trabecular bone...
  57. ncbi Stat1 controls postnatal bone formation by regulating fibroblast growth factor signaling in osteoblasts
    Liping Xiao
    Department of Medicine, University of Connecticut Health Center, Farmington, Connecticut 06030 1850, USA
    J Biol Chem 279:27743-52. 2004
    ....
  58. ncbi A twist code determines the onset of osteoblast differentiation
    Peter Bialek
    Department of Molecular and Human Genetics, Bone Disease Program of Texas, Baylor College of Medicine, One Baylor Plaza, Houston, TX 77030, USA
    Dev Cell 6:423-35. 2004
    ..In vivo mutagenesis confirms the antiosteogenic function of the Twist box. Thus, relief of inhibition by Twist proteins is a mandatory event precluding osteoblast differentiation...
  59. ncbi Signalling by fibroblast growth factor receptor 3 and parathyroid hormone-related peptide coordinate cartilage and bone development
    Norio Amizuka
    Department of Oral Biological Science, Graduate School for Medical and Dental Sciences, Niigata University Faculty of Dentistry, Niigata 951 8514, Japan
    Bone 34:13-25. 2004
    ....
  60. ncbi Fibroblast growth factor (FGF) homologous factors share structural but not functional homology with FGFs
    Shaun K Olsen
    Department of Pharmacology, New York University School of Medicine, New York, New York 10016, USA
    J Biol Chem 278:34226-36. 2003
    ..Hence, FHFs and FGFs bear striking structural similarity but have diverged to direct related surfaces toward interaction with distinct protein targets...
  61. ncbi Conditional inactivation of FGF receptor 2 reveals an essential role for FGF signaling in the regulation of osteoblast function and bone growth
    Kai Yu
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    Development 130:3063-74. 2003
    ..Although differentiation of the osteoblast lineage was not disturbed, the proliferation of osteoprogenitors and the anabolic function of mature osteoblasts were severely affected...
  62. ncbi Fibroblast growth factor receptor 3 signaling regulates the onset of oligodendrocyte terminal differentiation
    Luke Y S Oh
    Department of Neuroscience, University of Connecticut Medical School, Farmington, Connecticut 06030 3401, USA
    J Neurosci 23:883-94. 2003
    ....
  63. ncbi Twist regulates cytokine gene expression through a negative feedback loop that represses NF-kappaB activity
    Drazen Sosic
    Department of Molecular Biology, University of Texas Southwestern Medical Center, 6000 Harry Hines Boulevard, Dallas, TX 75390, USA
    Cell 112:169-80. 2003
    ..These findings reveal an evolutionarily conserved signaling circuit in which twist proteins regulate cytokine signaling by establishing a negative feedback loop that represses the NF-kappaB-dependent cytokine pathway...
  64. ncbi Fgfr3 expression by astrocytes and their precursors: evidence that astrocytes and oligodendrocytes originate in distinct neuroepithelial domains
    Nigel P Pringle
    Wolfson Institute for Biomedical Research and Department of Biology, University College London, Gower Street, London WC1E 6BT, UK
    Development 130:93-102. 2003
    ..In addition, we found that mice with a targeted deletion in the Fgfr3 locus strongly upregulate Gfap in grey matter (protoplasmic) astrocytes, implying that signalling through Fgfr3 normally represses Gfap expression in vivo...
  65. ncbi Interaction of FGF, Ihh/Pthlh, and BMP signaling integrates chondrocyte proliferation and hypertrophic differentiation
    Eleonora Minina
    Otto Warburg Laboratory, Max Planck Institute for Molecular Genetics, Ihnestrasse 73, 14195 Berlin, Germany
    Dev Cell 3:439-49. 2002
    ..We propose a model in which the balance of BMP and FGF signaling adjusts the pace of the differentiation process to the proliferation rate...
  66. pmc FGF signaling in the developing endochondral skeleton
    David M Ornitz
    Department of Molecular Biology and Pharmacology, Washington University Medical School, Campus Box 8103, 660 S Euclid Ave, St Louis, MO 63110, USA
    Cytokine Growth Factor Rev 16:205-13. 2005
    ..In this review, I will focus on the role of FGF signaling in chondrocytes and osteoblasts and how FGFs regulate the growth and development of endochondral bone...
  67. ncbi Fgf9 induces proliferation and nuclear localization of FGFR2 in Sertoli precursors during male sex determination
    Jennifer Schmahl
    Department of Cell Biology, Duke University, Durham, NC 27710, USA
    Development 131:3627-36. 2004
    ..The nuclear localization of FGFR2 coincides with the initiation of Sry expression and the nuclear localization of SOX9 during the early differentiation of Sertoli cells and the determination of male fate...
  68. ncbi FGF22 and its close relatives are presynaptic organizing molecules in the mammalian brain
    Hisashi Umemori
    Department of Anatomy and Neurobiology, Washington University Medical School, St Louis, MO 63110, USA
    Cell 118:257-70. 2004
    ..Inactivation of FGFR2 has similar effects. These results indicate that FGF22 and its relatives are presynaptic organizing molecules in the mammalian brain and suggest new functions for this family of signaling molecules...
  69. ncbi Fgf9 signaling regulates inner ear morphogenesis through epithelial-mesenchymal interactions
    Ulla Pirvola
    Institute of Biotechnology, University of Helsinki, 00014 Helsinki, Finland
    Dev Biol 273:350-60. 2004
    ..Together, these data show that Fgf9 signaling is required for inner ear morphogenesis...
  70. pmc Mutations that cause osteoglophonic dysplasia define novel roles for FGFR1 in bone elongation
    Kenneth E White
    Department of Medical and Molecular Genetics, Indiana University School of Medicine, Indianapolis, IN, USA
    Am J Hum Genet 76:361-7. 2005
    ....
  71. ncbi Endocardial and epicardial derived FGF signals regulate myocardial proliferation and differentiation in vivo
    Kory J Lavine
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, MO 63110, USA
    Dev Cell 8:85-95. 2005
    ..FGFs thus constitute all or part of the epicardial signal regulating myocardial growth and differentiation...
  72. ncbi Evolution of the Fgf and Fgfr gene families
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Yoshida Shimoadachi, Sakyo, Kyoto 606 8501, Japan
    Trends Genet 20:563-9. 2004
    ..The expansion of the Fgf and Fgfr gene families has enabled this signaling system to acquire functional diversity and, therefore, an almost ubiquitous involvement in developmental and physiological processes...
  73. ncbi Sequential roles of Hedgehog and Wnt signaling in osteoblast development
    Hongliang Hu
    Department of Medicine, Washington University Medical School, St Louis, MO 63110, USA
    Development 132:49-60. 2005
    ..Finally Wnt7b is identified as a potential endogenous ligand regulating osteogenesis. These data support a model that integrates Hh and Wnt signaling in the regulation of osteoblast development...
  74. ncbi Non-syndromic vestibular disorder with otoconial agenesis in tilted/mergulhador mice caused by mutations in otopetrin 1
    Belen Hurle
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Ave, St Louis, MO 63110, USA
    Hum Mol Genet 12:777-89. 2003
    ..Otop1 and Otop1-like paralogues, Otop2 and Otop3, define a new gene family with homology to the C. elegans and D. melanoganster DUF270 genes...
  75. ncbi Functional evolutionary history of the mouse Fgf gene family
    Nobuyuki Itoh
    Department of Genetic Biochemistry, Kyoto University Graduate School of Pharmaceutical Sciences, Sakyo, Kyoto, Japan
    Dev Dyn 237:18-27. 2008
    ..During the evolution of early vertebrates, the Fgf subfamilies further expanded to contain three or four members in each subfamily...
  76. pmc Otopetrin 1 is required for otolith formation in the zebrafish Danio rerio
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Washington University Medical School, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 276:391-402. 2004
    ..These studies demonstrate that Otop1 has an essential and conserved role in the timing of formation and the size and shape of the developing otolith...
  77. ncbi Regulation of osteocalcin gene expression by a novel Ku antigen transcription factor complex
    David M Willis
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:37280-91. 2002
    ..In toto, these data indicate that a novel Ku antigen complex assembles on the OC promoter, functioning in concert with Msx2 and Runx2 to regulate OC gene expression...
  78. ncbi Ataxia and paroxysmal dyskinesia in mice lacking axonally transported FGF14
    Qing Wang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis 63110, USA
    Neuron 35:25-38. 2002
    ..Together, these studies identify a novel function for FGF14 in neuronal signaling and implicate FGF14 in axonal trafficking and synaptosomal function...
  79. ncbi The FGF14(F145S) mutation disrupts the interaction of FGF14 with voltage-gated Na+ channels and impairs neuronal excitability
    Fernanda Laezza
    Department of Molecular Biology and Pharmacology, Washington University Medical School, St Louis, Missouri 63110, USA
    J Neurosci 27:12033-44. 2007
    ....
  80. pmc A genetic model for a central (septum transversum) congenital diaphragmatic hernia in mice lacking Slit3
    Wenlin Yuan
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:5217-22. 2003
    ..This study establishes the first genetic model for CDH and identifies a previously unsuspected role for Slit3 in regulating the development of the diaphragm...
  81. ncbi Molecular mechanisms underlying ectopic otoconia-like particles in the endolymphatic sac of embryonic mice
    Elena G Ignatova
    Department of Otolaryngology, Washington University School of Medicine, 660 S Euclid Avenue, P O Box 8115, St Louis, MO 63110, USA
    Hear Res 194:65-72. 2004
    ....
  82. ncbi Heparan and chondroitin sulfate on growth plate perlecan mediate binding and delivery of FGF-2 to FGF receptors
    Simone M L Smith
    Department of Molecular Medicine, College of Medicine, University of South Florida, 12901 Bruce B Downs Blvd, MDC Box 7 Tampa, FL 33612, USA
    Matrix Biol 26:175-84. 2007
    ..These data show that growth plate perlecan binds to FGF-2 by its HS chains but can only deliver FGF-2 to FGF receptors when its CS chains are removed...
  83. ncbi Impaired hippocampal synaptic transmission and plasticity in mice lacking fibroblast growth factor 14
    Maolei Xiao
    Department of Molecular Biology and Pharmacology, Campus Box 8103, Washington University Medical School, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Mol Cell Neurosci 34:366-77. 2007
    ..These findings suggest a novel role for FGF14 in regulating synaptic plasticity via presynaptic mechanisms by affecting the mobilization, trafficking, or docking of synaptic vesicles to presynaptic active zones...
  84. pmc Receptor specificity of the fibroblast growth factor family. The complete mammalian FGF family
    Xiuqin Zhang
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 281:15694-700. 2006
    ..This study completes the mitogenesis-based comparison of receptor specificity of the entire FGF family under standard conditions and should help in interpreting and predicting in vivo biological activity...
  85. pmc Impaired spatial learning and defective theta burst induced LTP in mice lacking fibroblast growth factor 14
    David F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 26:14-26. 2007
    ..Impaired theta burst initiated long-term synaptic potentiation was also found in hippocampal slices from Fgf14(-/-) mice. These results suggest a role for FGF14 in certain spatial learning functions and synaptic plasticity...
  86. ncbi Defective bone mineralization and osteopenia in young adult FGFR3-/- mice
    Gladys Valverde-Franco
    Department of Medicine and Centre for Bone and Periodontal Research, McGill University, Royal Victoria Hospital, 687 Pine Avenue West, Montreal, Quebec, Canada H3A 1A1
    Hum Mol Genet 13:271-84. 2004
    ..Our observations reveal a role for FGFR3 in post-natal bone growth and remodelling, which identifies it as a potential therapeutic target for osteopenic disorders and those associated with defective bone mineralization...
  87. pmc Fibroblast growth factor homologous factors control neuronal excitability through modulation of voltage-gated sodium channels
    Mitchell Goldfarb
    Department of Biological Sciences, Hunter College of City University, New York, NY 10021, USA
    Neuron 55:449-63. 2007
    ..These findings offer a physiological mechanism underlying human spinocerebellar ataxia induced by Fhf4 mutation and suggest a broad role for FHFs in the control of excitability throughout the CNS...
  88. pmc Mixing model systems: using zebrafish and mouse inner ear mutants and other organ systems to unravel the mystery of otoconial development
    Inna Hughes
    Department of Molecular Biology and Pharmacology, Rm 3902 South Building Campus Box 8103, Washington University in St Louis, School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res 1091:58-74. 2006
    ....
  89. ncbi Conserved roles for Slit and Robo proteins in midline commissural axon guidance
    Hua Long
    Howard Hughes Medical Institute, Department of Biological Sciences, Stanford University, Stanford, CA 94305, USA
    Neuron 42:213-23. 2004
    ..These results demonstrate a key role for Slit/Robo signaling in midline commissural axon guidance in vertebrates...