KAREN L O'MALLEY

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death
    Neeraj Pandey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 7:e45149. 2012
  2. ncbi request reprint Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons
    KAREN L O'MALLEY
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28210-9. 2003
  3. pmc 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
    Alison I Bernstein
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St, Louis, MO 63110, USA
    Mol Neurodegener 6:2. 2011
  4. ncbi request reprint Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons
    KAREN L O'MALLEY
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurobiol Dis 14:43-51. 2003
  5. ncbi request reprint Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:30469-80. 2005
  6. ncbi request reprint Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics
    William A Holtz
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 99:54-69. 2006
  7. pmc Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:5412-25. 2012
  8. pmc Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:35827-38. 2009
  9. pmc Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus
    Carolyn A Purgert
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, and Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 34:4589-98. 2014
  10. ncbi request reprint Rat tyrosine hydroxylase promoter directs tetracycline-inducible foreign gene expression in dopaminergic cell types
    Mossa Gardaneh
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res Mol Brain Res 126:173-80. 2004

Research Grants

Collaborators

Detail Information

Publications23

  1. pmc Sequences located within the N-terminus of the PD-linked LRRK2 lead to increased aggregation and attenuation of 6-hydroxydopamine-induced cell death
    Neeraj Pandey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri, USA
    PLoS ONE 7:e45149. 2012
    ..Finally, in support of the hypothesis that aggregates represent a self-protection strategy, aggregated N-terminal LRRK2 constructs significantly attenuated cell death induced by the PD-mimetic, 6-hydroxydopamine (6-OHDA)...
  2. ncbi request reprint Activation of metabotropic glutamate receptor mGlu5 on nuclear membranes mediates intranuclear Ca2+ changes in heterologous cell types and neurons
    KAREN L O'MALLEY
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 278:28210-9. 2003
    ..Similarly, activation of mGlu5 receptors expressed on neuronal nuclei led to sustained Ca2+ oscillatory responses. These results suggest mGlu5 may mediate intranuclear signaling pathways...
  3. pmc 6-OHDA generated ROS induces DNA damage and p53- and PUMA-dependent cell death
    Alison I Bernstein
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St, Louis, MO 63110, USA
    Mol Neurodegener 6:2. 2011
    ..abstract:..
  4. ncbi request reprint Targeted expression of BCL-2 attenuates MPP+ but not 6-OHDA induced cell death in dopaminergic neurons
    KAREN L O'MALLEY
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurobiol Dis 14:43-51. 2003
    ..Thus, differential cell death pathways are associated with these cytotoxic signals in primary models of Parkinson's disease...
  5. ncbi request reprint Functional metabotropic glutamate receptors on nuclei from brain and primary cultured striatal neurons. Role of transporters in delivering ligand
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 280:30469-80. 2005
    ..These studies demonstrated that mGlu5 receptors play a dynamic role in signaling both on and off the plasma membrane...
  6. ncbi request reprint Oxidative stress-triggered unfolded protein response is upstream of intrinsic cell death evoked by parkinsonian mimetics
    William A Holtz
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 99:54-69. 2006
    ..Taken together, 6-OHDA-mediated cell death in dopaminergic cells proceeds via ROS-dependent UPR up-regulation which leads to an interaction with the intrinsic mitochondrial pathway and downstream caspase activation...
  7. pmc Activation of intracellular metabotropic glutamate receptor 5 in striatal neurons leads to up-regulation of genes associated with sustained synaptic transmission including Arc/Arg3.1 protein
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 287:5412-25. 2012
    ..Taken together, these data highlight the importance of intracellular mGluR5 in the cascade of events associated with sustained synaptic transmission...
  8. pmc Intracellular metabotropic glutamate receptor 5 (mGluR5) activates signaling cascades distinct from cell surface counterparts
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 284:35827-38. 2009
    ..Glutamate activation of intracellular mGluR5 serves an important role in the regulation of nuclear Ca(2+), transcriptional activation, and gene expression necessary for physiological processes such as synaptic plasticity...
  9. pmc Intracellular mGluR5 can mediate synaptic plasticity in the hippocampus
    Carolyn A Purgert
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, and Department of Psychiatry and Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine, St Louis, Missouri 63110
    J Neurosci 34:4589-98. 2014
    ..These data suggest a physiologically relevant and important role for intracellular mGluR5 in hippocampal synaptic plasticity. ..
  10. ncbi request reprint Rat tyrosine hydroxylase promoter directs tetracycline-inducible foreign gene expression in dopaminergic cell types
    Mossa Gardaneh
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, St Louis, MO 63110, USA
    Brain Res Mol Brain Res 126:173-80. 2004
    ..Taken together, these data suggest that targeted, inducible gene expression can be achieved in dopaminergic cell types...
  11. ncbi request reprint Wld(S) mice are protected against the Parkinsonian mimetic MPTP
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Campus Box 8108, 660 S Euclid Ave, St Louis, MO 63110, USA
    Exp Neurol 202:93-9. 2006
    ..These results suggest new therapeutic avenues for Parkinson's disease...
  12. ncbi request reprint Cell stress induced by the parkinsonian mimetic, 6-hydroxydopamine, is concurrent with oxidation of the chaperone, ERp57, and aggresome formation
    Jeong Sook Kim-Han
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Antioxid Redox Signal 9:2255-64. 2007
    ..Understanding the signaling mechanisms associated with parkinsonian mimetics, as well as their temporal induction, may aid in designing better interventions in models of PD...
  13. pmc Activated nuclear metabotropic glutamate receptor mGlu5 couples to nuclear Gq/11 proteins to generate inositol 1,4,5-trisphosphate-mediated nuclear Ca2+ release
    Vikas Kumar
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 283:14072-83. 2008
    ..Thus the nucleus can function as an autonomous organelle independent of signals originating in the cytoplasm, and nuclear mGlu5 receptors play a dynamic role in mobilizing Ca2+ in a specific, localized fashion...
  14. ncbi request reprint Nuclear localization of functional metabotropic glutamate receptor mGlu1 in HEK293 cells and cortical neurons: role in nuclear calcium mobilization and development
    Yuh Jiin I Jong
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 101:458-69. 2007
    ....
  15. pmc The parkinsonian mimetic, MPP+, specifically impairs mitochondrial transport in dopamine axons
    Jeong Sook Kim-Han
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    J Neurosci 31:7212-21. 2011
    ..Since these drugs also rescued processes from degeneration, these findings emphasize the need to develop therapeutics aimed at axons as well as cell bodies to preserve "normal" circuitry and function as long as possible...
  16. pmc MPP+-induces PUMA- and p53-dependent, but ATF3-independent cell death
    Alison I Bernstein
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Toxicol Lett 219:93-8. 2013
    ..These studies revealed that PUMA and p53, but not ATF3, are required for MPP(+)-induced cell death, suggesting that UPR activation is parallel to the induction of MPP(+)-induced cell death...
  17. pmc WldS but not Nmnat1 protects dopaminergic neurites from MPP+ neurotoxicity
    Jo Ann V Antenor-Dorsey
    Department of Anatomy and Neurobiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Mol Neurodegener 7:5. 2012
    ..Here, we used dissociated dopaminergic cultures to test the hypothesis that catalytically active Nmnat1 protects dopaminergic neurons from toxin-mediated axonal injury...
  18. pmc The Parkinsonian mimetic, 6-OHDA, impairs axonal transport in dopaminergic axons
    Xi Lu
    Department of Biomedical Engineering, Washington University in Saint Louis, 1 Brookings Drive, Campus Box 1097, St, Louis, MO 63130, USA
    Mol Neurodegener 9:17. 2014
    ..The results from the study suggest that ROS-mediated transport dysfunction occurs early and plays a significant role in inducing axonal degeneration in response to 6-OHDA treatment. ..
  19. ncbi request reprint Dopamine depletion does not protect against acute 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine toxicity in vivo
    Daphne M Hasbani
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:9428-33. 2005
    ..These results suggest that DA does not contribute to acute MPTP toxicity in vivo...
  20. ncbi request reprint Alpha-synuclein protects naive but not dbcAMP-treated dopaminergic cell types from 1-methyl-4-phenylpyridinium toxicity
    Penny J Jensen
    Washington University School of Medicine, Anatomy and Neurobiology Department, St Louis, Missouri 63110, USA
    J Neurochem 86:196-209. 2003
    ..These results suggest that the normal physiological role for alpha-synuclein may change during development...
  21. pmc A microdevice platform for visualizing mitochondrial transport in aligned dopaminergic axons
    Xi Lu
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Neurosci Methods 209:35-9. 2012
    ..The methodology and device that we have described here will allow further study of the role of mitochondrial transport defects play in major neurodegenerative diseases...
  22. ncbi request reprint Microarray expression profiling identifies early signaling transcripts associated with 6-OHDA-induced dopaminergic cell death
    William A Holtz
    Washington University School of Medicine, Anatomy and Neurobiology Department, St Louis, MO 63110, USA
    Antioxid Redox Signal 7:639-48. 2005
    ..Taken together, these data support the notion that oxidative stress and protein dysfunction play a role in Parkinson's disease, as well as provide a time course for many of the molecular events associated with 6-OHDA neurotoxicity...
  23. pmc Reduced striatal dopamine underlies the attention system dysfunction in neurofibromatosis-1 mutant mice
    Jacquelyn A Brown
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    Hum Mol Genet 19:4515-28. 2010
    ..Collectively, these data establish abnormal DA homeostasis as the primary biochemical defect underlying the attention system dysfunction in Nf1 GEM relevant to children with NF1...

Research Grants40

  1. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 1990
    ..Understanding such structural requirements will help us understand the mechanisms which contribute to neuronal phonotypic diversity and development and perhaps, atypical catecholamine expression...
  2. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2005
    ....
  3. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 2000
    ..Taken together these studies will significantly extend our ongoing efforts to understand the complex receptor/presynaptic effector interactions involved in the reinforcing and behavioral sensitization effects of cocaine. ..
  4. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2000
    ..Conceivably, knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  5. Signaling By Nuclear G-Protein Coupled Receptors
    KAREN O MALLEY; Fiscal Year: 2005
    ..Direct nuclear calcium regulation represents a novel signaling strategy by which intracellular receptors such as mGlu5 may play a pivotal role in generating and shaping intracellular Ca2+ signals ..
  6. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 2001
    ..Taken together these studies will significantly extend our ongoing efforts to understand the complex receptor/presynaptic effector interactions involved in the reinforcing and behavioral sensitization effects of cocaine. ..
  7. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2004
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  8. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2003
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  9. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2009
    ....
  10. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2006
    ....
  11. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2004
    ....
  12. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2009
    ....
  13. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2005
    ..We anticipate that these investigations of mGluR dimerization will deepen our understanding of neural communication and signal transduction, processes that underlie brain function and dysfunction. ..
  14. Functional Consequences of Nuclear mGlu5 Receptor Activation
    KAREN O MALLEY; Fiscal Year: 2007
    ....
  15. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2007
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  16. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN O MALLEY; Fiscal Year: 2007
    ....
  17. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2006
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  18. Metabotropic Receptors: Structure/Function/Regulation
    KAREN O MALLEY; Fiscal Year: 2006
    ..We anticipate that these investigations of mGluR dimerization will deepen our understanding of neural communication and signal transduction, processes that underlie brain function and dysfunction. ..
  19. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 1999
    ..Conceivably, knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  20. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 1991
    ..Understanding such structural requirements will help us understand the mechanisms which contribute to neuronal phonotypic diversity and development and perhaps, atypical catecholamine expression...
  21. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2001
    ..Conceivably, knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  22. MODULATION OF DOPAMINE AUTORECEPTOR FUNCTION BY COCAINE
    KAREN O MALLEY; Fiscal Year: 1999
    ..Taken together these studies will significantly extend our ongoing efforts to understand the complex receptor/presynaptic effector interactions involved in the reinforcing and behavioral sensitization effects of cocaine. ..
  23. TRANSCRIPTIONAL CONTROL OF NEUROENDOCRINE GENES
    KAREN O MALLEY; Fiscal Year: 2005
    ..Knowledge gained from these studies may offer new routes for therapeutic intervention. ..
  24. MECHANISMS OF NEURONAL DEATH IN PARKINSON'S DISEASE
    KAREN L O apos MALLEY; Fiscal Year: 2010
    ....