J W Olney

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 133:115-26. 2002
  2. ncbi NMDA receptor hypofunction model of schizophrenia
    J W Olney
    Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110 1093, USA
    J Psychiatr Res 33:523-33. 1999
  3. ncbi Excitotoxicity, apoptosis and neuropsychiatric disorders
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63124, USA
    Curr Opin Pharmacol 3:101-9. 2003
  4. ncbi New insights and new issues in developmental neurotoxicology
    John W Olney
    Departments of Psychiatry and Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurotoxicology 23:659-68. 2002
  5. ncbi Drug-induced apoptotic neurodegeneration in the developing brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 12:488-98. 2002
  6. ncbi The enigma of fetal alcohol neurotoxicity
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Med 34:109-19. 2002
  7. ncbi Glutamate signaling and the fetal alcohol syndrome
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ment Retard Dev Disabil Res Rev 7:267-75. 2001
  8. ncbi Ethanol-induced apoptotic neurodegeneration in the developing brain
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Apoptosis 5:515-21. 2000
  9. ncbi Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:1234-40. 1997
  10. ncbi Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer's disease
    D F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 5:305-22. 1998

Collaborators

Detail Information

Publications51

  1. ncbi Ethanol-induced apoptotic neurodegeneration in the developing C57BL/6 mouse brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 133:115-26. 2002
    ....
  2. ncbi NMDA receptor hypofunction model of schizophrenia
    J W Olney
    Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110 1093, USA
    J Psychiatr Res 33:523-33. 1999
    ..In this article, we examine this hypothesis in terms of its strengths and weaknesses, its therapeutic implications and ways in which it can be further tested...
  3. ncbi Excitotoxicity, apoptosis and neuropsychiatric disorders
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63124, USA
    Curr Opin Pharmacol 3:101-9. 2003
    ..Recent findings shed new light on this issue, especially with respect to in vivo apoptosis, and views that are contrary to prevailing interpretations are expressed, especially in the burgeoning apoptosis field of inquiry...
  4. ncbi New insights and new issues in developmental neurotoxicology
    John W Olney
    Departments of Psychiatry and Pathology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurotoxicology 23:659-68. 2002
    ..Many other chemicals in the human environment remain to be evaluated for their ability to cause developing CNS neurons to commit suicide, and this provides an exciting challenge for the field of developmental neurotoxicology...
  5. ncbi Drug-induced apoptotic neurodegeneration in the developing brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Brain Pathol 12:488-98. 2002
    ....
  6. ncbi The enigma of fetal alcohol neurotoxicity
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Med 34:109-19. 2002
    ....
  7. ncbi Glutamate signaling and the fetal alcohol syndrome
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ment Retard Dev Disabil Res Rev 7:267-75. 2001
    ....
  8. ncbi Ethanol-induced apoptotic neurodegeneration in the developing brain
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Apoptosis 5:515-21. 2000
    ....
  9. ncbi Excitotoxic neurodegeneration in Alzheimer disease. New hypothesis and new therapeutic strategies
    J W Olney
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:1234-40. 1997
    ....
  10. ncbi Disseminated corticolimbic neuronal degeneration induced in rat brain by MK-801: potential relevance to Alzheimer's disease
    D F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Neurobiol Dis 5:305-22. 1998
    ..The cell death process evolved relatively slowly and was still ongoing 7 days posttreatment. Relevance of these results to AD is discussed...
  11. ncbi A comparative evaluation of the neurotoxic properties of ketamine and nitrous oxide
    V Jevtovic-Todorovic
    Department of Anesthesiology, Washington University School of Medicine, 660 S Euclid Ave, P O Box 8054, St Louis, MO 63110, USA
    Brain Res 895:264-7. 2001
    ..In this study we found that ketamine has this same age and sex dependency profile, and N(2)O has the same age but not sex dependency. Male and female rats are equally sensitive to N(2)O neurotoxicity...
  12. ncbi Propofol and sodium thiopental protect against MK-801-induced neuronal necrosis in the posterior cingulate/retrosplenial cortex
    V Jevtovic-Todorovic
    Department of Anesthesiology, Washington University School of Medicine, 660 South Euclid Avenue, P O Box 8054, St Louis, MO 63110, USA
    Brain Res 913:185-9. 2001
    ..Here we show that two GABAmimetic anesthetic agents--propofol and sodium thiopental--protect against the irreversible neurodegenerative reaction induced by the powerful NMDA antagonist, MK-801...
  13. ncbi Ethanol-induced neuronal apoptosis in vivo requires BAX in the developing mouse brain
    C Young
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Death Differ 10:1148-55. 2003
    ..Therefore, it appears that ethanol-induced neuroapoptosis is an intrinsic pathway-mediated phenomenon involving Bax-induced disruption of mitochondrial membranes and cytochrome c release as early events leading to caspase-3 activation...
  14. ncbi The glutamate synapse in neuropsychiatric disorders. Focus on schizophrenia and Alzheimer's disease
    N B Farber
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 6310 1093, USA
    Prog Brain Res 116:421-37. 1998
    ....
  15. pmc Acute neonatal glucocorticoid exposure produces selective and rapid cerebellar neural progenitor cell apoptotic death
    K K Noguchi
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110 1093, USA
    Cell Death Differ 15:1582-92. 2008
    ..This vulnerability may be related to the physiological role of glucocorticoids in regulating programmed cell death in the mammalian cerebellum...
  16. ncbi Apoptosis in the in vivo mammalian forebrain
    K Dikranian
    Department of Psychiatry Washington University School of Medicine, 4940 Children's Place, St. Louis, Missouri 63110, USA
    Neurobiol Dis 8:359-79. 2001
    ....
  17. ncbi The intact isolated (ex vivo) retina as a model system for the study of excitotoxicity
    C Romano
    Department of Ophthalmology, Washington University School of Medicine, St. Louis, MO 63110, USA
    Prog Retin Eye Res 17:465-83. 1998
    ..This paper summarizes the use of isolated retina as a model system for studies of excitotoxicity from a theoretical and methodological point of view, and reviews results obtained from studies utilizing this system...
  18. ncbi Redox modulation of T-type calcium channels in rat peripheral nociceptors
    S M Todorovic
    Department of Anesthesiology, Washington University School of Medicine, 63110, St Louis, MO, USA
    Neuron 31:75-85. 2001
    ..These data strongly suggest a role for T channels in peripheral nociception. Redox sites on T channels in peripheral nociceptors could be important targets for agents that modify pain perception...
  19. ncbi Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    N B Farber
    Washington University, Department of Psychiatry, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1009, USA
    Arch Gen Psychiatry 57:1165-73. 2000
    ....
  20. ncbi Olanzapine and fluperlapine mimic clozapine in preventing MK-801 neurotoxicity
    N B Farber
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Schizophr Res 21:33-7. 1996
    ....
  21. ncbi Distribution of metabotropic glutamate receptor mGluR5 immunoreactivity in rat brain
    C Romano
    Department of Ophthalmology and Visual Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    J Comp Neurol 355:455-69. 1995
    ..Light and electron microscopic evidence indicates that some mGluR5 immunoreactivity is located in presynaptic axon terminals, suggesting that mGluR5 may function as a presynaptic receptor...
  22. ncbi Behavioral phenotyping of GFAP-apoE3 and -apoE4 transgenic mice: apoE4 mice show profound working memory impairments in the absence of Alzheimer's-like neuropathology
    R E Hartman
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Exp Neurol 170:326-44. 2001
    ..Our findings suggest that apoE4 expression in the brain may have selective deleterious effects on memory function in the absence of typical Alzheimer's-like neuropathology...
  23. ncbi Morphological and electrophysiological evidence for an ionotropic GABA receptor of novel pharmacology
    D W Shen
    Department of Ophthalmology and Visual Science, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurophysiol 87:250-6. 2002
    ..Understanding the molecular properties of this receptor will be important for understanding both physiological GABA neurotransmission and the pathology of GABA receptor overactivation...
  24. pmc Potential of ketamine and midazolam, individually or in combination, to induce apoptotic neurodegeneration in the infant mouse brain
    Chainllie Young
    Department of Psychiatry, School of Medicine, Washington University in St Louis, Campus Box 8134, 660, South Euclid, St Louis, MO 63110, U S A
    Br J Pharmacol 146:189-97. 2005
    ..We conclude that relatively mild exposure to ketamine, midazolam or a combination of these drugs can trigger apoptotic neurodegeneration in the developing mouse brain...
  25. ncbi Neuroapoptosis in the infant mouse brain triggered by a transient small increase in blood alcohol concentration
    Chainllie Young
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Neurobiol Dis 22:548-54. 2006
    ..Since blood ethanol elevations in this range are commonly achieved by humans in a social drinking context, a mother with only a moderate drinking habit might expose her fetus to such elevations on multiple occasions during pregnancy...
  26. ncbi Low doses of memantine disrupt memory in adult rats
    Catherine Creeley
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:3923-32. 2006
    ..We conclude that, in the adult rat, memantine behaves like other NMDA antagonists in that it is neuroprotective only at doses that produce intolerable side effects, including memory impairment...
  27. ncbi Physiological activity depresses synaptic function through an effect on vesicle priming
    Krista L Moulder
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 26:6618-26. 2006
    ..These results show that glutamatergic neurotransmission persistently adapts to changes in electrical activity over a wide physiological range...
  28. ncbi Role of caspase-3 in ethanol-induced developmental neurodegeneration
    Chainllie Young
    Department of Psychiatry, Campus Box 8134, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Neurobiol Dis 20:608-14. 2005
    ..We conclude that absence of functional caspase-3 alters the time course and morphological characteristics of the neurodegenerative process but does not prevent ethanol-induced neuron death...
  29. pmc Spatiotemporal evolution of apoptotic neurodegeneration following traumatic injury to the developing rat brain
    Philip V Bayly
    Mechanical and Aerospace Engineering, Washington University in St Louis, MO 63130, USA
    Brain Res 1107:70-81. 2006
    ..Prevention of these apoptotic waves of brain damage is a realistic goal in view of the long delay between the impact event and onset of apoptotic degeneration...
  30. pmc Donepezil markedly potentiates memantine neurotoxicity in the adult rat brain
    Catherine E Creeley
    Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, St Louis, MO 63110, USA
    Neurobiol Aging 29:153-67. 2008
    ..These findings raise questions about using this drug combination in AD, especially in the absence of evidence that the combination is beneficial, or that either drug arrests or reverses the disease process...
  31. ncbi Cathepsin D deficiency induces persistent neurodegeneration in the absence of Bax-dependent apoptosis
    John J Shacka
    Department of Pathology, Neuropathology Division, University of Alabama at Birmingham, Birmingham, Alabama 35294, USA
    J Neurosci 27:2081-90. 2007
    ....
  32. ncbi Isoflurane-induced neuroapoptosis in the developing brain of nonhypoglycemic mice
    Stephen A Johnson
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Neurosurg Anesthesiol 20:21-8. 2008
    ..These findings are consistent with other recent evidence demonstrating that brief exposure to ethanol, ketamine, or midazolam triggers neuroapoptosis in the developing mouse brain...
  33. doi PRO: Anesthesia-induced developmental neuroapoptosis: status of the evidence
    Vesna Jevtovic-Todorovic
    Anesth Analg 106:1659-63. 2008
  34. doi Subanesthetic doses of propofol induce neuroapoptosis in the infant mouse brain
    Davide Cattano
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, PO BOX 8134, St Louis, MO 63110, USA
    Anesth Analg 106:1712-4. 2008
    ..p.) and found that doses >or=50 mg/kg induce a significant neuroapoptosis response. We conclude that propofol induces neuroapoptosis at 1/4 the dose required for surgical anesthesia...
  35. ncbi Ethanol-induced neuroapoptosis in the developing rodent cerebellum and related brain stem structures
    Krikor Dikranian
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Brain Res Dev Brain Res 155:1-13. 2005
    ....
  36. ncbi Calcium-stimulated adenylyl cyclases modulate ethanol-induced neurodegeneration in the neonatal brain
    James W Maas
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 25:2376-85. 2005
    ..Thus, AC1 and AC8 are critical modulators of neurodegeneration induced by activity blockade in the neonatal brain and represent genetic loci that may potentially modify the severity of fetal alcohol syndrome...
  37. ncbi Apoptotic neurodegeneration induced by ethanol in neonatal mice is associated with profound learning/memory deficits in juveniles followed by progressive functional recovery in adults
    David F Wozniak
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Dis 17:403-14. 2004
    ..We hypothesize that neuroapoptotic damage in homologous regions of human brain underlies cognitive deficits in FAS and the human brain of FAS victims has a similar capacity to effect functional recovery...
  38. ncbi Role of ammonia in reversal of glutamate-mediated Müller cell swelling in the rat retina
    Yukitoshi Izumi
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri
    Glia 48:44-50. 2004
    ..Rather, conversion of glutamate to glutamine in a reaction involving ammonia helps reverse Müller cell swelling following exposure to exogenous glutamate...
  39. ncbi Glutamate transporters and retinal excitotoxicity
    Yukitoshi Izumi
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Glia 39:58-68. 2002
    ..We conclude that TBOA-sensitive glutamate transporters play an important role in regulating the neurodegenerative effects of glutamate in the rat retina...
  40. pmc Antiepileptic drugs and apoptotic neurodegeneration in the developing brain
    Petra Bittigau
    Department of Pediatric Neurology, Children s Hospital, Charite Virchow Clinics, Humboldt University, Augustenburger Platz 1, 13353 Berlin, Germany
    Proc Natl Acad Sci U S A 99:15089-94. 2002
    ..Our findings present one possible mechanism to explain cognitive impairment and reduced brain mass associated with prenatal or postnatal exposure of humans to antiepileptic therapy...
  41. ncbi PDAPP; YFP double transgenic mice: a tool to study amyloid-beta associated changes in axonal, dendritic, and synaptic structures
    Robert P Brendza
    Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 456:375-83. 2003
    ....
  42. ncbi Early exposure to common anesthetic agents causes widespread neurodegeneration in the developing rat brain and persistent learning deficits
    Vesna Jevtovic-Todorovic
    Department of Anesthesiology, University of Virginia Health System, Charlottesville, Virginia 22908, USA
    J Neurosci 23:876-82. 2003
    ....
  43. ncbi Ethanol-induced apoptosis in the developing visual system during synaptogenesis
    Tatyana Tenkova
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Invest Ophthalmol Vis Sci 44:2809-17. 2003
    ..The present study was undertaken to determine to what extent the developing visual system is vulnerable to the apoptogenic effects of ethanol...
  44. ncbi Involvement of glutamate in ischemic neurodegeneration in isolated retina
    Yukitoshi Izumi
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Vis Neurosci 20:97-107. 2003
    ..These results suggest that simulated ischemia enhances glutamate-mediated neurotoxicity in part by depressing glutamate uptake. When glutamate transport is impaired, sub-millimolar glutamate concentrations become profoundly neurotoxic...
  45. ncbi Drugs of abuse that cause developing neurons to commit suicide
    Nuri B Farber
    Department of Psychiatry, Washington University, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Brain Res Dev Brain Res 147:37-45. 2003
    ..g. phencyclidine, ketamine, benzodiazepines, barbiturates) also suppress neuronal activity and drive developing neurons to commit suicide...
  46. ncbi Do pediatric drugs cause developing neurons to commit suicide?
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, St Louis, MO 63110, USA
    Trends Pharmacol Sci 25:135-9. 2004
  47. ncbi Excitotoxic versus apoptotic mechanisms of neuronal cell death in perinatal hypoxia/ischemia
    Chainllie Young
    Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Curr Mol Med 4:77-85. 2004
    ....
  48. ncbi Fetal alcohol syndrome at the cellular level
    John W Olney
    Addict Biol 9:137-49; discussion 151. 2004
    ..These recent findings help clarify important aspects of the fetal alcohol syndrome, and demonstrate the usefulness of an in vivo infant rodent model for studying the neurotoxic effects of ethanol on the developing central nervous system...
  49. ncbi Anesthesia-induced developmental neuroapoptosis. Does it happen in humans?
    John W Olney
    Anesthesiology 101:273-5. 2004
  50. ncbi Ethanol-induced caspase-3 activation in the in vivo developing mouse brain
    John W Olney
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Neurobiol Dis 9:205-19. 2002
    ....
  51. ncbi Multiple episodes of mild traumatic brain injury result in impaired cognitive performance in mice
    Catherine E Creeley
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Acad Emerg Med 11:809-19. 2004
    ....

Research Grants43

  1. DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSE
    John W Olney; Fiscal Year: 2010
    ..abstract_text> ..
  2. DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSE
    John Olney; Fiscal Year: 2004
    ....
  3. NEUROPROTECTION AGAINST RETINAL ISCHEMIA
    John Olney; Fiscal Year: 2001
    ..These studies will be conducted studies using Muller cell cultures to test this hypothesis. ..
  4. ACUTE BRAIN INJURY, MECHANISMS AND PROTECTION
    John Olney; Fiscal Year: 2001
    ..The long term goals are to clarify the underlying mechanisms and develop improved methods of treating human pediatric acute brain injury conditions. ..
  5. Anesthesia-Induced Developmental Neuroapoptosis in non-Human Primates
    John Olney; Fiscal Year: 2007
    ....
  6. DEVELOPMENTAL BRAIN DAMAGE BY DRUGS OF ABUSE
    John Olney; Fiscal Year: 2007
    ....
  7. Anesthesia-Induced Developmental Neuroapoptosis in non-Human Primates
    John W Olney; Fiscal Year: 2010
    ....
  8. Acute Brain Injury, Mechanisms and Consequences
    John Olney; Fiscal Year: 2007
    ..abstract_text> ..
  9. NEUROPROTECTION AGAINST RETINAL ISCHEMIA
    John Olney; Fiscal Year: 1993
    ....
  10. PCP, SIGMA OPIATES, AND GLUTAMERGIC TRANSMISSION
    John Olney; Fiscal Year: 1991
    ..In rat hippocampal slices we will study the ability of PCP/sigma opiate compounds to block long term potentiation...