Affiliation: Washington University School of Medicine
Country: USA


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    Ohlemiller K. Contributions of mouse models to understanding of age- and noise-related hearing loss. Brain Res. 2006;1091:89-102 pubmed
    ..Using these models, it should be possible to identify genes and alleles that promote the major forms of ARHL and their combinations. ..
  2. Ohlemiller K. Recent findings and emerging questions in cochlear noise injury. Hear Res. 2008;245:5-17 pubmed publisher
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    Ohlemiller K, Lett J, Gagnon P. Cellular correlates of age-related endocochlear potential reduction in a mouse model. Hear Res. 2006;220:10-26 pubmed
    ..Our results indicate that the sequence of strial degeneration in BALBs is like that suggested for humans. Additional strain comparisons we have performed suggest that genes governing strial melanin production do not play a role. ..
  4. Ohlemiller K, Rosen A, Gagnon P. A major effect QTL on chromosome 18 for noise injury to the mouse cochlear lateral wall. Hear Res. 2010;260:47-53 pubmed publisher
  5. Ohlemiller K, Dahl A, Gagnon P. Divergent aging characteristics in CBA/J and CBA/CaJ mouse cochleae. J Assoc Res Otolaryngol. 2010;11:605-23 pubmed publisher
    ..We conclude that CBA/CaJ mice differ both quantitatively and qualitatively from CBA/J in age-related cochlear pathology, and model different types of presbycusis. ..
  6. Ohlemiller K, Rybak Rice M, Rosen A, Montgomery S, Gagnon P. Protection by low-dose kanamycin against noise-induced hearing loss in mice: dependence on dosing regimen and genetic background. Hear Res. 2011;280:141-7 pubmed publisher
    ..Their human analogs may partly determine who is at elevated risk of acquired hearing loss. ..
  7. Ohlemiller K, Kaur T, Warchol M, Withnell R. The endocochlear potential as an indicator of reticular lamina integrity after noise exposure in mice. Hear Res. 2018;361:138-151 pubmed publisher
    ..The heightened vulnerability of young adult animals to noise exposure may in part reflect special sensitivity of the organ of Corti to acute lateral wall dysfunction at younger ages. This feature appears genetically modifiable. ..
  8. Ohlemiller K, Gagnon P. Genetic dependence of cochlear cells and structures injured by noise. Hear Res. 2007;224:34-50 pubmed
    ..Even within species, cellular targets of acute and permanent cochlear noise injury may vary with genetic makeup...
  9. Ohlemiller K, Jones S, Johnson K. Application of Mouse Models to Research in Hearing and Balance. J Assoc Res Otolaryngol. 2016;17:493-523 pubmed
    ..Here, we recount some of the history and successes of the use of mice in hearing and vestibular studies and offer guidelines to those considering how to apply mouse models. ..

More Information


  1. Ohlemiller K, Rice M, Lett J, Gagnon P. Absence of strial melanin coincides with age-associated marginal cell loss and endocochlear potential decline. Hear Res. 2009;249:1-14 pubmed publisher
    ..For any individual, genetic background, environmental influences, and stochastic events may work together to determine whether marginal cell density or function falls below some critical level, and thus whether EP decline occurs. ..
  2. Ohlemiller K, Kiener A, Gagnon P. QTL Mapping of Endocochlear Potential Differences between C57BL/6J and BALB/cJ mice. J Assoc Res Otolaryngol. 2016;17:173-94 pubmed publisher
    ..18 that includes Zeb1, Arhgap12, Mpp7, and Gjd4. This study marks the first exploration of natural gene variants that modulate the EP. Their orthologs may underlie some human hearing loss that originates in the lateral wall. ..
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    Ohlemiller K, Gagnon P. Apical-to-basal gradients in age-related cochlear degeneration and their relationship to "primary" loss of cochlear neurons. J Comp Neurol. 2004;479:103-16 pubmed
    ..Our findings suggest that these changes share a common triggering influence...
  4. Ohlemiller K. Mechanisms and genes in human strial presbycusis from animal models. Brain Res. 2009;1277:70-83 pubmed publisher
    ..Additional studies of these and other inbred mouse and rat models should reveal candidate processes and genes that promote EP decline in humans...
  5. Ohlemiller K, Rybak Rice M, Rellinger E, Ortmann A. Divergence of noise vulnerability in cochleae of young CBA/J and CBA/CaJ mice. Hear Res. 2011;272:13-20 pubmed publisher
    ..Since the cochlear cells whose fragility defines the early window appear to be hair cells, these loci may principally impact the mechanical or metabolic resiliency of hair cells or the organ of Corti...