Genomes and Genes
Affiliation: Washington University School of Medicine
- Cooper P, McClenaghan C, Chen X, Stary Weinzinger A, Nichols C. Conserved functional consequences of disease-associated mutations in the slide helix of Kir6.1 and Kir6.2 subunits of the ATP-sensitive potassium channel. J Biol Chem. 2017;292:17387-17398 pubmed publisher..This raises the possibility that, at least for some CS mutations, sulfonylurea therapy may not prove to be successful and highlights the need for detailed pharmacogenomic analyses of CS mutations. ..
- Nichols C, Singh G, Grange D. KATP channels and cardiovascular disease: suddenly a syndrome. Circ Res. 2013;112:1059-72 pubmed publisher..This realization of previously unconsidered consequences provides significant insight into the roles of the KATP channel in the cardiovascular system and suggests novel therapeutic possibilities. ..
- Levin M, Zhang H, Uchida K, Grange D, Singh G, Nichols C. Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome. Heart Rhythm. 2015;12:2316-24 pubmed publisher..The primary electrophysiologic consequence of cardiac KATP GOF is on the conduction system, particularly the AV node, resulting in conduction abnormalities in CS patients who carry KATP GOF mutations. ..
- Wang S, Borschel W, Heyman S, Hsu P, Nichols C. Conformational changes at cytoplasmic intersubunit interactions control Kir channel gating. J Biol Chem. 2017;292:10087-10096 pubmed publisher..We conclude that the removal of stabilizing CD-I salt bridges results in a collapsed state of the Kir domain. ..