Research Topics
Genomes and Genes
Species | Rodney D NewberrySummaryAffiliation: Washington University School of Medicine Country: USA Publications
Research Grants
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Detail Information
Publications
Aging impacts isolated lymphoid follicle fevelopment and functionKeely G McDonald
Department of Internal Medicine, Washington University School of Medicine, St, Louis, Missouri 63110, USA
Immun Ageing 8:1. 2011..abstract:..
Intestinal lymphoid tissues: is variety an asset or a liability?Rodney D Newberry
Department of Internal Medicine Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
Curr Opin Gastroenterol 24:121-8. 2008..This review summarizes recent progress in understanding the variety, formation, and function of these structures...- Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissuesKeely G McDonald
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Am J Pathol 176:2367-77. 2010..These results reveal DC participation in ILF transformation and maintenance and suggest that in part this may be due to CXCL13 production by these cells... - Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitisMatthew A Ciorba
Division of Gastroenterology, Washington University, St Louis, MO 63110, USA
J Immunol 184:3907-16. 2010..These findings support the possibility that targeted induction of IDO-1 is an approach deserving further investigation as a therapeutic strategy for diseases of intestinal inflammation... - Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestineJeremiah R McDole
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Nature 483:345-9. 2012..The preferential delivery of antigens to DCs with tolerogenic properties implies a key role for this GC function in intestinal immune homeostasis... 
Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid folliclesKeely G McDonald
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 174:5720-8. 2005..These observations indicate that ILFs contain Ag-naive lymphocytes, and suggest that events occurring within ILFs shape subsequent immune responses mediated by these lymphocytes...- Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue developmentCaihong Wang
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
Inflamm Bowel Dis 16:1751-62. 2010.... - Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoidsKeely G McDonald
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Pathol 180:984-97. 2012..These findings demonstrate in vivo roles for the expression of epithelial CRBPII and lumenal retinoids to imprint local gut DCs with an intestinal phenotype... - Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formationCaihong Wang
Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 181:4052-61. 2008.... - CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid folliclesKeely G McDonald
Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Pathol 170:1229-40. 2007..These observations define an essential role for CCR6 expression by B lymphocytes in localizing to intestinal lymphoid structures and in ILF development... - TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestineTerrence E Riehl
Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Am J Physiol Gastrointest Liver Physiol 286:G166-73. 2004..The immunolocalization of TNFR1 and COX-2 expression to subepithelial fibroblasts following LPS administration suggests that this cell type plays an intermediate role in LPS-induced radioprotection in the intestine... - Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in miceGregory J Gurtner
Division of Gastroenteroloyg, Washington University School of Medicine, St Louis, Missouri 63110, USA
Gastroenterology 125:1762-73. 2003..IDO is highly expressed in the mammalian intestine. We sought to determine whether IDO played a regulatory role in the T-cell helper 1 (Th1)-mediated trinitrobenzene sulfonic acid (TNBS) model of colitis... - AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of NotchJacob S Lee
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
Nat Immunol 13:144-51. 2012..Thus, AHR was essential for ILC22 cells and postnatal intestinal lymphoid tissues. Moreover, ILC22 subsets were heterogeneous in their requirement for Notch and their effect on the generation of intestinal lymphoid tissues... - PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterizationSatheesh K Sainathan
Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
Protein Expr Purif 44:94-103. 2005..This simplified approach for the expression, purification, and modification of a biologically potent form of murine GM-CSF should facilitate the study of central mechanisms of action in murine disease models... - Organizing a mucosal defenseRodney D Newberry
Department of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St. Louis, MO, USA
Immunol Rev 206:6-21. 2005..This review compares and contrasts the development and function of the four main organized gastrointestinal lymphoid tissues: CPs, isolated lymphoid follicles, PPs, and mesenteric LNs... - Whole-mount techniques to evaluate subepithelial cellular populations in the adult mouse intestineKeely G McDonald
Washington University School of Medicine, St. Louis, MO 63110, USA
Biotechniques 43:50, 52, 54 passim. 2007 - Microanatomy of the intestinal lymphatic systemMark J Miller
Department of Pathology and Immunology, St Louis, Missouri, USA
Ann N Y Acad Sci 1207:E21-8. 2010.... - Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) miceValerie Blanc
Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
Cancer Res 67:8565-73. 2007..These findings suggest that deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation... - Isolated Lymphoid Follicles are Dynamic Reservoirs for the Induction of Intestinal IgAKathryn A Knoop
Department of Internal Medicine, Washington University School of Medicine St Louis, MO, USA
Front Immunol 3:84. 2012..The ability of ILFs to expand and respond to help control the enteric flora makes this dynamic reservoir an important arm of IgA inductive sites in intestinal immunity... - Patients with late-adult-onset ulcerative colitis have better outcomes than those with early onset diseaseChristina Y Ha
Division of Gastroenterology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
Clin Gastroenterol Hepatol 8:682-687.e1. 2010..Given potential age-related differences in risk factors and immune function, we sought to determine if disease behavior or clinical outcomes differed between patients diagnosed with UC in later versus earlier stages of adulthood... - Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic disseminationScott A Handley
Washington University School of Medicine, Department of Molecular Microbiology, 660 S. Euclid Ave, Campus Box 8230, St. Louis, MO, 63110, USA
Infect Immun 73:8453-5. 2005..The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes... - Postgestational lymphotoxin/lymphotoxin beta receptor interactions are essential for the presence of intestinal B lymphocytesRodney D Newberry
Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Immunol 168:4988-97. 2002..Based upon the severity of the deficit of LP B lymphocytes we observed, these novel LT/LTbetaR-dependent events are of primary importance in directing the entry and residence of LP B lymphocytes... - Isolated lymphoid follicles can function as sites for induction of mucosal immune responsesRobin G Lorenz
Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 730, Birmingham, AL 35294 2170, USA
Ann N Y Acad Sci 1029:44-57. 2004..These findings support the concept that ILFs are formed in response to mucosal challenges, and may play a physiological role in the production of antigen-specific intestinal IgA... - Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I functionRobin G Lorenz
Department of Pathology, University of Alabama, Birmingham, AL 35294, USA
J Immunol 170:5475-82. 2003..These findings suggest that ILFs are organized intestinal lymphoid structures whose formation can be induced and whose mass can be expanded in response to mucosal challenges... - Villous B cells of the small intestine are specialized for invariant NK T cell dependencePeter Velazquez
Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
J Immunol 180:4629-38. 2008..These findings define a distinct population of conventional B cells in small intestinal villi, and suggest an immunologic link between CD1-restricted invariant NK T cells and this B cell population... - Lymphotoxin-independent expression of TNF-related activation-induced cytokine by stromal cells in cryptopatches, isolated lymphoid follicles, and Peyer's patchesRebekah T Taylor
Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
J Immunol 178:5659-67. 2007..These findings suggest that TRANCE on stromal cells contributes to the differentiation and maintenance of organized lymphoid aggregates in the small intestine... - Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotypeCaihong Wang
Dept. of Internal Medicine, Washington Univ. School of Medicine, 660 S. Euclid Ave, Box 8124, St. Louis, MO 63110, USA
Am J Physiol Gastrointest Liver Physiol 291:G595-604. 2006....
Research Grants
- Immunomodulatory role of lamina propria stromal cellsRodney Newberry; Fiscal Year: 2003..abstract_text> ..
- INTESTINAL MECHANISMS OF TOLERANCERodney Newberry; Fiscal Year: 2003..We believe that understanding how the gastrointestinal immune system maintains a state of tolerance to ingested soluble antigens is of paramount importance in understanding the pathogenesis of gastrointestinal inflammatory diseases. ..
- Isolated Lymphoid Follicle in AgingRodney Newberry; Fiscal Year: 2007..Future studies will attempt to manipulate specific steps in this process in a therapeutic manner. ..