Rodney D Newberry

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Aging impacts isolated lymphoid follicle fevelopment and function
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, Missouri 63110, USA
    Immun Ageing 8:1. 2011
  2. doi request reprint Intestinal lymphoid tissues: is variety an asset or a liability?
    Rodney D Newberry
    Department of Internal Medicine Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Gastroenterol 24:121-8. 2008
  3. pmc Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Pathol 176:2367-77. 2010
  4. pmc Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis
    Matthew A Ciorba
    Division of Gastroenterology, Washington University, St Louis, MO 63110, USA
    J Immunol 184:3907-16. 2010
  5. pmc Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 180:984-97. 2012
  6. pmc Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 38:769-81. 2013
  7. pmc Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    Jeremiah R McDole
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 483:345-9. 2012
  8. ncbi request reprint Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 174:5720-8. 2005
  9. pmc Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development
    Caihong Wang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Inflamm Bowel Dis 16:1751-62. 2010
  10. pmc Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation
    Caihong Wang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:4052-61. 2008

Research Grants

  1. Immunomodulatory role of lamina propria stromal cells
    Rodney Newberry; Fiscal Year: 2003
  2. INTESTINAL MECHANISMS OF TOLERANCE
    Rodney Newberry; Fiscal Year: 2003
  3. Isolated Lymphoid Follicle in Aging
    Rodney Newberry; Fiscal Year: 2007

Collaborators

Detail Information

Publications32

  1. pmc Aging impacts isolated lymphoid follicle fevelopment and function
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St, Louis, Missouri 63110, USA
    Immun Ageing 8:1. 2011
    ..abstract:..
  2. doi request reprint Intestinal lymphoid tissues: is variety an asset or a liability?
    Rodney D Newberry
    Department of Internal Medicine Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Gastroenterol 24:121-8. 2008
    ..This review summarizes recent progress in understanding the variety, formation, and function of these structures...
  3. pmc Dendritic cells produce CXCL13 and participate in the development of murine small intestine lymphoid tissues
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Pathol 176:2367-77. 2010
    ..These results reveal DC participation in ILF transformation and maintenance and suggest that in part this may be due to CXCL13 production by these cells...
  4. pmc Induction of IDO-1 by immunostimulatory DNA limits severity of experimental colitis
    Matthew A Ciorba
    Division of Gastroenterology, Washington University, St Louis, MO 63110, USA
    J Immunol 184:3907-16. 2010
    ..These findings support the possibility that targeted induction of IDO-1 is an approach deserving further investigation as a therapeutic strategy for diseases of intestinal inflammation...
  5. pmc Epithelial expression of the cytosolic retinoid chaperone cellular retinol binding protein II is essential for in vivo imprinting of local gut dendritic cells by lumenal retinoids
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 180:984-97. 2012
    ..These findings demonstrate in vivo roles for the expression of epithelial CRBPII and lumenal retinoids to imprint local gut DCs with an intestinal phenotype...
  6. pmc Intraepithelial type 1 innate lymphoid cells are a unique subset of IL-12- and IL-15-responsive IFN-γ-producing cells
    Anja Fuchs
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Immunity 38:769-81. 2013
    ..Thus, intraepithelial ILC1 may initiate IFN-γ responses against pathogens but contribute to pathology when dysregulated...
  7. pmc Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine
    Jeremiah R McDole
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nature 483:345-9. 2012
    ..The preferential delivery of antigens to DCs with tolerogenic properties implies a key role for this GC function in intestinal immune homeostasis...
  8. ncbi request reprint Adaptive immune responses are dispensable for isolated lymphoid follicle formation: antigen-naive, lymphotoxin-sufficient B lymphocytes drive the formation of mature isolated lymphoid follicles
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 174:5720-8. 2005
    ..These observations indicate that ILFs contain Ag-naive lymphocytes, and suggest that events occurring within ILFs shape subsequent immune responses mediated by these lymphocytes...
  9. pmc Effect of α4β7 blockade on intestinal lymphocyte subsets and lymphoid tissue development
    Caihong Wang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Inflamm Bowel Dis 16:1751-62. 2010
    ....
  10. pmc Alpha4beta7/MAdCAM-1 interactions play an essential role in transitioning cryptopatches into isolated lymphoid follicles and a nonessential role in cryptopatch formation
    Caihong Wang
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 181:4052-61. 2008
    ....
  11. pmc CC chemokine receptor 6 expression by B lymphocytes is essential for the development of isolated lymphoid follicles
    Keely G McDonald
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 170:1229-40. 2007
    ..These observations define an essential role for CCR6 expression by B lymphocytes in localizing to intestinal lymphoid structures and in ILF development...
  12. pmc IDO1 metabolites activate β-catenin signaling to promote cancer cell proliferation and colon tumorigenesis in mice
    Ameet I Thaker
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 145:416-25.e1-4. 2013
    ..We used genetic and pharmacologic approaches to manipulate IDO1 activity in mice with colitis-associated cancer and human colon cancer cell lines...
  13. pmc Transepithelial antigen delivery in the small intestine: different paths, different outcomes
    Kathryn A Knoop
    Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Gastroenterol 29:112-8. 2013
    ....
  14. pmc Murine isolated lymphoid follicles contain follicular B lymphocytes with a mucosal phenotype
    Caihong Wang
    Dept of Internal Medicine, Washington Univ School of Medicine, 660 S Euclid Ave, Box 8124, St Louis, MO 63110, USA
    Am J Physiol Gastrointest Liver Physiol 291:G595-604. 2006
    ....
  15. ncbi request reprint TNFR1 mediates the radioprotective effects of lipopolysaccharide in the mouse intestine
    Terrence E Riehl
    Division of Gastroenterology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Gastrointest Liver Physiol 286:G166-73. 2004
    ..The immunolocalization of TNFR1 and COX-2 expression to subepithelial fibroblasts following LPS administration suggests that this cell type plays an intermediate role in LPS-induced radioprotection in the intestine...
  16. ncbi request reprint PEGylated murine Granulocyte-macrophage colony-stimulating factor: production, purification, and characterization
    Satheesh K Sainathan
    Division of Gastroenterology, Department of Medicine, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Protein Expr Purif 44:94-103. 2005
    ..This simplified approach for the expression, purification, and modification of a biologically potent form of murine GM-CSF should facilitate the study of central mechanisms of action in murine disease models...
  17. pmc Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens
    Ansuman T Satpathy
    Department of Pathology and Immunology, School of Medicine, Washington University in St Louis, Missouri, USA
    Nat Immunol 14:937-48. 2013
    ..rodentium, but CD103(+) cDCs dependent on the transcription factor Batf3 were not. Our results demonstrate a nonredundant function for CD11b(+) cDCs in the response to pathogens in vivo. ..
  18. ncbi request reprint Inhibition of indoleamine 2,3-dioxygenase augments trinitrobenzene sulfonic acid colitis in mice
    Gregory J Gurtner
    Division of Gastroenteroloyg, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gastroenterology 125:1762-73. 2003
    ..IDO is highly expressed in the mammalian intestine. We sought to determine whether IDO played a regulatory role in the T-cell helper 1 (Th1)-mediated trinitrobenzene sulfonic acid (TNBS) model of colitis...
  19. pmc AHR drives the development of gut ILC22 cells and postnatal lymphoid tissues via pathways dependent on and independent of Notch
    Jacob S Lee
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Nat Immunol 13:144-51. 2012
    ..Thus, AHR was essential for ILC22 cells and postnatal intestinal lymphoid tissues. Moreover, ILC22 subsets were heterogeneous in their requirement for Notch and their effect on the generation of intestinal lymphoid tissues...
  20. ncbi request reprint Organizing a mucosal defense
    Rodney D Newberry
    Department of Internal Medicine, Division of Gastroenterology, Washington University School of Medicine, St Louis, MO, USA
    Immunol Rev 206:6-21. 2005
    ..This review compares and contrasts the development and function of the four main organized gastrointestinal lymphoid tissues: CPs, isolated lymphoid follicles, PPs, and mesenteric LNs...
  21. ncbi request reprint Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice
    Valerie Blanc
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer Res 67:8565-73. 2007
    ..These findings suggest that deletion of apobec-1, by modulating expression of AU-rich RNA targets, provides an important mechanism for attenuating a dominant genetic restriction point in intestinal adenoma formation...
  22. ncbi request reprint Whole-mount techniques to evaluate subepithelial cellular populations in the adult mouse intestine
    Keely G McDonald
    Washington University School of Medicine, St Louis, MO 63110, USA
    Biotechniques 43:50, 52, 54 passim. 2007
  23. pmc Microanatomy of the intestinal lymphatic system
    Mark J Miller
    Department of Pathology and Immunology, St Louis, Missouri, USA
    Ann N Y Acad Sci 1207:E21-8. 2010
    ....
  24. doi request reprint Identification of a functional TPH1 polymorphism associated with irritable bowel syndrome bowel habit subtypes
    Helmut Grasberger
    Department of Internal Medicine, University of Michigan Medical Center, Ann Arbor, Michigan, USA
    Am J Gastroenterol 108:1766-74. 2013
    ..In this study, we assessed the only common TPH1 proximal promoter variant (-347C/A; rs7130929) and its association with bowel habit predominance in IBS...
  25. pmc Isolated Lymphoid Follicles are Dynamic Reservoirs for the Induction of Intestinal IgA
    Kathryn A Knoop
    Department of Internal Medicine, Washington University School of Medicine St Louis, MO, USA
    Front Immunol 3:84. 2012
    ..The ability of ILFs to expand and respond to help control the enteric flora makes this dynamic reservoir an important arm of IgA inductive sites in intestinal immunity...
  26. pmc Patients with late-adult-onset ulcerative colitis have better outcomes than those with early onset disease
    Christina Y Ha
    Division of Gastroenterology, Washington University in St Louis School of Medicine, St Louis, Missouri 63110, USA
    Clin Gastroenterol Hepatol 8:682-687.e1. 2010
    ..Given potential age-related differences in risk factors and immune function, we sought to determine if disease behavior or clinical outcomes differed between patients diagnosed with UC in later versus earlier stages of adulthood...
  27. pmc Yersinia enterocolitica invasin-dependent and invasin-independent mechanisms of systemic dissemination
    Scott A Handley
    Washington University School of Medicine, Department of Molecular Microbiology, 660 S Euclid Ave, Campus Box 8230, St Louis, MO, 63110, USA
    Infect Immun 73:8453-5. 2005
    ..The invasin-dependent route is clearly discernible in mice devoid of intestinal Peyer's patches and mesenteric lymph nodes...
  28. ncbi request reprint Postgestational lymphotoxin/lymphotoxin beta receptor interactions are essential for the presence of intestinal B lymphocytes
    Rodney D Newberry
    Division of Gastroenterology, Department of Internal Medicine, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Immunol 168:4988-97. 2002
    ..Based upon the severity of the deficit of LP B lymphocytes we observed, these novel LT/LTbetaR-dependent events are of primary importance in directing the entry and residence of LP B lymphocytes...
  29. ncbi request reprint Isolated lymphoid follicles can function as sites for induction of mucosal immune responses
    Robin G Lorenz
    Department of Pathology, University of Alabama at Birmingham, 845 19th Street South BBRB 730, Birmingham, AL 35294 2170, USA
    Ann N Y Acad Sci 1029:44-57. 2004
    ..These findings support the concept that ILFs are formed in response to mucosal challenges, and may play a physiological role in the production of antigen-specific intestinal IgA...
  30. ncbi request reprint Isolated lymphoid follicle formation is inducible and dependent upon lymphotoxin-sufficient B lymphocytes, lymphotoxin beta receptor, and TNF receptor I function
    Robin G Lorenz
    Department of Pathology, University of Alabama, Birmingham, AL 35294, USA
    J Immunol 170:5475-82. 2003
    ..These findings suggest that ILFs are organized intestinal lymphoid structures whose formation can be induced and whose mass can be expanded in response to mucosal challenges...
  31. pmc Villous B cells of the small intestine are specialized for invariant NK T cell dependence
    Peter Velazquez
    Department of Pathology and Laboratory Medicine, University of California, Los Angeles, CA 90095, USA
    J Immunol 180:4629-38. 2008
    ..These findings define a distinct population of conventional B cells in small intestinal villi, and suggest an immunologic link between CD1-restricted invariant NK T cells and this B cell population...
  32. ncbi request reprint Lymphotoxin-independent expression of TNF-related activation-induced cytokine by stromal cells in cryptopatches, isolated lymphoid follicles, and Peyer's patches
    Rebekah T Taylor
    Department of Pathology and Laboratory Medicine, Emory University School of Medicine, 615 Michael Street, Atlanta, GA 30322, USA
    J Immunol 178:5659-67. 2007
    ..These findings suggest that TRANCE on stromal cells contributes to the differentiation and maintenance of organized lymphoid aggregates in the small intestine...

Research Grants3

  1. Immunomodulatory role of lamina propria stromal cells
    Rodney Newberry; Fiscal Year: 2003
    ..abstract_text> ..
  2. INTESTINAL MECHANISMS OF TOLERANCE
    Rodney Newberry; Fiscal Year: 2003
    ..We believe that understanding how the gastrointestinal immune system maintains a state of tolerance to ingested soluble antigens is of paramount importance in understanding the pathogenesis of gastrointestinal inflammatory diseases. ..
  3. Isolated Lymphoid Follicle in Aging
    Rodney Newberry; Fiscal Year: 2007
    ..Future studies will attempt to manipulate specific steps in this process in a therapeutic manner. ..