Research Topics
Genomes and Genes | Rosalind J NeumanSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Association between DQB1 and cervical cancer in patients with human papillomavirus and family controlsR J Neuman
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Obstet Gynecol 95:134-40. 2000..To overcome problems of misleading causal inferences common in traditional case-control studies, a family-based test, the transmission/disequilibrium test, was used...
Prenatal smoking exposure and dopaminergic genotypes interact to cause a severe ADHD subtypeRosalind J Neuman
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Biol Psychiatry 61:1320-8. 2007..We examined the joint effects of genetic and prenatal substance exposures on DSM-IV and population-defined subtypes of ADHD...
Estimation of prevalence of DSM-IV and latent class-defined ADHD subtypes in a population-based sample of child and adolescent twinsRosalind J Neuman
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Twin Res Hum Genet 8:392-401. 2005..As clinical samples are most commonly composed of male combined subtypes, the inattentive subtype of both sexes in the general population is an under-treated segment of the general population...
Clustering methods applied to allele sharing dataR J Neuman
Department of Psychiatry, Washington University, St Louis, Missouri 63110, USA
Genet Epidemiol 19:S57-63. 2000..These analyses indicate that classification tools may be useful for detecting susceptibility genes for complex traits...
Replication of linkage of familial hypobetalipoproteinemia to chromosome 3p in six kindredsRosalind J Neuman
Washington University School of Medicine, Department of Psychiatry, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
J Lipid Res 43:407-15. 2002..1-22. Haplotype analysis identified several meiotic crossover events, allowing us to narrow the critical region from 10 cM to 2.0 cM, between markers D3S2407 and D3S1767...
Clustering of eating disorder symptoms in a general population female twin sample: a latent class analysisAlexis E Duncan
Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Psychol Med 37:1097-107. 2007..The objective of the current study was to examine the clustering of ED symptoms in a general population sample using latent class analysis (LCA)...
Gene-environment interactions in the development of combined type ADHD: evidence for a synapse-based modelRichard D Todd
Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
Am J Med Genet B Neuropsychiatr Genet 144:971-5. 2007..The subtype specificity of these findings supports the concept that ADHD is composed of a group of distinct disorders...
Predictors of stability of attention-deficit/hyperactivity disorder subtypes from childhood to young adulthoodRichard D Todd
Department of Psychiatry, Washington University School of Medicine, Campus Box 8134, 660 S Euclid Avenue, St Louis, MO 63110, USA
J Am Acad Child Adolesc Psychiatry 47:76-85. 2008..To determine the 5-year prospective stability of population-based and DSM-IV subtypes of attention-deficit/hyperactivity disorder (ADHD) as well as to explore predictors of stability...
A risk allele for nicotine dependence in CHRNA5 is a protective allele for cocaine dependenceRichard A Grucza
Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
Biol Psychiatry 64:922-9. 2008..The goal of this study was to examine the association of this variant with cocaine dependence...
Familial clustering of latent class and DSM-IV defined attention-deficit/hyperactivity disorder (ADHD) subtypesErik R Rasmussen
Departments of Psychiatry and Genetics, Washington University School of Medicine, St Louis, MO 63110-1093, USA
J Child Psychol Psychiatry 45:589-98. 2004..These findings further extend previous work and are most consistent with the presence of multiple independent forms of ADHD...
Validation of population-based ADHD subtypes and identification of three clinically impaired subtypesHeather E Volk
Doctoral Program in Public Health Studies, Saint Louis University School of Public Health, Saint Louis, Missouri, USA
Am J Med Genet B Neuropsychiatr Genet 141:312-8. 2006..Comorbidity with CD, ODD, or MD does not significantly increase impairment among ADHD subtypes. The mild combined ADHD subtype represents a clinically significant but under-studied form of ADHD...
Association of a single nucleotide polymorphism in neuronal acetylcholine receptor subunit alpha 5 (CHRNA5) with smoking status and with 'pleasurable buzz' during early experimentation with smokingRichard Sherva
Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
Addiction 103:1544-52. 2008..To extend the previously identified association between a single nucleotide polymorphism (SNP) in neuronal acetylcholine receptor subunit alpha-5 (CHRNA5) and nicotine dependence to current smoking and initial smoking-experience phenotypes...
Collaborative analysis of DRD4 and DAT genotypes in population-defined ADHD subtypesRichard D Todd
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Child Psychol Psychiatry 46:1067-73. 2005..The goal of the current study is to test whether population-based ADHD subtypes defined by latent class analysis help resolve issues of variable findings across individual gene association studies...
CHRNB3 is more strongly associated with Fagerström test for cigarette dependence-based nicotine dependence than cigarettes per day: phenotype definition changes genome-wide association studies resultsJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 107:2019-28. 2012..e., CPD versus Fagerström test for cigarette dependence (FTCD) score as a measure of nicotine dependence) on genome-wide association studies of nicotine dependence...
Genetic analysis of the maximum drinks phenotypeScott F Saccone
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
BMC Genet 6:S124. 2005..The evidence suggests that chromosome 7 may harbor an additional locus influencing the maximum drinks consumption phenotype...
Gamma-aminobutyric acid receptor genes and nicotine dependence: evidence for association from a case-control studyArpana Agrawal
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 103:1027-38. 2008....
Reliability and stability of a semistructured DSM-IV interview designed for family studiesRichard D Todd
Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Campus Box 8134, St Louis, MO 63110, USA
J Am Acad Child Adolesc Psychiatry 42:1460-8. 2003....
A genome-wide association study of alcohol dependenceLaura J Bierut
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:5082-7. 2010..11 and 1.16. Further dissection of the alcoholism phenotype, to disentangle the influence of comorbid substance-use disorders, will be a next step in identifying genetic variants associated with alcohol dependence...
Discrimination of DSM-IV and latent class attention-deficit/hyperactivity disorder subtypes by educational and cognitive performance in a population-based sample of child and adolescent twinsRichard D Todd
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
J Am Acad Child Adolesc Psychiatry 41:820-8. 2002..This report contrasts two ADHD subtyping approaches on the prediction of cognitive function and educational achievement...
Replication of the latent class structure of Attention-Deficit/Hyperactivity Disorder (ADHD) subtypes in a sample of Australian twinsErik R Rasmussen
Washington University School of Medicine, St. Louis, MO 63110-1093, USA
J Child Psychol Psychiatry 43:1018-28. 2002..LCA and DSM-IV systems of ADHD classification identify different phenotypic groups, and the basis of this disparity merits further investigation...
Novel mutations of APOB cause ApoB truncations undetectable in plasma and familial hypobetalipoproteinemiaPin Yue
Division of Atherosclerosis, Nutrition and Lipid Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
Hum Mutat 20:110-6. 2002..5 readily detectable in plasma. Sequencing of the ApoB gene in families 1, 5, 18, 58, and 59 did not reveal mutations...
Lifetime psychiatric comorbidity of alcohol dependence and bulimia nervosa in womenAlexis E Duncan
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Drug Alcohol Depend 84:122-32. 2006..These results suggest that BN+AD+ women exhibit more severe psychopathology than either BN+AD- or BN-AD+ women and may represent a distinct subgroup within bulimia nervosa or alcohol dependence...
Reliability and stability of mothers' reports about their pregnancies with twinsWendy Reich
School of Medicine, Department of Psychiatry, Washington University, Campus Box 8134, 660 South Euclid, St Louis, MO 63110, USA
Twin Res 6:85-8. 2003..Kappas were equally high for the 47 mothers that were re-interviewed 6 to 18 months later. Mothers show good reliability and stability of reporting about events during pregnancy...
Comparison of male adolescent-report of attention-deficit/hyperactivity disorder (ADHD) symptoms across two cultures using latent class and principal components analysisErik R Rasmussen
Washington University School of Medicine, St Louis, MO 63110-1093, USA
J Child Psychol Psychiatry 43:797-805. 2002..The current findings indicate that if male adolescents endorse any ADHD symptoms there is a tendency for them to report combined type problems...
A systematic evaluation of ADHD and comorbid psychopathology in a population-based twin sampleHeather E Volk
Doctoral Program in Public Health Studies, Saint Louis University School of Public Health, St. Louis, MO 63110, USA
J Am Acad Child Adolesc Psychiatry 44:768-75. 2005..20; 95% CI, 0.30-4.77) classes. CONCLUSIONS: Internalizing and externalizing disorders did not cluster differentially within ADHD subtypes. LCA may provide a more precise characterization of comorbidity with ADHD...
Comorbidity between ADHD and symptoms of bipolar disorder in a community sample of children and adolescentsWendy Reich
Departments of Genetics and Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
Twin Res Hum Genet 8:459-66. 2005..Episodes of possible bipolar disorders as defined by DSM-IV are uncommon in this nonreferred sample. Children and adolescents with ADHD appear to be only modestly at increased risk for bipolar disorders...
Evidence for a quantitative trait locus affecting low levels of apolipoprotein B and low density lipoprotein on chromosome 10 in Caucasian familiesRichard Sherva
Washington University School of Medicine, St Louis, MO 63110, USA
J Lipid Res 48:2632-9. 2007....
Genetic analysis of maximum cigarette-use phenotypesNancy L Saccone
Department of Genetics, Washington University School of Medicine, St, Louis, Missouri, USA
BMC Genet 4:S105. 2003..Adjustments were made for the significant covariates of gender and year of birth, and sib-pair based linkage analysis was performed...
Age and birth cohort effects on rates of alcohol dependenceJohn P Rice
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Alcohol Clin Exp Res 27:93-9. 2003..This suggests additional influences of birth cohort or period effects so that individuals in later-born cohorts have an increased lifetime risk...
Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twinsMichael T Lynskey
Queensland Institute of Medical Research, Brisbane, Queensland, Australia
Twin Res Hum Genet 8:574-84. 2005....
Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterolLatisha Love-Gregory
Department of Medicine, Center for Human Nutrition, Division of Biostatistics, Washington University School of Medicine, St Louis, MO 63110, USA
Hum Mol Genet 17:1695-704. 2008..0059). Fifteen additional SNPs associated with HDL-C (P = 0.0028-0.044). We conclude that CD36 variants may impact MetS pathophysiology and HDL metabolism, both predictors of the risk of heart disease and type 2 diabetes...
A comparison of the latent class structure of cannabis problems among adult men and women who have used cannabis repeatedlyJulia D Grant
Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Addiction 101:1133-42. 2006..Current evidence is not conclusive regarding gender differences for cannabis use, abuse and dependence. It is not known if symptom profiles differ by gender...
Accuracy of mothers' retrospective reports of smoking during pregnancy: comparison with twin sister informant ratingsAndrew C Heath
Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Twin Res 6:297-301. 2003..We conclude that retrospective smoking data can safely be used to identify potential associations of later child outcomes with maternal smoking during pregnancy...
Are there subgroups of bulimia nervosa based on comorbid psychiatric disorders?Alexis E Duncan
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63108, USA
Int J Eat Disord 37:19-25. 2005..The current study sought to determine whether there are subtypes of bulimia nervosa (BN) differentiated by comorbid psychiatric disorders...
Gene-gene interactions lead to higher risk for development of type 2 diabetes in an Ashkenazi Jewish populationRosalind J Neuman
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 5:e9903. 2010..Our goal was to evaluate interactions among SNPs within genes frequently identified as associated with T2D...
Multistage analysis strategies for genome-wide association studies: summary of group 3 contributions to Genetic Analysis Workshop 16Rosalind J Neuman
Department of Psychiatry, Washington University Medical School, St Louis, Missouri 63108, USA
Genet Epidemiol 33:S19-23. 2009..The hope is that the intense computational methods highlighted in this group of papers will become useful tools in future GWAS...
Brain-derived neurotrophic factor and autoantibodies to neural antigens in sera of children with autistic spectrum disorders, Landau-Kleffner syndrome, and epilepsyAnne M Connolly
Department of Neurology and Pediatrics, Washington University School of Medicine, St. Louis, Missouri 63110, USA
Biol Psychiatry 59:354-63. 2006..The presence of both BDNF AAs and elevated BDNF levels in some children with autism and CDD suggests a previously unrecognized interaction between the immune system and BDNF...
The latent class structure of ADHD is stable across informantsRobert R Althoff
Department of Psychiatry, University of Vermont, Burlington, Vermont 05405, United States of America
Twin Res Hum Genet 9:507-22. 2006..Results from LCA using Dutch twins with the CRS show stability across informants suggesting that more stable phenotypes may be accessible for genotyping using a multi-informant approach...
