O Lynne Nelson
Affiliation: Washington State University
- Echocardiographic and radiographic changes associated with systemic hypertension in catsLynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164 7060, USA
J Vet Intern Med 16:418-25. 2002..The distal aortic root measurements and ratios evaluated by echocardiography were significantly different between the 2 groups of cats (P = .0001) and were significantly correlated with SBP (P = .0001) but not age (P > .3)...
- Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophyMichael H Radke
Department of Neuromuscular and Cardiovascular Cell Biology, Max Delbruck Center for Molecular Medicine, D 13122 Berlin Buch, Germany
Proc Natl Acad Sci U S A 104:3444-9. 2007..The N2B-KO mouse is the first titin-based model of diastolic dysfunction and, considering the high prevalence of diastolic heart failure, it could provide future mechanistic insights into the disease process...
- Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bearsO Lynne Nelson
College of Veterinary Medicine, Washington State Univ, Pullman, WA 99164, USA
Am J Physiol Heart Circ Physiol 295:H366-71. 2008..Thus our work identified changes in the alternative splicing of cardiac titin as a major adaptive response in hibernating grizzly bears...
- The utility of plasma D-dimer to identify thromboembolic disease in dogsO Lynne Nelson
Internal Medicine and Cardiology, Washington State University, Pullman, WA 99164 7060, USA
J Vet Intern Med 17:830-4. 2003..5% (sensitivity, 36%). FDPs were not high in any TE patient; thus, they may be an insensitive indicator of thromboembolism, with or without overt disseminated intravascular coagulation (DIC)...
- Comparison of echocardiography-guided and fluoroscopy-guided endomyocardial biopsy techniquesO Lynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 7060, USA
Vet Radiol Ultrasound 46:131-4. 2005..Clear definition of endocardial surface as afforded by echocardiography may enhance tissue sample quality and lower potential complications from this procedure...
- Cardiac function adaptations in hibernating grizzly bears (Ursus arctos horribilis)O Lynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, 100 Grimes Way, Room 17, Pullman, WA 99164, USA
J Comp Physiol B 180:465-73. 2010..These findings will aid in rational approaches to identifying underlying molecular mechanisms...
- The use of an implantable cardioverter defibrillator in a Boxer Dog to control clinical signs of arrhythmogenic right ventricular cardiomyopathyO Lynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, College of Veterinary Medicine, Pullman 99164, USA
J Vet Intern Med 20:1232-7. 2006
- Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB/c miceRuriko Nakao
School of Food Science, Washington State University, Pullman, WA 99164, USA
Anticancer Res 30:2171-5. 2010..This suggests that an adequate blood astaxanthin status is needed to protect against tumor initiation; conversely, astaxanthin supplementation after tumor initiation may be contraindicated...
- The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphismMelissa F Jackson
School of Molecular Biosciences, Department of Veterinary Microbiology and Pathology, 124 ASLB, Washington Center for Muscle Biology, Washington State University, Pullman, Washington 99164, USA
J Endocrinol 213:263-75. 2012..Additional studies are nevertheless needed to definitively assess potential risks to cardiac function...
- Evaluation of cardiac function in active and hibernating grizzly bearsO Lynne Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
J Am Vet Med Assoc 223:1170-5. 2003..To evaluate cardiac function parameters in a group of active and hibernating grizzly bears...
- Temporal organization of activity in the brown bear (Ursus arctos): roles of circadian rhythms, light, and food entrainmentJasmine V Ware
Departments of Veterinary Comparative Anatomy, Pharmacology, and Physiology, Washington State Univ, Pullman, WA 99164, USA
Am J Physiol Regul Integr Comp Physiol 303:R890-902. 2012..Activity shifted entirely to a nocturnal pattern. Thus daily activity in brown bears is highly modifiable by photoperiod and food availability in a stereotypic seasonal fashion...
- Minimal seasonal alterations in the skeletal muscle of captive brown bearsJohn D Hershey
Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164, USA
Physiol Biochem Zool 81:138-47. 2008..These results agreed with a study that showed minimal skeletal muscle atrophy between seasons in wild black bears...
- Effect of astaxanthin supplementation on inflammation and cardiac function in BALB/c miceRuriko Nakao
School of Food Science, Washington State University, Pullman, WA 99164, USA
Anticancer Res 30:2721-5. 2010..08% astaxanthin had higher (p<0.05) heart mitochondrial membrane potential and contractility index compared to the control group. These results support the possible use of dietary astaxanthin for cardiac protection...
- Energy homeostasis regulatory peptides in hibernating grizzly bearsJanos Gardi
First Department of Internal Medicine, University of Szeged, Koranyi fasor 8 10, H 6720 Szeged, Hungary
Gen Comp Endocrinol 172:181-3. 2011..Our results suggest that ghrelin plays a potential role in the regulation of metabolic changes and energy homeostasis during hibernation in grizzly bears...
- Split parturition observed in a captive North American brown bear (Ursus arctos)Jasmine V Ware
Deparmentt of Veterinary and Comparative Anatomy, Pharmacology and Physiology VCAPP, Washington State University, Pullman, Washington, USA
Zoo Biol 31:255-9. 2012..When normalized to age, cub growth rates did not differ. To our knowledge, this is the first documented case of markedly different birth dates in a single litter of brown bear cubs...
- Use of the D-dimer assay for diagnosing thromboembolic disease in the dogO Lynne Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99194, USA
J Am Anim Hosp Assoc 41:145-9. 2005..This paper examines the use of D-dimer assays and other clinical modalities in the diagnostic approach to thromboembolic disease in small animals...
- Myostatin represses physiological hypertrophy of the heart and excitation-contraction couplingBuel D Rodgers
Department of Animal Sciences and School of Molecular BioSciences, Washington State University, Pullman, WA 99164, USA
J Physiol 587:4873-86. 2009..Thus, the controlled inhibition of myostatin action could potentially help repair damaged cardiac muscle by inducing physiological hypertrophy...
- Cardiovascular dysfunction in dogs associated with critical illnessesO Lynne Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 7060, USA
J Am Anim Hosp Assoc 42:344-9. 2006..Fifteen dogs were presented with generalized weakness as a part of their clinical complaint. Twelve (75%) of 16 dogs died or were euthanized within 15 days of admission to the hospital. The average time until death was 3.6 days...
- Disease association and clinical assessment of feline pericardial effusionBenjamin J Davidson
Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Washington State University, P O Box 647060, Pullman, Washington 99164, USA
J Am Anim Hosp Assoc 44:5-9. 2008..Feline pericardial effusion remains an infrequent diagnosis, but its clinical relevance and association with severe cardiac and extracardiac disease warrant diagnostic evaluation...
- Decreased bone turnover with balanced resorption and formation prevent cortical bone loss during disuse (hibernation) in grizzly bears (Ursus arctos horribilis)Meghan E McGee
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA
Bone 42:396-404. 2008..These results support the idea that bears possess a biological mechanism to prevent disuse osteoporosis...