O Lynne Nelson
Affiliation: Washington State University
- Echocardiographic and radiographic changes associated with systemic hypertension in catsLynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164 7060, USA
J Vet Intern Med 16:418-25. 2002..The distal aortic root measurements and ratios evaluated by echocardiography were significantly different between the 2 groups of cats (P = .0001) and were significantly correlated with SBP (P = .0001) but not age (P > .3)...
- Targeted deletion of titin N2B region leads to diastolic dysfunction and cardiac atrophyMichael H Radke
Department of Neuromuscular and Cardiovascular Cell Biology, Max Delbruck Center for Molecular Medicine, D 13122 Berlin Buch, Germany
Proc Natl Acad Sci U S A 104:3444-9. 2007..The N2B-KO mouse is the first titin-based model of diastolic dysfunction and, considering the high prevalence of diastolic heart failure, it could provide future mechanistic insights into the disease process...
- Cardiac function adaptations in hibernating grizzly bears (Ursus arctos horribilis)O Lynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, 100 Grimes Way, Room 17, Pullman, WA 99164, USA
J Comp Physiol B 180:465-73. 2010..These findings will aid in rational approaches to identifying underlying molecular mechanisms...
- Titin isoform switching is a major cardiac adaptive response in hibernating grizzly bearsO Lynne Nelson
College of Veterinary Medicine, Washington State Univ, Pullman, WA 99164, USA
Am J Physiol Heart Circ Physiol 295:H366-71. 2008..Thus our work identified changes in the alternative splicing of cardiac titin as a major adaptive response in hibernating grizzly bears...
- The use of an implantable cardioverter defibrillator in a Boxer Dog to control clinical signs of arrhythmogenic right ventricular cardiomyopathyO Lynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, College of Veterinary Medicine, Pullman 99164, USA
J Vet Intern Med 20:1232-7. 2006
- The utility of plasma D-dimer to identify thromboembolic disease in dogsO Lynne Nelson
Internal Medicine and Cardiology, Washington State University, Pullman, WA 99164 7060, USA
J Vet Intern Med 17:830-4. 2003..5% (sensitivity, 36%). FDPs were not high in any TE patient; thus, they may be an insensitive indicator of thromboembolism, with or without overt disseminated intravascular coagulation (DIC)...
- Comparison of echocardiography-guided and fluoroscopy-guided endomyocardial biopsy techniquesO Lynne Nelson
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 7060, USA
Vet Radiol Ultrasound 46:131-4. 2005..Clear definition of endocardial surface as afforded by echocardiography may enhance tissue sample quality and lower potential complications from this procedure...
- Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB/c miceRuriko Nakao
School of Food Science, Washington State University, Pullman, WA 99164, USA
Anticancer Res 30:2171-5. 2010..This suggests that an adequate blood astaxanthin status is needed to protect against tumor initiation; conversely, astaxanthin supplementation after tumor initiation may be contraindicated...
- The aging myostatin null phenotype: reduced adiposity, cardiac hypertrophy, enhanced cardiac stress response, and sexual dimorphismMelissa F Jackson
School of Molecular Biosciences, Department of Veterinary Microbiology and Pathology, 124 ASLB, Washington Center for Muscle Biology, Washington State University, Pullman, Washington 99164, USA
J Endocrinol 213:263-75. 2012..Additional studies are nevertheless needed to definitively assess potential risks to cardiac function...
- Evaluation of cardiac function in active and hibernating grizzly bearsO Lynne Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
J Am Vet Med Assoc 223:1170-5. 2003..To evaluate cardiac function parameters in a group of active and hibernating grizzly bears...
- Temporal organization of activity in the brown bear (Ursus arctos): roles of circadian rhythms, light, and food entrainmentJasmine V Ware
Departments of Veterinary Comparative Anatomy, Pharmacology, and Physiology, Washington State Univ, Pullman, WA 99164, USA
Am J Physiol Regul Integr Comp Physiol 303:R890-902. 2012..Activity shifted entirely to a nocturnal pattern. Thus daily activity in brown bears is highly modifiable by photoperiod and food availability in a stereotypic seasonal fashion...
- Increase in cardiac myosin heavy-chain (MyHC) alpha protein isoform in hibernating ground squirrels, with echocardiographic visualization of ventricular wall hypertrophy and prolonged contractionO Lynne Nelson
College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
J Exp Biol 216:4678-90. 2013....
- Effect of astaxanthin supplementation on inflammation and cardiac function in BALB/c miceRuriko Nakao
School of Food Science, Washington State University, Pullman, WA 99164, USA
Anticancer Res 30:2721-5. 2010..08% astaxanthin had higher (p<0.05) heart mitochondrial membrane potential and contractility index compared to the control group. These results support the possible use of dietary astaxanthin for cardiac protection...
- Minimal seasonal alterations in the skeletal muscle of captive brown bearsJohn D Hershey
Department of Veterinary Comparative Anatomy, Pharmacology and Physiology, Washington State University, Pullman, Washington 99164, USA
Physiol Biochem Zool 81:138-47. 2008..These results agreed with a study that showed minimal skeletal muscle atrophy between seasons in wild black bears...
- Energy homeostasis regulatory peptides in hibernating grizzly bearsJanos Gardi
First Department of Internal Medicine, University of Szeged, Koranyi fasor 8 10, H 6720 Szeged, Hungary
Gen Comp Endocrinol 172:181-3. 2011..Our results suggest that ghrelin plays a potential role in the regulation of metabolic changes and energy homeostasis during hibernation in grizzly bears...
- Split parturition observed in a captive North American brown bear (Ursus arctos)Jasmine V Ware
Deparmentt of Veterinary and Comparative Anatomy, Pharmacology and Physiology VCAPP, Washington State University, Pullman, Washington, USA
Zoo Biol 31:255-9. 2012..When normalized to age, cub growth rates did not differ. To our knowledge, this is the first documented case of markedly different birth dates in a single litter of brown bear cubs...
- Use of the D-dimer assay for diagnosing thromboembolic disease in the dogO Lynne Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99194, USA
J Am Anim Hosp Assoc 41:145-9. 2005..This paper examines the use of D-dimer assays and other clinical modalities in the diagnostic approach to thromboembolic disease in small animals...
- Myostatin represses physiological hypertrophy of the heart and excitation-contraction couplingBuel D Rodgers
Department of Animal Sciences and School of Molecular BioSciences, Washington State University, Pullman, WA 99164, USA
J Physiol 587:4873-86. 2009..Thus, the controlled inhibition of myostatin action could potentially help repair damaged cardiac muscle by inducing physiological hypertrophy...
- Disease association and clinical assessment of feline pericardial effusionBenjamin J Davidson
Department of Veterinary Clinical Sciences, Veterinary Teaching Hospital, Washington State University, P O Box 647060, Pullman, Washington 99164, USA
J Am Anim Hosp Assoc 44:5-9. 2008..Feline pericardial effusion remains an infrequent diagnosis, but its clinical relevance and association with severe cardiac and extracardiac disease warrant diagnostic evaluation...
- Cardiovascular dysfunction in dogs associated with critical illnessesO Lynne Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 7060, USA
J Am Anim Hosp Assoc 42:344-9. 2006..Fifteen dogs were presented with generalized weakness as a part of their clinical complaint. Twelve (75%) of 16 dogs died or were euthanized within 15 days of admission to the hospital. The average time until death was 3.6 days...
- Validation of a novel cognitive bias task based on difference in quantity of reinforcement for assessing environmental enrichmentHeidi A Keen
Center for the Study of Animal Well being, Washington State University, Pullman, WA, USA
Anim Cogn 17:529-41. 2014..The data provide some support for use of cognitive bias tasks based on quantity differences in animal welfare assessments involving captive wildlife...
- Immobilization of grizzly bears (Ursus arctos) with dexmedetomidine, tiletamine, and zolazepamJustin E Teisberg
1 School of Biological Sciences, Washington State University, Pullman, Washington 99164, USA
J Wildl Dis 50:74-83. 2014..Field trials confirmed that the dexMTZ + atipamezole protocol is safe, reliable, and predictable when administered to wild grizzly bears, especially during helicopter capture operations...
- Decreased bone turnover with balanced resorption and formation prevent cortical bone loss during disuse (hibernation) in grizzly bears (Ursus arctos horribilis)Meghan E McGee
Department of Biomedical Engineering, Michigan Technological University, Houghton, MI 49931, USA
Bone 42:396-404. 2008..These results support the idea that bears possess a biological mechanism to prevent disuse osteoporosis...