Elliot C Nelson

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    JAMA Psychiatry 70:325-33. 2013
  2. pmc A family study of adult twins with and without a history of childhood abuse: stability of retrospective reports of maltreatment and associated family measures
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, Midwest Alcoholism Research Center, St Louis, MO 63110, United States of America
    Twin Res Hum Genet 13:121-30. 2010
  3. ncbi request reprint Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study
    Elliot C Nelson
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Psychol Med 36:1473-83. 2006
  4. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
  5. pmc H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, USA
    Addict Biol 15:1-11. 2010
  6. pmc Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression
    Carolyn E Sartor
    Department of Psychiatry, Yale School of Medicine, VA Connecticut Healthcare System, USA
    Arch Gen Psychiatry 69:293-9. 2012
  7. pmc Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2047-56. 2009
  8. ncbi request reprint Stimulant use and symptoms of abuse/dependence: epidemiology and associations with cannabis use--a twin study
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
    Drug Alcohol Depend 86:147-53. 2007
  9. pmc Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arch Gen Psychiatry 69:732-40. 2012
  10. pmc Examining the association of NRXN3 SNPs with borderline personality disorder phenotypes in heroin dependent cases and socio-economically disadvantaged controls
    Vassilis N Panagopoulos
    Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 128:187-93. 2013

Detail Information

Publications45

  1. pmc ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    JAMA Psychiatry 70:325-33. 2013
    ..The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging...
  2. pmc A family study of adult twins with and without a history of childhood abuse: stability of retrospective reports of maltreatment and associated family measures
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, Midwest Alcoholism Research Center, St Louis, MO 63110, United States of America
    Twin Res Hum Genet 13:121-30. 2010
    ....
  3. ncbi request reprint Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study
    Elliot C Nelson
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Psychol Med 36:1473-83. 2006
    ..This study examined the relationships between self-reported childhood sexual abuse (CSA) and drug-related outcomes in an Australian twin panel...
  4. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
    ..A high genetic correlation between these measures would suggest that a continuous measure of consumption may have a useful role in the discovery of genes contributing to dependence risk...
  5. pmc H2 haplotype at chromosome 17q21.31 protects against childhood sexual abuse-associated risk for alcohol consumption and dependence
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, USA
    Addict Biol 15:1-11. 2010
    ..Our results also suggest that severe early trauma may prove to be an important clinical covariate in the treatment of alcohol dependence...
  6. pmc Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression
    Carolyn E Sartor
    Department of Psychiatry, Yale School of Medicine, VA Connecticut Healthcare System, USA
    Arch Gen Psychiatry 69:293-9. 2012
    ....
  7. pmc Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2047-56. 2009
    ..In this study, we examine whether age at first drink moderates genetic and environmental influences, via gene x environment interactions, on DSM-IV alcohol dependence symptoms...
  8. ncbi request reprint Stimulant use and symptoms of abuse/dependence: epidemiology and associations with cannabis use--a twin study
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
    Drug Alcohol Depend 86:147-53. 2007
    ....
  9. pmc Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arch Gen Psychiatry 69:732-40. 2012
    ..The endocannabinoid system has been implicated in stress adaptation and the regulation of mood in rodent studies, but few human association studies have examined these links and replications are limited...
  10. pmc Examining the association of NRXN3 SNPs with borderline personality disorder phenotypes in heroin dependent cases and socio-economically disadvantaged controls
    Vassilis N Panagopoulos
    Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 128:187-93. 2013
    ..The current report focuses on the association of neurexin 3 (NRXN3) single nucleotide polymorphisms (SNPs) with BPD symptoms in heroin dependent cases and controls...
  11. ncbi request reprint Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sample
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America
    Twin Res Hum Genet 9:523-30. 2006
    ..Aggregation of population-level data may obscure important subgroup differences in patterns of illicit drug use and psychiatric comorbidity. Further exploration of a 'self-medicating' subgroup is needed...
  12. pmc Childhood sexual abuse and early substance use in adolescent girls: the role of familial influences
    Carolyn E Sartor
    Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06516, USA
    Addiction 108:993-1000. 2013
    ..To assess the extent to which the association between childhood sexual abuse (CSA) and early use of alcohol, cigarettes and cannabis in adolescent girls is mediated by risk factors that tend to cluster in families where CSA occurs...
  13. pmc Posttraumatic stress disorder and alcohol dependence in young women
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Stud Alcohol Drugs 71:810-8. 2010
    ....
  14. pmc An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Twin Res Hum Genet 15:631-41. 2012
    ....
  15. pmc A quantitative-trait genome-wide association study of alcoholism risk in the community: findings and implications
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 70:513-8. 2011
    ....
  16. pmc Correlates of alcohol abuse/dependence in early-onset alcohol-using women
    Mitchell B Jenkins
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Am J Addict 20:429-34. 2011
    ....
  17. pmc Association of OPRD1 polymorphisms with heroin dependence in a large case-control series
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA Queensland Institute of Medical Research, Australia National Drug and Alcohol Research Centre, University of New South Wales, Australia Burnet Institute, Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, Australia
    Addict Biol 19:111-21. 2014
    ..Support was not found for similar association involving either OPRM1 or OPRK1 SNPs...
  18. pmc The association between cannabis abuse and dependence and childhood physical and sexual abuse: evidence from an offspring of twins design
    Alexis E Duncan
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:990-7. 2008
    ....
  19. ncbi request reprint Genetic epidemiology of alcohol-induced blackouts
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine and St Louis University School of Public Health, St Louis, O 63108, USA
    Arch Gen Psychiatry 61:257-63. 2004
    ..Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention...
  20. ncbi request reprint Genetic effects on alcohol dependence risk: re-evaluating the importance of psychiatric and other heritable risk factors
    Valerie S Knopik
    Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Psychol Med 34:1519-30. 2004
    ..Genetic influences have been shown to play a major role in determining the risk of alcohol dependence (AD) in both women and men; however, little attention has been directed to identifying the major sources of genetic variation in AD risk...
  21. ncbi request reprint Duration of cannabis use--a novel phenotype?
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
    Addict Behav 31:984-94. 2006
    ..While there were high genetic correlations in both women and men, lifetime duration of cannabis may be uniquely informative in assessing components of liability to cannabis use...
  22. pmc Investigating the association between childhood sexual abuse and alcohol use disorders in women: does it matter how we ask about sexual abuse?
    Carolyn E Sartor
    Department of Psychiatry, Yale School of Medicine, New Haven, Connecticut, USA
    J Stud Alcohol Drugs 73:740-8. 2012
    ....
  23. ncbi request reprint Gene-environment interaction effects on behavioral variation and risk of complex disorders: the example of alcoholism and other psychiatric disorders
    Andrew C Heath
    Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis 63108, USA
    Twin Res 5:30-7. 2002
    ..Since few separated twin pairs will be available for study in the future, we also consider methods for modifying variance components linkage analysis to allow for environmental interactions with linked loci...
  24. pmc A candidate gene association study of alcohol consumption in young women
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Clin Exp Res 35:550-8. 2011
    ..We used data on a previously defined alcohol consumption factor score in a sample of 827 young women to investigate association with 1,014 single-nucleotide polymorphisms in genes related to addiction...
  25. pmc The interpretability of family history reports of alcoholism in general community samples: findings in a midwestern U.S. twin birth cohort
    Mary Waldron
    School of Education, Indiana University, Bloomington, IN 47405, USA
    Alcohol Clin Exp Res 36:1091-8. 2012
    ..Although there is a long tradition in alcoholism research of using family history ratings, the interpretability of family history reports of alcoholism from general community samples has yet to be established...
  26. pmc Risk for suicidal thoughts and behavior after childhood sexual abuse in women and men
    Saaniya Bedi
    Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO, USA
    Suicide Life Threat Behav 41:406-15. 2011
    ..Our findings suggest that these disorders partially mediate CSA-associated risk...
  27. pmc Childhood sexual abuse and the course of alcohol dependence development: findings from a female twin sample
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Drug Alcohol Depend 89:139-44. 2007
    ..Findings indicate that CSA and elevated risk for AD may be linked via early age at first drink and that progression from first drink to AD follows a similar course among women with and without histories of CSA...
  28. ncbi request reprint PTSD risk associated with a functional DRD2 polymorphism in heroin-dependent cases and controls is limited to amphetamine-dependent individuals
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Addict Biol 19:700-7. 2014
    ..These findings suggest roles for impairment in inhibitory control in the pathophysiology of PTSD and raise questions about stimulant use in certain populations (e.g. those in combat). ..
  29. pmc A CRHR1 haplotype moderates the effect of adverse childhood experiences on lifetime risk of major depressive episode in African-American women
    Henry R Kranzler
    Department of Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
    Am J Med Genet B Neuropsychiatr Genet 156:960-8. 2011
    ..The complex structure of CRHR1 may help to explain why some variants in the gene moderate the effects of an ACE only on depression risk while others moderate the effect of an ACE only on AD risk...
  30. pmc Reporting bias in the association between age at first alcohol use and heavy episodic drinking
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 35:1418-25. 2011
    ....
  31. pmc Age at trauma exposure and PTSD risk in young adult women
    Vivia V McCutcheon
    Department of Psychiatry, Washington University School of Medicine, WA, USA
    J Trauma Stress 23:811-4. 2010
    ..Early sexual assault was the strongest predictor of risk, but additional traumatic events increased risk even in its presence...
  32. pmc A 3p26-3p25 genetic linkage finding for DSM-IV major depression in heavy smoking families
    Michele L Pergadia
    Department of Psychiatry, WashingtonUniversity School of Medicine, Saint Louis, MO 63110, USA
    Am J Psychiatry 168:848-52. 2011
    ..The authors tested for genetic linkage of DSM-IV-diagnosed major depressive disorder in families that were ascertained for cigarette smoking...
  33. ncbi request reprint Association between self-reported childhood sexual abuse and adverse psychosocial outcomes: results from a twin study
    Elliot C Nelson
    Washington University School of Medicine, Department of Psychiatry, 40 N Kingshighway, Suite 1, St Louis, MO 63108, USA
    Arch Gen Psychiatry 59:139-45. 2002
    ..Increased risk for serious adverse outcomes has been associated with a history of childhood sexual abuse (CSA). Whether these risks are directly attributable to CSA rather than family background remains controversial...
  34. ncbi request reprint Genetic and environmental risk for major depression in african-american and European-american women
    Alexis E Duncan
    George Warren Brown School of Social Work, Washington University, St Louis, MO, USA
    Twin Res Hum Genet 17:244-53. 2014
    ..In spite of a marked elevation in the prevalence of environmental risk exposures related to MDD among AA women, there were no significant differences in lifetime prevalence or heritability of MDD between AA and EA young women. ..
  35. pmc Body mass index and regular smoking in young adult women
    Alexis E Duncan
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, United States
    Addict Behav 35:983-8. 2010
    ..57, 95% CI: 1.05-2.35 and OR=1.73, 95% CI: 1.35-2.20, respectively). These results suggest that experiencing CSA alters the association between BMI and regular smoking in women who have experimented with cigarettes...
  36. ncbi request reprint Ascertainment of a mid-western US female adolescent twin cohort for alcohol studies: assessment of sample representativeness using birth record data
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, USA
    Twin Res 5:107-12. 2002
    ..Sampling biases were however small. The unusual cooperativeness in research of families with twins persists...
  37. pmc Clustering of trauma and associations with single and co-occurring depression and panic attack over twenty years
    Vivia V McCutcheon
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Twin Res Hum Genet 13:57-65. 2010
    ..Assaultive trauma outweighed associations of familial effects and nonassaultive trauma with risk for 10 years following first trauma...
  38. ncbi request reprint Zygosity diagnosis in the absence of genotypic data: an approach using latent class analysis
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Twin Res 6:22-6. 2003
    ..In the absence of genotypic data, or as a safeguard against sample duplication, application of LCA for zygosity assignment or confirmation is strongly recommended...
  39. ncbi request reprint Effects of the interaction between genotype and environment. Research into the genetic epidemiology of alcohol dependence
    Andrew C Heath
    Missouri Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Res Health 26:193-201. 2002
    ..These GxE interaction effects can be determined by appropriately designed family and molecular epidemiological studies, such as studies of children of twins and prospective family studies...
  40. ncbi request reprint Escalation of drug use in early-onset cannabis users vs co-twin controls
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    JAMA 289:427-33. 2003
    ..Previous studies have reported that early initiation of cannabis (marijuana) use is a significant risk factor for other drug use and drug-related problems...
  41. ncbi request reprint Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Arch Gen Psychiatry 61:1026-32. 2004
    ..Previous research has reported both a moderate degree of comorbidity between cannabis dependence and major depressive disorder (MDD) and that early-onset cannabis use is associated with increased risks for MDD...
  42. ncbi request reprint Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 8:574-84. 2005
    ....
  43. ncbi request reprint The Obsessive Compulsive Scale of the Child Behavior Checklist predicts obsessive-compulsive disorder: a receiver operating characteristic curve analysis
    James J Hudziak
    Department of Psychiatry, University of Vermont, Given B229, Burlington, VT 05405, USA
    J Child Psychol Psychiatry 47:160-6. 2006
    ....
  44. ncbi request reprint Genetic and environmental contributions to the Child Behavior Checklist Obsessive-Compulsive Scale: a cross-cultural twin study
    James J Hudziak
    Department of Psychiatry, University of Vermont, Burlington Vrije University, Amsterdam, The Netherlands
    Arch Gen Psychiatry 61:608-16. 2004
    ..Twin studies of obsessive-compulsive disorder have indicated a significant genetic component to its expression...
  45. ncbi request reprint Genetic research and smoking behavior
    Laura Jean Bierut
    JAMA 297:809; author reply 810. 2007