Peter Nagele

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, Missouri Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St Louis, St Louis, Missouri Electronic address
    Biol Psychiatry 78:10-8. 2015
  2. pmc A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics
    C M Blake
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Pharmacol Ther 94:394-9. 2013
  3. pmc Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Anesthesiology 119:19-28. 2013
  4. pmc High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA
    Am Heart J 166:325-332.e1. 2013
  5. pmc Genetic variation, β-blockers, and perioperative myocardial infarction
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesthesiology 115:1316-27. 2011
  6. pmc Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia
    Peter Nagele
    Department of Anesthesiology, Washington University, St Louis, MO, USA
    Anesthesiology 117:321-8. 2012
  7. pmc Nitrous oxide anesthesia and plasma homocysteine in adolescents
    Peter Nagele
    Department of Anesthesiology, Washington University, St Louis, MO, USA
    Anesth Analg 113:843-8. 2011
  8. pmc Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pharmacogenet Genomics 21:426-31. 2011
  9. pmc Postoperative myocardial injury after major head and neck cancer surgery
    Peter Nagele
    Department of Anesthesiology, Washington University, St Louis, MO 63110, USA
    Head Neck 33:1085-91. 2011
  10. doi request reprint A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pharmacogenet Genomics 19:325-9. 2009

Collaborators

Detail Information

Publications19

  1. doi request reprint Nitrous Oxide for Treatment-Resistant Major Depression: A Proof-of-Concept Trial
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, Missouri Taylor Family Institute for Innovative Psychiatric Research, Washington University School of Medicine in St Louis, St Louis, Missouri Electronic address
    Biol Psychiatry 78:10-8. 2015
    ..We hypothesized that nitrous oxide, an inhalational general anesthetic and N-methyl-D-aspartate receptor antagonist, may also be a rapidly acting treatment for TRD...
  2. pmc A meta-analysis of CYP2D6 metabolizer phenotype and metoprolol pharmacokinetics
    C M Blake
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Pharmacol Ther 94:394-9. 2013
    ..This study demonstrates a marked effect of CYP2D6 metabolizer phenotype on metoprolol pharmacokinetics and confirms enantiomer-specific metabolism of metoprolol...
  3. pmc Influence of nitrous oxide anesthesia, B-vitamins, and MTHFR gene polymorphisms on perioperative cardiac events: the vitamins in nitrous oxide (VINO) randomized trial
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Anesthesiology 119:19-28. 2013
    ....
  4. pmc High-sensitivity cardiac troponin T in prediction and diagnosis of myocardial infarction and long-term mortality after noncardiac surgery
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine in St Louis, St Louis, MO 63110, USA
    Am Heart J 166:325-332.e1. 2013
    ..We hypothesized that preoperative cardiac troponin T detected with a novel high-sensitivity (hs-cTnT) assay will identify patients at risk for acute MI and long-term mortality after major noncardiac surgery...
  5. pmc Genetic variation, β-blockers, and perioperative myocardial infarction
    Peter Nagele
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Anesthesiology 115:1316-27. 2011
    ....
  6. pmc Postoperative QT interval prolongation in patients undergoing noncardiac surgery under general anesthesia
    Peter Nagele
    Department of Anesthesiology, Washington University, St Louis, MO, USA
    Anesthesiology 117:321-8. 2012
    ..Many perioperatively administered drugs and conditions prolong the QT interval. Despite several reports of perioperative torsades de pointes, systematic evidence regarding perioperative QT interval prolongation is limited...
  7. pmc Nitrous oxide anesthesia and plasma homocysteine in adolescents
    Peter Nagele
    Department of Anesthesiology, Washington University, St Louis, MO, USA
    Anesth Analg 113:843-8. 2011
    ..Prolonged exposure to nitrous oxide can lead to neuropathy, spinal cord degeneration, and even death in children. We tested the hypothesis that nitrous oxide anesthesia causes a significant increase in plasma tHcy in children...
  8. pmc Genetic and environmental determinants of plasma total homocysteine levels: impact of population-wide folate fortification
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pharmacogenet Genomics 21:426-31. 2011
    ..This investigation sought to determine the impact of folate fortification on the relative contribution of environmental and genetic factors to the variability of plasma tHcy...
  9. pmc Postoperative myocardial injury after major head and neck cancer surgery
    Peter Nagele
    Department of Anesthesiology, Washington University, St Louis, MO 63110, USA
    Head Neck 33:1085-91. 2011
    ..The aim of this study was to determine the risk of postoperative myocardial injury in patients undergoing major head and neck cancer surgery...
  10. doi request reprint A common gene variant in methionine synthase reductase is not associated with peak homocysteine concentrations after nitrous oxide anesthesia
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, Missouri, USA
    Pharmacogenet Genomics 19:325-9. 2009
    ..Thus, we hypothesized that patients with this gene variant develop higher plasma total homocysteine concentrations after nitrous oxide anesthesia than wild-type patients...
  11. doi request reprint Influence of methylenetetrahydrofolate reductase gene polymorphisms on homocysteine concentrations after nitrous oxide anesthesia
    Peter Nagele
    Department of Anesthesiology, Critical Care Medicine and Pain Therapy, Medical University of Vienna, Vienna, Austria
    Anesthesiology 109:36-43. 2008
    ..This study tested the hypothesis that patients with common MTHFR 677C>T or 1298A>C mutations develop higher plasma homocysteine concentrations after nitrous oxide anesthesia than wild-type patients...
  12. pmc Perioperative torsade de pointes: a systematic review of published case reports
    Joshua Johnston
    Division of Clinical and Translational Research, Department of Anesthesiology, Washington University School of Medicine, 660 S Euclid Ave, Box 8054, St Louis, MO 63110
    Anesth Analg 117:559-64. 2013
    ..To improve our understanding, we performed a systematic review and meta-analysis of all published case reports of perioperative torsade de pointes...
  13. doi request reprint Pediatric trauma in the Austrian Alps: the epidemiology of sport-related injuries in helicopter emergency medical service
    Harald F Selig
    Department of Anesthesiology and General Intensive Care and Pain Therapy, Medical University of Vienna, Vienna, Austria
    High Alt Med Biol 13:112-7. 2012
    ..We aimed to examine the epidemiological characteristics and injury patterns of pediatric trauma in helicopter emergency medical service (HEMS) caused by sports/outdoor activities in alpine environment...
  14. doi request reprint High-Fidelity Analysis of Perioperative QTc Prolongation
    Andreas Duma
    From the Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri Cardiovascular Division, Department of Internal Medicine, Washington University in St Louis, St Louis, Missouri and Division of Biostatistics, Washington University in St Louis, St Louis, Missouri
    Anesth Analg 122:439-48. 2016
    ..However, it is unknown whether QTc prolongation is an isolated postoperative phenomenon or occurs regularly during surgery, or whether the type of anesthesia influences its incidence...
  15. doi request reprint The hematological effects of nitrous oxide anesthesia in pediatric patients
    Andreas Duma
    From the Department of Anesthesiology, Washington University in St Louis, St Louis, Missouri and Department of Anesthesiology and Intensive Care, Medical University of Vienna, Vienna, Austria
    Anesth Analg 120:1325-30. 2015
    ..However, it is unclear whether nitrous oxide doses used in clinical practice cause adverse hematological effects in pediatric patients...
  16. ncbi request reprint Xenon acts by inhibition of non-N-methyl-D-aspartate receptor-mediated glutamatergic neurotransmission in Caenorhabditis elegans
    Peter Nagele
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, USA
    Anesthesiology 103:508-13. 2005
    ..Here, the authors ask in Caenorhabditis elegans whether xenon, like nitrous oxide, acts by a NMDA receptor-mediated mechanism...
  17. pmc The effect of nitrous oxide anesthesia on early postoperative opioid consumption and pain
    Andreas Duma
    From the Department of Anesthesiology, Washington University in St Louis, St Louis, MO and Department of Anesthesiology and General Intensive Care, Medical University of Vienna, Vienna, Austria
    Reg Anesth Pain Med 39:31-6. 2014
    ..A similar effect of N₂O is plausible, yet understudied. The goal of this study was to determine the effects of N₂O anesthesia on early postsurgical opioid consumption and pain...
  18. doi request reprint Prehospital pediatric emergencies in Austrian helicopter emergency medical service - a nationwide, population-based cohort study
    Harald F Selig
    Department of Anesthesiology and General Intensive Care and Pain Therapy, Medical University of Vienna, Vienna, Austria
    Wien Klin Wochenschr 123:552-8. 2011
    ....
  19. ncbi request reprint Multicenter randomized comparison of the efficacy and safety of xenon and isoflurane in patients undergoing elective surgery
    Rolf Rossaint
    Department of Anesthesiology of the University Hospital, RWTH Aachen, Germany
    Anesthesiology 98:6-13. 2003
    ..The aim of this clinical multicenter trial was to test the hypothesis of whether recovery after xenon anesthesia is faster compared with an accepted, standardized anesthetic regimen and that it is as effective and safe...