David G Mutch

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Randomized phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer
    David G Mutch
    Washington University School of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, St Louis, MO 63110, USA
    J Clin Oncol 25:2811-8. 2007
  2. ncbi request reprint Surgical management of ovarian cancer
    David G Mutch
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Oncol 29:3-8. 2002
  3. ncbi request reprint RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers
    David G Mutch
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Obstet Gynecol 190:935-42. 2004
  4. ncbi request reprint Gemcitabine combination chemotherapy of ovarian cancer
    David G Mutch
    Department of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 90:S16-20. 2003
  5. ncbi request reprint Gemcitabine in cervical cancer
    David G Mutch
    Department of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 90:S8-15. 2003
  6. ncbi request reprint Preoperative lymph node staging of early-stage cervical carcinoma by [18F]-fluoro-2-deoxy-D-glucose-positron emission tomography
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, Missouri 63110, USA
    Cancer 104:2484-91. 2005
  7. pmc Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history
    Barbara M Buttin
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 74:1262-9. 2004
  8. doi request reprint Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis
    Elizabeth A Kidd
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Box 8224, St Louis, MO 63110, USA
    J Clin Oncol 28:2108-13. 2010
  9. ncbi request reprint CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer
    Zhengyan Zhang
    Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8064, St Louis, MO 63110, USA
    Cancer Res 67:11202-8. 2007
  10. ncbi request reprint Lack of benefit of concurrent chemotherapy in patients with cervical cancer and negative lymph nodes by FDG-PET
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:444-9. 2005

Collaborators

Detail Information

Publications94

  1. ncbi request reprint Randomized phase III trial of gemcitabine compared with pegylated liposomal doxorubicin in patients with platinum-resistant ovarian cancer
    David G Mutch
    Washington University School of Medicine, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, St Louis, MO 63110, USA
    J Clin Oncol 25:2811-8. 2007
    ..On the basis of promising phase II results, gemcitabine was compared with PLD for efficacy and safety in taxane-pretreated Pt-R OC patients...
  2. ncbi request reprint Surgical management of ovarian cancer
    David G Mutch
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Semin Oncol 29:3-8. 2002
    ..Data are emerging that clearly suggest that gynecologic oncologists should be involved in both the surgical and medical management of patients with ovarian cancer...
  3. ncbi request reprint RAS/RAF mutation and defective DNA mismatch repair in endometrial cancers
    David G Mutch
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Obstet Gynecol 190:935-42. 2004
    ..This study investigated the spectrum and frequency of mutations in BRAF and KRAS2 in endometrial carcinomas on the basis of mismatch repair status...
  4. ncbi request reprint Gemcitabine combination chemotherapy of ovarian cancer
    David G Mutch
    Department of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 90:S16-20. 2003
    ....
  5. ncbi request reprint Gemcitabine in cervical cancer
    David G Mutch
    Department of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 90:S8-15. 2003
    ..The broad clinical effectiveness and low toxicity of gemcitabine in other human malignancies suggest that it might be useful in treating cervical tumors...
  6. ncbi request reprint Preoperative lymph node staging of early-stage cervical carcinoma by [18F]-fluoro-2-deoxy-D-glucose-positron emission tomography
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Alvin J Siteman Cancer Center, St Louis, Missouri 63110, USA
    Cancer 104:2484-91. 2005
    ..The objective of this study was to determine the sensitivity and specificity of PET in detecting lymph node metastasis in women with early-stage cervical carcinoma...
  7. pmc Penetrance and expressivity of MSH6 germline mutations in seven kindreds not ascertained by family history
    Barbara M Buttin
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Hum Genet 74:1262-9. 2004
    ..A combination of MSI and immunohistochemistry analyses may be helpful in screening for MSH6 mutation carriers...
  8. doi request reprint Lymph node staging by positron emission tomography in cervical cancer: relationship to prognosis
    Elizabeth A Kidd
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Box 8224, St Louis, MO 63110, USA
    J Clin Oncol 28:2108-13. 2010
    ..27 (95% CI 16.56 to 55.34). CONCLUSION Nodal involvement detected by FDG-PET in cervical cancer relates to clinical stage, is comparable to historical data, and stratifies patient recurrence and survival outcomes...
  9. ncbi request reprint CD83 gene polymorphisms increase susceptibility to human invasive cervical cancer
    Zhengyan Zhang
    Department of Obstetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8064, St Louis, MO 63110, USA
    Cancer Res 67:11202-8. 2007
    ..None of seven nearby genes was differentially expressed in cervical cancer. The importance of CD83 in epithelial versus dendritic cells needs to be determined, as does its role in promoting cervical cancer...
  10. ncbi request reprint Lack of benefit of concurrent chemotherapy in patients with cervical cancer and negative lymph nodes by FDG-PET
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 61:444-9. 2005
    ..To compare the outcome of patients with cervical cancer and negative lymph nodes by fluorodeoxyglucose-positron emission tomography (FDG-PET) treated with irradiation (RT) and concurrent chemotherapy or RT alone...
  11. ncbi request reprint DNA mismatch repair and TP53 defects are early events in uterine carcinosarcoma tumorigenesis
    Nicholas P Taylor
    Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Mod Pathol 19:1333-8. 2006
    ..The high rate of concordance for these molecular defects between the carcinoma and sarcoma components adds to existing molecular evidence that carcinosarcomas are clonal malignancies...
  12. ncbi request reprint Differential methylation hybridization array of endometrial cancers reveals two novel cancer-specific methylation markers
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Clin Cancer Res 13:2882-9. 2007
    ..To identify novel endometrial cancer-specific methylation markers and to determine their association with clinicopathologic variables and survival outcomes...
  13. ncbi request reprint Bevacizumab combination therapy in recurrent, platinum-refractory, epithelial ovarian carcinoma: A retrospective analysis
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 107:83-9. 2006
    ..The study was undertaken to determine the safety and efficacy of the monoclonal, antivascular endothelial growth factor antibody bevacizumab in combination with cytotoxic chemotherapy for women with platinum-refractory ovarian cancer...
  14. doi request reprint Clinical outcomes of definitive intensity-modulated radiation therapy with fluorodeoxyglucose-positron emission tomography simulation in patients with locally advanced cervical cancer
    Elizabeth A Kidd
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 77:1085-91. 2010
    ..This study aimed to evaluate the toxicity and clinical outcomes for cervical cancer patients treated definitively with intensity-modulated radiation therapy (IMRT) compared with non-IMRT treatment...
  15. ncbi request reprint Microsatellite instability and epigenetic inactivation of MLH1 and outcome of patients with endometrial carcinomas of the endometrioid type
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Oncol 25:2042-8. 2007
    ..We sought to determine whether MSI and MLH1 methylation are associated with clinicopathologic variables and survival outcomes in a large series of patients with endometrial carcinomas of the endometrioid type...
  16. ncbi request reprint Evidence for heritable predisposition to epigenetic silencing of MLH1
    Huiping Chen
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Cancer 120:1684-8. 2007
    ..Identification of risk alleles for MLH1 methylation could shed light on mechanisms of epigenetic silencing and may ultimately lead to new approaches to the prevention or treatment of malignancies associated with MLH1 inactivation...
  17. pmc Timing of referral for genetic counseling and genetic testing in patients with ovarian, fallopian tube, or primary peritoneal carcinoma
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Int J Gynecol Cancer 23:1016-21. 2013
    ..The objective of this study was to assess patients' preferences of the timing of referral for genetic counseling and testing in relation to the diagnosis, treatment, and recurrence of ovarian, tubal, or primary peritoneal cancers...
  18. ncbi request reprint Patterns of care, predictors, and outcomes of chemotherapy in elderly women with early-stage uterine carcinosarcoma: a population-based analysis
    Gunjal Garg
    Division of Gynecologic Oncology, Washington University School of Medicine, Siteman Cancer Center, St Louis, MO, USA Electronic address
    Gynecol Oncol 133:242-9. 2014
    ..To examine the patterns of care, predictors, and impact of chemotherapy on survival in elderly women diagnosed with early-stage uterine carcinosarcoma...
  19. pmc Multicenter phase II trial of topotecan, cisplatin and bevacizumab for recurrent or persistent cervical cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO, USA
    Gynecol Oncol 130:64-8. 2013
    ..We evaluated the activity and safety of the combination of topotecan, cisplatin and bevacizumab in patients with recurrent or persistent carcinoma of the cervix...
  20. doi request reprint The risk of lymph node metastasis with positive peritoneal cytology in endometrial cancer
    Gunjal Garg
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Int J Gynecol Cancer 23:90-7. 2013
    ..To determine the correlation between positive peritoneal cytology (PPC) and lymph node metastasis in patients with endometrial cancer grossly confined to the uterus...
  21. doi request reprint Surveillance FDG-PET detection of asymptomatic recurrences in patients with cervical cancer
    Rebecca A Brooks
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 112:104-9. 2009
    ..To evaluate survival after detection of recurrent cervical cancer by FDG-PET in symptomatic versus asymptomatic patients...
  22. ncbi request reprint FDG-PET evaluation of vaginal carcinoma
    Wayne T Lamoreaux
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 62:733-7. 2005
    ..To compare the results of CT and positron emission tomography (PET) and F-18 fluorodeoxyglucose (FDG) in the detection of the primary tumor and lymph node metastases in carcinoma of the vagina...
  23. ncbi request reprint Defective DNA mismatch repair and XRCC2 mutation in uterine carcinosarcomas
    Nicholas P Taylor
    Department of Ob Gyn, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, Maternity Building, 3rd Floor, St Louis, MO 63110, USA
    Gynecol Oncol 100:107-10. 2006
    ..We sought to determine if XRCC2 mutation is important to uterine carcinosarcoma tumorigenesis and whether the XRCC2 poly-T tract is a target for mutation in cells lacking MMR...
  24. ncbi request reprint Prospective evaluation of FDG-PET for detecting pelvic and para-aortic lymph node metastasis in uterine corpus cancer
    Neil S Horowitz
    Division of Gynecologic Oncology, Departments of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 95:546-51. 2004
    ....
  25. ncbi request reprint Human papillomavirus triage for young women with atypical squamous cells of undetermined significance
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 107:822-9. 2006
    ..We sought to estimate the usefulness of human papillomavirus testing for young women with atypical squamous cells of undetermined significance...
  26. pmc Clustering of Lynch syndrome malignancies with no evidence for a role of DNA mismatch repair
    Ashley S Case
    Divison of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 3rd Floor Maternity, St Louis, MO 63110, USA
    Gynecol Oncol 108:438-44. 2008
    ....
  27. doi request reprint Phase II evaluation of topotecan and navelbine in patients with recurrent ovarian, fallopian tube or primary peritoneal cancer
    Thomas J Herzog
    Division of Gynecologic Oncology, Columbia University, College of Physicians and Surgeons, Irving Cancer Center, New York, NY 10032, USA
    Gynecol Oncol 111:467-73. 2008
    ..To assess the efficacy and toxicity profile in patients with recurrent ovarian or primary peritoneal cancer treated with topotecan at 2.5 mg/m(2) days 1 and 8 plus vinorelbine at 25 mg/m(2) days 1 and 8 every 3 weeks...
  28. ncbi request reprint External radiotherapy versus vaginal brachytherapy for patients with intermediate risk endometrial cancer
    Lilie L Lin
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 106:215-20. 2007
    ..To determine if brachytherapy alone is adequate adjuvant local therapy in patients classified as intermediate risk after complete surgical staging for endometrioid adenocarcinoma...
  29. pmc ATR mutation in endometrioid endometrial cancer is associated with poor clinical outcomes
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
    J Clin Oncol 27:3091-6. 2009
    ..Knowledge of ATR mutation status may hold promise for individualized treatment and targeted therapies in patients with endometrial cancer...
  30. ncbi request reprint Utility of parametrectomy for early stage cervical cancer treated with radical hysterectomy
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, New York 10032, USA
    Cancer 110:1281-6. 2007
    ..Parametrectomy results in significant morbidity. The objective of the study was to determine factors predictive of parametrial tumor spread and to define a subset of patients at low risk for parametrial disease...
  31. doi request reprint Chemoradiation in locally advanced cervical carcinoma: an analysis of cisplatin dosing and other clinical prognostic factors
    Elizabeth K Nugent
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, 4th Floor Maternity, St Louis, MO 63110, USA
    Gynecol Oncol 116:438-41. 2010
    ..The aim of this study was to evaluate the effect of number of chemotherapy cycles and other clinical and pathologic factors on progression-free (PFS) and overall survival (OS) in patients with newly diagnosed cervical cancer...
  32. doi request reprint "Surgical Apgar Score" predicts postoperative complications after cytoreduction for advanced ovarian cancer
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 116:370-3. 2010
    ..We sought to estimate the ability of this metric to predict major postoperative complications in women undergoing ovarian cancer cytoreductive procedures...
  33. ncbi request reprint Cervical dysplasia in adolescents
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 106:115-20. 2005
    ..We determined the natural history and outcome of adolescents with low-grade squamous intraepithelial lesions (LSIL) and high-grade squamous intraepithelial lesions (HSIL)...
  34. ncbi request reprint MLH3 mutation in endometrial cancer
    Nicholas P Taylor
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Cancer Res 66:7502-8. 2006
    ..The identification of inherited missense variants, somatic missense mutations (present in 3 of 57 tumors), and LOH in the tumor from a patient with a germ line missense change suggest a role for MLH3 in endometrial tumorigenesis...
  35. doi request reprint The effects of body mass index on complications and survival outcomes in patients with cervical carcinoma undergoing curative chemoradiation therapy
    Nora T Kizer
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 117:948-56. 2011
    ..The effect of body mass index (BMI) on treatment outcomes for patients with locally advanced cervical carcinoma who receive definitive chemoradiation is unclear...
  36. doi request reprint Lymphovascular space invasion is an independent risk factor for nodal disease and poor outcomes in endometrioid endometrial cancer
    Saketh R Guntupalli
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Gynecol Oncol 124:31-5. 2012
    ..We sought to determine whether LVSI alone or in combination with other histologic factors predicts lymph node (LN) metastasis in patients with endometrioid endometrial cancer...
  37. ncbi request reprint Comparison of high-dose-rate and low-dose-rate brachytherapy in the treatment of endometrial carcinoma
    Alaa Fayed
    Department of Radiation Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 67:480-4. 2007
    ..To compare the outcomes for endometrial carcinoma patients treated with either high-dose-rate (HDR) or low-dose-rate (LDR) brachytherapy...
  38. ncbi request reprint Body mass index: relationship to clinical, pathologic and features of microsatellite instability in endometrial cancer
    Carolyn K McCourt
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO, USA
    Gynecol Oncol 104:535-9. 2007
    ....
  39. ncbi request reprint Posttherapy surveillance monitoring of cervical cancer by FDG-PET
    Perry W Grigsby
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:907-13. 2003
    ....
  40. doi request reprint Wilms' tumor 1 protein and estrogen receptor beta expression are associated with poor outcomes in uterine carcinosarcoma
    Saketh R Guntupalli
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, University of Colorado School of Medicine at Denver, Denver, CO, USA
    Ann Surg Oncol 20:2373-9. 2013
    ..Increased expression of Wilms' tumor 1 (WT1) protein and estrogen receptor beta (ER-β) protein is associated with worse outcomes in gynecologic cancers; therefore, we sought to assess this association in CS patients...
  41. pmc The utility and management of vaginal cytology after treatment for endometrial cancer
    Akiva P Novetsky
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Obstet Gynecol 121:129-35. 2013
    ..To estimate the accuracy of vaginal cytology in postoperative surveillance for detecting recurrent endometrial cancer and to estimate the optimal management of squamous abnormalities detected in this setting...
  42. ncbi request reprint Effect of a T0 radical hysterectomy specimen on survival for early stage cervical cancer
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, 161 Fort Washington Ave, 8th Floor, New York, NY 10032, USA
    Gynecol Oncol 107:280-4. 2007
    ..The goal of this study was to evaluate the outcome of patients with no residual tumor (T0) in their hysterectomy specimens...
  43. ncbi request reprint Acute toxicity of postoperative IMRT and chemotherapy for endometrial cancer
    Ryan M Tierney
    Department of Radiation Oncology, Box 8224, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, Lower Level, St Louis, MO 63110, USA
    Radiat Med 25:439-45. 2007
    ..The aim of this study was to determine the acute toxicity of postoperative intensity-modulated radiotherapy (IMRT) with and without chemotherapy in patients with endometrial cancer...
  44. ncbi request reprint Outcomes in 24 selected patients with stage IVB cervical cancer and excellent performance status treated with radiotherapy and chemotherapy
    Israel Zighelboim
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Alvin J Siteman Cancer Center, St Louis, MO, USA
    Radiat Med 24:625-30. 2006
    ..We sought to review outcomes in patients with stage IVB carcinoma of the cervix treated with irradiation in combination with chemotherapy...
  45. ncbi request reprint Cervical carcinoma in the elderly: an analysis of patterns of care and outcome
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 103:85-91. 2005
    ..Advanced age often is considered a poor prognostic factor for cervical carcinoma. The authors investigated the patterns of care and treatment outcomes of elderly women with cervical carcinoma...
  46. ncbi request reprint CA-125 response in patients with recurrent ovarian or primary peritoneal cancer treated with pegylated liposomal doxorubicin or topotecan
    Gabrielle Gossner
    Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:212-8. 2006
    ..In this study, we sought to gain insight into response patterns regarding CA-125 in responders vs. non-responders and to determine whether specific "cut-off" values could help predict ultimate clinical response...
  47. ncbi request reprint Phase II evaluation of a 3-day infusion of topotecan in patients with recurrent ovarian or primary peritoneal cancer
    Thomas J Herzog
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:637-41. 2006
    ..To assess the efficacy and toxicity profile in patients treated with topotecan at 2.0 mg/m2/day x 3 days every 3 weeks...
  48. ncbi request reprint Ribosomal DNA methylation in patients with endometrial carcinoma: an independent prognostic marker
    Matthew A Powell
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cancer 94:2941-52. 2002
    ..The objective of this study was to investigate the prognostic significance of ribosomal DNA (rDNA) methylation in patients with endometrial carcinoma...
  49. ncbi request reprint Relationship of ovarian neoplasms and body mass index
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Reprod Med 50:595-602. 2005
    ..To describe the distribution of benign and malignant ovarian neoplasms among overweight and obese women...
  50. ncbi request reprint Increased risk for hereditary nonpolyposis colorectal cancer-associated synchronous and metachronous malignancies in patients with microsatellite instability-positive endometrial carcinoma lacking MLH1 promoter methylation
    Barbara M Buttin
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 10:481-90. 2004
    ..The aim of this study was to evaluate number and types of synchronous and metachronous malignancies in patients with endometrial carcinoma with and without microsatellite instability (MSI)...
  51. pmc Excess of early onset multiple myeloma in endometrial cancer probands and their relatives suggests common susceptibility
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, 4911 Barnes Jewish Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 105:390-4. 2007
    ..Determine whether there is an association between uterine cancer and multiple myeloma...
  52. ncbi request reprint The role of topotecan for extending the platinum-free interval in recurrent ovarian cancer: an in vitro model
    Neil S Horowitz
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 94:67-73. 2004
    ....
  53. pmc Intra-tumor heterogeneity of MLH1 promoter methylation revealed by deep single molecule bisulfite sequencing
    Katherine E Varley
    Department of Genetics, Center for Genome Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Nucleic Acids Res 37:4603-12. 2009
    ..This high-resolution analysis allowed us to measure the clonality of methylation in individual tumors and gain insight into the accumulation of aberrant promoter methylation on both alleles during tumorigenesis...
  54. ncbi request reprint Long-term outcome of women who undergo panniculectomy at the time of gynecologic surgery
    Jason D Wright
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 102:86-91. 2006
    ..The goal of this study was to determine the long-term outcomes and patient satisfaction of women who underwent panniculectomy at the time of pelvic surgery...
  55. pmc Prevalence of defective DNA mismatch repair and MSH6 mutation in an unselected series of endometrial cancers
    Paul J Goodfellow
    Department of Surgery, Washington University School of Medicine, Campus Box 8109, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:5908-13. 2003
    ..The minimum estimate of the prevalence of inherited MSH6 mutation in endometrial cancer is 1.6% (7 of 441), comparable with the predicted prevalence for patients with colorectal cancer...
  56. ncbi request reprint In vitro chemoresponse to cisplatin and outcomes in cervical cancer
    Perry W Grigsby
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 130:188-91. 2013
    ..The aim of this study was to report clinical outcomes of cervical cancer patients treated with weekly cisplatin chemo-radiation therapy (chemoRT) stratified by pre-treatment cisplatin in vitro chemosensitivity...
  57. ncbi request reprint Intestinal perforation in gynecologic oncology: do all patients benefit from surgical management?
    Gunjal Garg
    Division of Gynecologic Oncology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Gynecol Oncol 129:538-43. 2013
    ..To identify those patients with gynecologic cancers and intestinal perforation in whom conservative management may be appropriate...
  58. doi request reprint The utility of peritoneal biopsy and omentectomy in the upstaging of apparent early ovarian cancer
    Rupal Shroff
    Washington University School of Medicine, St Louis, MO, USA
    Int J Gynecol Cancer 21:1208-12. 2011
    ..Few studies have been done examining this question of whether the biopsies of grossly normal-appearing peritoneal tissue are of benefit to the surgical staging procedure...
  59. doi request reprint Wound complications after gynecologic cancer surgery
    Elizabeth K Nugent
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, Barnes Jewish Hospital and Siteman Cancer Center, St Louis, MO 63110, USA
    Gynecol Oncol 121:347-52. 2011
    ..To explore clinical correlates of wound complications in high-risk women undergoing abdominal gynecologic surgery in a tertiary referral center...
  60. doi request reprint The value of perioperative imaging in patients with uterine sarcomas
    Elizabeth K Nugent
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, USA
    Gynecol Oncol 115:37-40. 2009
    ..To explore the yield and impact of perioperative imaging on management among patients undergoing surgical resection and treatment of uterine sarcomas...
  61. ncbi request reprint Three cases of hemolytic uremic syndrome in ovarian cancer patients treated with combination gemcitabine and pegylated liposomal doxorubicin
    Sharyn N Lewin
    Division of Gynecologic Oncology, Washington University School of Medicine, 4911 Barnes Jewish Hospital Plaza, Box 8064, St Louis, MO 63110 1094, USA
    Gynecol Oncol 97:228-33. 2005
    ..To our knowledge, no case reports of HUS in ovarian cancer patients receiving treatment with combination gemcitabine and pegylated liposomal doxorubicin (PLD) have been reported...
  62. ncbi request reprint Bevacizumab combination therapy in heavily pretreated, recurrent cervical cancer
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 103:489-93. 2006
    ..To report the utility of the monoclonal, anti-vascular endothelial growth factor antibody bevacizumab in combination with cytotoxic chemotherapy for women with recurrent cervical cancer...
  63. pmc DICER1 expression and outcomes in endometrioid endometrial adenocarcinoma
    Israel Zighelboim
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, MO 63110, USA
    Cancer 117:1446-53. 2011
    ..The authors also explored DNA methylation and haploinsufficiency as potential mechanisms related to altered DICER1 expression in these tumors...
  64. ncbi request reprint Panniculectomy: improving lymph node yield in morbidly obese patients with endometrial neoplasms
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 94:436-41. 2004
    ..The goal of this study was to determine the effect of panniculectomy on staging adequacy and lymph node yield in obese women with endometrial carcinoma undergoing staging laparotomy...
  65. ncbi request reprint MSI in endometrial carcinoma: absence of MLH1 promoter methylation is associated with increased familial risk for cancers
    Alison J Whelan
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Int J Cancer 99:697-704. 2002
    ..1 years vs. 65.4, p < or = 0.01). Age of onset and tumor MSI not associated with MLH1 promoter methylation may point to women with a genetic susceptibility to malignancies...
  66. pmc Lower uterine segment involvement is associated with poor outcomes in early-stage endometrioid endometrial carcinoma
    Nora T Kizer
    Department of Obstetrics and Gynecology, Washington University School of Medicine, Saint Louis, MO, USA
    Ann Surg Oncol 18:1419-24. 2011
    ..The clinicopathologic significance of lower uterine segment involvement (LUSI) in endometrial cancer patients remains unclear. Although LUSI has been reported to be a prognostic indicator, literature is limited...
  67. ncbi request reprint Stable suppression of MDR-1 gene using siRNA expression vector to reverse drug resistance in a human uterine sarcoma cell line
    Jun Hua
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, Box 8064, 4911 Barnes Hospital Plaza, St Louis, MO 63110, USA
    Gynecol Oncol 98:31-8. 2005
    ..The impact of transfecting the RNAi upon MDR-1 mRNA and P-glycoprotein expression as well as resultant chemotherapy resistance was assessed...
  68. ncbi request reprint Human papillomavirus type and tobacco use as predictors of survival in early stage cervical carcinoma
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 98:84-91. 2005
    ..The aim of this study was to define the prognostic significance of HPV 18 and its phylogenetically related viruses and smoking on survival in patients with early stage cervical cancer...
  69. ncbi request reprint Liquid-based cytology for the postirradiation surveillance of women with gynecologic malignancies
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, MO 63110, USA
    Gynecol Oncol 91:134-8. 2003
    ..To determine the performance of liquid-based cytology using ThinPrep in the postirradiation surveillance of women with gynecologic malignancies...
  70. pmc Aberrant methylation of the X-linked ribosomal S6 kinase RPS6KA6 (RSK4) in endometrial cancers
    Summer B Dewdney
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine and Siteman Cancer Center, St Louis, Missouri 63110, USA
    Clin Cancer Res 17:2120-9. 2011
    ..RPS6KA6 (RSK4) is a putative tumor suppressor gene and is a target of the ERK signaling pathway. We explored the role of RSK4 in endometrial cancer...
  71. ncbi request reprint A multi-institutional review of outcomes of endometrial stromal sarcoma
    Charles A Leath
    Department of Obstetrics, Division of Gynecologic Oncology, The University of Alabama at Birmingham, Birmingham, AL, USA
    Gynecol Oncol 105:630-4. 2007
    ..To compare the clinical behavior and outcomes of low- and high-grade endometrial stromal sarcomas (LGESS and HGESS), respectively...
  72. ncbi request reprint Bevacizumab therapy in patients with recurrent uterine neoplasms
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Anticancer Res 27:3525-8. 2007
    ..Angiogenesis plays an important role in endometrial carcinogenesis. We reviewed our experience with the anti-VEGF monoclonal antibody bevacizumab for the treatment of recurrent uterine neoplasms...
  73. ncbi request reprint Frequent HOXA11 and THBS2 promoter methylation, and a methylator phenotype in endometrial adenocarcinoma
    Bradford P Whitcomb
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 9:2277-87. 2003
    ..This study was designed to determine whether there is a methylator phenotype in stage I and II endometrioid endometrial adenocarcinoma, and if so, whether methylation correlates with recurrence...
  74. ncbi request reprint Epithelial ovarian tumors of low malignant potential: the role of microinvasion
    Barbara M Buttin
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Obstet Gynecol 99:11-7. 2002
    ..To identify prognostic factors that may be used to predict an aggressive disease course and poor outcome in patients with epithelial ovarian tumors of low malignant potential (borderline tumors)...
  75. ncbi request reprint Prospective evaluation of positron emission tomography for the detection of groin node metastases from vulvar cancer
    David E Cohn
    Division of Gynecologic Oncology, Washington University School of Medicine, St Louis, Missouri, USA
    Gynecol Oncol 85:179-84. 2002
    ..We set out to determine the ability of positron emission tomography with fluorodeoxyglucose to detect groin lymph node metastases from vulvar cancer...
  76. ncbi request reprint Hemolytic uremic syndrome presenting after treatment of endodermal sinus tumor
    Dele A Ogunleye
    Department of Obstetrics and Gynecology, Good Samaritan Hospital, Cincinnati, Ohio, USA
    Obstet Gynecol 104:1184-7. 2004
    ..Hemolytic uremic syndrome is a rare multisystem disorder that is caused by infections, preeclampsia, autoimmune disorders, or oral contraceptive agents, and rarely in association with different cancers and chemotherapeutic agents...
  77. ncbi request reprint Evaluation of 111In-DTPA-folate as a receptor-targeted diagnostic agent for ovarian cancer: initial clinical results
    Barry A Siegel
    Division of Nuclear Medicine, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 44:700-7. 2003
    ..We report here the initial clinical study of such an agent, (111)In-diethylenetriaminepentaacetic acid (DTPA)-folate, evaluated for diagnosis of ovarian malignancy...
  78. ncbi request reprint The significance of pneumatosis intestinalis or bowel perforation in patients with gynecologic malignancies
    Neil S Horowitz
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Gynecol Oncol 86:79-84. 2002
    ..The objectives of this study were to evaluate the clinical significance and outcome of pneumatosis intestinalis or bowel perforation in patients with gynecologic malignancies...
  79. ncbi request reprint Treatment of high-risk gestational trophoblastic tumors
    Jason D Wright
    Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Obstet Gynecol 46:593-606. 2003
  80. doi request reprint Long-term assessment of bladder and bowel dysfunction after radical hysterectomy
    Rebecca A Brooks
    Washington University School of Medicine Barnes Jewish Hospital, Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, 4911 Barnes Jewish Hospital Plaza Box 8064, Saint Louis, MO 63110, USA
    Gynecol Oncol 114:75-9. 2009
    ..To determine the long-term effects of radical hysterectomy on bladder and bowel function...
  81. doi request reprint Phase I study and preliminary pharmacology of the novel innate immune modulator rBBX-01 in gynecologic cancers
    Janet S Rader
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Clin Cancer Res 14:3089-97. 2008
    ..This phase I trial was done to determine the safety and basic pharmacology of rBBX-01...
  82. ncbi request reprint Cervical sarcomas: an analysis of incidence and outcome
    Jason D Wright
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Washington University School of Medicine, 4911 Barnes Hospital Plaza, Box 8064, St Louis, MO 63110, USA
    Gynecol Oncol 99:348-51. 2005
    ..Cervical sarcomas are exceedingly rare neoplasms associated with a poor prognosis. The objective of this study was to examine the treatment and outcome of women with cervical sarcomas...
  83. pmc Absence of MGMT promoter methylation in endometrial cancer
    B J Rimel
    Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, Washington University School of Medicine, USA
    Gynecol Oncol 112:224-8. 2009
    ..MGMT gene silencing and benefit from temozolomide in glioblastoma. N Engl J Med 2005;352:997-1003]. We sought to determine if MGMT promoter methylation plays a role in endometrial cancer...
  84. ncbi request reprint Gynecologic manifestations of hereditary nonpolyposis colorectal cancer. From inherited to sporadic disease
    Nicholas Taylor
    Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Oncology (Williston Park) 20:85-94; discussion 94-6, 100. 2006
    ..It is important to identify patients with HNPCC, as families of mutation carriers may benefit from genetic counseling, testing, and intensified cancer surveillance...
  85. ncbi request reprint Gene therapy in gynecological cancer
    Rebecca A Brooks
    Department of Obstetrics and Gynecology, Washington University, St Louis, MO, USA
    Expert Rev Anticancer Ther 6:1013-32. 2006
    ....
  86. ncbi request reprint Retrorectal tumors: a diagnostic and therapeutic challenge
    Sean C Glasgow
    Department of Surgery, Section of Colon and Rectal Surgery, Siteman Cancer Center, Washington University, St Louis, Missouri 63110, USA
    Dis Colon Rectum 48:1581-7. 2005
    ..The utility of newer imaging techniques has not been extensively described, and operative approach is variable. This study examined the diagnosis, treatment, and outcome of retrorectal tumors at a tertiary referral center...
  87. pmc Clear cell carcinoma of the cervix: a multi-institutional review in the post-DES era
    M Bijoy Thomas
    Division of Gynecologic Surgery, Mayo Clinic, Rochester, Minnesota 55905, USA
    Gynecol Oncol 109:335-9. 2008
    ..To conduct an outcome analysis of patients with cervical clear cell carcinoma (CCCC) in the post-DES era...
  88. ncbi request reprint Should the presence of lymphvascular space involvement be used to assign patients to adjuvant therapy following hysterectomy for unstaged endometrial cancer?
    David E Cohn
    Division of Gynecologic Oncology, Department of Obstetrics and Gynecology, Arthur G James Cancer Hospital and Solove Research Institute, The Ohio State University College of Medicine, Columbus, Ohio 43210, USA
    Gynecol Oncol 87:243-6. 2002
    ..As such, the presence of LVSI may indicate the need for lymphadenectomy or adjuvant therapy for potential regional lymph node metastases in patients with unstaged endometrial cancer...
  89. ncbi request reprint Stage IC adenocarcinoma of the endometrium: survival comparisons of surgically staged patients with and without adjuvant radiation therapy
    J Michael Straughn
    University of Alabama at Birmingham, 35249, USA
    Gynecol Oncol 89:295-300. 2003
    ..The goal of this study was to determine the outcomes of stage IC endometrial carcinoma patients who are managed with and without adjuvant radiation therapy after comprehensive surgical staging...
  90. ncbi request reprint Society of Gynecologic Oncologists Education Committee statement on risk assessment for inherited gynecologic cancer predispositions
    Johnathan M Lancaster
    H Lee Moffitt Cancer Center and Research Institute, Tampa, FL, USA
    Gynecol Oncol 107:159-62. 2007
    ..This commentary provides guidance on identification of patients who may benefit from hereditary cancer risk assessment for Hereditary Breast/Ovarian Cancer and the Lynch/Hereditary Non-Polyposis Colorectal Cancer syndrome...
  91. ncbi request reprint Pelvic irradiation with concurrent chemotherapy versus pelvic and para-aortic irradiation for high-risk cervical cancer: an update of radiation therapy oncology group trial (RTOG) 90-01
    Patricia J Eifel
    Department of Radiation Oncology, Unit 97, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Blvd, Houston, TX 77030, USA
    J Clin Oncol 22:872-80. 2004
    ....
  92. ncbi request reprint Carcinosarcoma of the ovary-a case series
    Teresa L Rutledge
    University of Oklahoma Health Sciences Center, Oklahoma City, OK 73104, USA
    Gynecol Oncol 100:128-32. 2006
    ..To evaluate our experience with ovarian carcinosarcoma and identify prognostic factors...
  93. ncbi request reprint Low allele frequency of MLH1 D132H in American colorectal and endometrial cancer patients
    Brian Y Shin
    Division of Hematology Oncology, Department of Medicine, University of California Irvine, 92697, USA
    Dis Colon Rectum 48:1723-7. 2005
    ....
  94. doi request reprint Carboplatin dosing in obese women with ovarian cancer: a Gynecologic Oncology Group study
    Jason D Wright
    Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Gynecol Oncol 109:353-8. 2008
    ..Obese women may therefore receive a sub-therapeutic carboplatin dose. This study assessed the association between BMI and outcome for ovarian cancer patients treated with carboplatin-based chemotherapy...