ANTHONY MUSLIN

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint 14-3-3 proteins: regulation of subcellular localization by molecular interference
    A J Muslin
    Center for Cardiovascular Research, Department of Medicine, School of Medicine, Washington University, Box 8086 Cardiology, 660 South Euclid Avenue, 63110, St Louis, MO, USA
    Cell Signal 12:703-9. 2000
  2. ncbi request reprint Role of raf proteins in cardiac hypertrophy and cardiomyocyte survival
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Trends Cardiovasc Med 15:225-9. 2005
  3. pmc Phenotypic high-throughput screening in atherosclerosis research: focus on macrophages
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA
    J Cardiovasc Transl Res 3:448-53. 2010
  4. doi request reprint The physician scientist training program in internal medicine at Washington University School of Medicine
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Acad Med 84:468-71. 2009
  5. pmc MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
    Anthony J Muslin
    Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Clin Sci (Lond) 115:203-18. 2008
  6. ncbi request reprint Getting the iron out: preventing and treating heart failure in transfusion-dependent thalassemia
    Danish A Jabbar
    Department of Internal Medicine, Saint Luke s Hospital, Saint Louis, MO 63017, USA
    Cleve Clin J Med 74:807-10, 813-6. 2007
  7. doi request reprint Akt2: a critical regulator of cardiomyocyte survival and metabolism
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA
    Pediatr Cardiol 32:317-22. 2011
  8. ncbi request reprint Septic shock induced from an implantable cardioverter-defibrillator lead-associated Candida albicans vegetation
    Sandeep Hindupur
    Barnes Jewish Hospital, One Barnes Jewish Hospital Plaza, Washington University in St Louis, Saint Louis, MO 63110, USA
    J Interv Card Electrophysiol 14:55-9. 2005
  9. ncbi request reprint Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload
    Ian S Harris
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circulation 110:718-23. 2004
  10. pmc The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival
    Jeffrey M C Lau
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 27:1455-66. 2007

Collaborators

  • Clay F Semenkovich
  • Zhouji Chen
  • Danish A Jabbar
  • Kerry Kornfeld
  • Haibo Zhao
  • S Hindupur
  • F Ross
  • R P Mecham
  • Brian N Finck
  • Makoto Kodama
  • Ken ichi Watanabe
  • MICHAEL BARRY KASTAN
  • Jie Ren
  • Shaosong Zhang
  • Narasimman Gurusamy
  • Jeffrey M C Lau
  • Attila Kovacs
  • Brandon M Proctor
  • Traian S Lupu
  • Yoram Etzion
  • Carla Weinheimer
  • Joan Avery
  • Xiaohua Jin
  • Jochen G Schneider
  • Brian DeBosch
  • Meilei Ma
  • Yoshifusa Aizawa
  • Michael Courtois
  • Ilya Treskov
  • Yibin Wang
  • Tanawat Jirakulaporn
  • Chunlai Wu
  • Andrew M Siedlecki
  • Brian J DeBosch
  • Rajarajan A Thandavarayan
  • Nandakumar Sambandam
  • Ian S Harris
  • Cindy E Zhang
  • Scott P Heximer
  • Janelle J Bruinsma
  • Bassel Beitinjaneh
  • Jacob Grand
  • Sharon Etzion
  • Bill Nolan
  • Alice Hackett
  • Thomas Ellenberger
  • Punniyakoti T Veeraveedu
  • Louis J Muglia
  • Suresh S Palaniyandi
  • Trey Coleman
  • Kenichi Hirabayashi
  • Kara N Standley
  • Paras Prakash
  • Masatoshi Takagi
  • Kirsteen H Maclean
  • Iya Treskov
  • Carlos Bernal-Mizrachi
  • Alec M Cheng
  • Thomas H Steinberg
  • Russell H Knutsen
  • J Michael Wyss
  • Man Hee Rhee
  • Antonio Oliveira-dos-Santos
  • Kendall J Blumer
  • Josef M Penninger
  • Xiaoguang Sun
  • Ning Peng
  • Kevin M Kaltenbronn

Detail Information

Publications36

  1. ncbi request reprint 14-3-3 proteins: regulation of subcellular localization by molecular interference
    A J Muslin
    Center for Cardiovascular Research, Department of Medicine, School of Medicine, Washington University, Box 8086 Cardiology, 660 South Euclid Avenue, 63110, St Louis, MO, USA
    Cell Signal 12:703-9. 2000
    ..14-3-3 may affect the localization of a protein by interfering with the function of a nearby targeting sequence, such as a nuclear localization sequence (NLS) or a nuclear export sequence (NES), on the binding partner...
  2. ncbi request reprint Role of raf proteins in cardiac hypertrophy and cardiomyocyte survival
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Trends Cardiovasc Med 15:225-9. 2005
    ..Raf proteins also have antiapoptotic activity that is independent of MKK and ERK. In this review, the role of Raf family members in the regulation of cardiomyocyte survival and growth will be discussed...
  3. pmc Phenotypic high-throughput screening in atherosclerosis research: focus on macrophages
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA
    J Cardiovasc Transl Res 3:448-53. 2010
    ..Additional phenotypic screens can be envisaged that address cellular processes in active atherosclerotic lesions including macrophage apoptosis and efferocytosis...
  4. doi request reprint The physician scientist training program in internal medicine at Washington University School of Medicine
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Acad Med 84:468-71. 2009
    ..In this article, the rationale for the development of the PSTP, its structure, and the initial outcomes of the program are described...
  5. pmc MAPK signalling in cardiovascular health and disease: molecular mechanisms and therapeutic targets
    Anthony J Muslin
    Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Clin Sci (Lond) 115:203-18. 2008
    ..Despite the complexities of this field of research, attractive targets for pharmacological therapy are emerging...
  6. ncbi request reprint Getting the iron out: preventing and treating heart failure in transfusion-dependent thalassemia
    Danish A Jabbar
    Department of Internal Medicine, Saint Luke s Hospital, Saint Louis, MO 63017, USA
    Cleve Clin J Med 74:807-10, 813-6. 2007
    ..The quantity of iron deposited in the heart is a key determinant of outcome. Early diagnosis and intensive chelation of the cardiac iron can avert heart failure and its fatal outcome...
  7. doi request reprint Akt2: a critical regulator of cardiomyocyte survival and metabolism
    Anthony J Muslin
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA
    Pediatr Cardiol 32:317-22. 2011
    ..These results demonstrate the differential roles of Akt family members and the importance of Akt2 in cardiomyocyte survival...
  8. ncbi request reprint Septic shock induced from an implantable cardioverter-defibrillator lead-associated Candida albicans vegetation
    Sandeep Hindupur
    Barnes Jewish Hospital, One Barnes Jewish Hospital Plaza, Washington University in St Louis, Saint Louis, MO 63110, USA
    J Interv Card Electrophysiol 14:55-9. 2005
    ..This case report presents the second such case. A review of the literature regarding fungal endocarditis as well as diagnosis and therapy of this rare and dangerous disease is discussed...
  9. ncbi request reprint Raf-1 kinase is required for cardiac hypertrophy and cardiomyocyte survival in response to pressure overload
    Ian S Harris
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO, USA
    Circulation 110:718-23. 2004
    ..Mechanical stress in the heart results in the activation of the small GTPase ras and the Raf-1/MEK/ERK signaling cascade in addition to other signaling pathways...
  10. pmc The 14-3-3tau phosphoserine-binding protein is required for cardiomyocyte survival
    Jeffrey M C Lau
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Mol Cell Biol 27:1455-66. 2007
    ..These results demonstrate that 14-3-3tau plays a critical antiapoptotic function in cardiomyocytes and that therapeutic agents that increase 14-3-3tau activity may be beneficial to patients with myocardial infarction...
  11. doi request reprint An unbiased chemical biology screen identifies agents that modulate uptake of oxidized LDL by macrophages
    Yoram Etzion
    Center for Cardiovascular Research, Washington University School of Medicine, Box 8086, 660 South Euclid Ave, St Louis, MO 63110, USA
    Circ Res 105:148-57. 2009
    ..The results support a model in which oxLDL uptake is dependent on the activation of multiple intracellular signaling pathways that culminate in actin-mediated lipoprotein internalization...
  12. ncbi request reprint Grb2 is required for atherosclerotic lesion formation
    Brandon M Proctor
    Center for Cardiovascular Research, Washington University School of Medicine, 660 South Euclid Avenue, Box 8086, St Louis, MO 63110, USA
    Arterioscler Thromb Vasc Biol 27:1361-7. 2007
    ..However, Grb2 heterozygous mice appear normal at birth. To test the role of the Grb2 adapter protein in atherosclerotic lesion formation, we generated Grb2+/- mice in the apoE-/- genetic background...
  13. ncbi request reprint Beta3 integrin deficiency promotes cardiac hypertrophy and inflammation
    Jie Ren
    Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    J Mol Cell Cardiol 42:367-77. 2007
    ..These results suggest that alpha(v)beta(3) expression in bone marrow has a generalized suppressive effect on cardiac inflammation...
  14. pmc Akt2 regulates cardiac metabolism and cardiomyocyte survival
    Brian DeBosch
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, 4940 Parkview Place, St Louis, MO 63110, USA
    J Biol Chem 281:32841-51. 2006
    ..These results implicate Akt2 in the regulation of cardiomyocyte metabolism and survival...
  15. ncbi request reprint Role of p38alpha MAPK in cardiac apoptosis and remodeling after myocardial infarction
    Jie Ren
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, Box 8086, 660 South Euclid Avenue, St Louis, MO 63110, USA
    J Mol Cell Cardiol 38:617-23. 2005
    ..These results establish that p38 MAPK activity is required for pathological remodeling after MI and suggest that p38 MAPK may promote cardiomyocyte apoptosis through Bcl-X(L) deamidation...
  16. pmc TRB3 function in cardiac endoplasmic reticulum stress
    Joan Avery
    Center for Cardiovascular Research, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circ Res 106:1516-23. 2010
    ..TRB3 gene expression is highly regulated in many cell types, and amino acid starvation, hypoxia, or endoplasmic reticulum (ER) stress promotes TRB3 expression in noncardiac cells...
  17. pmc The application of phenotypic high-throughput screening techniques to cardiovascular research
    Yoram Etzion
    Center for Cardiovascular Research, Washington University School of Medicine, MO 63110, USA
    Trends Cardiovasc Med 19:207-12. 2009
    ..In this review, the role of phenotypic screening techniques to identify novel therapeutic agents for the treatment of cardiovascular disease will be discussed...
  18. pmc Uremic cardiac hypertrophy is reversed by rapamycin but not by lowering of blood pressure
    Andrew M Siedlecki
    The Center for Cardiovascular Research, John Milliken Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Kidney Int 75:800-8. 2009
    ..Reduction of blood pressure, however, by hydralazine had no effect. These studies suggest that uremic cardiomyopathy is mediated by activation of a pathway that involves the mTOR pathway...
  19. pmc The role of the Grb2-p38 MAPK signaling pathway in cardiac hypertrophy and fibrosis
    Shaosong Zhang
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:833-41. 2003
    ....
  20. ncbi request reprint Cation diffusion facilitator proteins modulate Raf-1 activity
    Tanawat Jirakulaporn
    Center for Cardiovascular Research, The Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 279:27807-15. 2004
    ..Furthermore, we show that Zn(2+) inhibits Raf-1 binding to ZnT-1. We propose a model in which CDF protein binding facilitates Raf-1 activation...
  21. ncbi request reprint Role of 14-3-3-mediated p38 mitogen-activated protein kinase inhibition in cardiac myocyte survival
    Shaosong Zhang
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Circ Res 93:1026-8. 2003
    ....
  22. ncbi request reprint Akt1 is required for physiological cardiac growth
    Brian DeBosch
    Center for Cardiovascular Research, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Circulation 113:2097-104. 2006
    ..A signaling cascade that includes the protein kinase Akt regulates the growth and survival of many cell types, but the precise role of Akt1 in either form of cardiac hypertrophy is unknown...
  23. ncbi request reprint Zinc ions and cation diffusion facilitator proteins regulate Ras-mediated signaling
    Janelle J Bruinsma
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Cell 2:567-78. 2002
    ..These findings suggest that Zn(2+) negatively regulates a conserved element of the signaling pathway and that Zn(2+) regulation is important for maintaining the inactive state of the Ras pathway...
  24. ncbi request reprint Differential role of 14-3-3 family members in Xenopus development
    Jeffrey M C Lau
    Center for Cardiovascular Research, Department of Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 235:1761-76. 2006
    ..Reduction of 14-3-3 gamma (gamma) protein resulted in eye defects without gastrulation abnormalities. Therefore, individual 14-3-3 genes have separable functions in vertebrate embryonic development...
  25. ncbi request reprint Role of 14-3-3 proteins in early Xenopus development
    Chunlai Wu
    Department of Medicine, Center for Cardiovascular Research, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 119:45-54. 2002
    ..These phenotypic defects were caused by impaired fibroblast growth factor signaling in R18-injected embryos. These results establish the importance of 14-3-3 proteins in vertebrate embryonic development...
  26. doi request reprint Analysis of 14-3-3 family member function in Xenopus embryos by microinjection of antisense morpholino oligos
    Jeffrey M C Lau
    Center for Cardiovascular Research, Department of Medicine, Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO, USA
    Methods Mol Biol 518:31-41. 2009
    ..These and other results demonstrate the power and specificity of the morpholino antisense oligo microinjection technique...
  27. pmc Hypertension and prolonged vasoconstrictor signaling in RGS2-deficient mice
    Scott P Heximer
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 111:445-52. 2003
    ....
  28. pmc Requirement for p38 mitogen-activated protein kinase activity in neointima formation after vascular injury
    Brandon M Proctor
    Center for Cardiovascular Research, Department of Medicine, Washington University, St Louis, School of Medicine, St Louis, MO, USA
    Circulation 118:658-66. 2008
    ..In this study, the role of vascular SMC p38alpha MAPK in neointimal development was examined...
  29. ncbi request reprint ATM-dependent suppression of stress signaling reduces vascular disease in metabolic syndrome
    Jochen G Schneider
    Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Cell Metab 4:377-89. 2006
    ..These results suggest that ATM-dependent stress pathways mediate susceptibility to the metabolic syndrome and that chloroquine or related agents promoting ATM activity could modulate insulin resistance and decrease vascular disease...
  30. ncbi request reprint Dominant negative 14-3-3 promotes cardiomyocyte apoptosis in early stage of type I diabetes mellitus through activation of JNK
    Narasimman Gurusamy
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Niigata City, Japan
    Biochem Biophys Res Commun 320:773-80. 2004
    ..These results indicate for the first time that 14-3-3 protein plays a critical anti-apoptotic role in diabetic myocardium by inhibiting the JNK pathway...
  31. ncbi request reprint Glycogen synthase kinase 3beta together with 14-3-3 protein regulates diabetic cardiomyopathy: effect of losartan and tempol
    Narasimman Gurusamy
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, 5 13 2 Kamishinei cho, Niigata City, Japan
    FEBS Lett 580:1932-40. 2006
    ..Our results suggest that GSK3beta together with 14-3-3 protein plays essential roles in the signaling of diabetic cardiomyopathy, and treatment with either losartan or tempol prevents these changes...
  32. doi request reprint 14-3-3 protein regulates Ask1 signaling and protects against diabetic cardiomyopathy
    Rajarajan A Thandavarayan
    Department of Clinical Pharmacology, Faculty of Pharmaceutical Sciences, Niigata University of Pharmacy and Applied Life Sciences, 265 1 Higashijima, Niigata City, Japan
    Biochem Pharmacol 75:1797-806. 2008
    ....
  33. ncbi request reprint Tuning cardiomyocyte Gq signaling with RGS2
    Anthony J Muslin
    J Mol Cell Cardiol 41:14-6. 2006
  34. ncbi request reprint Inactivation of 14-3-3 protein exacerbates cardiac hypertrophy and fibrosis through enhanced expression of protein kinase C beta 2 in experimental diabetes
    Narasimman Gurusamy
    Department of Clinical Pharmacology, Niigata University of Pharmacy and Applied Life Sciences, Japan
    Biol Pharm Bull 28:957-62. 2005
    ..Our results indicate for the first time that 14-3-3 protein negatively regulates cardiac hypertrophy and fibrosis, possibly through controlling the expression of PKCbeta2 in the diabetic myocardium...
  35. ncbi request reprint Differential functions of 14-3-3 isoforms in vertebrate development
    Anthony J Muslin
    Center for Cardiovascular Research, Department of Medicine, and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Top Dev Biol 65:211-28. 2005
  36. ncbi request reprint Swimming stress in DN 14-3-3 mice triggers maladaptive cardiac remodeling: role of p38 MAPK
    Ken ichi Watanabe
    Dept of Clinical Pharmacology, Niigata Univ of Pharmacy and Applied Life Sciences, Higashijima, Niigata City, Japan
    Am J Physiol Heart Circ Physiol 292:H1269-77. 2007
    ..These results indicate for the first time that 14-3-3 protein along with p38 MAPK plays a crucial role in left ventricular remodeling associated with swimming stress...

Research Grants22

  1. RGS PROTEIN FUNCTION IN CARDIAC PHYSIOLOGY
    ANTHONY MUSLIN; Fiscal Year: 2007
    ..These experiments will help define the role of RGS proteins in the pathogenesis of cardiac hypertrophy and contractile dysfunction and may provide important information for the development of novel therapeutic agents. ..
  2. PRINCIPLES IN CARDIOVASCULAR RESEARCH TRAINING PROGRAM
    ANTHONY MUSLIN; Fiscal Year: 2007
    ..Candidates for the 6 positions requested each year are selected based on past achievements and the likelihood that they will pursue an academic research career. (End of Abstract) ..
  3. MAP Kinase and AKT Signaling in Congestive Heart Failure
    ANTHONY MUSLIN; Fiscal Year: 2007
    ..Our findings will help to identify specific signaling mechanisms involved in the regulation of cardiac myocyte growth and metabolism. ..
  4. MAP Kinase and AKT Signaling in Congestive Heart Failure
    ANTHONY MUSLIN; Fiscal Year: 2009
    ..Our findings will help to identify specific signaling mechanisms involved in the regulation of cardiac myocyte growth and metabolism. ..
  5. 14-3-3 PROTEIN FUNCTION IN CELL GROWTH AND MOTILITY
    ANTHONY MUSLIN; Fiscal Year: 2001
    ..The expectation is that the results of these experiments will establish the importance of the 14-3-3 signaling molecules in cell growth regulation and development. ..
  6. RGS PROTEIN FUNCTION IN CARDIAC PHYSIOLOGY
    ANTHONY MUSLIN; Fiscal Year: 2003
    ..abstract_text> ..
  7. ALTERED CARDIAC MYOCYTE SIGNALING IN DIABETIC MYOCARDIUM AND FUNCTIONAL SEQUELAE
    ANTHONY MUSLIN; Fiscal Year: 2009
    ..The analysis of the role of Akt2 in diabetic cardiomyopathy may lead to new therapies that may help to reduce the high mortality rate associated with diabetes. ..