Jared T Muenzer

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Evidence for a novel blood RNA diagnostic for pediatric appendicitis: the riboleukogram
    Jared T Muenzer
    Center for Critical Illness and Health Engineering, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatr Emerg Care 26:333-8. 2010
  2. pmc Characterization and modulation of the immunosuppressive phase of sepsis
    Jared T Muenzer
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Infect Immun 78:1582-92. 2010
  3. pmc IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
    Shigeaki Inoue
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:1401-9. 2010
  4. doi request reprint Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis
    Steven J Schwulst
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Shock 30:127-34. 2008
  5. pmc IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
    Jacqueline Unsinger
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:3768-79. 2010
  6. pmc Increased susceptibility to Candida infection following cecal ligation and puncture
    Christopher G Davis
    Department of Anesthesiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 414:37-43. 2011
  7. doi request reprint Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study
    Eizo Watanabe
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Lab Invest 89:549-61. 2009
  8. pmc Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis
    Jonathan E McDunn
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, 63110, USA
    FASEB J 22:561-8. 2008
  9. doi request reprint Lymphocyte phenotyping to distinguish septic from nonseptic critical illness
    Steven J Schwulst
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Am Coll Surg 206:335-42. 2008
  10. ncbi request reprint Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis
    Katherine C Chang
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    FASEB J 21:708-19. 2007

Collaborators

Detail Information

Publications16

  1. doi request reprint Evidence for a novel blood RNA diagnostic for pediatric appendicitis: the riboleukogram
    Jared T Muenzer
    Center for Critical Illness and Health Engineering, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatr Emerg Care 26:333-8. 2010
    ..To test the hypothesis that gene expression analysis of circulating white blood cells and/or plasma cytokines could be used to improve diagnostic accuracy in children being evaluated for appendicitis...
  2. pmc Characterization and modulation of the immunosuppressive phase of sepsis
    Jared T Muenzer
    Department of Pediatrics, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Infect Immun 78:1582-92. 2010
    ..However, by 7 days post-CLP, the host's immune system has recovered sufficiently to mount an effective immune response. Modulation of the immunosuppressive phase of sepsis may aid in the development of new therapeutic strategies...
  3. pmc IL-15 prevents apoptosis, reverses innate and adaptive immune dysfunction, and improves survival in sepsis
    Shigeaki Inoue
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:1401-9. 2010
    ..IL-15 represents a potentially novel therapy of this highly lethal disorder...
  4. doi request reprint Bim siRNA decreases lymphocyte apoptosis and improves survival in sepsis
    Steven J Schwulst
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Shock 30:127-34. 2008
    ..05). Treatment with Bim siRNA in vivo has the potential to be an effective therapy in the treatment of sepsis...
  5. pmc IL-7 promotes T cell viability, trafficking, and functionality and improves survival in sepsis
    Jacqueline Unsinger
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 184:3768-79. 2010
    ..If additional animal studies support its efficacy in sepsis and if current clinical trials continue to confirm its safety in diverse settings, rhIL-7 should be strongly considered for clinical trials in sepsis...
  6. pmc Increased susceptibility to Candida infection following cecal ligation and puncture
    Christopher G Davis
    Department of Anesthesiology, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 414:37-43. 2011
    ....
  7. doi request reprint Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study
    Eizo Watanabe
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Lab Invest 89:549-61. 2009
    ..However, it is not possible to determine whether the increase in autophagic vacuolization is an adaptive response or a harbinger of cell death...
  8. pmc Peptide-mediated activation of Akt and extracellular regulated kinase signaling prevents lymphocyte apoptosis
    Jonathan E McDunn
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO, 63110, USA
    FASEB J 22:561-8. 2008
    ..Molecular approaches to activate the antiapoptotic Akt and ERK signaling pathways may provide a novel tool to study these signaling pathways, as well as a new antiapoptotic strategy for the treatment of sepsis and other acute injuries...
  9. doi request reprint Lymphocyte phenotyping to distinguish septic from nonseptic critical illness
    Steven J Schwulst
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    J Am Coll Surg 206:335-42. 2008
    ..In this study, we hypothesized that lymphocyte phenotype can distinguish between septic and nonseptic critical illness...
  10. ncbi request reprint Multiple triggers of cell death in sepsis: death receptor and mitochondrial-mediated apoptosis
    Katherine C Chang
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    FASEB J 21:708-19. 2007
    ..If siRNA becomes practical therapeutically, proapoptotic proteins would be potential targets...
  11. ncbi request reprint Pneumonia after cecal ligation and puncture: a clinically relevant "two-hit" model of sepsis
    Jared T Muenzer
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Shock 26:565-70. 2006
    ....
  12. doi request reprint TLR3 agonist improves survival to secondary pneumonia in a double injury model
    Christopher G Davis
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Surg Res 182:270-6. 2013
    ....
  13. pmc An anti-apoptotic peptide improves survival in lethal total body irradiation
    Jonathan E McDunn
    Department of Anesthesiology, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Biochem Biophys Res Commun 382:657-62. 2009
    ....
  14. pmc Detection of viruses in young children with fever without an apparent source
    Joshua M Colvin
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Pediatrics 130:e1455-62. 2012
    ..Fever without an apparent source is common in young children. Currently in the United States, serious bacterial infection is unusual. Our objective was to determine specific viruses that might be responsible...
  15. ncbi request reprint Anti-apoptotic peptides protect against radiation-induced cell death
    Kevin W McConnell
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Biochem Biophys Res Commun 355:501-7. 2007
    ..Thus, by targeting steps within the apoptosis signaling pathway it is possible to develop post-exposure treatments to protect radio-sensitive tissues...
  16. ncbi request reprint The role of TCR engagement and activation-induced cell death in sepsis-induced T cell apoptosis
    Jacqueline Unsinger
    Department of Anesthesiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 177:7968-73. 2006
    ..We conclude that lymphocyte apoptosis in sepsis does not require proliferation, TCR engagement, or AICD. Thus the immunosuppression observed in sepsis cannot be the result of T cell deletion via the TCR...