John Morris

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Biomarkers predicting Alzheimer's disease in cognitively normal aging
    Yong S Shim
    Department of Neurology, Bucheon St Mary s Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea
    J Clin Neurol 7:60-8. 2011
  2. pmc Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementia
    John C Morris
    Departments of Neurology, Pathology, and Immunology and Programs in Physical Therapy and Occupational Therapy, Washington University, St Louis, MO 63108, USA
    Arch Neurol 69:700-8. 2012
  3. pmc Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease
    Odity Mukherjee
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    BMC Genet 8:3. 2007
  4. pmc APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    John C Morris
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Ann Neurol 67:122-31. 2010
  5. ncbi request reprint Dementia update 2003
    John C Morris
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Alzheimer Dis Assoc Disord 17:245-58. 2003
  6. ncbi request reprint Workshop reports from the third Asia-pacific regional meeting of the international working group on harmonization of dementia drug guidelines
    John C Morris
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:313. 2006
  7. ncbi request reprint Mild cognitive impairment and preclinical Alzheimer's disease
    John C Morris
    Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 101, St Louis, MO 63108, USA
    Geriatrics . 2005
  8. ncbi request reprint The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers
    John C Morris
    Washington University, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:210-6. 2006
  9. ncbi request reprint Dementia update 2005
    John C Morris
    Department of Neurology and the Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Alzheimer Dis Assoc Disord 19:100-17. 2005
  10. pmc Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    John C Morris
    Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
    Arch Neurol 66:1469-75. 2009

Research Grants

  1. Center For Aging
    John Morris; Fiscal Year: 2006

Detail Information

Publications93

  1. pmc Biomarkers predicting Alzheimer's disease in cognitively normal aging
    Yong S Shim
    Department of Neurology, Bucheon St Mary s Hospital, The Catholic University of Korea College of Medicine, Bucheon, Korea
    J Clin Neurol 7:60-8. 2011
    ..The presence of preclinical AD provides a critical opportunity for potential interventions with disease-modifying therapy. This review focuses on the studies of antecedent biomarkers for preclinical AD...
  2. pmc Revised criteria for mild cognitive impairment may compromise the diagnosis of Alzheimer disease dementia
    John C Morris
    Departments of Neurology, Pathology, and Immunology and Programs in Physical Therapy and Occupational Therapy, Washington University, St Louis, MO 63108, USA
    Arch Neurol 69:700-8. 2012
    ....
  3. pmc Haplotype-based association analysis of the MAPT locus in late onset Alzheimer's disease
    Odity Mukherjee
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    BMC Genet 8:3. 2007
    ..A recent study showed a significant haplotype association (H1c) with AD. The current study is an attempt to replicate this association in an independently ascertained cohort...
  4. pmc APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    John C Morris
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Ann Neurol 67:122-31. 2010
    ..To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging...
  5. ncbi request reprint Dementia update 2003
    John C Morris
    Washington University School of Medicine, St Louis, Missouri 63108, USA
    Alzheimer Dis Assoc Disord 17:245-58. 2003
    ..Topics covered include: 1) diagnosis of dementia; 2) risk factors and biomarkers; 3) mild cognitive impairment; 4) the scientific basis for treatment advances in AD; and 5) other dementing disorders...
  6. ncbi request reprint Workshop reports from the third Asia-pacific regional meeting of the international working group on harmonization of dementia drug guidelines
    John C Morris
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:313. 2006
  7. ncbi request reprint Mild cognitive impairment and preclinical Alzheimer's disease
    John C Morris
    Department of Neurology, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 101, St Louis, MO 63108, USA
    Geriatrics . 2005
    ..Another goal of current research is to develop antecedent biomarkers that can be used to detect AD prior to the appearance of symptoms and before substantial and irreversible brain damage occurs...
  8. ncbi request reprint The Uniform Data Set (UDS): clinical and cognitive variables and descriptive data from Alzheimer Disease Centers
    John C Morris
    Washington University, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 20:210-6. 2006
    ..Data obtained with the UDS are submitted to the National Alzheimer's Coordinating Center and represent a unique and valuable source of data to support and stimulate collaborative research...
  9. ncbi request reprint Dementia update 2005
    John C Morris
    Department of Neurology and the Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Alzheimer Dis Assoc Disord 19:100-17. 2005
  10. pmc Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    John C Morris
    Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
    Arch Neurol 66:1469-75. 2009
    ..To determine whether preclinical Alzheimer disease (AD), as detected by the amyloid-imaging agent Pittsburgh Compound B (PiB) in cognitively normal older adults, is associated with risk of symptomatic AD...
  11. ncbi request reprint Mild cognitive impairment (MCI) represents early-stage Alzheimer's disease
    John C Morris
    Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St Louis, Missouri 6108, USA
    J Alzheimers Dis 7:235-9; discussion 255-62. 2005
  12. pmc Neuropathology of nondemented aging: presumptive evidence for preclinical Alzheimer disease
    Joseph L Price
    Department of Anatomy and Neurobiology, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO, USA
    Neurobiol Aging 30:1026-36. 2009
    ..To determine the frequency and possible cognitive effect of histological Alzheimer's disease (AD) in autopsied older nondemented individuals...
  13. ncbi request reprint Brief screening tests for the diagnosis of dementia: comparison with the mini-mental state exam
    Sandy Kilada
    Department of Neurology, Johns Hopkins Hospital, Baltimore, Maryland, USA
    Alzheimer Dis Assoc Disord 19:8-16. 2005
    ..Combining these two tests further improves sensitivity and specificity, surpassing the MMSE, to detect dementia in individuals with memory complaints...
  14. ncbi request reprint White matter lesions are prevalent but differentially related with cognition in aging and early Alzheimer disease
    Jeffrey M Burns
    Department of Neurology, Washington University, St Louis, MO, USA
    Arch Neurol 62:1870-6. 2005
    ..White matter lesions (WMLs) are prevalent in nondemented aging and in Alzheimer disease (AD). Their relationship with cognition in the earliest stages of AD is unknown...
  15. pmc Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition
    Martha Storandt
    Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1476-81. 2009
    ..To examine the relation of amyloid-beta peptide (Abeta) levels in the cerebral cortex with structural brain integrity and cognitive performance in cognitively healthy older people...
  16. ncbi request reprint Clinical and psychometric distinction of frontotemporal and Alzheimer dementias
    Rajka M Liscic
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Arch Neurol 64:535-40. 2007
    ..Thus, the clinical phenotypes of the 2 disorders may overlap...
  17. pmc Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    Kelvin Y Liang
    From the Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
    Ann Neurol 68:311-8. 2010
    ..The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-beta (Abeta)(42), tau, and phosphorylated tau (ptau)(181) biomarkers...
  18. ncbi request reprint Verbal and visuospatial deficits in dementia with Lewy bodies
    David K Johnson
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 65:1232-8. 2005
    ..To investigate the cognitive decline in dementia with Lewy bodies (DLBs) and characterize the contribution of Lewy bodies (LBs) to cognitive impairment in the presence of concurrent Alzheimer disease (AD)...
  19. pmc Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report
    Nigel J Cairns
    Alzheimer s Disease Research Center, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1557-62. 2009
    ....
  20. pmc Informant-based dementia screening in a population-based sample of African Americans
    Theodore K Malmstrom
    Department of Neurology and Psychiatry, School of Medicine, St Louis University, 1438 South Grand Boulevard, St Louis, MO 63104, USA
    Alzheimer Dis Assoc Disord 23:117-23. 2009
    ..An informant-based screening tool for dementia may be useful in population-based studies of minority populations...
  21. ncbi request reprint Differential vulnerability of anterior white matter in nondemented aging with minimal acceleration in dementia of the Alzheimer type: evidence from diffusion tensor imaging
    Denise Head
    Howard Hughes Medical Institute, Washington University, St Louis, MO 63130, USA
    Cereb Cortex 14:410-23. 2004
    ..The dissociation between the regional effects of age and dementia status suggests that the mechanisms underlying age-associated cognitive decline are likely distinct from those underlying DAT...
  22. ncbi request reprint Association studies testing for risk for late-onset Alzheimer's disease with common variants in the beta-amyloid precursor protein (APP)
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 144:469-74. 2007
    ..However, we cannot rule out the possibility that multiple rare variants that increase APP expression or Abeta production might influence the risk for LOAD...
  23. pmc Alzheimer's disease risk variants show association with cerebrospinal fluid amyloid beta
    John S K Kauwe
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Neurogenetics 10:13-7. 2009
    ....
  24. pmc Apolipoprotein E (APOE) genotype has dissociable effects on memory and attentional-executive network function in Alzheimer's disease
    David A Wolk
    Department of Neurology, University of Pennsylvania, Philadelphia, PA 19104, USA
    Proc Natl Acad Sci U S A 107:10256-61. 2010
    ....
  25. ncbi request reprint Extreme cerebrospinal fluid amyloid beta levels identify family with late-onset Alzheimer's disease presenilin 1 mutation
    John S K Kauwe
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Ann Neurol 61:446-53. 2007
    ..Mutations in presenilin 1 (PSEN1) are known to cause AD and change Abeta levels. In this study, we have investigated DNA sequence variation in the presenilin (PSEN1) gene using CSF Abeta levels as an endophenotype for AD...
  26. pmc The cortical signature of Alzheimer's disease: regionally specific cortical thinning relates to symptom severity in very mild to mild AD dementia and is detectable in asymptomatic amyloid-positive individuals
    Bradford C Dickerson
    Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02129, USA
    Cereb Cortex 19:497-510. 2009
    ....
  27. ncbi request reprint Association studies between risk for late-onset Alzheimer's disease and variants in insulin degrading enzyme
    Petra Nowotny
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 136:62-8. 2005
    ..Although our results are not universally negative, we were unable to replicate the results of previous studies and conclude that common variants or haplotypes of these variants in IDE are not major risk factors for LOAD...
  28. pmc Variation in MAPT is associated with cerebrospinal fluid tau levels in the presence of amyloid-beta deposition
    John S K Kauwe
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 105:8050-4. 2008
    ....
  29. ncbi request reprint Relationships among cerebrospinal fluid biomarkers in dementia of the Alzheimer type
    John G Csernansky
    Alzheimer Disease Research Center, St Louis, Missouri, USA
    Alzheimer Dis Assoc Disord 16:144-9. 2002
    ..Increased CSF concentrations of tau significantly discriminated DAT and control subjects, as did the ratios of tau to Abeta and tau to Abeta(1-42)...
  30. pmc BDNF polymorphism rs6265 and hippocampal structure and memory performance in healthy control subjects
    Meghana S Karnik
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Psychiatry Res 178:425-9. 2010
    ..We concluded that in a large cohort of healthy human subjects, the Met allele of rs6265 is not associated with hippocampal structure or memory performance...
  31. pmc HDDD2 is a familial frontotemporal lobar degeneration with ubiquitin-positive, tau-negative inclusions caused by a missense mutation in the signal peptide of progranulin
    Odity Mukherjee
    Washington University Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 60:314-22. 2006
    ....
  32. pmc Relationship of dementia screening tests with biomarkers of Alzheimer's disease
    James E Galvin
    Alzheimer s Disease Research Centre, Washington University, St Louis, MO 63108, USA
    Brain 133:3290-300. 2010
    ....
  33. ncbi request reprint Absence of effect of depression on cognitive performance in early-stage Alzheimer disease
    Kimberly K Powlishta
    Department of Psychology, St Louis University, St Louis, MO, USA
    Arch Neurol 61:1265-8. 2004
    ....
  34. pmc Unified Parkinson's Disease Rating Scale-Motor Exam: inter-rater reliability of advanced practice nurse and neurologist assessments
    Janice L Palmer
    Saint Louis University School of Nursing, St Louis, Missouri, USA
    J Adv Nurs 66:1382-7. 2010
    ..This paper is a report of a study to establish the inter-rater reliability of advanced practice nurse and neurologist neurological assessments which included ratings with the Unified Parkinson's Disease Rating Scale-Motor Exam...
  35. ncbi request reprint Rates of progression in mild cognitive impairment and early Alzheimer's disease
    Martha Storandt
    Department of Psychology and Alzheimer Disease Research Center, Washington University, St Louis, MO 63108, USA
    Neurology 59:1034-41. 2002
    ..To compare rates of progression in the very mildest stages of AD, including the stage currently identified as mild cognitive impairment (MCI), and to identify predictors of those rates...
  36. ncbi request reprint Testing correlation of cognitive decline at adjacent stages of dementia
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    J Alzheimers Dis 5:409-18. 2003
    ..This method is applied to several composite psychometric factor scores in the longitudinal database from the Alzheimer's Disease Research Center (ADRC) at Washington University in St. Louis...
  37. doi request reprint Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
    Anthony F Fotenos
    Division of Biology and Biomedical Sciences, Washington University Medical School, St Louis, Missouri, USA
    Arch Neurol 65:113-20. 2008
    ..To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD)...
  38. ncbi request reprint Assessing statistical applications in publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 28:235-45. 2007
    ..To evaluate statistical applications in publications on Alzheimer's disease (AD)...
  39. pmc Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 65:176-83. 2009
    ..The objective of this study was to determine whether cerebrospinal fluid (CSF) biomarkers for AD suggest the presence of brain damage in the preclinical stage of AD...
  40. ncbi request reprint Open Access Series of Imaging Studies (OASIS): cross-sectional MRI data in young, middle aged, nondemented, and demented older adults
    Daniel S Marcus
    Washington University, MO 63110, USA
    J Cogn Neurosci 19:1498-507. 2007
    ..Automated calculation of whole-brain volume and estimated total intracranial volume are presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease...
  41. ncbi request reprint Evaluation of cognitive impairment in older adults: combining brief informant and performance measures
    James E Galvin
    Department of Neurology, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 64:718-24. 2007
    ..To combine the AD8, a brief informant interview, with performance measures to develop a brief screening tool to improve detection of cognitive impairment and dementia in general practice...
  42. ncbi request reprint Combining correlated diagnostic tests: application to neuropathologic diagnosis of Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, Missouri 63110, USA
    Med Decis Making 24:659-69. 2004
    ....
  43. pmc Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake
    Catherine M Roe
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 65:1467-71. 2008
    ..To evaluate the cognitive reserve hypothesis by examining whether individuals of greater educational attainment have better cognitive function than individuals with less education in the presence of elevated fibrillar brain amyloid levels...
  44. ncbi request reprint Changes in hippocampal volume and shape across time distinguish dementia of the Alzheimer type from healthy aging
    Lei Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 20:667-82. 2003
    ..These results suggest that different patterns of hippocampal shape change in time as well as different rates of hippocampal volume loss distinguish very mild DAT from healthy aging...
  45. pmc Vitamin D deficiency is associated with worse cognitive performance and lower bone density in older African Americans
    Consuelo H Wilkins
    Department of Medicine, Division of Geriatrics and Nutritional Science, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Natl Med Assoc 101:349-54. 2009
    ..The detrimental effects of vitamin D deficiency on the bone are widely known; however, recent data suggest that vitamin D deficiency may contribute to other disorders, including low mood, cognitive impairment, and impaired mobility...
  46. pmc Open access series of imaging studies: longitudinal MRI data in nondemented and demented older adults
    Daniel S Marcus
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cogn Neurosci 22:2677-84. 2010
    ..Automated calculation of whole-brain volume is presented to demonstrate use of the data for measuring differences associated with normal aging and Alzheimer's disease...
  47. ncbi request reprint Cerebrospinal fluid sulfatide is decreased in subjects with incipient dementia
    Xianlin Han
    Division of Bioorganic Chemistry and Molecular Pharmacology, and the Departments of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 54:115-9. 2003
    ..The cerebrospinal fluid ST to phosphatidylinositol ratio may be a very useful biomarker for the earliest clinical stage of Alzheimer's disease...
  48. pmc Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    EMBO Mol Med 1:371-80. 2009
    ..These findings have important implications for preclinical AD diagnosis and treatment...
  49. pmc Barriers and facilitators of African American participation in Alzheimer disease biomarker research
    Monique M Williams
    Alzheimer s Disease Research Center, Department of Medicine, Washington University in St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 24:S24-9. 2010
    ..Pervasive barriers impede African American participation in AD research but can be overcome through a sustained presence in the community...
  50. pmc Ascertainment bias in the clinical diagnosis of Alzheimer disease
    Martha Storandt
    Alzheimer Disease Research Center, Washington University, 4488 Forest Park Ave, Ste 130, St Louis, MO 63108, USA
    Arch Neurol 67:1364-9. 2010
    ..The clinical diagnosis of Alzheimer disease (AD) is often based, at least in part, on poor cognitive test performance compared with normative values...
  51. pmc Identification and validation of novel cerebrospinal fluid biomarkers for staging early Alzheimer's disease
    Richard J Perrin
    Division of Neuropathology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 6:e16032. 2011
    ..To discover such biomarkers, we measured AD-associated changes in the cerebrospinal fluid (CSF) proteome...
  52. ncbi request reprint Correlations between antemortem hippocampal volume and postmortem neuropathology in AD subjects
    John G Csernansky
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alzheimer Dis Assoc Disord 18:190-5. 2004
    ..The data suggest that hippocampal volume assessed in living subjects with probable AD is both a good marker of dementia severity and of an underlying element of the AD disease process...
  53. ncbi request reprint Fluctuations of CSF amyloid-beta levels: implications for a diagnostic and therapeutic biomarker
    Randall J Bateman
    Dept of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 68:666-9. 2007
    ..To investigate the stability and time course of human CSF amyloid-beta (Abeta) levels over hours...
  54. pmc Abnormalities of hippocampal surface structure in very mild dementia of the Alzheimer type
    Lei Wang
    Alzheimer s Disease Research Center and The Department of Psychiatry Box 8134, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Neuroimage 30:52-60. 2006
    ..Neurology 55, 1636--1643.] and suggest that inward deformities of the hippocampal surface in proximity to the CA1 subfield and subiculum can be used to distinguish subjects with very mild DAT from nondemented subjects...
  55. ncbi request reprint Driving and dementia in older adults: Implementation and evaluation of a continuing education project
    Thomas M Meuser
    Director of Education, Alzheimer s Disease Research Center, Washington University School of Medicine, 4488 Forest Park Avenue, Suite 130, St Louis, MO 63108, USA
    Gerontologist 46:680-7. 2006
    ....
  56. ncbi request reprint Clinical phenotype of Parkinson disease dementia
    James E Galvin
    Department of Neurology, Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 67:1605-11. 2006
    ..To determine which clinical features best characterize Parkinson disease dementia (PDD), compared with Alzheimer disease (AD) and dementia with Lewy bodies (DLB), and to determine the pathologic basis for PDD...
  57. pmc Autobiographical memory task in assessing dementia
    Denise Maue Dreyfus
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Arch Neurol 67:862-6. 2010
    ..Since 1979, our clinicians have used an autobiographical memory task testing for events that occurred over the most recent week and most recent month in their semistructured interview when assessing for dementia...
  58. ncbi request reprint Patient's rating of cognitive ability: using the AD8, a brief informant interview, as a self-rating tool to detect dementia
    James E Galvin
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 64:725-30. 2007
    ..To test the ability of patients to rate their own cognitive ability using the AD8 compared with informant and clinician ratings of cognitive status...
  59. ncbi request reprint The neuropathology of Alzheimer disease in African American and white individuals
    Consuelo H Wilkins
    Department of Internal Medicine, Neurology, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 63:87-90. 2006
    ..Data from neuropathologic studies of the frequency of Alzheimer disease (AD) among African American persons conflict as to whether the neuropathologic phenotype of AD is identical in African American and white persons...
  60. pmc Human amyloid-beta synthesis and clearance rates as measured in cerebrospinal fluid in vivo
    Randall J Bateman
    Department of Neurology, Washington University School of Medicine, 660 South Euclid Avenue, Box 8111, St Louis, Missouri 63110, USA
    Nat Med 12:856-61. 2006
    ....
  61. ncbi request reprint Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    ..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis...
  62. ncbi request reprint Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Arch Neurol 64:343-9. 2007
    ....
  63. ncbi request reprint Education and Alzheimer disease without dementia: support for the cognitive reserve hypothesis
    Catherine M Roe
    Division of Biostatistics, Washington University School of Medicine, 660 S Euclid Ave, Box 8067, St Louis, MO 63110, USA
    Neurology 68:223-8. 2007
    ..The cognitive reserve hypothesis suggests that at a particular level of AD pathology, highly educated individuals are less likely to manifest clinical symptoms of dementia vs less-educated individuals...
  64. ncbi request reprint Novel presenilin 1 mutation (S170F) causing Alzheimer disease with Lewy bodies in the third decade of life
    B Joy Snider
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 62:1821-30. 2005
    ..We describe herein a kindred with very early-onset FAD (age, <40 years) with unusual pathological features and a novel mutation in the presenilin 1 (PSEN1) gene (S170F) and review the existing literature on very early-onset FAD...
  65. pmc Plasma cortisol and progression of dementia in subjects with Alzheimer-type dementia
    John G Csernansky
    Alzheimer s Disease Research Center and the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 163:2164-9. 2006
    ....
  66. ncbi request reprint Substantial sulfatide deficiency and ceramide elevation in very early Alzheimer's disease: potential role in disease pathogenesis
    Xianlin Han
    Division of Bioorganic Chemistry and Molecular Pharmacology, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurochem 82:809-18. 2002
    ..The findings demonstrate that a marked decrease in sulfatides is associated with AD pathology even in subjects with very mild dementia and that these changes may be linked with early events in the pathological process of AD...
  67. pmc Autoregulation of cerebral blood flow to changes in arterial pressure in mild Alzheimer's disease
    Allyson R Zazulia
    Department of Neurology, Washington University, St Louis, Missouri 63110, USA
    J Cereb Blood Flow Metab 30:1883-9. 2010
    ..30, 95% CI=-7.7 to 2.7). The absence of significant change in CBF with a 10 to 15 mm Hg reduction in MAP within the normal autoregulatory range demonstrates that there is neither a generalized nor local defect of autoregulation in AD...
  68. pmc Voxelwise genome-wide association study (vGWAS)
    Jason L Stein
    Laboratory of Neuro Imaging, Department of Neurology, University of California, Los Angeles School of Medicine, Neuroscience Research Building 225E, 635 Charles Young Drive, Los Angeles, CA 90095 1769, USA
    Neuroimage 53:1160-74. 2010
    ..These genes have high relevance to brain structure. This is the first voxelwise genome wide association study to our knowledge, and offers a novel method to discover genetic influences on brain structure...
  69. ncbi request reprint Predictors of preclinical Alzheimer disease and dementia: a clinicopathologic study
    James E Galvin
    Department of Neurology, Alzheimer s Disease Research Center, School of Medicine, Washington University, St Louis, MO 63108, USA
    Arch Neurol 62:758-65. 2005
    ..To understand the earliest signs of cognitive decline caused by Alzheimer disease (AD) and other illnesses causing dementia, information is needed from well-characterized individuals without dementia studied longitudinally until autopsy...
  70. ncbi request reprint ADCS Prevention Instrument Project: ADCS-clinicians' global impression of change scales (ADCS-CGIC), self-rated and study partner-rated versions
    Lon S Schneider
    Keck School of Medicine, University of Southern California, Los Angeles, CA 90033, USA
    Alzheimer Dis Assoc Disord 20:S124-38. 2006
    ..An important consideration was whether global assessments are specific and sensitive measures of change during a prevention trial...
  71. pmc A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease
    Andrew Grupe
    Celera Diagnostics, Alameda, CA, USA
    Am J Hum Genet 78:78-88. 2006
    ..0165). These results indicate that variants in the RPS3A homologue are associated with LOAD and implicate this gene, adjacent genes, or other functional variants (e.g., noncoding RNAs) in the pathogenesis of this disorder...
  72. ncbi request reprint Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    ..These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment...
  73. ncbi request reprint Older adult drivers with cognitive impairment
    David B Carr
    Department of Medicine, Washington University, School of Medicine, St Louis, Missouri 63108, USA
    Am Fam Physician 73:1029-34. 2006
    ..Some states require reporting of specific medical conditions to their departments of motor vehicles...
  74. ncbi request reprint Accuracy of collateral source reports in very mild to mild dementia of the Alzheimer type
    Pamela Z Cacchione
    University of Iowa, Gerontological Nursing Intervention Center, College of Nursing, Iowa City, Iowa, USA
    J Am Geriatr Soc 51:819-23. 2003
    ..To examine the reporting accuracy of collateral sources (knowledgeable informants) regarding very mild and mild dementia of the Alzheimer type (DAT) and to identify characteristics associated with collateral source accuracy...
  75. ncbi request reprint Perspectives on depression, mild cognitive impairment, and cognitive decline
    David C Steffens
    Department of Psychiatry and Behavioral Sciences, Duke University School of Medicine, Durham, NC 27710, USA
    Arch Gen Psychiatry 63:130-8. 2006
    ....
  76. ncbi request reprint Imaging of Alzheimer's disease
    Benjamin C P Lee
    Department of Radiology, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuroimaging 13:199-214. 2003
    ....
  77. ncbi request reprint Alzheimer neuropathology in nondemented aging: keeping mind over matter
    Carol F Lippa
    Neurology 66:1801-2. 2006
  78. pmc Association of late-onset Alzheimer's disease with genetic variation in multiple members of the GAPD gene family
    Yonghong Li
    Celera Diagnostics, Alameda, CA 94502, USA
    Proc Natl Acad Sci U S A 101:15688-93. 2004
    ..Our observations raise the possibility that GAPD genes are AD risk factors, a hypothesis that is consistent with the role of GAPD in neuronal apoptosis...
  79. ncbi request reprint Demystifying lobar degenerations: tauopathies vs Gehrigopathies
    Paul G Ince
    Neurology 66:8-9. 2006
  80. ncbi request reprint A parametric comparison of diagnostic accuracy with three ordinal diagnostic groups
    Chengjie Xiong
    Division of Biostatistics, Washington University in St Louis, St Louis, MO 63110, USA
    Biom J 49:682-93. 2007
    ..Finally, we apply our proposed methodology to a real data set of 118 subjects to compare the diagnostic accuracy of early stage Alzheimer's disease (AD) from multiple neuropsychological tests...
  81. ncbi request reprint Vitamin D deficiency is associated with low mood and worse cognitive performance in older adults
    Consuelo H Wilkins
    Department of Medicine, Division of Geriatrics and Nutritional Science, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Am J Geriatr Psychiatry 14:1032-40. 2006
    ..This study examined the relationship among vitamin D status, cognitive performance, mood, and physical performance in older adults...
  82. ncbi request reprint Evidence that common variation in NEDD9 is associated with susceptibility to late-onset Alzheimer's and Parkinson's disease
    Yonghong Li
    Celera, 1401 Harbor Bay Parkway, Alameda, CA 94502, USA
    Hum Mol Genet 17:759-67. 2008
    ..These data implicate NEDD9 as a novel susceptibility gene for LOAD and possibly PD...
  83. ncbi request reprint Genetic association of the APP binding protein 2 gene (APBB2) with late onset Alzheimer disease
    Yonghong Li
    Celera Diagnostics, Alameda, California 94502, USA
    Hum Mutat 25:270-7. 2005
    ..43 [95% CI: 1.61-3.67]; OR(het)=2.15 [95% CI: 1.46-3.17]; P=0.00006) in the combined sample set. Our data raise the possibility that genetic variations in APBB2 may affect LOAD susceptibility...
  84. pmc Evaluating the quality of longitudinal statistical applications in original publications on Alzheimer's disease
    Chengjie Xiong
    Division of Biostatistics, Washington University, St Louis, MO 63110, USA
    Neuroepidemiology 30:112-9. 2008
    ..To evaluate the quality of longitudinal statistical applications in published studies on Alzheimer's disease (AD)...
  85. pmc TAR DNA-binding protein 43 immunohistochemistry reveals extensive neuritic pathology in FTLD-U: a midwest-southwest consortium for FTLD study
    Kimmo J Hatanpaa
    Department of Pathology, University of Texas Southwestern School of Medicine, Dallas, Texas 75390, USA
    J Neuropathol Exp Neurol 67:271-9. 2008
    ..Moreover, assessment of abnormalities in both the hippocampus and frontal cortex may be diagnostically important in FTLD-U...
  86. pmc Interaction of neuritic plaques and education predicts dementia
    Catherine M Roe
    Alzheimer s Disease Research Center, Washington University School of Medicine, 4488 Forest Park Avenue, St Louis, MO 63108, USA
    Alzheimer Dis Assoc Disord 22:188-93. 2008
    ..Among individuals with Alzheimer disease neuropathology, educational attainment, as a surrogate of cognitive reserve, modifies the influence of neuritic, but not diffuse, plaque neuropathology on the expression of dementia...
  87. ncbi request reprint Frontal-hippocampal double dissociation between normal aging and Alzheimer's disease
    Denise Head
    Howard Hughes Medical Institute, One Brookings Drive, Department of Psychology, Washington University, St Louis, MO 63130, USA
    Cereb Cortex 15:732-9. 2005
    ..A separate process, ubiquitous in aging, affects brain white matter with an anterior-to-posterior gradient and may underlie the executive difficulties common in aging...
  88. ncbi request reprint Differing neuropsychological and neuroanatomical correlates of abnormal reading in early-stage semantic dementia and dementia of the Alzheimer type
    Brian T Gold
    Department of Anatomy and Neurobiology, University of Kentucky, MN214 Chandler Medical Center, Lexington, KY 40536 0298, USA
    Neuropsychologia 43:833-46. 2005
    ....
  89. ncbi request reprint Cerebrospinal fluid tau and beta-amyloid: how well do these biomarkers reflect autopsy-confirmed dementia diagnoses?
    Christopher M Clark
    Departments of Neurology, Center for Neuerodegenerative Disease Research, Alzheimer s Disease Center, Philadelphia, PA 19104, USA
    Arch Neurol 60:1696-702. 2003
    ..To understand their value as predictors of disease-specific pathology, levels determined during life must be correlated with definitive diagnoses in mixed dementia groups and cognitively normal subjects...
  90. ncbi request reprint Longitudinal driving performance in early-stage dementia of the Alzheimer type
    Janet M Duchek
    Department of Psychology, Washington University School of Medicine, St Louis, Missouri 63130, USA
    J Am Geriatr Soc 51:1342-7. 2003
    ..To longitudinally assess on-road driving performance in healthy older adults and those with early-stage dementia of the Alzheimer type (DAT)...
  91. ncbi request reprint Longitudinal course and neuropathologic outcomes in original vs revised MCI and in pre-MCI
    Martha Storandt
    Department of Psychology, Washington University, St Louis, MO, USA
    Neurology 67:467-73. 2006
    ..To compare the natural history of individuals classified with mild cognitive impairment (MCI) in accordance with original criteria to the natural history of individuals classified with revised MCI criteria...
  92. ncbi request reprint Clinical outcomes of possible versus probable Alzheimer's disease
    Dennis T Villareal
    Division of Geriatrics and Gerontology, and the Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 61:661-7. 2003
    ..To determine whether Alzheimer's disease (AD) associated with comorbidities or atypical features (possible AD) is marked by differences in clinical course and outcomes compared with uncomplicated AD (probable AD)...
  93. pmc Prediction of on-road driving performance in patients with early Alzheimer's disease
    Laura B Brown
    Department of Psychiatry and Human Behavior, Brown University, Providence, Rhode Island, USA
    J Am Geriatr Soc 53:94-8. 2005
    ..Physicians and family members frequently are asked to provide information about driving ability in patients with Alzheimer's disease (AD), yet there has been little research on the validity of their assessments of driving performance...

Research Grants7

  1. Center For Aging
    John Morris; Fiscal Year: 2006
    ..Dr. Morris is firmly committed to accomplishing these aims and, with this award and with outstanding institutional support, to establishing a preeminent Center for Aging at Washington University. ..