J C Morris

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease
    J C Morris
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63108, USA
    J Mol Neurosci 17:101-18. 2001
  2. ncbi request reprint Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype
    L Berg
    Alzheimer s Disease Center of Washington University, St Louis, Mo 63108 2293, USA
    Arch Neurol 55:326-35. 1998
  3. pmc Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease
    C M Roe
    Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 76:501-10. 2011
  4. pmc Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study
    B M Ances
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Neurology 75:111-5. 2010
  5. pmc Cancer linked to Alzheimer disease but not vascular dementia
    C M Roe
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 74:106-12. 2010
  6. ncbi request reprint Absence of cognitive impairment or decline in preclinical Alzheimer's disease
    W P Goldman
    Department of Neurology, and the Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110, USA
    Neurology 56:361-7. 2001
  7. ncbi request reprint Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    N B Farber
    Washington University, Department of Psychiatry, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1009, USA
    Arch Gen Psychiatry 57:1165-73. 2000
  8. ncbi request reprint A prospective study of cognitive function and onset of dementia in cognitively healthy elders
    E H Rubin
    Department of Psychiatry, Alzheimer s Disease Research Center, Washington University, St Louis, MO 63110, USA
    Arch Neurol 55:395-401. 1998
  9. ncbi request reprint The AD8: a brief informant interview to detect dementia
    J E Galvin
    Department of Neurology, Alzheimer Disease Research Center, Washington University, St Louis, MO 63108, USA
    Neurology 65:559-64. 2005
  10. ncbi request reprint The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs
    J M Burns
    Department of Neurology, Washington University, St Louis, MO, USA
    Neurology 64:1397-403. 2005

Detail Information

Publications55

  1. ncbi request reprint Pathologic correlates of nondemented aging, mild cognitive impairment, and early-stage Alzheimer's disease
    J C Morris
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63108, USA
    J Mol Neurosci 17:101-18. 2001
    ..These data provide strong support for anti-amyloid intervention as a preventive therapy for AD. It is now critical to develop methods to detect preclinical AD during life...
  2. ncbi request reprint Clinicopathologic studies in cognitively healthy aging and Alzheimer's disease: relation of histologic markers to dementia severity, age, sex, and apolipoprotein E genotype
    L Berg
    Alzheimer s Disease Center of Washington University, St Louis, Mo 63108 2293, USA
    Arch Neurol 55:326-35. 1998
    ....
  3. pmc Improving CSF biomarker accuracy in predicting prevalent and incident Alzheimer disease
    C M Roe
    Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 76:501-10. 2011
    ....
  4. pmc Cognitively unimpaired HIV-positive subjects do not have increased 11C-PiB: a case-control study
    B M Ances
    Department of Neurology, Washington University, St Louis, MO 63110, USA
    Neurology 75:111-5. 2010
    ..We evaluated the amyloid-binding agent (11)C-Pittsburgh compound B ((11)C-PiB), a biomarker for Alphabeta42 deposition, in cognitively unimpaired HIV+ (n = 10) participants and matched community controls without dementia (n = 20)...
  5. pmc Cancer linked to Alzheimer disease but not vascular dementia
    C M Roe
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 74:106-12. 2010
    ..To investigate whether cancer is associated with Alzheimer disease (AD) and vascular dementia (VaD)...
  6. ncbi request reprint Absence of cognitive impairment or decline in preclinical Alzheimer's disease
    W P Goldman
    Department of Neurology, and the Alzheimer's Disease Research Center, Washington University, St. Louis, MO 63110, USA
    Neurology 56:361-7. 2001
    ..CONCLUSIONS: Pathologically confirmed preclinical AD is not associated with cognitive impairment or decline, even on measures shown to be sensitive to very mild DAT...
  7. ncbi request reprint Increased neocortical neurofibrillary tangle density in subjects with Alzheimer disease and psychosis
    N B Farber
    Washington University, Department of Psychiatry, Campus Box 8134, 660 S Euclid Ave, St Louis, MO 63110 1009, USA
    Arch Gen Psychiatry 57:1165-73. 2000
    ....
  8. ncbi request reprint A prospective study of cognitive function and onset of dementia in cognitively healthy elders
    E H Rubin
    Department of Psychiatry, Alzheimer s Disease Research Center, Washington University, St Louis, MO 63110, USA
    Arch Neurol 55:395-401. 1998
    ..To examine the earliest cognitive changes associated with the onset of dementia as well as changes associated with normal aging...
  9. ncbi request reprint The AD8: a brief informant interview to detect dementia
    J E Galvin
    Department of Neurology, Alzheimer Disease Research Center, Washington University, St Louis, MO 63108, USA
    Neurology 65:559-64. 2005
    ..Brief measures that accurately discriminate normal cognitive aging from very mild dementia are lacking. Cognitive tests often are insensitive to very mild dementia. Informant-based measures may be more sensitive in detecting early dementia...
  10. ncbi request reprint The pathology of the substantia nigra in Alzheimer disease with extrapyramidal signs
    J M Burns
    Department of Neurology, Washington University, St Louis, MO, USA
    Neurology 64:1397-403. 2005
    ..Extrapyramidal signs (EPS) are common in Alzheimer disease (AD) and increase in prevalence as AD advances. The neuropathologic substrate responsible for EPS in AD remains to be fully characterized...
  11. ncbi request reprint Early DAT is distinguished from aging by high-dimensional mapping of the hippocampus. Dementia of the Alzheimer type
    J G Csernansky
    Alzheimer s Disease Research Center and the Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110
    Neurology 55:1636-43. 2000
    ....
  12. ncbi request reprint Reliability of the Washington University Road Test. A performance-based assessment for drivers with dementia of the Alzheimer type
    L A Hunt
    Program in Occupational Therapy, Washington University School of Medicine, St Louis, MO, USA
    Arch Neurol 54:707-12. 1997
    ..To assess the reliability and stability of a standardized road test for healthy aging people and those with dementia of the Alzheimer type (DAT)...
  13. pmc Cognitive profiles in dementia: Alzheimer disease vs healthy brain aging
    D K Johnson
    Alzheimer Disease Research Center, Washington University, St Louis, MO 63108, USA
    Neurology 71:1783-9. 2008
    ..To re-examine proposed models of cognitive test performance that concluded separate factor structures were required for people with Alzheimer disease (AD) and older adults without dementia...
  14. ncbi request reprint Mild cognitive impairment represents early-stage Alzheimer disease
    J C Morris
    Alzheimer's Disease Research Center, Washington University School of Medicine, 4488 Forest Park Ave, Suite 130, St Louis, MO 63178, USA
    Arch Neurol 58:397-405. 2001
    ..We conclude that MCI generally represents early-stage AD...
  15. ncbi request reprint Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD
    A F Fotenos
    Division of Biology and Biomedical Sciences, Psychology Department, HHMI, Washington University, St Louis, MO 63108, USA
    Neurology 64:1032-9. 2005
    ....
  16. pmc Suggestive synergy between genetic variants in TF and HFE as risk factors for Alzheimer's disease
    J S K Kauwe
    Department of Psychiatry and Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Med Genet B Neuropsychiatr Genet 153:955-9. 2010
    ..002, OR = 2.4). These results validate those of the previous report and support the hypothesis that iron transport and regulation play a role in AD pathology...
  17. ncbi request reprint Neuron number in the entorhinal cortex and CA1 in preclinical Alzheimer disease
    J L Price
    Department of Anatomy, Campus Box 8108, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Arch Neurol 58:1395-402. 2001
    ....
  18. pmc CSF VILIP-1 predicts rates of cognitive decline in early Alzheimer disease
    R Tarawneh
    Department of Neurology, Hope Center for Neurological Disorders, Washington University School of Medicine, St Louis, MO, USA
    Neurology 78:709-19. 2012
    ..Visinin-like protein-1 (VILIP-1) has demonstrated potential utility as a marker of neuronal injury. We here investigate the utility of VILIP-1 and VILIP-1/Aβ42 in predicting rates of cognitive decline in early AD...
  19. pmc CSF biomarkers of Alzheimer disease in HIV-associated neurologic disease
    D B Clifford
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 73:1982-7. 2009
    ..CSF amyloid measurements in HAND have been reported to be similar to those in dementia of the Alzheimer type (DAT). Confirmatory evaluation of this finding in carefully evaluated subjects is needed...
  20. ncbi request reprint Genetic association studies between dementia of the Alzheimer's type and three receptors for apolipoprotein E in a Caucasian population
    C L Lendon
    Department of Psychiatry, Washington University Medical School, St Louis, MO 63110, USA
    Neurosci Lett 222:187-90. 1997
    ..Nevertheless, LRP is a plausible candidate gene and we may be observing a minor risk factor that will require further examination in other large independent samples to assess whether it truly modifies susceptibility to DAT...
  21. ncbi request reprint So what if tangles precede plaques?
    J L Price
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurobiol Aging 25:721-3; discussion 743-6. 2004
  22. pmc Alzheimer disease identification using amyloid imaging and reserve variables: proof of concept
    C M Roe
    Alzheimer s Disease Research Center, Department of Neurology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Neurology 75:42-8. 2010
    ..We tested whether factors thought to influence the association of AD pathology and dementia help to accurately identify dementia of the Alzheimer type (DAT) when considered together with amyloid imaging...
  23. ncbi request reprint The clock drawing test is a poor screen for very mild dementia
    K K Powlishta
    Department of Neurology, Washington University, St Louis, MO, USA
    Neurology 59:898-903. 2002
    ..To determine whether performance on the clock drawing test varies as a function of dementia severity and particularly whether it differentiates cognitively normal older adults from those with very mild dementia...
  24. ncbi request reprint Preclinical detection of Alzheimer's disease: hippocampal shape and volume predict dementia onset in the elderly
    J G Csernansky
    Department of Psychiatry, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuroimage 25:783-92. 2005
    ..These results suggest that inward deformation of the left hippocampal surface in a zone corresponding to the CA1 subfield is an early predictor of the onset of DAT in nondemented elderly subjects...
  25. ncbi request reprint Variability in annual Mini-Mental State Examination score in patients with probable Alzheimer disease: a clinical perspective of data from the Consortium to Establish a Registry for Alzheimer's Disease
    C M Clark
    Department of Neurology, Alzheimer s Disease Center, University of Pennsylvania, Philadelphia 19104, USA
    Arch Neurol 56:857-62. 1999
    ..To determine the variability in annual Mini-Mental State Examination scores of patients with Alzheimer disease enrolled in the Consortium to Establish a Registry for Alzheimer's Disease (CERAD)...
  26. ncbi request reprint Effect of APOE genotype and promoter polymorphism on risk of Alzheimer's disease
    J C Wang
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 55:1644-9. 2000
    ..To verify the association between APOE gene promoter polymorphisms and the development of AD and to determine whether the effect of promoter polymorphisms on AD is independent of the APOE epsilon4 allele...
  27. ncbi request reprint Familial dementia with Lewy bodies: clinicopathologic analysis of two kindreds
    J E Galvin
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63108, USA
    Neurology 59:1079-82. 2002
    ..Familial DLB is clinically heterogeneous and occurs with or without coexistent AD, suggesting the relevance of LB pathology for the developing dementia...
  28. ncbi request reprint Progressive posterior cortical dysfunction: a clinicopathologic series
    J A Renner
    Department of Psychiatry, Washington University, St Louis, MO, USA
    Neurology 63:1175-80. 2004
    ..The neuropathologic correlates of PPCD remain poorly defined...
  29. ncbi request reprint Neuropathology for the neuroradiologist: plaques and tangles
    F J Wippold
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO, USA
    AJNR Am J Neuroradiol 29:18-22. 2008
    ..The purpose of this report is to review the significance of plaques and neurofibrillary tangles in the context of Alzheimer disease...
  30. ncbi request reprint Clinically significant depressive symptoms and very mild to mild dementia of the Alzheimer type
    E H Rubin
    Department of Psychiatry and the Alzheimer s Disease Research Center, Washington University, St Louis, MO 63110, USA
    Int J Geriatr Psychiatry 16:694-701. 2001
    ..To compare depressive symptoms reported by persons with very mild or mild dementia of the Alzheimer type (DAT) with those reported for the person by a collateral source...
  31. ncbi request reprint Evidence that age-associated memory impairment is not a normal variant of aging
    W P Goldman
    Department of Neurology, and the Alzheimer's Disease Research Center, Washington University, St. Louis, Missouri 63108, USA
    Alzheimer Dis Assoc Disord 15:72-9. 2001
    ..Hence, AAMI may represent a dementia prodrome rather than a benign variant of aging...
  32. ncbi request reprint Attention and driving performance in Alzheimer's disease
    J M Duchek
    Program in Occupational Therapy, Washington University School of Medicine, St Louis, MO 63108, USA
    J Gerontol B Psychol Sci Soc Sci 53:P130-41. 1998
    ..However, measures of selective attention may serve to better differentiate safe versus unsafe drivers, especially in the DAT population...
  33. ncbi request reprint Autosomal dominant Kufs' disease: a cause of early onset dementia
    S A Josephson
    Alzheimer's Disease Research Center, Washington University School of Medicine, St. Louis, MO 63110, USA
    J Neurol Sci 188:51-60. 2001
    ..Dementia is prominent but is almost always associated with generalized seizures and motoric disturbances early in the disease course. Kufs' disease should be considered in the differential diagnosis of early onset, atypical dementia...
  34. ncbi request reprint Current concepts in mild cognitive impairment
    R C Petersen
    Department of Neurology, Mayo Clinic Rochester, 200 First St SW, Rochester, MN 55905, USA
    Arch Neurol 58:1985-92. 2001
    ..While no treatments are recommended for MCI currently, clinical trials regarding potential therapies are under way. Recommendations concerning ethical issues in the diagnosis and the management of subjects with MCI were made...
  35. ncbi request reprint Home-based multidisciplinary diagnosis and treatment of inner-city elders with dementia
    D F Edwards
    Program in Occupational Therapy, Washington University School of Medicine, St Louis, MO 63110, USA
    Gerontologist 39:483-8. 1999
    ..Treatment was hampered by the absence or limitations of caregivers. Despite the complexities of these cases, the MAPS staff have been generally successful in addressing client problems...
  36. ncbi request reprint Alzheimer disease and cancer
    C M Roe
    Division of Biostatistics, Washington University School of Medicine, 660 South Euclid Avenue, Box 8067, St Louis, MO 63110, USA
    Neurology 64:895-8. 2005
    ..001) and that the risk of developing DAT may be less for participants with a history of cancer (p = 0.060)...
  37. ncbi request reprint [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease
    M A Mintun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 67:446-52. 2006
    ..The authors used this imaging technique to investigate whether abnormal binding occurs in clinically normal individuals, prior to the development of cognitive changes...
  38. ncbi request reprint Alcohol withdrawal seizures
    J C Morris
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri
    Emerg Med Clin North Am 5:827-39. 1987
    ..Drug therapy with benodiazepines may be effective during the withdrawal period but long-term anticonvulsant treatment is of no value...
  39. ncbi request reprint Association studies using novel polymorphisms in BACE1 and BACE2
    P Nowotny
    Department of Psychiatry (B8134, Washington University School of Medicine, 660 S. Euclid, St. Louis, MO 63110-1093, USA
    Neuroreport 12:1799-802. 2001
    ....
  40. ncbi request reprint Understanding of informed consent by demented individuals
    V D Buckles
    Department of Neurology, Washington University School of Medicine, USA
    Neurology 61:1662-6. 2003
    ..The authors developed a brief test addressing the elements of informed consent for a specific minimum-risk nontreatment research protocol...
  41. ncbi request reprint Cholinesterase inhibitors for Alzheimer's disease
    J Grutzendler
    Alzheimer Disease Research Center and Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Drugs 61:41-52. 2001
    ..We believe the benefits of their use outweigh the risks and costs and, therefore, ChEls should be considered as primary therapy for patients with mild to moderate AD...
  42. ncbi request reprint Association of missense and 5'-splice-site mutations in tau with the inherited dementia FTDP-17
    M Hutton
    Mayo Clinic Jacksonville, Florida 32224, USA
    Nature 393:702-5. 1998
    ..The increase in exon 10+ messenger RNA will increase the proportion of Tau containing four microtubule-binding repeats, which is consistent with the neuropathology described in several families with FTDP-17...
  43. pmc A longitudinal study of drivers with Alzheimer disease
    B R Ott
    Department of Clinical Neurosciences, Brown University, Providence, RI, USA
    Neurology 70:1171-8. 2008
    ..The goal of this study was to define the natural progression of driving impairment in persons who initially have very mild to mild dementia...
  44. ncbi request reprint Rofecoxib: no effect on Alzheimer's disease in a 1-year, randomized, blinded, controlled study
    S A Reines
    Merck Research Laboratories, 10 Sentry Parkway, Blue Bell, PA 19422, USA
    Neurology 62:66-71. 2004
    ..This study sought to evaluate the effect of rofecoxib, a nonsteroidal anti-inflammatory drug that selectively inhibits cyclo-oxygenase-2, in slowing the progression of dementia in patients with established AD...
  45. pmc Labeled cortical mantle distance maps of the cingulate quantify differences between dementia of the Alzheimer type and healthy aging
    M I Miller
    Center for Imaging Science, The Johns Hopkins University, Baltimore, MD 21218, USA
    Proc Natl Acad Sci U S A 100:15172-7. 2003
    ..The "shape of the cortical mantle" as measured by the cortical mantle distance profiles manifests a pronounced increase in variability with mild DAT...
  46. ncbi request reprint The BDNF Val66Met polymorphism is not associated with late onset Alzheimer's disease in three case-control samples
    Y Li
    Mol Psychiatry 10:809-10. 2005
  47. ncbi request reprint Mutation-specific functional impairments in distinct tau isoforms of hereditary FTDP-17
    M Hong
    Center for Neurodegenerative Disease Research, Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA
    Science 282:1914-7. 1998
    ....
  48. ncbi request reprint Clinical delineation and localization to chromosome 9p13.3-p12 of a unique dominant disorder in four families: hereditary inclusion body myopathy, Paget disease of bone, and frontotemporal dementia
    M J Kovach
    Division of Genetics and Metabolism, Department of Pediatrics, Southern Illinois University School of Medicine, Springfield, Illinois, USA
    Mol Genet Metab 74:458-75. 2001
    ..Hence, autosomal dominant inclusion body myopathy (HIBM), Paget disease of bone (PDB), and frontotemporal dementia (FTD) localizes to a 1.08-6.46 cM critical interval on 9p13.3-12 in the region of autosomal recessive IBM2...
  49. ncbi request reprint Radioiodine therapy of colon cancer following tissue-specific sodium iodide symporter gene transfer
    I V Scholz
    Department of Internal Medicine II, Klinikum Grosshadern, Ludwig Maximilians University Munich, Germany
    Gene Ther 12:272-80. 2005
    ..This study demonstrates the potential of NIS as a therapeutic gene allowing radioiodine therapy of colon cancer following tumor-specific NIS gene transfer...
  50. ncbi request reprint Substantial linkage disequilibrium across the insulin-degrading enzyme locus but no association with late-onset Alzheimer's disease
    R Abraham
    Department of Psychological Medicine, University of Wales College of Medicine, Cardiff CF14 4XN, Wales, UK
    Hum Genet 109:646-52. 2001
    ..We conclude that IDE does not make a substantial contribution to the aetiology of LOAD and therefore cannot account for the linkage between LOAD and 10q...
  51. ncbi request reprint A multicenter, randomized, placebo controlled, multiple-dose, safety and pharmacokinetic study of AIT-082 (Neotrofin) in mild Alzheimer's disease patients
    M Grundman
    Department of Neurosciences, University of California San Diego, 9500 Gilman, La Jolla, CA 92093, USA
    Life Sci 73:539-53. 2003
    ..No problems with tolerability or safety were found. AIT-082 appears suitable for testing in larger clinical trials for the treatment of AD and other neurologic disorders...
  52. ncbi request reprint Contribution of APOE promoter polymorphisms to Alzheimer's disease risk
    J C Lambert
    INSERM U508, Institut Pasteur de Lille, Lille, France
    Neurology 59:59-66. 2002
    ..To determine whether the effects of APOE promoter polymorphisms on AD are independent of the APOE-epsilon4 allele...
  53. ncbi request reprint Complement activation in very early Alzheimer disease
    H Zanjani
    Andrus Gerontology Center and Department of Biological Science, University of Southern California Los Angeles, California, USA
    Alzheimer Dis Assoc Disord 19:55-66. 2005
    ..However, C-system regulators CD59, CR1, DAF, and MCP were not detected on plaques or tangles at any stage, indicating that C-activation related to AD is incompletely controlled...
  54. ncbi request reprint Alpha-fetoprotein promoter-targeted sodium iodide symporter gene therapy of hepatocellular carcinoma
    M J Willhauck
    Department of Internal Medicine II, Ludwig Maximilians University, Munich, Germany
    Gene Ther 15:214-23. 2008
    ..This study demonstrates the potential of tumor-specific NIS gene therapy as an innovative treatment strategy for HCC...
  55. ncbi request reprint Interobserver disagreements on clinical dementia rating assessment: interpretation and implications for training
    R E Tractenberg
    Alzheimer's Disease Cooperative Study, Department of Neurosciences, University of California, 9500 Gilman Drive, San Diego, La Jolla, CA 92093-0949
    Alzheimer Dis Assoc Disord 15:155-61. 2001
    ....