Thalachallour Mohanakumar

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint A significant role for histocompatibility in human islet transplantation
    T Mohanakumar
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 82:180-7. 2006
  2. pmc Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway
    Nayan J Sarma
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA
    PLoS ONE 7:e50826. 2012
  3. pmc Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis
    Sabarinathan Ramachandran
    Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA
    PLoS ONE 8:e70744. 2013
  4. pmc Antibodies to MHC class II molecules induce autoimmunity: critical role for macrophages in the immunopathogenesis of obliterative airway disease
    Masashi Takenaka
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e42370. 2012
  5. ncbi request reprint Cross-talk of alloimmune response and autoimmunity: role in pathogenesis of chronic rejection
    Venkataswarup Tiriveedhi
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Discov Med 9:229-35. 2010
  6. pmc Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Muscle Nerve 43:120-6. 2011
  7. ncbi request reprint Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejection
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 83:150-8. 2007
  8. pmc Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allografts
    Deepti Saini
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 30:624-31. 2011
  9. pmc Donor graft steatosis influences immunity to hepatitis C virus and allograft outcome after liver transplantation
    Vijay Subramanian
    Department of Surgery, Washington University, St Louis, MO 63110, USA
    Transplantation 92:1259-68. 2011
  10. pmc Critical role for IL-17A/F in the immunopathogenesis of obliterative airway disease induced by Anti-MHC I antibodies
    Haseeb Ilias Basha
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 95:293-300. 2013

Research Grants

  1. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
  2. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2004
  3. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2004
  4. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2005
  5. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2005
  6. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2005
  7. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2006
  8. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2006
  9. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2007
  10. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2009

Collaborators

Detail Information

Publications63

  1. ncbi request reprint A significant role for histocompatibility in human islet transplantation
    T Mohanakumar
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 82:180-7. 2006
    ..The purpose of this study was to determine the role of pretransplant sensitization to human leukocyte antigen (HLA) in islet transplantation...
  2. pmc Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathway
    Nayan J Sarma
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA
    PLoS ONE 7:e50826. 2012
    ....
  3. pmc Hepatitis C virus induced miR200c down modulates FAP-1, a negative regulator of Src signaling and promotes hepatic fibrosis
    Sabarinathan Ramachandran
    Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA
    PLoS ONE 8:e70744. 2013
    ....
  4. pmc Antibodies to MHC class II molecules induce autoimmunity: critical role for macrophages in the immunopathogenesis of obliterative airway disease
    Masashi Takenaka
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS ONE 7:e42370. 2012
    ....
  5. ncbi request reprint Cross-talk of alloimmune response and autoimmunity: role in pathogenesis of chronic rejection
    Venkataswarup Tiriveedhi
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Discov Med 9:229-35. 2010
    ..This review details our current understanding of two distinct yet inter-dependent immune processes in the immunopathogenesis of chronic rejection...
  6. pmc Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Muscle Nerve 43:120-6. 2011
    ..The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness...
  7. ncbi request reprint Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejection
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 83:150-8. 2007
    ..However, the pathogenesis of BOS remains unclear. We hypothesized that the early posttransplant inflammation would promote the development of donor anti-human leukocyte antigen (HLA) alloimmunity and predispose to BOS...
  8. pmc Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allografts
    Deepti Saini
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 30:624-31. 2011
    ..We sought to better understand the relationship between alloimmune responses and autoimmunity and, subsequently, how autoimmunity leads to chronic rejection...
  9. pmc Donor graft steatosis influences immunity to hepatitis C virus and allograft outcome after liver transplantation
    Vijay Subramanian
    Department of Surgery, Washington University, St Louis, MO 63110, USA
    Transplantation 92:1259-68. 2011
    ..The aim of this study was to test the hypothesis that allograft steatosis alters immune responses to HCV and self-antigens promoting allograft fibrosis...
  10. pmc Critical role for IL-17A/F in the immunopathogenesis of obliterative airway disease induced by Anti-MHC I antibodies
    Haseeb Ilias Basha
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 95:293-300. 2013
    ..Using a murine model of OAD, we determined the role of IL-17 family members in induction of autoimmunity leading to OAD after ligation of MHC class I...
  11. pmc Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejection
    Ankit Bharat
    Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Thorac Surg 90:1094-101. 2010
    ..Primary graft dysfunction (PGD) is a known risk factor for bronchiolitis obliterans syndrome (BOS) after lung transplantation. Here, we report that preformed antibodies to self-antigens increase PGD risk and promote BOS...
  12. pmc Respiratory virus-induced dysregulation of T-regulatory cells leads to chronic rejection
    Ankit Bharat
    Department of Surgery Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Ann Thorac Surg 90:1637-44; discussion 1644. 2010
    ..Because CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Treg) control autoimmunity, we tested the hypothesis that respiratory virus-induced Treg dysfunction leads to BOS...
  13. pmc Increased erythrocyte C4D is associated with known alloantibody and autoantibody markers of antibody-mediated rejection in human lung transplant recipients
    Angali Golocheikine
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 29:410-6. 2010
    ..This study evaluated whether erythrocyte-bound C4d (E-C4d) is associated with known alloimmune and autoimmune markers of antibody-mediated rejection after human lung transplantation (LTx)...
  14. pmc Anti-human leukocyte antigen antibodies and preemptive antibody-directed therapy after lung transplantation
    Ramsey R Hachem
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 29:973-80. 2010
    ....
  15. doi request reprint Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosis
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 84:1704-7. 2007
    ..Further, sCD30 may represent a novel marker for surveillance of hepatic cirrhosis in transplant recipients with chronic HCV infection...
  16. pmc Immune response to extracellular matrix collagen in chronic hepatitis C-induced liver fibrosis
    Brian B Borg
    Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Liver Transpl 17:814-23. 2011
    ..Our results demonstrate that in HCV-infected patients, the levels of Abs to ECM Col1, Col2, and Col5 positively correlate with liver fibrosis, which is associated with a predominantly T(h) 2 and T(h) 17 cytokine profile...
  17. pmc Complement activation is not required for obliterative airway disease induced by antibodies to major histocompatibility complex class I: Implications for chronic lung rejection
    Masashi Takenaka
    Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Heart Lung Transplant 31:1214-22. 2012
    ....
  18. pmc Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejection
    Naohiko Fukami
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 182:309-18. 2009
    ..Therefore, approaches to prevent autoimmunity should be considered for the treatment of chronic rejection postlung transplantation...
  19. pmc A role for antibodies to human leukocyte antigens, collagen-V, and K-α1-Tubulin in antibody-mediated rejection and cardiac allograft vasculopathy
    Dilip S Nath
    Division of Cardiothoracic Surgery, Washington UniversitySchool of Medicine, St Louis, MO 63110, USA
    Transplantation 91:1036-43. 2011
    ....
  20. pmc De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejection
    Trudie A Goers
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
    J Immunol 180:4487-94. 2008
    ....
  21. pmc Pre-transplant antibodies to Kα1 tubulin and collagen-V in lung transplantation: clinical correlations
    Venkataswarup Tiriveedhi
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Heart Lung Transplant 32:807-14. 2013
    ....
  22. ncbi request reprint The significance of a single episode of minimal acute rejection after lung transplantation
    Ramsey R Hachem
    Division of Pulmonary and Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 80:1406-13. 2005
    ..Acute rejection has been identified as the primary risk factor for BOS, but the impact of minimal acute rejection, especially a solitary episode, has usually been discounted as clinically insignificant...
  23. pmc Mechanism of accommodation in a sensitized human leukocyte antigen transgenic murine cardiac transplant model
    Naohiko Fukami
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 93:364-72. 2012
    ....
  24. pmc Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantation
    Deepti Saini
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 29:1330-6. 2010
    ....
  25. pmc The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockade
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosurg 112:386-93. 2010
    ....
  26. pmc IL-12 p80 is an innate epithelial cell effector that mediates chronic allograft dysfunction
    Cassandra L Mikols
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 174:461-70. 2006
    ..Thus, we hypothesized that epithelial cell IL-12 family members could mediate lung allograft dysfunction...
  27. ncbi request reprint Role of intra-islet endothelial cells in islet allo-immunity
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 84:1316-23. 2007
    ..Therefore, we investigated whether accommodation of IECs would prevent hyperacute rejection of islets in sensitized recipients...
  28. pmc Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndrome
    Raksha Jain
    Department of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 29:531-7. 2010
    ..However, these studies did not include a non-treated BOS control cohort or perform survival analysis. This study was undertaken to estimate the effect of azithromycin treatment on survival in lung transplant recipients with BOS...
  29. pmc Acute antibody-mediated rejection after lung transplantation
    Chad A Witt
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri Electronic address
    J Heart Lung Transplant 32:1034-40. 2013
    ..Antibody-mediated rejection (AMR) after lung transplantation remains enigmatic, and there is no consensus on the characteristic clinical, immunologic and histologic features...
  30. pmc Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejection
    Dilip S Nath
    Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Organ Transplant 15:16-20. 2010
    ..The present review details recent findings for the two distinct yet interdependent immune processes in the immunopathogenesis of chronic rejection...
  31. ncbi request reprint Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantation
    Ryan C Fields
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 82:1596-601. 2006
    ..Because there is strong evidence that alloimmunity plays a significant role in the pathogenesis of BOS, we investigated whether soluble CD30 (sCD30), a T-cell activation marker, would correlate with BOS...
  32. ncbi request reprint Minimal acute rejection after lung transplantation: a risk for bronchiolitis obliterans syndrome
    Anthony P Khalifah
    Department of Internal Medicine, University of Texas Southwestern Medical Center, Divisions of Pulmonary and Critical Care Medicine and Cardiothoracic Surgery at Washington University School of Medicine, St Louis, Missouri, USA
    Am J Transplant 5:2022-30. 2005
    ..We conclude that minimal rejection is associated with an increased risk for BOS development and progression that is comparable to A2 rejection...
  33. ncbi request reprint Respiratory viral infection in obliterative airway disease after orthotopic tracheal transplantation
    Elbert Kuo
    Department of Surgery, Washington University, St Louis, Missouri 63110, USA
    Ann Thorac Surg 82:1043-50. 2006
    ..The goal of this study was to investigate the role of respiratory viral infections in chronic lung allograft rejection using the murine orthotopic tracheal transplantation model...
  34. ncbi request reprint Prolonged cold-preservation of nerve allografts
    Ida K Fox
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8328, St Louis, Missouri 63110, USA
    Muscle Nerve 31:59-69. 2005
    ..Prolonged cold-preservation of nerve allograft tissue could serve as a means to produce unlimited graft material for use in peripheral nerve reconstruction...
  35. pmc Oleanolic Acid, a plant triterpenoid, significantly improves survival and function of islet allograft
    Angaswamy Nataraju
    Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA
    Transplantation 88:987-94. 2009
    ..CONCLUSIONS.: In conclusion, OA is an attractive, dietary nontoxic plant triterpenoid, which suppresses the production of proinflammatory cytokines and delays graft-specific immune responses to prolong islet allograft survival...
  36. ncbi request reprint Inhibition of obliterative airway disease development following heterotopic murine tracheal transplantation by costimulatory molecule blockade using anti-CD40 ligand alone or in combination with donor bone marrow
    Felix G Fernandez
    Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 24:S232-8. 2005
    ..Whether tolerance induction by the administration of anti-CD40 ligand monoclonal anti-body (MR-1) alone or in conjunction with donor-derived bone marrow cells (BMCs) can prevent the development of OAD was tested in this study...
  37. pmc Engraftment of cells from porcine islets of Langerhans following transplantation of pig pancreatic primordia in non-immunosuppressed diabetic rhesus macaques
    Sharon A Rogers
    Washington University School of Medicine, St Louis, MO, USA
    Organogenesis 7:154-62. 2011
    ..The data are consistent with tolerance to a cell component of porcine islets induced by previous transplantation of E28 pig pancreatic primordia...
  38. pmc Temporal association between increased virus-specific Th17 response and spontaneous recovery from recurrent hepatitis C in a liver transplant recipient
    Anil B Seetharam
    Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
    Transplantation 92:1364-70. 2011
    ..Here, we present detailed immunological analysis of an interferon naive OLT recipient receiving uninterrupted immunosuppression who cleared HCV spontaneously 2 years after transplantation...
  39. ncbi request reprint Chimerism after vascularized limb versus bone marrow transplantation
    Michael Cohen
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Reconstr Microsurg 22:375-84. 2006
    ..The marrow component of a limb allograft is thus more effective at inducing microchimerism compared to a comparable dose of bone marrow suspension...
  40. pmc Hepatitis C virus-induced changes in microRNA 107 (miRNA-107) and miRNA-449a modulate CCL2 by targeting the interleukin-6 receptor complex in hepatitis
    Nayan J Sarma
    Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Virol 88:3733-43. 2014
    ....
  41. pmc Characterization of immune responses to cardiac self-antigens myosin and vimentin in human cardiac allograft recipients with antibody-mediated rejection and cardiac allograft vasculopathy
    Dilip S Nath
    Division of Cardiothoracic Surgery, Barnes Jewish Hospital, St Louis, Missouri, USA
    J Heart Lung Transplant 29:1277-85. 2010
    ....
  42. doi request reprint Cutoff values and data handling for solid-phase testing for antibodies to HLA: effects on listing unacceptable antigens for thoracic organ transplantation
    Chang Liu
    Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
    Hum Immunol 73:597-604. 2012
    ..This single laboratory experience is an example of establishing statistically robust cutoff values and validation across different data handling methods for use of SPI in virtual crossmatch...
  43. ncbi request reprint Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signaling
    Ankit Bharat
    Department of Surgery, Washington University School of Medicine, St Louis MO 63110, USA
    J Immunol 177:5631-8. 2006
    ..The predominant col-V-specific T cells produce IL-10 that suppresses autoreactive Th1 cells independently of direct cellular contact. Tregs are pivotal for the induction of these "suppressor" T IL-10 cells...
  44. doi request reprint Cooperative signaling for angiogenesis and neovascularization by VEGF and HGF following islet transplantation
    Anjali Golocheikine
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Transplantation 90:725-31. 2010
    ..In this study, using a murine model of subcutaneous islet transplantation with matrigel basement membrane matrix, we determined the role of the proangiogenic growth factors in enhancing the islet engraftment...
  45. pmc Mechanisms of chronic cardiac allograft rejection
    John P Costello
    Division of Cardiovascular Surgery Drs Costello and Nath, Children s National Medical Center, Washington, DC 20010 and Departments of Surgery and Pathology and Immunology Dr Mohanakumar, Washington University School of Medicine, St Louis, Missouri 63110
    Tex Heart Inst J 40:395-9. 2013
    ..Further research initiatives are needed to identify patient-specific immunosuppressive drug regimens and to elucidate factors that contribute to the chronic rejection of cardiac transplant allografts. ..
  46. pmc Perioperative blood transfusion affects hepatitis C virus (HCV)-specific immune responses and outcome following liver transplantation in HCV-infected patients
    Vijay Subramanian
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    HPB (Oxford) 16:282-94. 2014
    ..This study was conducted to investigate whether the immunomodulatory effects of packed red blood cells (PRBC) and platelets administered in the perioperative period might affect immune responses to HCV and thus outcomes in LT recipients...
  47. ncbi request reprint Induction of obliterative airway disease in murine tracheal allografts by CD8+ CTLs recognizing a single minor histocompatibility antigen
    Toru Higuchi
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 174:1871-8. 2005
    ..In conclusion, a single mHAg mismatch can induce the development of OAD. These data also suggest that mHAg-reactive CD8+ CTLs may play an important role in the pathogenesis of chronic lung allograft rejection in humans...
  48. pmc Anti-major histocompatibility complex-induced obliterative airway disease: selective role for CD4 and CD8 T cells in inducing immune responses to self-antigens
    Venkataswarup Tiriveedhi
    Departments of Surgery, ashington University School of Medicine, St Louis, Missouri 63110, USA
    J Heart Lung Transplant 32:714-22. 2013
    ..The goal of this study was to define the role of T-cell sub-sets in the pathogenesis of autoimmunity-induced obliterative airway disease by passive transfer of CD8+ or CD4+ T cells...
  49. pmc Cutting edge: Pseudomonas aeruginosa abolishes established lung transplant tolerance by stimulating B7 expression on neutrophils
    Sumiharu Yamamoto
    Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Immunol 189:4221-5. 2012
    ..These data show that neutrophils enhance T cell activation through B7 trans-costimulation and suggest that inhibiting neutrophil-mediated alloimmunity can be accomplished without compromising bacterial immune surveillance...
  50. pmc Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allografts
    Christopher D Anderson
    Departments of Surgery, Washington University, St Louis, MO 63110, USA
    Liver Transpl 17:189-200. 2011
    ..These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft...
  51. doi request reprint Chronic rejection: a significant role for Th17-mediated autoimmune responses to self-antigens
    Vijay Subramanian
    Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
    Expert Rev Clin Immunol 8:663-72. 2012
    ..These self-perpetuate each other leading to activation of profibrotic and proinflammatory cascades that ultimately result in the development of chronic rejection...
  52. ncbi request reprint Autoimmunity and lung transplantation
    Ankit Bharat
    Department of Surgery Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Front Biosci (Elite Ed) 4:2378-88. 2012
    ..In this review, we discuss recent studies and concepts related to the role of autoimmunity in the development of BOS...
  53. doi request reprint Virtual crossmatch by identification of donor-specific anti-human leukocyte antigen antibodies by solid-phase immunoassay: a 30-month analysis in living donor kidney transplantation
    Gerald P Morris
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
    Hum Immunol 71:268-73. 2010
    ..Interestingly, patients with weak DSA and negative CXM had equivalent graft survival over an 18 month follow-up period, suggesting that weak DSA may not preclude transplantation...
  54. ncbi request reprint Effects of Schwann cells and donor antigen on long-nerve allograft regeneration
    Michael J Brenner
    Department of Otolaryngology, Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Microsurgery 25:61-70. 2005
    ..Serial mixed lymphocyte assays demonstrated suppression of the recipient immune response to the donor antigen after pretreatment, but no additional neuroregenerative effect of donor alloantigen pretreatment...
  55. ncbi request reprint Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejection
    Wilson Z Ray
    Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    Muscle Nerve 43:120-6. 2011
    ..The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness. Muscle Nerve, 2011...
  56. ncbi request reprint Interleukin-1beta is prominent in the early pulmonary inflammatory response after hepatic injury
    Sean C Glasgow
    Department of Surgery, Section of Abdominal Transplantation, Washington University, St Louis, MO 63110, USA
    Surgery 138:64-70. 2005
    ..Acute lung injury and inflammation can occur after hepatic ischemia/reperfusion or cryoablation. The etiology of this response is uncertain although it involves NF-kappaB-mediated cytokine release from the liver...
  57. pmc ATHLATES: accurate typing of human leukocyte antigen through exome sequencing
    Chang Liu
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nucleic Acids Res 41:e142. 2013
    ..This novel approach should be broadly applicable to research and clinical laboratories. ..
  58. pmc Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in nonimmune-suppressed diabetic rats
    Sharon A Rogers
    Renal Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Pathol 177:854-64. 2010
    ..The data are consistent with tolerance induction to a cell component of porcine islets induced by previous transplantation of E28 pig pancreatic primordia...
  59. ncbi request reprint Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and death
    Anthony P Khalifah
    Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 170:181-7. 2004
    ....
  60. ncbi request reprint Anti-CD40 ligand monoclonal antibody induces a permissive state, but not tolerance, for murine peripheral nerve allografts
    Michael J Brenner
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Exp Neurol 186:59-69. 2004
    ..Active blockade of the CD40 costimulatory pathway with murine anti-CD40 ligand antibody therefore induces a permissive state conducive to nerve regeneration across allografts but does not establish long-term tolerance...
  61. ncbi request reprint Chronic rejection: failure of immune regulation
    Jeremy Goodman
    Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Front Biosci 8:s838-44. 2003
    ..We present here an overview of the major immune components thought to be involved in chronic rejection...
  62. ncbi request reprint Effect of age on thrombosis and morbidity in the mouse-limb transplantation model
    Thomas H H Tung
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    J Reconstr Microsurg 18:47-52. 2002
    ..01). The authors conclude that although smaller, juvenile, inbred mice have a higher anastomotic patency rate, with greater collateral vasculature in the hindlimbs, and are therefore more suitable for limb transplantation research...
  63. pmc Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID mice
    George Vlad
    Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
    Diabetes 57:1878-86. 2008
    ..The aim of our study was to explore the immunomodulatory activity of soluble immunoglobulin (Ig)-like transcript (ILT) 3-Fc in pancreatic islet transplantation and to determine its mechanism of action...

Research Grants40

  1. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
  2. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ....
  3. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ..Further, this project is intended to develop an in vitro method for differentiating HCV recurrence and acute cellular rejection following OLT that will have immediate benefit in the management of the HCV-infected OLT recipients. ..
  4. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2005
    ....
  5. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2005
    ..abstract_text> ..
  6. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2005
    ..Further, this project is intended to develop an in vitro method for differentiating HCV recurrence and acute cellular rejection following OLT that will have immediate benefit in the management of the HCV-infected OLT recipients. ..
  7. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2006
    ..Further, this project is intended to develop an in vitro method for differentiating HCV recurrence and acute cellular rejection following OLT that will have immediate benefit in the management of the HCV-infected OLT recipients. ..
  8. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2006
    ..abstract_text> ..
  9. Immune Response to Hepatitis C in Liver Transplantation
    Thalachallour Mohanakumar; Fiscal Year: 2007
    ..Further, this project is intended to develop an in vitro method for differentiating HCV recurrence and acute cellular rejection following OLT that will have immediate benefit in the management of the HCV-infected OLT recipients. ..
  10. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2009
    ....
  11. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2003
    ..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
  12. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2000
    ....
  13. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2001
    ..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
  14. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2001
    ....
  15. PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANS
    Thalachallour Mohanakumar; Fiscal Year: 2002
    ..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
  16. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2003
    ....
  17. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2010
    ....
  18. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2009
    ....
  19. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2007
    ..abstract_text> ..
  20. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 1999
    ....
  21. HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2006
    ....
  22. IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTS
    Thalachallour Mohanakumar; Fiscal Year: 2004
    ..abstract_text> ..
  23. ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)
    Thalachallour Mohanakumar; Fiscal Year: 2010
    ....