Research Topics
Genomes and Genes | Thalachallour MohanakumarSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
A significant role for histocompatibility in human islet transplantationT Mohanakumar
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Transplantation 82:180-7. 2006..The purpose of this study was to determine the role of pretransplant sensitization to human leukocyte antigen (HLA) in islet transplantation...- Cross-talk of alloimmune response and autoimmunity: role in pathogenesis of chronic rejectionVenkataswarup Tiriveedhi
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Discov Med 9:229-35. 2010..This review details our current understanding of two distinct yet inter-dependent immune processes in the immunopathogenesis of chronic rejection... 
Alloimmunity-induced autoimmunity as a potential mechanism in the pathogenesis of chronic rejection of human lung allograftsDeepti Saini
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Heart Lung Transplant 30:624-31. 2011..We sought to better understand the relationship between alloimmune responses and autoimmunity and, subsequently, how autoimmunity leads to chronic rejection...- Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejectionWilson Z Ray
Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
Muscle Nerve 43:120-6. 2011..The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness... - Anti-human leukocyte antigen antibodies and preemptive antibody-directed therapy after lung transplantationRamsey R Hachem
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Heart Lung Transplant 29:973-80. 2010.... - Increased erythrocyte C4D is associated with known alloantibody and autoantibody markers of antibody-mediated rejection in human lung transplant recipientsAngali Golocheikine
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Heart Lung Transplant 29:410-6. 2010..This study evaluated whether erythrocyte-bound C4d (E-C4d) is associated with known alloimmune and autoimmune markers of antibody-mediated rejection after human lung transplantation (LTx)... - Respiratory virus-induced dysregulation of T-regulatory cells leads to chronic rejectionAnkit Bharat
Department of Surgery Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Ann Thorac Surg 90:1637-44; discussion 1644. 2010..Because CD4(+)CD25(+)Foxp3(+) regulatory T-cells (Treg) control autoimmunity, we tested the hypothesis that respiratory virus-induced Treg dysfunction leads to BOS... - Antibodies to self-antigens predispose to primary lung allograft dysfunction and chronic rejectionAnkit Bharat
Department of Surgery, Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Thorac Surg 90:1094-101. 2010..Primary graft dysfunction (PGD) is a known risk factor for bronchiolitis obliterans syndrome (BOS) after lung transplantation. Here, we report that preformed antibodies to self-antigens increase PGD risk and promote BOS... - Donor graft steatosis influences immunity to hepatitis C virus and allograft outcome after liver transplantationVijay Subramanian
Department of Surgery, Washington University, St Louis, MO 63110, USA
Transplantation 92:1259-68. 2011..The aim of this study was to test the hypothesis that allograft steatosis alters immune responses to HCV and self-antigens promoting allograft fibrosis... - IL-12 p80 is an innate epithelial cell effector that mediates chronic allograft dysfunctionCassandra L Mikols
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
Am J Respir Crit Care Med 174:461-70. 2006.... - Early posttransplant inflammation promotes the development of alloimmunity and chronic human lung allograft rejectionAnkit Bharat
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Transplantation 83:150-8. 2007..However, the pathogenesis of BOS remains unclear. We hypothesized that the early posttransplant inflammation would promote the development of donor anti-human leukocyte antigen (HLA) alloimmunity and predispose to BOS... 
A role for antibodies to human leukocyte antigens, collagen-V, and K-α1-Tubulin in antibody-mediated rejection and cardiac allograft vasculopathyDilip S Nath
Division of Cardiothoracic Surgery, Washington UniversitySchool of Medicine, St Louis, MO 63110, USA
Transplantation 91:1036-43. 2011....- Antibodies to MHC class I induce autoimmunity: role in the pathogenesis of chronic rejectionNaohiko Fukami
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 182:309-18. 2009..Therefore, approaches to prevent autoimmunity should be considered for the treatment of chronic rejection postlung transplantation... - Mechanism of accommodation in a sensitized human leukocyte antigen transgenic murine cardiac transplant modelNaohiko Fukami
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Transplantation 93:364-72. 2012.... - Synergistic effect of antibodies to human leukocyte antigens and defensins in pathogenesis of bronchiolitis obliterans syndrome after human lung transplantationDeepti Saini
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Heart Lung Transplant 29:1330-6. 2010.... - Immune response to extracellular matrix collagen in chronic hepatitis C-induced liver fibrosisBrian B Borg
Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Liver Transpl 17:814-23. 2011..Our results demonstrate that in HCV-infected patients, the levels of Abs to ECM Col1, Col2, and Col5 positively correlate with liver fibrosis, which is associated with a predominantly T(h) 2 and T(h) 17 cytokine profile... - De novo production of K-alpha1 tubulin-specific antibodies: role in chronic lung allograft rejectionTrudie A Goers
Department of Surgery, Washington University School of Medicine, Saint Louis, MO 63110, USA
J Immunol 180:4487-94. 2008.... - Azithromycin is associated with increased survival in lung transplant recipients with bronchiolitis obliterans syndromeRaksha Jain
Department of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Heart Lung Transplant 29:531-7. 2010..However, these studies did not include a non-treated BOS control cohort or perform survival analysis. This study was undertaken to estimate the effect of azithromycin treatment on survival in lung transplant recipients with BOS... - Elevated soluble CD30 characterizes patients with hepatitis C virus-induced liver allograft cirrhosisAnkit Bharat
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Transplantation 84:1704-7. 2007..Further, sCD30 may represent a novel marker for surveillance of hepatic cirrhosis in transplant recipients with chronic HCV infection... - Role of intra-islet endothelial cells in islet allo-immunityAnkit Bharat
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Transplantation 84:1316-23. 2007..Therefore, we investigated whether accommodation of IECs would prevent hyperacute rejection of islets in sensitized recipients... - The significance of a single episode of minimal acute rejection after lung transplantationRamsey R Hachem
Division of Pulmonary and Critical Care, Washington University School of Medicine, St Louis, MO 63110, USA
Transplantation 80:1406-13. 2005..Acute rejection has been identified as the primary risk factor for BOS, but the impact of minimal acute rejection, especially a solitary episode, has usually been discounted as clinically insignificant... - Prolonged cold-preservation of nerve allograftsIda K Fox
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 660 South Euclid Avenue, Box 8328, St. Louis, Missouri 63110, USA
Muscle Nerve 31:59-69. 2005..Prolonged cold-preservation of nerve allograft tissue could serve as a means to produce unlimited graft material for use in peripheral nerve reconstruction... - Inhibition of obliterative airway disease development following heterotopic murine tracheal transplantation by costimulatory molecule blockade using anti-CD40 ligand alone or in combination with donor bone marrowFelix G Fernandez
Department of Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Heart Lung Transplant 24:S232-8. 2005..Whether tolerance induction by the administration of anti-CD40 ligand monoclonal anti-body (MR-1) alone or in conjunction with donor-derived bone marrow cells (BMCs) can prevent the development of OAD was tested in this study... - Oleanolic Acid, a plant triterpenoid, significantly improves survival and function of islet allograftAngaswamy Nataraju
Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA
Transplantation 88:987-94. 2009..CONCLUSIONS.: In conclusion, OA is an attractive, dietary nontoxic plant triterpenoid, which suppresses the production of proinflammatory cytokines and delays graft-specific immune responses to prolong islet allograft survival... - The role of T helper cell differentiation in promoting nerve allograft survival with costimulation blockadeWilson Z Ray
Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosurg 112:386-93. 2010.... - Engraftment of cells from porcine islets of Langerhans following transplantation of pig pancreatic primordia in non-immunosuppressed diabetic rhesus macaquesSharon A Rogers
Washington University School of Medicine, St Louis, MO, USA
Organogenesis 7:154-62. 2011..The data are consistent with tolerance to a cell component of porcine islets induced by previous transplantation of E28 pig pancreatic primordia... - Temporal association between increased virus-specific Th17 response and spontaneous recovery from recurrent hepatitis C in a liver transplant recipientAnil B Seetharam
Department of Medicine, Washington University School of Medicine, St Louis, MO, USA
Transplantation 92:1364-70. 2011..Here, we present detailed immunological analysis of an interferon naive OLT recipient receiving uninterrupted immunosuppression who cleared HCV spontaneously 2 years after transplantation... - Antihuman leukocyte antigen antibody-induced autoimmunity: role in chronic rejectionDilip S Nath
Division of Cardiothoracic Surgery, Washington University School of Medicine, St Louis, Missouri 63110, USA
Curr Opin Organ Transplant 15:16-20. 2010..The present review details recent findings for the two distinct yet interdependent immune processes in the immunopathogenesis of chronic rejection... - Chimerism after vascularized limb versus bone marrow transplantationMichael Cohen
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St. Louis, Missouri 63110, USA
J Reconstr Microsurg 22:375-84. 2006..The marrow component of a limb allograft is thus more effective at inducing microchimerism compared to a comparable dose of bone marrow suspension... - Cutoff values and data handling for solid-phase testing for antibodies to HLA: effects on listing unacceptable antigens for thoracic organ transplantationChang Liu
Department of Pathology and Immunology, Washington University, St Louis, MO 63110, USA
Hum Immunol 73:597-604. 2012..This single laboratory experience is an example of establishing statistically robust cutoff values and validation across different data handling methods for use of SPI in virtual crossmatch... - Elevated soluble CD30 correlates with development of bronchiolitis obliterans syndrome following lung transplantationRyan C Fields
Department of Surgery, Washington University School of Medicine, St. Louis, MO, USA
Transplantation 82:1596-601. 2006..001). sCD30 levels declined in the BOS+ patients but were still elevated compared to BOS- (48.52+/-5.04 vs. 7.19+/-2.9, P < 0.0001). CONCLUSIONS: We conclude that sCD30 may represent a novel marker to monitor the development of BOS... - Induction of IL-10 suppressors in lung transplant patients by CD4+25+ regulatory T cells through CTLA-4 signalingAnkit Bharat
Department of Surgery, Washington University School of Medicine, St Louis MO 63110, USA
J Immunol 177:5631-8. 2006..The predominant col-V-specific T cells produce IL-10 that suppresses autoreactive Th1 cells independently of direct cellular contact. Tregs are pivotal for the induction of these "suppressor" T IL-10 cells... - Respiratory viral infection in obliterative airway disease after orthotopic tracheal transplantationElbert Kuo
Department of Surgery, Washington University, St. Louis, Missouri 63110, USA
Ann Thorac Surg 82:1043-50. 2006..Early treatment or vaccination against the respiratory infections may represent a viable intervention to reduce the risk of chronic rejection... - Cooperative signaling for angiogenesis and neovascularization by VEGF and HGF following islet transplantationAnjali Golocheikine
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Transplantation 90:725-31. 2010..In this study, using a murine model of subcutaneous islet transplantation with matrigel basement membrane matrix, we determined the role of the proangiogenic growth factors in enhancing the islet engraftment... - Endoplasmic reticulum stress is a mediator of posttransplant injury in severely steatotic liver allograftsChristopher D Anderson
Departments of Surgery, Washington University, St Louis, MO 63110, USA
Liver Transpl 17:189-200. 2011..These data confirm ER stress in steatotic allografts and implicate this as a mediating mechanism of inflammation and hepatocyte death in the steatotic liver allograft... - Characterization of immune responses to cardiac self-antigens myosin and vimentin in human cardiac allograft recipients with antibody-mediated rejection and cardiac allograft vasculopathyDilip S Nath
Division of Cardiothoracic Surgery, Barnes Jewish Hospital, St Louis, Missouri, USA
J Heart Lung Transplant 29:1277-85. 2010.... - Autoimmunity and lung transplantationAnkit Bharat
Department of Surgery Cardiothoracic Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
Front Biosci (Elite Ed) 4:2378-88. 2012..In this review, we discuss recent studies and concepts related to the role of autoimmunity in the development of BOS... - Cutting edge: Pseudomonas aeruginosa abolishes established lung transplant tolerance by stimulating B7 expression on neutrophilsSumiharu Yamamoto
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 189:4221-5. 2012..These data show that neutrophils enhance T cell activation through B7 trans-costimulation and suggest that inhibiting neutrophil-mediated alloimmunity can be accomplished without compromising bacterial immune surveillance... - Hepatitis C virus mediated changes in miRNA-449a modulates inflammatory biomarker YKL40 through components of the NOTCH signaling pathwayNayan J Sarma
Department of Surgery, Washington University School of Medicine, Saint Louis, MO, USA
PLoS ONE 7:e50826. 2012.... - Costimulation blockade inhibits the indirect pathway of allorecognition in nerve allograft rejectionWilson Z Ray
Department of Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
Muscle Nerve 43:120-6. 2011..The indirect pathway is required to induce costimulatory blockade immune hyporesponsiveness. Muscle Nerve, 2011... - Virtual crossmatch by identification of donor-specific anti-human leukocyte antigen antibodies by solid-phase immunoassay: a 30-month analysis in living donor kidney transplantationGerald P Morris
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, Missouri, USA
Hum Immunol 71:268-73. 2010..Interestingly, patients with weak DSA and negative CXM had equivalent graft survival over an 18 month follow-up period, suggesting that weak DSA may not preclude transplantation... - Effects of Schwann cells and donor antigen on long-nerve allograft regenerationMichael J Brenner
Department of Otolaryngology, Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110-1093, USA
Microsurgery 25:61-70. 2005..Serial mixed lymphocyte assays demonstrated suppression of the recipient immune response to the donor antigen after pretreatment, but no additional neuroregenerative effect of donor alloantigen pretreatment... - Induction of obliterative airway disease in murine tracheal allografts by CD8+ CTLs recognizing a single minor histocompatibility antigenToru Higuchi
Department of Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Immunol 174:1871-8. 2005..In conclusion, a single mHAg mismatch can induce the development of OAD. These data also suggest that mHAg-reactive CD8+ CTLs may play an important role in the pathogenesis of chronic lung allograft rejection in humans... - Engraftment of cells from porcine islets of Langerhans and normalization of glucose tolerance following transplantation of pig pancreatic primordia in nonimmune-suppressed diabetic ratsSharon A Rogers
Renal Division, Department of Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Pathol 177:854-64. 2010..The data are consistent with tolerance induction to a cell component of porcine islets induced by previous transplantation of E28 pig pancreatic primordia... - Antibodies to MHC class II molecules induce autoimmunity: critical role for macrophages in the immunopathogenesis of obliterative airway diseaseMasashi Takenaka
Department of Surgery, Washington University School of Medicine, St Louis, Missouri, United States of America
PLoS ONE 7:e42370. 2012.... - Interleukin-1beta is prominent in the early pulmonary inflammatory response after hepatic injurySean C Glasgow
Department of Surgery, Section of Abdominal Transplantation, Washington University, St Louis, MO 63110, USA
Surgery 138:64-70. 2005..Acute lung injury and inflammation can occur after hepatic ischemia/reperfusion or cryoablation. The etiology of this response is uncertain although it involves NF-kappaB-mediated cytokine release from the liver... - Anti-CD40 ligand monoclonal antibody induces a permissive state, but not tolerance, for murine peripheral nerve allograftsMichael J Brenner
Department of Otolaryngology-Head and Neck Surgery, Washington University School of Medicine, St. Louis, MO 63110, USA
Exp Neurol 186:59-69. 2004..Active blockade of the CD40 costimulatory pathway with murine anti-CD40 ligand antibody therefore induces a permissive state conducive to nerve regeneration across allografts but does not establish long-term tolerance... - Chronic rejection: a significant role for Th17-mediated autoimmune responses to self-antigensVijay Subramanian
Department of Surgery, Washington University School of Medicine, St Louis, MO, USA
Expert Rev Clin Immunol 8:663-72. 2012..These self-perpetuate each other leading to activation of profibrotic and proinflammatory cascades that ultimately result in the development of chronic rejection... - Respiratory viral infections are a distinct risk for bronchiolitis obliterans syndrome and deathAnthony P Khalifah
Division of Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Respir Crit Care Med 170:181-7. 2004.... - Chronic rejection: failure of immune regulationJeremy Goodman
Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Front Biosci 8:s838-44. 2003..We present here an overview of the major immune components thought to be involved in chronic rejection... - Effect of age on thrombosis and morbidity in the mouse-limb transplantation modelThomas H H Tung
Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
J Reconstr Microsurg 18:47-52. 2002..01). The authors conclude that although smaller, juvenile, inbred mice have a higher anastomotic patency rate, with greater collateral vasculature in the hindlimbs, and are therefore more suitable for limb transplantation research... - Minimal acute rejection after lung transplantation: a risk for bronchiolitis obliterans syndromeAnthony P Khalifah
Department of Internal Medicine, University of Texas Southwestern Medical Center, Divisions of Pulmonary and Critical Care Medicine and Cardiothoracic Surgery at Washington University School of Medicine, St. Louis, Missouri, USA
Am J Transplant 5:2022-30. 2005..We conclude that minimal rejection is associated with an increased risk for BOS development and progression that is comparable to A2 rejection... - Immunoglobulin-like transcript 3-Fc suppresses T-cell responses to allogeneic human islet transplants in hu-NOD/SCID miceGeorge Vlad
Department of Pathology, College of Physicians and Surgeons of Columbia University, New York, New York, USA
Diabetes 57:1878-86. 2008..The aim of our study was to explore the immunomodulatory activity of soluble immunoglobulin (Ig)-like transcript (ILT) 3-Fc in pancreatic islet transplantation and to determine its mechanism of action...
Research Grants
- HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2006....
- IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2010....
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2009....
- IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2009....
- IMMUNE MECHANISMS OF REJECTION IN HUMAN LUNG ALLOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2007..abstract_text> ..
- Immune Response to Hepatitis C in Liver TransplantationThalachallour Mohanakumar; Fiscal Year: 2007..Further, this project is intended to develop an in vitro method for differentiating HCV recurrence and acute cellular rejection following OLT that will have immediate benefit in the management of the HCV-infected OLT recipients. ..
- PATHOGENESIS OF POST-TRANSPLANT BRONCHIOLITIS OBLITERANSThalachallour Mohanakumar; Fiscal Year: 2004..The overall goal of this proposal is to employ this unique murine preclinical model of OAD in order to define the cellular and molecular mechanism leading to BOS following clinical lung transplantation. ..
- HUMAN IMMUNE RESPONSE TO PORCINE XENOGRAFTSThalachallour Mohanakumar; Fiscal Year: 2001....
- ALLOANTIBODIES TO MHC INDUCES AUTOIMMUNITY AND OBLITERATIVE AIRWAY DISEASE (OAD)Thalachallour Mohanakumar; Fiscal Year: 2010....