Bettina Mittendorfer

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women
    Gordon I Smith
    School of Medicine, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 3:e1875. 2008
  2. pmc Sexually dimorphic effect of aging on skeletal muscle protein synthesis
    Gordon I Smith
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue Campus, Box 8031, Saint Louis, MO 63110, USA
    Biol Sex Differ 3:11. 2012
  3. pmc Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants
    B Mittendorfer
    Washington University School of Medicine, Division of Geriatrics and Nutritional Sciences, 660 South Euclid Avenue Campus Box 8031, St Louis, MO 63110, USA
    J Physiol 563:203-11. 2005
  4. ncbi request reprint Sexual dimorphism in human lipid metabolism
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO, USA
    J Nutr 135:681-6. 2005
  5. ncbi request reprint Insulin resistance: sex matters
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Sciences, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Clin Nutr Metab Care 8:367-72. 2005
  6. pmc Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 14:535-41. 2011
  7. pmc Relationship between body fat mass and free fatty acid kinetics in men and women
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:1872-7. 2009
  8. pmc Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women
    Xuewen Wang
    Washington Univ School of Medicine, Division of Geriatrics and Nutritional Science, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 302:E740-6. 2012
  9. pmc No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in middle-aged adults
    Gordon I Smith
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8031, St Louis, MO 63110, USA
    J Appl Physiol (1985) 107:1308-15. 2009
  10. pmc Multiorgan insulin sensitivity in lean and obese subjects
    Caterina Conte
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 35:1316-21. 2012

Research Grants

  1. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2004
  2. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2005
  3. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2006
  4. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2007

Detail Information

Publications70

  1. pmc Differences in muscle protein synthesis and anabolic signaling in the postabsorptive state and in response to food in 65-80 year old men and women
    Gordon I Smith
    School of Medicine, Washington University, St Louis, Missouri, United States of America
    PLoS ONE 3:e1875. 2008
    ..05) in both sexes. Thus, there is sexual dimorphism in MPS and its control in older adults; a greater basal rate of MPS, operating over most of the day may partially explain the slower loss of muscle in older women...
  2. pmc Sexually dimorphic effect of aging on skeletal muscle protein synthesis
    Gordon I Smith
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue Campus, Box 8031, Saint Louis, MO 63110, USA
    Biol Sex Differ 3:11. 2012
    ..abstract:..
  3. pmc Protein synthesis rates in human muscles: neither anatomical location nor fibre-type composition are major determinants
    B Mittendorfer
    Washington University School of Medicine, Division of Geriatrics and Nutritional Sciences, 660 South Euclid Avenue Campus Box 8031, St Louis, MO 63110, USA
    J Physiol 563:203-11. 2005
    ..05), were within approximately 15%, biologically probably insignificant. The rates of collagen synthesis were not affected by amino acid infusion and varied by < 5% between muscles and experimental conditions...
  4. ncbi request reprint Sexual dimorphism in human lipid metabolism
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO, USA
    J Nutr 135:681-6. 2005
    ....
  5. ncbi request reprint Insulin resistance: sex matters
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Sciences, Washington University, School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Clin Nutr Metab Care 8:367-72. 2005
    ....
  6. pmc Origins of metabolic complications in obesity: adipose tissue and free fatty acid trafficking
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Clin Nutr Metab Care 14:535-41. 2011
    ..The ways by which fatty acid 're-routing' may affect metabolic function are summarized in this article...
  7. pmc Relationship between body fat mass and free fatty acid kinetics in men and women
    Bettina Mittendorfer
    Division of Geriatrics and Nutritional Science and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 17:1872-7. 2009
    ....
  8. pmc Testosterone increases the muscle protein synthesis rate but does not affect very-low-density lipoprotein metabolism in obese premenopausal women
    Xuewen Wang
    Washington Univ School of Medicine, Division of Geriatrics and Nutritional Science, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 302:E740-6. 2012
    ..001). We conclude that testosterone is a potent skeletal muscle protein anabolic agent, but not an important regulator of plasma lipid homeostasis in obese women...
  9. pmc No major sex differences in muscle protein synthesis rates in the postabsorptive state and during hyperinsulinemia-hyperaminoacidemia in middle-aged adults
    Gordon I Smith
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Ave, Campus Box 8031, St Louis, MO 63110, USA
    J Appl Physiol (1985) 107:1308-15. 2009
    ..25). We conclude that there are no major differences in the rate of MPS and its intracellular control during basal conditions and during hyperinsulinemia-hyperaminoacidema between young and middle-aged adult men and women...
  10. pmc Multiorgan insulin sensitivity in lean and obese subjects
    Caterina Conte
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes Care 35:1316-21. 2012
    ..To provide a comprehensive assessment of multiorgan insulin sensitivity in lean and obese subjects with normal glucose tolerance...
  11. pmc Testosterone and progesterone, but not estradiol, stimulate muscle protein synthesis in postmenopausal women
    Gordon I Smith
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Endocrinol Metab 99:256-65. 2014
    ....
  12. pmc Effect of weight loss on the rate of muscle protein synthesis during fasted and fed conditions in obese older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 20:1780-6. 2012
    ..Thus, the loss of muscle mass must be mediated predominately by adverse effects of dietary calorie restriction on muscle proteolysis...
  13. pmc Estrogen deficiency after menopause does not result in male very-low-density lipoprotein metabolism phenotype
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    J Clin Endocrinol Metab 95:3377-84. 2010
    ..The mechanisms responsible for this are unclear but are thought to be related to differences in the sex hormone milieu in men and women...
  14. ncbi request reprint What does the measurement of whole-body fatty acid rate of appearance in plasma by using a fatty acid tracer really mean?
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Diabetes 52:1641-8. 2003
    ....
  15. pmc Omega-3 polyunsaturated fatty acids augment the muscle protein anabolic response to hyperinsulinaemia-hyperaminoacidaemia in healthy young and middle-aged men and women
    Gordon I Smith
    Center for Human Nutrition, Division of Geriatrics and Nutritional Sciences, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Sci (Lond) 121:267-78. 2011
    ..e. muscle cell size) were both greater (P<0.05) after LCn-3PUFA supplementation. We conclude that LCn-3PUFAs have anabolic properties in healthy young and middle-aged adults...
  16. pmc Gastric bypass and banding equally improve insulin sensitivity and β cell function
    David Bradley
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 122:4667-74. 2012
    ..We conclude that marked weight loss itself is primarily responsible for the therapeutic effects of RYGB and LAGB on insulin sensitivity, β cell function, and oral glucose tolerance in nondiabetic obese adults...
  17. pmc Basal adipose tissue and hepatic lipid kinetics are not affected by a single exercise bout of moderate duration and intensity in sedentary women
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Clin Sci (Lond) 116:327-34. 2009
    ..We conclude that, in women, as in men, a single session of exercise of moderate intensity and duration is not sufficient to bring about the alterations in VLDL metabolism that have been linked to post-exercise hypotriacylglycerolaemia...
  18. pmc A ~60-min brisk walk increases insulin-stimulated glucose disposal but has no effect on hepatic and adipose tissue insulin sensitivity in older women
    Xuewen Wang
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, Missouri, USA
    J Appl Physiol (1985) 114:1563-8. 2013
    ..Therefore, we conclude that a single bout of brisk walking for ∼1 h improves muscle insulin sensitivity but has no effect on liver and adipose tissue insulin sensitivity in older women...
  19. pmc Tauroursodeoxycholic Acid may improve liver and muscle but not adipose tissue insulin sensitivity in obese men and women
    Marleen Kars
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 59:1899-905. 2010
    ..The purpose of this study was to determine the effect of TUDCA therapy on multiorgan insulin action and metabolic factors associated with insulin resistance in obese men and women...
  20. pmc Dietary omega-3 fatty acid supplementation increases the rate of muscle protein synthesis in older adults: a randomized controlled trial
    Gordon I Smith
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 93:402-12. 2011
    ..Omega-3 (n-3) fatty acids stimulate protein anabolism in animals and might therefore be useful for the treatment of sarcopenia. However, the effect of omega-3 fatty acids on human protein metabolism is unknown...
  21. ncbi request reprint Effect of sex and obesity on basal VLDL-triacylglycerol kinetics
    Bettina Mittendorfer
    Center for Human Nutrition and the Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Clin Nutr 77:573-9. 2003
    ..Plasma fatty acid availability is a major regulator of VLDL-triacylglycerol production. Basal whole-body lipolysis is higher in women than in men and is higher in persons with abdominal obesity than in lean individuals...
  22. ncbi request reprint A single 1-h bout of evening exercise increases basal FFA flux without affecting VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics in untrained lean men
    Faidon Magkos
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 292:E1568-74. 2007
    ....
  23. pmc Free fatty acid kinetics in the late phase of postexercise recovery: importance of resting fatty acid metabolism and exercise-induced energy deficit
    Faidon Magkos
    Washington University School of Medicine, St Louis, MO 63110, USA Department of Nutrition and Dietetics, Harokopio University, Athens 17671, Greece
    Metabolism 58:1248-55. 2009
    ....
  24. ncbi request reprint Women produce fewer but triglyceride-richer very low-density lipoproteins than men
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 92:1311-8. 2007
    ..The concentrations of VLDL particles and VLDL-triglyceride (TG) in plasma are lower in women than men, but the mechanisms responsible for these differences are unclear...
  25. pmc Recombinant human leptin treatment does not improve insulin action in obese subjects with type 2 diabetes
    Bettina Mittendorfer
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Diabetes 60:1474-7. 2011
    ..The purpose of the current study was to determine whether leptin treatment has weight loss-independent effects on insulin action in obese subjects with type 2 diabetes...
  26. pmc Validation of a novel index to assess insulin resistance of adipose tissue lipolytic activity in obese subjects
    Elisa Fabbrini
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 53:321-4. 2012
    ..854, P < 0.001). These results demonstrate that the ATIRI provides a reliable index of adipose tissue insulin resistance in obese subjects...
  27. pmc One day of mixed meal overfeeding reduces hepatic insulin sensitivity and increases VLDL particle but not VLDL-triglyceride secretion in overweight and obese men
    Gordon I Smith
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 98:3454-62. 2013
    ..The exact mechanisms responsible for increased plasma triglyceride (TG) concentration in obese people are unclear, and it is not known whether excess energy intake per se is involved in the pathophysiology of this abnormality...
  28. pmc Resveratrol supplementation does not improve metabolic function in nonobese women with normal glucose tolerance
    Jun Yoshino
    Center for Human Nutrition and Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Cell Metab 16:658-64. 2012
    ..These findings demonstrate that resveratrol supplementation does not have beneficial metabolic effects in nonobese, postmenopausal women with normal glucose tolerance...
  29. ncbi request reprint No effect of menstrual cycle phase on basal very-low-density lipoprotein triglyceride and apolipoprotein B-100 kinetics
    Faidon Magkos
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 291:E1243-9. 2006
    ..We conclude that VLDL-TG and VLDL-apoB-100 metabolism is not affected by menstrual cycle phase...
  30. pmc Muscle protein synthesis response to exercise training in obese, older men and women
    Gordon I Smith
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO 63110, USA
    Med Sci Sports Exerc 44:1259-66. 2012
    ..Whether older women are also resistant to the anabolic effect of exercise is not known...
  31. pmc Timing of the initial muscle biopsy does not affect the measured muscle protein fractional synthesis rate during basal, postabsorptive conditions
    Gordon I Smith
    Washington Univ School of Medicine, 660 South Euclid Ave, Campus Box 8031, St Louis, MO 63110, USA
    J Appl Physiol (1985) 108:363-8. 2010
    ....
  32. ncbi request reprint VLDL-triglyceride kinetics during hyperglycemia-hyperinsulinemia: effects of sex and obesity
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E708-15. 2003
    ..Glucose and insulin decrease VLDL-TG production in both lean men and lean women; obesity is associated with resistance to the glucose- and insulin-mediated suppression of VLDL-TG secretion in women, but not in men...
  33. pmc Metabolic actions of insulin in men and women
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
    Nutrition 26:686-93. 2010
    ..g., weight loss and exercise) that are known to alter insulin sensitivity. However, these areas have not been studied comprehensively enough to draw firm conclusions...
  34. ncbi request reprint Excess body fat in men decreases plasma fatty acid availability and oxidation during endurance exercise
    Bettina Mittendorfer
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 286:E354-62. 2004
    ..However, the rate of total fat oxidation was similar in all groups because of a compensatory increase in the oxidation of nonsystemic fatty acids...
  35. pmc Blunted lipolysis and fatty acid oxidation during moderate exercise in HIV-infected subjects taking HAART
    W Todd Cade
    Department of Medicine, Washington University School of Medicine, 4444 Forest Park Blvd, St Louis, MO 63108 2212, USA
    Am J Physiol Endocrinol Metab 292:E812-9. 2007
    ..Regional differences in adipose tissue lipolysis during rest and moderate exercise may be important in HIV and warrant further study...
  36. pmc Randomized trial of exercise effect on intrahepatic triglyceride content and lipid kinetics in nonalcoholic fatty liver disease
    Shelby Sullivan
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO Atkins Center of Excellence in Obesity Medicine, Washington University School of Medicine, St Louis, Mo Division of Gastroenterology, Washington University School of Medicine, St Louis, MO
    Hepatology 55:1738-45. 2012
    ..7 ± 3.9 μmol/min before and 16.8 ± 5.4 μmol/min after training) or VLDL-apoB-100 secretion rate (1.5 ± 0.5 nmol/min before and 1.6 ± 0.6 nmol/min after training)...
  37. pmc Regular multicomponent exercise increases physical fitness and muscle protein anabolism in frail, obese, older adults
    Dennis T Villareal
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Department of Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 19:312-8. 2011
    ....
  38. ncbi request reprint Effect of weight loss on VLDL-triglyceride and apoB-100 kinetics in women with abdominal obesity
    Bettina Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 284:E549-56. 2003
    ..There is a dissociation in the effect of weight loss on VLDL-TG and apoB-100 metabolic pathways that may affect VLDL particle size...
  39. pmc Low-dose dexamethasone administration for 3 weeks favorably affects plasma HDL concentration and composition but does not affect very low-density lipoprotein kinetics
    Xuewen Wang
    Division of Geriatrics and Nutritional Science, Washington University School of Medicine, Center for Human Nutrition, St Louis, Missouri 63110, USA
    Eur J Endocrinol 167:217-23. 2012
    ..However, the metabolic effects of glucocorticoid administration to mimic subclinical glucocorticoid excess have not been evaluated...
  40. ncbi request reprint Improved insulin sensitivity after a single bout of exercise is curvilinearly related to exercise energy expenditure
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Clin Sci (Lond) 114:59-64. 2008
    ..We conclude that improved whole-body insulin resistance after a single bout of exercise is curvilinearly related to exercise energy expenditure, and requires unfeasible amounts of exercise for most sedentary individuals...
  41. ncbi request reprint Effect of gender on lipid kinetics during endurance exercise of moderate intensity in untrained subjects
    Bettina Mittendorfer
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 283:E58-65. 2002
    ..However, total fat oxidation is the same in both groups because of a reciprocal decrease in the oxidation rate of fatty acids derived from nonplasma sources, presumably intramuscular and possibly plasma triglycerides, in women...
  42. pmc Subclinical hypothyroidism and hyperthyroidism have opposite effects on hepatic very-low-density lipoprotein-triglyceride kinetics
    Elisa Fabbrini
    Center for Human Nutrition, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 97:E414-8. 2012
    ..Clinically overt thyroid dysfunction is associated with alterations in triglyceride (TG) metabolism. The effect of subclinical thyroid disease on very-low-density lipoprotein (VLDL) kinetics is not known...
  43. ncbi request reprint Gastric bypass surgery improves metabolic and hepatic abnormalities associated with nonalcoholic fatty liver disease
    Samuel Klein
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Gastroenterology 130:1564-72. 2006
    ....
  44. doi request reprint Gender differences in lipid metabolism and the effect of obesity
    Faidon Magkos
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Obstet Gynecol Clin North Am 36:245-65, vii. 2009
    ..Currently, observations in this area are predominantly descriptive. The mechanisms responsible for sexual dimorphism in lipid metabolism are largely unknown...
  45. ncbi request reprint Lipid metabolism response to a single, prolonged bout of endurance exercise in healthy young men
    Faidon Magkos
    Washington Univ School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 290:E355-62. 2006
    ..Acutely, therefore, the cardioprotective lowering of plasma TG and VLDL concentrations by exercise is counteracted by a proatherogenic increase in IDL concentration...
  46. pmc One day of overfeeding impairs nocturnal glucose but not fatty acid homeostasis in overweight men
    Faidon Magkos
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri, USA
    Obesity (Silver Spring) 22:435-40. 2014
    ..We tested the hypothesis that overfeeding induces insulin resistance and increases nocturnal but not daytime plasma FFA availability in human subjects...
  47. ncbi request reprint Measurement of human mixed muscle protein fractional synthesis rate depends on the choice of amino acid tracer
    Gordon I Smith
    Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 293:E666-71. 2007
    ..Thus different precursor amino acid tracers cannot be used interchangeably for the evaluation of muscle protein synthesis, and data from studies using different tracer amino acids can be compared qualitatively but not quantitatively...
  48. ncbi request reprint Are peristaltic pumps as reliable as syringe pumps for metabolic research? Assessment of accuracy, precision, and metabolic kinetics
    B Selma Mohammed
    Division of Geriatrics and Nutritional Sciences and Center for Human Nutrition, Washington University School of Medicine, St Louis, MO, USA
    Metabolism 53:875-8. 2004
    ..Moreover, the assessment of in vivo substrate kinetics in human subjects is the same when either pump is used to infuse isotope tracers...
  49. pmc Human muscle protein turnover--why is it so variable?
    Gordon I Smith
    Division of Geriatrics and Nutritional Science, Washington Univ School of Medicine, 660 South Euclid Ave, Campus Box 8031, St Louis, MO 63110, USA
    J Appl Physiol (1985) 110:480-91. 2011
    ..g., choice of precursor pool) and 2) considerable within-subject variability. The summary of the results from our analysis can be used as guidelines for "normal" average basal FSR values at rest in healthy adults...
  50. pmc Plasma lipid transfer enzymes in non-diabetic lean and obese men and women
    Faidon Magkos
    Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Lipids 44:459-64. 2009
    ..There are considerable differences in basal plasma lipid transfer enzyme concentrations between lean and obese subjects and between men and women, which may be partly responsible for respective differences in the plasma lipid profile...
  51. ncbi request reprint Reproducibility of stable isotope-labeled tracer measures of VLDL-triglyceride and VLDL-apolipoprotein B-100 kinetics
    Faidon Magkos
    Washington University School of Medicine, St Louis, MO, USA
    J Lipid Res 48:1204-11. 2007
    ..05 and a type II error rate of 0.20 (i.e., 80% power). These findings will be useful for future studies investigating FFA, VLDL-TG, and VLDL-apoB-100 kinetics with the methods described...
  52. pmc Sex differences in lipid and lipoprotein metabolism: it's not just about sex hormones
    Xuewen Wang
    Center for Human Nutrition, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Endocrinol Metab 96:885-93. 2011
    ..Thus, the underlying physiological modulators of plasma lipid metabolism responsible for the differences between men and women remain to be elucidated...
  53. pmc Systemic Delivery of Estradiol, but not Testosterone or Progesterone, Alters Very Low Density Lipoprotein-Triglyceride Kinetics in Postmenopausal Women
    Gordon I Smith
    Washington University School of Medicine, St Louis, Missouri 63110
    J Clin Endocrinol Metab 99:E1306-10. 2014
    ..1 ± 2.5 vs. 17.4 ± 2.7 mL/min; P < .01). Conclusions: Estradiol, but not progesterone or T, is a major regulator of VLDL-TG metabolism. ..
  54. pmc Reproducibility of postprandial lipemia tests and validity of an abbreviated 4-hour test
    Edward P Weiss
    Division of Geriatrics and Nutritional Science, Center for Human Nutrition, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 57:1479-85. 2008
    ..Furthermore, abbreviated 4-hour PPLTs are a valid surrogate for longer tests and may make PPLTs more feasible in a clinical setting...
  55. ncbi request reprint Mechanism for the increase in plasma triacylglycerol concentrations after consumption of short-term, high-carbohydrate diets
    B Mittendorfer
    Department of Surgery, The University of Texas Medical Branch, Galveston, USA
    Am J Clin Nutr 73:892-9. 2001
    ..However, an unfavorable effect of HC diets is an increase in plasma triacylglycerol concentrations. The underlying mechanisms of this effect are still unclear...
  56. ncbi request reprint Use of stable isotopically labeled tracers to measure very low density lipoprotein-triglyceride turnover
    Bruce W Patterson
    Center for Human Nutrition, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8031, St Louis, MO 63110, USA
    J Lipid Res 43:223-33. 2002
    ....
  57. ncbi request reprint Alterations in lipid kinetics in men with HIV-dyslipidemia
    D N Reeds
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Physiol Endocrinol Metab 285:E490-7. 2003
    ....
  58. pmc Effect of obesity on the plasma lipoprotein subclass profile in normoglycemic and normolipidemic men and women
    F Magkos
    Center for Human Nutrition, Division of Geriatrics and Nutritional Science, Washington University School of Medicine, St Louis, MO, USA
    Int J Obes (Lond) 32:1655-64. 2008
    ..To determine the effect of obesity without the confounding effect of metabolic complications on the lipoprotein subclass profile in men and women...
  59. ncbi request reprint Effect of aging on glucose and lipid metabolism during endurance exercise
    B Mittendorfer
    Center for Human Nutrition and Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO 63110, USA
    Int J Sport Nutr Exerc Metab 11:S86-91. 2001
    ....
  60. ncbi request reprint Gender differences in lipid and glucose kinetics during short-term fasting
    B Mittendorfer
    Department of Internal Medicine and Center for Human Nutrition, Washington University School of Medicine, St. Louis, Missouri 63110, USA
    Am J Physiol Endocrinol Metab 281:E1333-9. 2001
    ..6 vs 10 +/- 0.6 micromol x kg body wt(-1) x min(-1). These data demonstrate the presence of sexual dimorphism in lipid, but not glucose, metabolism during both basal and short-term fasting conditions...
  61. ncbi request reprint Tumor necrosis factor-alpha induces skeletal muscle insulin resistance in healthy human subjects via inhibition of Akt substrate 160 phosphorylation
    Peter Plomgaard
    Department of Infectious Diseases, Rigshopitalet University of Copenhagen, Denmark
    Diabetes 54:2939-45. 2005
    ..Thus, excessive concentrations of TNF-alpha negatively regulate insulin signaling and whole-body glucose uptake in humans. Our results provide a molecular link between low-grade systemic inflammation and the metabolic syndrome...
  62. pmc Insulin resistance of muscle protein metabolism in aging
    Blake B Rasmussen
    Department of Kinesiology, University of Southern California, Los Angeles, California, USA
    FASEB J 20:768-9. 2006
    ..89; P=0.0001) and blood flow (R=0.90; P<0.0001). In conclusion, skeletal muscle protein synthesis is resistant to the anabolic action of insulin in older subjects, which may be an important contributor to the development of sarcopenia...
  63. ncbi request reprint Inhibition of lipolysis stimulates peripheral glucose uptake but has no effect on endogenous glucose production in HIV lipodystrophy
    Birgitte Lindegaard
    Centre of Inflammation and Metabolism, Department of Infectious Diseases, Rigshospitalet, Copenhagen Ø, Denmark
    Diabetes 56:2070-7. 2007
    ..The increased glucose uptake may in part be explained by increased dephosphorylation of GS (site 3a + b), resulting in increased GS activity...
  64. ncbi request reprint Influence of TNF-alpha and IL-6 infusions on insulin sensitivity and expression of IL-18 in humans
    Rikke Krogh-Madsen
    Rigshospitalet, Section 7641, Blegdamsvej 9, DK 2100 Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 291:E108-14. 2006
    ....
  65. ncbi request reprint Stable isotope tracer dilution for quantifying very low-density lipoprotein-triacylglycerol kinetics in man
    Labros S Sidossis
    Laboratory of Nutrition and Clinical Dietetics, Department of Nutrition and Dietetics, Harokopio University, 70 El Venizelou Ave, 17671 Athens, Greece
    Clin Nutr 23:457-66. 2004
    ..The aim of the present study was to develop a conceptually straightforward method, based on the traditional tracer infusion technique, for quantifying VLDL-TG production rates in man using stable isotopes...
  66. ncbi request reprint Smoking impairs muscle protein synthesis and increases the expression of myostatin and MAFbx in muscle
    Anne Marie Winther Petersen
    Centre of Inflammation and Metabolism, Department of Infectious Diseases and Copenhagen Muscle Research Centre, Copenhagen, Denmark
    Am J Physiol Endocrinol Metab 293:E843-8. 2007
    ..We conclude that smoking impairs the muscle protein synthesis process and increases the expression of genes associated with impaired muscle maintenance; smoking therefore likely increases the risk of sarcopenia...
  67. ncbi request reprint Swings and roundabouts for muscle gain and loss: differences between sexes?
    Bettina Mittendorfer
    J Appl Physiol 100:375-6. 2006
  68. ncbi request reprint Influence of disposable, concentric needle electrodes on muscle enzyme and lactate serum levels
    Josef Finsterer
    Ludwig Boltzmann Institute for Research in Epilepsy and Neuromuscular Disorders, Vienna, Austria
    J Electromyogr Kinesiol 12:329-37. 2002
    ..In conclusion this study shows that muscle enzymes do not increase immediately or 24 h following EMG with disposable, concentric needle-electrodes, irrespective of age, gender, muscle, number of investigated sites and pre-EMG CK-levels...
  69. ncbi request reprint Reconsidering idiopathic CK-elevation
    Josef Finsterer
    Neurological Hospital Rosenhugel, Vienna, Austria
    Int J Neurosci 114:1333-42. 2004
    ..In 10 of these patients CK was normal at follow-up. CK-elevation remained idiopathic in 54%. Idiopathic CK-elevation should be comprehensively re-evaluated, even if CK is only slightly elevated or normal at follow-up...
  70. pmc Essential amino acids are primarily responsible for the amino acid stimulation of muscle protein anabolism in healthy elderly adults
    Elena Volpi
    Department of Internal Medicine, University of Texas Medical Branch, Galveston, USA
    Am J Clin Nutr 78:250-8. 2003
    ..We have shown that balanced amino acids stimulate muscle protein anabolism in the elderly, but it is unknown whether all amino acids are necessary to achieve this effect...

Research Grants5

  1. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2004
    ..This information should prove useful in developing novel therapeutic approaches aimed at maintaining muscle mass throughout a person's lifespan and in patients with conditions associated with muscle wasting. ..
  2. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2005
    ..This information should prove useful in developing novel therapeutic approaches aimed at maintaining muscle mass throughout a person's lifespan and in patients with conditions associated with muscle wasting. ..
  3. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2006
    ..This information should prove useful in developing novel therapeutic approaches aimed at maintaining muscle mass throughout a person's lifespan and in patients with conditions associated with muscle wasting. ..
  4. Effects of sex and adiposity on muscle protein synthesis
    Bettina Mittendorfer; Fiscal Year: 2007
    ..This information should prove useful in developing novel therapeutic approaches aimed at maintaining muscle mass throughout a person's lifespan and in patients with conditions associated with muscle wasting. ..