Mark Mintun

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain
    Mark A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:659-64. 2004
  2. pmc Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    Kelvin Y Liang
    From the Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
    Ann Neurol 68:311-8. 2010
  3. pmc Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data
    M A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:6859-64. 2001
  4. ncbi Utilizing advanced imaging and surrogate markers across the spectrum of Alzheimer's disease
    Mark A Mintun
    Mallinckrodt Institute of Radiology, Washington University Medical Center, Campus Box 8123, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
    CNS Spectr 10:13-6. 2005
  5. ncbi [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease
    M A Mintun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 67:446-52. 2006
  6. pmc Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition
    Martha Storandt
    Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1476-81. 2009
  7. pmc Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report
    Nigel J Cairns
    Alzheimer s Disease Research Center, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1557-62. 2009
  8. pmc Role of family history for Alzheimer biomarker abnormalities in the adult children study
    Chengjie Xiong
    Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 68:1313-9. 2011
  9. ncbi Cerebral blood flow changes during vagus nerve stimulation for depression
    Charles R Conway
    Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St Louis, MO 63104, USA
    Psychiatry Res 146:179-84. 2006
  10. pmc Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Biol Psychiatry 63:377-84. 2008

Research Grants

  1. Nicotine-Induced Dopamine Changes In Addicted Smokers
    Mark Mintun; Fiscal Year: 2003
  2. The Purchase of a Combined PET CT Scanner
    Mark Mintun; Fiscal Year: 2005
  3. NINDS Center Core for Brain Imaging
    Mark Mintun; Fiscal Year: 2007

Detail Information

Publications55

  1. pmc Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brain
    Mark A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 101:659-64. 2004
    ..Our observations support the hypothesis that an increase in the NADH/NAD(+) ratio activates signaling pathways to selectively increase CBF in the physiologically stimulated brain regions...
  2. pmc Exercise and Alzheimer's disease biomarkers in cognitively normal older adults
    Kelvin Y Liang
    From the Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
    Ann Neurol 68:311-8. 2010
    ..The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-beta (Abeta)(42), tau, and phosphorylated tau (ptau)(181) biomarkers...
  3. pmc Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental data
    M A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 98:6859-64. 2001
    ..These findings strongly indicate that the increase in CBF associated with physiological activation is regulated by factors other than local requirements in oxygen...
  4. ncbi Utilizing advanced imaging and surrogate markers across the spectrum of Alzheimer's disease
    Mark A Mintun
    Mallinckrodt Institute of Radiology, Washington University Medical Center, Campus Box 8123, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
    CNS Spectr 10:13-6. 2005
    ..Other possible uses include monitoring plaque loads in patients receiving anti-amyloid therapy for Alzheimer's disease, as well as assessing plaque formation in unaffected individuals as a means of evaluating future Alzheimer's disease...
  5. ncbi [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer disease
    M A Mintun
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Neurology 67:446-52. 2006
    ..The authors used this imaging technique to investigate whether abnormal binding occurs in clinically normal individuals, prior to the development of cognitive changes...
  6. pmc Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta deposition
    Martha Storandt
    Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1476-81. 2009
    ..To examine the relation of amyloid-beta peptide (Abeta) levels in the cerebral cortex with structural brain integrity and cognitive performance in cognitively healthy older people...
  7. pmc Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case report
    Nigel J Cairns
    Alzheimer s Disease Research Center, Washington University, St Louis, Missouri 63108, USA
    Arch Neurol 66:1557-62. 2009
    ....
  8. pmc Role of family history for Alzheimer biomarker abnormalities in the adult children study
    Chengjie Xiong
    Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    Arch Neurol 68:1313-9. 2011
    ..To assess whether family history (FH) of Alzheimer disease (AD) alone influences AD biomarker abnormalities...
  9. ncbi Cerebral blood flow changes during vagus nerve stimulation for depression
    Charles R Conway
    Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St Louis, MO 63104, USA
    Psychiatry Res 146:179-84. 2006
    ..Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve...
  10. pmc Altered emotional interference processing in affective and cognitive-control brain circuitry in major depression
    Christina L Fales
    Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Biol Psychiatry 63:377-84. 2008
    ....
  11. ncbi Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomography
    Mark A Mintun
    Department of Radiology, Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Biol Psychiatry 55:217-24. 2004
    ..Postmortem and positron emission tomography studies have reported both increased and decreased 5-HT(2A) receptor binding in different limbic and paralimbic regions...
  12. pmc Effects of age and amyloid deposition on Aβ dynamics in the human central nervous system
    Yafei Huang
    Department of Neurology, Washington University School of Medicine, 660 S Euclid, PO Box 8111, St Louis, MO 63110, USA
    Arch Neurol 69:51-8. 2012
    ..The amyloid hypothesis predicts that increased production or decreased clearance of β-amyloid (Aβ) leads to amyloidosis, which ultimately culminates in Alzheimer disease (AD)...
  13. ncbi FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxin
    Delphine L Chen
    Department of Radiology, Washington University School of Medicine, St Louis, MO, USA
    J Appl Physiol 100:1602-9. 2006
    ..We conclude that the inflammatory response to low-dose endotoxin in a single lung segment can be visualized and quantified by imaging with FDG-PET...
  14. pmc Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptake
    Catherine M Roe
    Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Arch Neurol 65:1467-71. 2008
    ..Design, Setting, and..
  15. doi Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factors
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Psychiatry 165:524-32. 2008
    ..Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined...
  16. pmc The default mode network and self-referential processes in depression
    Yvette I Sheline
    Department of Psychiatry, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 106:1942-7. 2009
    ..These findings provide a brain network framework within which to consider the pathophysiology of depression...
  17. doi Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserve
    Anthony F Fotenos
    Division of Biology and Biomedical Sciences, Washington University Medical School, St Louis, Missouri, USA
    Arch Neurol 65:113-20. 2008
    ..To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD)...
  18. pmc [18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluation
    Delphine L Chen
    Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Campus Box 8223, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 180:533-9. 2009
    ..Positron emission tomography with [(18)F]fluorodeoxyglucose (FDG-PET) is a promising new method that can be used to quantify pulmonary neutrophilic inflammation...
  19. pmc Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderly
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 67:584-7. 2010
    ....
  20. pmc Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's disease
    Anthony L Hinrichs
    Department of Psychiatry, Washington University School of Medicine, St Louis, Misouri, USA
    Biol Psychiatry 67:581-3. 2010
    ..Imaging of Abeta deposition in the human brain using Pittsburgh Compound B (PIB) offers the possibility of using cortical PIB binding as a quantitative endophenotype for genetic studies of late-onset Alzheimer's disease (LOAD)...
  21. pmc Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer disease
    John C Morris
    Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
    Arch Neurol 66:1469-75. 2009
    ..To determine whether preclinical Alzheimer disease (AD), as detected by the amyloid-imaging agent Pittsburgh Compound B (PiB) in cognitively normal older adults, is associated with risk of symptomatic AD...
  22. pmc APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal aging
    John C Morris
    Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
    Ann Neurol 67:122-31. 2010
    ..To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging...
  23. pmc Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexus
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:11020-5. 2010
    ....
  24. pmc Relationship of dementia screening tests with biomarkers of Alzheimer's disease
    James E Galvin
    Alzheimer s Disease Research Centre, Washington University, St Louis, MO 63108, USA
    Brain 133:3290-300. 2010
    ....
  25. pmc APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42
    Yvette I Sheline
    Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Neurosci 30:17035-40. 2010
    ....
  26. pmc Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's disease
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
    EMBO Mol Med 1:371-80. 2009
    ..These findings have important implications for preclinical AD diagnosis and treatment...
  27. pmc Quantifying pulmonary inflammation in cystic fibrosis with positron emission tomography
    Delphine L Chen
    Department of Radiology, Washington University School of Medicine, Campus Box 8223, 660 S Euclid Ave, St Louis, MO 63110, USA
    Am J Respir Crit Care Med 173:1363-9. 2006
    ..Positron emission tomographic imaging with [18F]fluorodeoxyglucose ([18FDG]) could be used as a noninvasive alternative to quantify lung inflammation...
  28. ncbi Greater loss of 5-HT(2A) receptors in midlife than in late life
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
    Am J Psychiatry 159:430-5. 2002
    ..In this study the authors used positron emission tomography (PET) and [(18)F]altanserin, a ligand with high affinity for the 5-HT(2A) receptor, to examine the relationship between 5-HT(2A) receptor density and age in more detail...
  29. ncbi Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memory
    Randy L Buckner
    Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
    J Neurosci 25:7709-17. 2005
    ..These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment...
  30. ncbi Comparison of methods to quantitate 18F-FDG uptake with PET during experimental acute lung injury
    Delphine L Chen
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Nucl Med 45:1583-90. 2004
    ..In the present study, we have reanalyzed data from that study to determine if simpler nonkinetic methods of quantifying the pulmonary uptake of 18F-FDG could be as powerful as calculating Ki...
  31. ncbi Positron emission tomography in limited-stage small-cell lung cancer: a prospective study
    Jeffrey D Bradley
    Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, St Louis, MO 63110, USA
    J Clin Oncol 22:3248-54. 2004
    ....
  32. ncbi Quantitation of pulmonary transgene expression with PET imaging
    Jean Christophe Richard
    Washington University School of Medicine, St Louis, Missouri, USA
    J Nucl Med 45:644-54. 2004
    ....
  33. ncbi Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomography
    Yvette I Sheline
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Neuropsychopharmacology 29:2235-41. 2004
    ..04) than previously treated subjects (n = 10). It may be that prior medication treatment provides a compensatory upregulation of the 5-HT(2A) receptor...
  34. ncbi In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSM
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Eur J Nucl Med Mol Imaging 30:844-50. 2003
    ..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy...
  35. ncbi Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary report
    Farrokh Dehdashti
    Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
    Int J Radiat Oncol Biol Phys 55:1233-8. 2003
    ..We have investigated whether pretreatment tumor hypoxia assessed by positron emission tomography (PET) with Cu-60 diacetyl-bis(N(4)-methylthiosemicarbazone) ((60)Cu-ATSM) predicts responsiveness to subsequent therapy in cervical cancer...
  36. pmc A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonist
    Kevin J Black
    Departments of Psychiatry, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:17113-8. 2002
    ....
  37. ncbi Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humans
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 59:512-9. 2006
    ..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis...
  38. ncbi Brain work and brain imaging
    Marcus E Raichle
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Annu Rev Neurosci 29:449-76. 2006
    ..Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity...
  39. ncbi Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adults
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
    Arch Neurol 64:343-9. 2007
    ....
  40. pmc Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderly
    Anne M Fagan
    Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Ann Neurol 65:176-83. 2009
    ..The objective of this study was to determine whether cerebrospinal fluid (CSF) biomarkers for AD suggest the presence of brain damage in the preclinical stage of AD...
  41. pmc Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) deposition
    Andrei G Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17763-7. 2010
    ....
  42. ncbi Cerebral perfusion response to successful treatment of depression with different serotoninergic agents
    Andrei Vlassenko
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuropsychiatry Clin Neurosci 16:360-3. 2004
    ..Amesergide differs from SSRIs in that it is also a highly selective 5-HT antagonist, which may in part account for differences in cerebral blood flow response to treatment...
  43. ncbi Human brain glucose metabolism may evolve during activation: findings from a modified FDG PET paradigm
    Andrei G Vlassenko
    Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, 510 South Kingshighway Blvd St, Louis, MO 63110, USA
    Neuroimage 33:1036-41. 2006
    ..Furthermore, the observed decline in glucose metabolism may reflect a shift from glycolytic to oxidative glucose metabolism with continued activation...
  44. ncbi Time-related increase of oxygen utilization in continuously activated human visual cortex
    Mark A Mintun
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd, St Louis, Missouri 63110, USA
    Neuroimage 16:531-7. 2002
    ..With continued activation, oxygen utilization increases reducing the need for excess glycolysis...
  45. pmc Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitus
    Jay F Piccirillo
    Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8115, St Louis, MO 63110, USA
    Arch Otolaryngol Head Neck Surg 137:221-8. 2011
    ..To examine the effectiveness and safety of low-frequency repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal junction in a cohort of patients with bothersome tinnitus...
  46. ncbi Imaging of Alzheimer's disease
    Benjamin C P Lee
    Department of Radiology, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
    J Neuroimaging 13:199-214. 2003
    ....
  47. ncbi Antidepressant efficacy of olanzapine as monotherapy in major depressive disorder, without psychosis: a pilot study
    Jose Mathews
    Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S Euclid, St Louis, MO 63110, USA
    Psychiatry Res 146:149-55. 2006
    ..Half the patients (n=6) showed > or =50% reduction in their HAMD17 scores. This study points to the potential of olanzapine as a therapeutic agent for the treatment of major depressive disorder without psychosis...
  48. pmc Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous system
    Chenbo Zeng
    Department of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
    Brain Res 1319:21-32. 2010
    ..for tracking the two populations of neurons generated at different time points. In conclusion, our results suggest that EdU staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system...
  49. pmc Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging study
    Joshua S Shimony
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Psychiatry 66:245-52. 2009
    ..However, no study of LLD to date has examined the integrity of white matter outside of WMH (i.e., in normal-appearing white matter)...
  50. pmc Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. Louis workshop
    Tammie L S Benzinger
    Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri, USA
    J Neurotrauma 26:2127-44. 2009
    ....
  51. pmc Regional aerobic glycolysis in the human brain
    S Neil Vaishnavi
    Department of Radiology, Washington University, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 107:17757-62. 2010
    ....
  52. pmc Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratio
    Andrei G Vlassenko
    Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:1964-9. 2006
    ....
  53. pmc [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamen
    Jinbin Xu
    Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
    Synapse 64:449-59. 2010
    ..A mathematical model for calculating the absolute densities of dopamine D(2) and D(3) receptors based on the in vitro receptor binding data of [3H]WC-10 and [3H]raclopride was developed...
  54. pmc [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterization
    Jinbin Xu
    Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Synapse 63:717-28. 2009
    ..In vitro autoradiography studies of rat and monkey brains show that [(3)H]WC-10 labeled D(3) sites in the striatal region...
  55. ncbi Consensus nomenclature for in vivo imaging of reversibly binding radioligands
    Robert B Innis
    National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
    J Cereb Blood Flow Metab 27:1533-9. 2007
    ..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...

Research Grants9

  1. Nicotine-Induced Dopamine Changes In Addicted Smokers
    Mark Mintun; Fiscal Year: 2003
    ..Ultimately, this information may lead to a better understanding of biological predispositions to nicotine dependence and potential treatment approaches for smoking cessation. ..
  2. The Purchase of a Combined PET CT Scanner
    Mark Mintun; Fiscal Year: 2005
    ..abstract_text> ..
  3. NINDS Center Core for Brain Imaging
    Mark Mintun; Fiscal Year: 2007
    ..abstract_text> ..