Research Topics
Species | Mark MintunSummaryAffiliation: Washington University School of Medicine Country: USA Publications
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Publications
Increased lactate/pyruvate ratio augments blood flow in physiologically activated human brainMark A Mintun
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 101:659-64. 2004..Our observations support the hypothesis that an increase in the NADH/NAD(+) ratio activates signaling pathways to selectively increase CBF in the physiologically stimulated brain regions...- Exercise and Alzheimer's disease biomarkers in cognitively normal older adultsKelvin Y Liang
From the Program in Neuroscience, Division of Biology and Biomedical Sciences, Washington University, St Louis, MO 63130, USA
Ann Neurol 68:311-8. 2010..The objective of this study was to elucidate the association between exercise and AD pathology in humans using Pittsburgh compound-B (PIB), amyloid-beta (Abeta)(42), tau, and phosphorylated tau (ptau)(181) biomarkers... - Blood flow and oxygen delivery to human brain during functional activity: theoretical modeling and experimental dataM A Mintun
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 98:6859-64. 2001..These findings strongly indicate that the increase in CBF associated with physiological activation is regulated by factors other than local requirements in oxygen... 
Utilizing advanced imaging and surrogate markers across the spectrum of Alzheimer's diseaseMark A Mintun
Mallinckrodt Institute of Radiology, Washington University Medical Center, Campus Box 8123, 510 S Kingshighway Boulevard, St Louis, MO 63110, USA
CNS Spectr 10:13-6. 2005..Other possible uses include monitoring plaque loads in patients receiving anti-amyloid therapy for Alzheimer's disease, as well as assessing plaque formation in unaffected individuals as a means of evaluating future Alzheimer's disease...- [11C]PIB in a nondemented population: potential antecedent marker of Alzheimer diseaseM A Mintun
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Neurology 67:446-52. 2006..The authors used this imaging technique to investigate whether abnormal binding occurs in clinically normal individuals, prior to the development of cognitive changes... - Cognitive decline and brain volume loss as signatures of cerebral amyloid-beta peptide deposition identified with Pittsburgh compound B: cognitive decline associated with Abeta depositionMartha Storandt
Department of Psychology, School of Arts and Sciences, Washington University, St Louis, Missouri 63108, USA
Arch Neurol 66:1476-81. 2009..To examine the relation of amyloid-beta peptide (Abeta) levels in the cerebral cortex with structural brain integrity and cognitive performance in cognitively healthy older people... - Absence of Pittsburgh compound B detection of cerebral amyloid beta in a patient with clinical, cognitive, and cerebrospinal fluid markers of Alzheimer disease: a case reportNigel J Cairns
Alzheimer s Disease Research Center, Washington University, St Louis, Missouri 63108, USA
Arch Neurol 66:1557-62. 2009.... - Role of family history for Alzheimer biomarker abnormalities in the adult children studyChengjie Xiong
Charles F and Joanne Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
Arch Neurol 68:1313-9. 2011..To assess whether family history (FH) of Alzheimer disease (AD) alone influences AD biomarker abnormalities... - Cerebral blood flow changes during vagus nerve stimulation for depressionCharles R Conway
Department of Psychiatry, Saint Louis University School of Medicine, 1221 South Grand Boulevard, St Louis, MO 63104, USA
Psychiatry Res 146:179-84. 2006..Decreases were found in the bilateral temporal cortex and right parietal area. Regions of change were consistent with brain structures associated with depression and the afferent pathways of the vagus nerve... - Altered emotional interference processing in affective and cognitive-control brain circuitry in major depressionChristina L Fales
Department of Psychology, Washington University in St Louis, St Louis, Missouri 63110, USA
Biol Psychiatry 63:377-84. 2008.... - Decreased hippocampal 5-HT2A receptor binding in major depressive disorder: in vivo measurement with [18F]altanserin positron emission tomographyMark A Mintun
Department of Radiology, Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, 510 South Kingshighway Boulevard, St Louis, MO 63110, USA
Biol Psychiatry 55:217-24. 2004..Postmortem and positron emission tomography studies have reported both increased and decreased 5-HT(2A) receptor binding in different limbic and paralimbic regions... - Effects of age and amyloid deposition on Aβ dynamics in the human central nervous systemYafei Huang
Department of Neurology, Washington University School of Medicine, 660 S Euclid, PO Box 8111, St Louis, MO 63110, USA
Arch Neurol 69:51-8. 2012..The amyloid hypothesis predicts that increased production or decreased clearance of β-amyloid (Aβ) leads to amyloidosis, which ultimately culminates in Alzheimer disease (AD)... - FDG-PET imaging of pulmonary inflammation in healthy volunteers after airway instillation of endotoxinDelphine L Chen
Department of Radiology, Washington University School of Medicine, St. Louis, MO, USA
J Appl Physiol 100:1602-9. 2006..We conclude that the inflammatory response to low-dose endotoxin in a single lung segment can be visualized and quantified by imaging with FDG-PET... - Alzheimer disease and cognitive reserve: variation of education effect with carbon 11-labeled Pittsburgh Compound B uptakeCatherine M Roe
Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
Arch Neurol 65:1467-71. 2008..Design, Setting, and.. 
Regional white matter hyperintensity burden in automated segmentation distinguishes late-life depressed subjects from comparison subjects matched for vascular risk factorsYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Am J Psychiatry 165:524-32. 2008..Correlations between neuropsychological performance and whole brain-segmented white matter hyperintensities and white and gray matter volumes were also examined...- The default mode network and self-referential processes in depressionYvette I Sheline
Department of Psychiatry, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 106:1942-7. 2009..These findings provide a brain network framework within which to consider the pathophysiology of depression... - Brain volume decline in aging: evidence for a relation between socioeconomic status, preclinical Alzheimer disease, and reserveAnthony F Fotenos
Division of Biology and Biomedical Sciences, Washington University Medical School, St Louis, Missouri, USA
Arch Neurol 65:113-20. 2008..To assess the relation between socioeconomic status (SES) and structural brain change in nondemented older adults and to ascertain the potential role of preclinical Alzheimer disease (AD)... - [18F]fluorodeoxyglucose positron emission tomography for lung antiinflammatory response evaluationDelphine L Chen
Mallinckrodt Institute of Radiology, Division of Nuclear Medicine, Campus Box 8223, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
Am J Respir Crit Care Med 180:533-9. 2009..Positron emission tomography with [(18)F]fluorodeoxyglucose (FDG-PET) is a promising new method that can be used to quantify pulmonary neutrophilic inflammation... - Amyloid plaques disrupt resting state default mode network connectivity in cognitively normal elderlyYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
Biol Psychiatry 67:584-7. 2010.... - Cortical binding of pittsburgh compound B, an endophenotype for genetic studies of Alzheimer's diseaseAnthony L Hinrichs
Department of Psychiatry, Washington University School of Medicine, St Louis, Misouri, USA
Biol Psychiatry 67:581-3. 2010..Imaging of Abeta deposition in the human brain using Pittsburgh Compound B (PIB) offers the possibility of using cortical PIB binding as a quantitative endophenotype for genetic studies of late-onset Alzheimer's disease (LOAD)... - Pittsburgh compound B imaging and prediction of progression from cognitive normality to symptomatic Alzheimer diseaseJohn C Morris
Alzheimer s Disease Research Center, St Louis, Missouri 63108, USA
Arch Neurol 66:1469-75. 2009..To determine whether preclinical Alzheimer disease (AD), as detected by the amyloid-imaging agent Pittsburgh Compound B (PiB) in cognitively normal older adults, is associated with risk of symptomatic AD... - APOE predicts amyloid-beta but not tau Alzheimer pathology in cognitively normal agingJohn C Morris
Alzheimer Disease Research Center, Washington University School of Medicine, St Louis, MO 63108, USA
Ann Neurol 67:122-31. 2010..To examine interactions of apolipoprotein E (APOE) genotype with age and with in vivo measures of preclinical Alzheimer disease (AD) in cognitively normal aging... - Resting-state functional MRI in depression unmasks increased connectivity between networks via the dorsal nexusYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:11020-5. 2010.... - Relationship of dementia screening tests with biomarkers of Alzheimer's diseaseJames E Galvin
Alzheimer s Disease Research Centre, Washington University, St Louis, MO 63108, USA
Brain 133:3290-300. 2010.... - APOE4 allele disrupts resting state fMRI connectivity in the absence of amyloid plaques or decreased CSF Aβ42Yvette I Sheline
Department of Psychiatry, The Knight Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Neurosci 30:17035-40. 2010.... - Cerebrospinal fluid tau and ptau(181) increase with cortical amyloid deposition in cognitively normal individuals: implications for future clinical trials of Alzheimer's diseaseAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO, USA
EMBO Mol Med 1:371-80. 2009..These findings have important implications for preclinical AD diagnosis and treatment... - Quantifying pulmonary inflammation in cystic fibrosis with positron emission tomographyDelphine L Chen
Department of Radiology, Washington University School of Medicine, Campus Box 8223, 660 S Euclid Ave, St Louis, MO 63110, USA
Am J Respir Crit Care Med 173:1363-9. 2006..Positron emission tomographic imaging with [18F]fluorodeoxyglucose ([18FDG]) could be used as a noninvasive alternative to quantify lung inflammation... - Greater loss of 5-HT(2A) receptors in midlife than in late lifeYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110 1093, USA
Am J Psychiatry 159:430-5. 2002..In this study the authors used positron emission tomography (PET) and [(18)F]altanserin, a ligand with high affinity for the 5-HT(2A) receptor, to examine the relationship between 5-HT(2A) receptor density and age in more detail... - Molecular, structural, and functional characterization of Alzheimer's disease: evidence for a relationship between default activity, amyloid, and memoryRandy L Buckner
Howard Hughes Medical Institute, Washington University School of Medicine, St Louis, Missouri 63105, USA
J Neurosci 25:7709-17. 2005..These cortical regions may be part of a network with the medial temporal lobe whose disruption contributes to memory impairment... - Comparison of methods to quantitate 18F-FDG uptake with PET during experimental acute lung injuryDelphine L Chen
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
J Nucl Med 45:1583-90. 2004..In the present study, we have reanalyzed data from that study to determine if simpler nonkinetic methods of quantifying the pulmonary uptake of 18F-FDG could be as powerful as calculating Ki... - Positron emission tomography in limited-stage small-cell lung cancer: a prospective studyJeffrey D Bradley
Department of Radiation Oncology, Mallinckrodt Institute of Radiology, Washington University School of Medicine, 4921 Parkview Place, St Louis, MO 63110, USA
J Clin Oncol 22:3248-54. 2004.... - Quantitation of pulmonary transgene expression with PET imagingJean-Christophe Richard
Washington University School of Medicine, St. Louis, Missouri, USA
J Nucl Med 45:644-54. 2004..CONCLUSION: In rodent lungs, (18)F-FHBG uptake appears to be a function of both transport into tissues expressing the transgene as well as the level of transgene expression itself... - Decreased hippocampal 5-HT(2A) receptor binding in older depressed patients using [18F]altanserin positron emission tomographyYvette I Sheline
Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
Neuropsychopharmacology 29:2235-41. 2004..04) than previously treated subjects (n = 10). It may be that prior medication treatment provides a compensatory upregulation of the 5-HT(2A) receptor... - In vivo assessment of tumor hypoxia in lung cancer with 60Cu-ATSMFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Eur J Nucl Med Mol Imaging 30:844-50. 2003..04; P=0.9). (60)Cu-ATSM-PET can be readily performed in patients with NSCLC and the tumor uptake of (60)Cu-ATSM reveals clinically unique information about tumor oxygenation that is predictive of tumor response to therapy... - Assessing tumor hypoxia in cervical cancer by positron emission tomography with 60Cu-ATSM: relationship to therapeutic response-a preliminary reportFarrokh Dehdashti
Division of Nuclear Medicine, Edward Mallinckrodt Institute of Radiology, St Louis, MO 63110, USA
Int J Radiat Oncol Biol Phys 55:1233-8. 2003..We have investigated whether pretreatment tumor hypoxia assessed by positron emission tomography (PET) with Cu-60 diacetyl-bis(N(4)-methylthiosemicarbazone) ((60)Cu-ATSM) predicts responsiveness to subsequent therapy in cervical cancer... - A possible substrate for dopamine-related changes in mood and behavior: prefrontal and limbic effects of a D3-preferring dopamine agonistKevin J Black
Departments of Psychiatry, School of Medicine, Washington University, 660 South Euclid Avenue, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 99:17113-8. 2002.... - Inverse relation between in vivo amyloid imaging load and cerebrospinal fluid Abeta42 in humansAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 59:512-9. 2006..This decrease may reflect plaques acting as an Abeta(42) "sink," hindering transport of soluble Abeta(42) between brain and CSF. We investigated this hypothesis... - Brain work and brain imagingMarcus E Raichle
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Annu Rev Neurosci 29:449-76. 2006..Finally, neuroimaging, with its unique metabolic perspective, has alerted us to the ongoing and costly intrinsic activity within brain systems that most likely represents the largest fraction of the brain's functional activity... - Cerebrospinal fluid tau/beta-amyloid(42) ratio as a prediction of cognitive decline in nondemented older adultsAnne M Fagan
Department of Neurology, Washington University School of Medicine, 660 S Euclid Ave, Box 8111, St Louis, MO 63110, USA
Arch Neurol 64:343-9. 2007.... - Decreased cerebrospinal fluid Abeta(42) correlates with brain atrophy in cognitively normal elderlyAnne M Fagan
Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
Ann Neurol 65:176-83. 2009..The objective of this study was to determine whether cerebrospinal fluid (CSF) biomarkers for AD suggest the presence of brain damage in the preclinical stage of AD... - Spatial correlation between brain aerobic glycolysis and amyloid-β (Aβ ) depositionAndrei G Vlassenko
Department of Radiology, Washington University School of Medicine, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:17763-7. 2010.... - Cerebral perfusion response to successful treatment of depression with different serotoninergic agentsAndrei Vlassenko
Department of Radiology, Washington University School of Medicine, St. Louis, Missouri, USA
J Neuropsychiatry Clin Neurosci 16:360-3. 2004..Amesergide differs from SSRIs in that it is also a highly selective 5-HT antagonist, which may in part account for differences in cerebral blood flow response to treatment... - Human brain glucose metabolism may evolve during activation: findings from a modified FDG PET paradigmAndrei G Vlassenko
Mallinckrodt Institute of Radiology, Box 8225, Washington University School of Medicine, 510 South Kingshighway Blvd. St, Louis, MO 63110, USA
Neuroimage 33:1036-41. 2006..Furthermore, the observed decline in glucose metabolism may reflect a shift from glycolytic to oxidative glucose metabolism with continued activation... - Time-related increase of oxygen utilization in continuously activated human visual cortexMark A Mintun
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Blvd, St. Louis, Missouri 63110, USA
Neuroimage 16:531-7. 2002..With continued activation, oxygen utilization increases reducing the need for excess glycolysis... - Low-frequency repetitive transcranial magnetic stimulation to the temporoparietal junction for tinnitusJay F Piccirillo
Department of Otolaryngology Head and Neck Surgery, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8115, St Louis, MO 63110, USA
Arch Otolaryngol Head Neck Surg 137:221-8. 2011..To examine the effectiveness and safety of low-frequency repetitive transcranial magnetic stimulation (rTMS) to the temporoparietal junction in a cohort of patients with bothersome tinnitus... - Imaging of Alzheimer's diseaseBenjamin C P Lee
Department of Radiology, Alzheimer s Disease Research Center, Washington University School of Medicine, St Louis, Missouri, USA
J Neuroimaging 13:199-214. 2003.... - Antidepressant efficacy of olanzapine as monotherapy in major depressive disorder, without psychosis: a pilot studyJose Mathews
Department of Psychiatry, Washington University School of Medicine, Box 8134, 660 S. Euclid, St. Louis, MO 63110, USA
Psychiatry Res 146:149-55. 2006..Half the patients (n=6) showed > or =50% reduction in their HAMD17 scores. This study points to the potential of olanzapine as a therapeutic agent for the treatment of major depressive disorder without psychosis... - Evaluation of 5-ethynyl-2'-deoxyuridine staining as a sensitive and reliable method for studying cell proliferation in the adult nervous systemChenbo Zeng
Department of Radiology, Washington University School of Medicine, 510 S Kingshighway Blvd, St Louis, MO 63110, USA
Brain Res 1319:21-32. 2010..for tracking the two populations of neurons generated at different time points. In conclusion, our results suggest that EdU staining is a fast, sensitive and reproducible method to study cell proliferation in the central nervous system... - Diffuse microstructural abnormalities of normal-appearing white matter in late life depression: a diffusion tensor imaging studyJoshua S Shimony
Mallinckrodt Institute of Radiology, Washington University School of Medicine, St Louis, Missouri, USA
Biol Psychiatry 66:245-52. 2009..However, no study of LLD to date has examined the integrity of white matter outside of WMH (i.e., in normal-appearing white matter)... - Blast-related brain injury: imaging for clinical and research applications: report of the 2008 st. Louis workshopTammie L S Benzinger
Mallinckrodt Institute of Radiology, Washington University, St Louis, Missouri, USA
J Neurotrauma 26:2127-44. 2009.... - Regional aerobic glycolysis in the human brainS Neil Vaishnavi
Department of Radiology, Washington University, St Louis, MO 63110, USA
Proc Natl Acad Sci U S A 107:17757-62. 2010.... - Regulation of blood flow in activated human brain by cytosolic NADH/NAD+ ratioAndrei G Vlassenko
Mallinckrodt Institute of Radiology, Washington University School of Medicine, 510 South Kingshighway Boulevard, St. Louis, MO 63110, USA
Proc Natl Acad Sci U S A 103:1964-9. 2006.... - [3H]4-(dimethylamino)-N-(4-(4-(2-methoxyphenyl)piperazin-1-yl) butyl)benzamide: a selective radioligand for dopamine D(3) receptors. II. Quantitative analysis of dopamine D(3) and D(2) receptor density ratio in the caudate-putamenJinbin Xu
Department of Radiology, Washington University School of Medicine, Saint Louis, Missouri 63110, USA
Synapse 64:449-59. 2010..A mathematical model for calculating the absolute densities of dopamine D(2) and D(3) receptors based on the in vitro receptor binding data of [3H]WC-10 and [3H]raclopride was developed... - [(3)H]4-(Dimethylamino)-N-[4-(4-(2-methoxyphenyl)piperazin- 1-yl)butyl]benzamide, a selective radioligand for dopamine D(3) receptors. I. In vitro characterizationJinbin Xu
Department of Radiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
Synapse 63:717-28. 2009..In vitro autoradiography studies of rat and monkey brains show that [(3)H]WC-10 labeled D(3) sites in the striatal region... - Consensus nomenclature for in vivo imaging of reversibly binding radioligandsRobert B Innis
National Institute of Mental Health, Molecular Imaging Branch, Bethesda, Maryland, USA
J Cereb Blood Flow Metab 27:1533-9. 2007..An international group of experts in pharmacokinetic modeling recommends a consensus nomenclature to describe in vivo molecular imaging of reversibly binding radioligands...
Research Grants
- Nicotine-Induced Dopamine Changes In Addicted SmokersMark Mintun; Fiscal Year: 2003..Ultimately, this information may lead to a better understanding of biological predispositions to nicotine dependence and potential treatment approaches for smoking cessation. ..
- The Purchase of a Combined PET CT ScannerMark Mintun; Fiscal Year: 2005..abstract_text> ..
- NINDS Center Core for Brain ImagingMark Mintun; Fiscal Year: 2007..abstract_text> ..