Jeffrey H Miner

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. Miner J. Glomerular basement membrane composition and the filtration barrier. Pediatr Nephrol. 2011;26:1413-7 pubmed publisher
    ..These results highlight the importance of the GBM for establishing and maintaining a properly functioning glomerular filtration barrier. ..
  2. Miner J. Organogenesis of the kidney glomerulus: focus on the glomerular basement membrane. Organogenesis. 2011;7:75-82 pubmed publisher
    ..These results highlight the importance of the GBM for establishing and maintaining a perfectly functioning, highly selective glomerular filter. ..
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    Miner J, Yurchenco P. Laminin functions in tissue morphogenesis. Annu Rev Cell Dev Biol. 2004;20:255-84 pubmed
    ..In this review we focus on the contributions of the laminins in invertebrate and vertebrate tissue morphogenesis. ..
  4. Lin M, Miller J, Kikkawa Y, Suleiman H, Tryggvason K, Hodges B, et al. Laminin-521 Protein Therapy for Glomerular Basement Membrane and Podocyte Abnormalities in a Model of Pierson Syndrome. J Am Soc Nephrol. 2018;29:1426-1436 pubmed publisher
  5. Funk S, Lin M, Miner J. Alport syndrome and Pierson syndrome: Diseases of the glomerular basement membrane. Matrix Biol. 2018;71-72:250-261 pubmed publisher
    ..laminin are likely due to very different pathogenic mechanisms. A better understanding of these mechanisms should lead to targeted therapeutic approaches that can help people with these rare but important diseases. ..
  6. Miner J. The glomerular basement membrane. Exp Cell Res. 2012;318:973-8 pubmed publisher
    ..These studies suggest that the GBM plays a crucial role in establishing and maintaining the glomerular filtration barrier. ..
  7. Lin C, Werner R, Ma L, Miner J. Requirement for basement membrane laminin α5 during urethral and external genital development. Mech Dev. 2016;141:62-9 pubmed publisher
    ..Perturbation of LAMA5, and possibly other basement membrane components, may cause hypospadias in humans. ..
  8. Malone A, Funk S, Alhamad T, Miner J. Functional assessment of a novel COL4A5 splice region variant and immunostaining of plucked hair follicles as an alternative method of diagnosis in X-linked Alport syndrome. Pediatr Nephrol. 2017;32:997-1003 pubmed publisher
    ..Examination of plucked hair follicles in suspected X-linked Alport syndrome patients may offer a less invasive alternative method of diagnosis and serve as a pathogenicity test for COL4A5 variants of uncertain significance. ..
  9. Funk S, Bayer R, Malone A, McKee K, Yurchenco P, Miner J. Pathogenicity of a Human Laminin β2 Mutation Revealed in Models of Alport Syndrome. J Am Soc Nephrol. 2018;29:949-960 pubmed publisher
    ..Our results also show the complexities of using model organisms to investigate genetic variants suspected of being pathogenic in humans. ..

More Information

Publications14

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    Miner J, Li C, Patton B. Laminins alpha2 and alpha4 in pancreatic acinar basement membranes are required for basal receptor localization. J Histochem Cytochem. 2004;52:153-6 pubmed
    ..Importantly, these laminins were required for proper basal localization on acinar cells of two laminin receptors, dystroglycan and integrin alpha6beta4 . ..
  2. Miner J, Go G, Cunningham J, Patton B, Jarad G. Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: implications for Pierson syndrome. Development. 2006;133:967-75 pubmed
    ..We conclude that muscle defects in Lamb2(-/-) mice are responsible for the severe failure to thrive phenotype, and that renal replacement therapy alone will be an inadequate treatment for Pierson syndrome. ..
  3. Lin M, Miner J. Fatty acid transport protein 1 can compensate for fatty acid transport protein 4 in the developing mouse epidermis. J Invest Dermatol. 2015;135:462-470 pubmed publisher
    ..These results suggest that increasing expression of FATP1 in suprabasal keratinocytes could normalize the skin of IPS patients and perhaps prevent the atopic manifestations. ..
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    Miner J, Li C, Mudd J, Go G, Sutherland A. Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation. Development. 2004;131:2247-56 pubmed
    ..These data suggest that both the molecular composition and the integrity of basement membranes are crucial for early developmental events. ..
  5. Kim S, Ahn S, Swat W, Miner J. DLG1 influences distal ureter maturation via a non-epithelial cell autonomous mechanism involving reduced retinoic acid signaling, Ret expression, and apoptosis. Dev Biol. 2014;390:160-9 pubmed publisher