J H Miner

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. pmc Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane
    Yamato Kikkawa
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 161:187-96. 2003
  2. ncbi A molecular look at the glomerular barrier
    Jeffrey H Miner
    Renal Division and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephron Exp Nephrol 94:e119-22. 2003
  3. pmc Mystery solved: discovery of a novel integrin ligand in the developing kidney
    J H Miner
    Department of Internal Medicine Renal Division, and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 154:257-9. 2001
  4. pmc Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation
    Jeffrey H Miner
    Department of Medicine, Renal Division, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 109:1065-72. 2002
  5. pmc Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
    B L Patton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 139:1507-21. 1997
  6. ncbi Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane
    J H Miner
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 217:278-89. 2000
  7. pmc The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:685-701. 1997
  8. pmc Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome
    K L Andrews
    Renal Division and the Division of Pulmonary and Critical Care Medicine, The Department of Internal Medicine, The Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Pathol 157:303-11. 2000
  9. ncbi Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo
    C L Moulson
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 222:101-14. 2001
  10. pmc CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain
    N Y Shih
    Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Pathol 159:2303-8. 2001

Collaborators

Detail Information

Publications83

  1. pmc Mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the glomerular basement membrane
    Yamato Kikkawa
    Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 161:187-96. 2003
    ..Our results elucidate a mechanism whereby mesangial cells organize the glomerular capillaries by adhering to the G domain of laminin alpha5 in the GBM...
  2. ncbi A molecular look at the glomerular barrier
    Jeffrey H Miner
    Renal Division and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Nephron Exp Nephrol 94:e119-22. 2003
    ..In this review, I discuss these three components, with particular emphasis on the barrier presumed to be imparted by a specialized podocyte cell-cell junction, the glomerular slit diaphragm...
  3. pmc Mystery solved: discovery of a novel integrin ligand in the developing kidney
    J H Miner
    Department of Internal Medicine Renal Division, and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Biol 154:257-9. 2001
    ..Nephronectin is a new extracellular matrix protein associated with the Wolffian duct and the ureteric bud, epithelial structures with well-defined roles in kidney development...
  4. pmc Transcriptional induction of slit diaphragm genes by Lmx1b is required in podocyte differentiation
    Jeffrey H Miner
    Department of Medicine, Renal Division, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, Missouri 63110, USA
    J Clin Invest 109:1065-72. 2002
    ..Our results indicate that reduced levels of proteins associated with foot processes and the glomerular slit diaphragm likely contribute, along with reduced levels of GBM collagens, to the nephropathy associated with NPS...
  5. pmc Distribution and function of laminins in the neuromuscular system of developing, adult, and mutant mice
    B L Patton
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 139:1507-21. 1997
    ..The ability of laminin 11 to serve as a stop signal for growing axons explains, in part, axonal behaviors observed at developing and regenerating synapses in vivo...
  6. ncbi Defective glomerulogenesis in the absence of laminin alpha5 demonstrates a developmental role for the kidney glomerular basement membrane
    J H Miner
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri, 63110, USA
    Dev Biol 217:278-89. 2000
    ....
  7. pmc The laminin alpha chains: expression, developmental transitions, and chromosomal locations of alpha1-5, identification of heterotrimeric laminins 8-11, and cloning of a novel alpha3 isoform
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 137:685-701. 1997
    ..Together, these results reveal remarkable diversity in BL composition and complexity in BL development...
  8. pmc Gelatinase B (MMP-9) is not essential in the normal kidney and does not influence progression of renal disease in a mouse model of Alport syndrome
    K L Andrews
    Renal Division and the Division of Pulmonary and Critical Care Medicine, The Department of Internal Medicine, The Washington University School of Medicine, St Louis, MO 63110, USA
    Am J Pathol 157:303-11. 2000
    ..Thus, gelB does not have a discernible role in the normal kidney and gelB is not involved in the progression of glomerulonephritis in a mouse model of Alport syndrome...
  9. ncbi Localization of Lutheran, a novel laminin receptor, in normal, knockout, and transgenic mice suggests an interaction with laminin alpha5 in vivo
    C L Moulson
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Dyn 222:101-14. 2001
    ..We propose that laminin alpha5 is involved in concentrating Lu on the basal surface of epithelial cells. This may be one mechanism by which basement membrane signals are transmitted to the cell...
  10. pmc CD2AP localizes to the slit diaphragm and binds to nephrin via a novel C-terminal domain
    N Y Shih
    Department of Pathology and Immunology, Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Pathol 159:2303-8. 2001
    ..These studies lend further support to the idea that CD2AP plays a role in the structural integrity of the slit diaphragm...
  11. ncbi CD2AP is expressed with nephrin in developing podocytes and is found widely in mature kidney and elsewhere
    C Li
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Physiol Renal Physiol 279:F785-92. 2000
    ..The severity of kidney disease in Cd2ap mutant mice may have eclipsed manifestation of defects in other tissues...
  12. pmc Collagen IV alpha 3, alpha 4, and alpha 5 chains in rodent basal laminae: sequence, distribution, association with laminins, and developmental switches
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110
    J Cell Biol 127:879-91. 1994
    ..Thus, collagen alpha 1 and alpha 2(IV) and laminin B1 appear to be fetal components of the glomerular BL, and there is a developmental switch to collagen alpha 3-alpha 5(IV) and S-laminin expression...
  13. pmc Roles for laminin in embryogenesis: exencephaly, syndactyly, and placentopathy in mice lacking the laminin alpha5 chain
    J H Miner
    Department of Medicine, Renal Division, St Louis, Missouri, USA
    J Cell Biol 143:1713-23. 1998
    ..Other laminin alpha chains accumulate in these BLs, but this compensation is apparently functionally inadequate. Our results identify new roles for laminins and BLs in diverse developmental processes...
  14. ncbi Expression patterns of laminin alpha1 and alpha5 in human lung during development
    R A Pierce
    Divisions of Pulmonary and Critical Care Medicine and Renal Diseases, Department of Medicine, Barnes Jewish Hospital and Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Respir Cell Mol Biol 23:742-7. 2000
    ..It is evident that laminin alpha1 and laminin alpha5 have different roles in the development of the human lung...
  15. ncbi The renal glomerulus of mice lacking s-laminin/laminin beta 2: nephrosis despite molecular compensation by laminin beta 1
    P G Noakes
    Department of Anatomy, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Nat Genet 10:400-6. 1995
    ..Laminin beta 2-deficient mice may provide a model for human congenital or idiopathic nephrotic syndromes...
  16. ncbi Congenital nephrotic syndrome in mice lacking CD2-associated protein
    N Y Shih
    Center for Immunology and Department of Pathology, Washington University, Saint Louis, MO 63110, USA
    Science 286:312-5. 1999
    ..Supporting a role for CD2AP in the specialized cell junction known as the slit diaphragm, CD2AP associated with nephrin, the primary component of the slit diaphragm...
  17. ncbi CD2-associated protein and the kidney
    A S Shaw
    Center for Immunology and Department of Pathology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Nephrol Hypertens 10:19-22. 2001
    ..The present review addresses these recent advances and discusses the implications of the findings...
  18. ncbi Identification and expression of mouse netrin-4
    Y Yin
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Mech Dev 96:115-9. 2000
    ..In postnatal brain, it is selectively expressed in subsets of neurons, including cerebellar granule and hippocampal pyramidal cells...
  19. ncbi (Alpha)3(beta)1 integrin regulates epithelial cytoskeletal organization
    Z Wang
    Department of Medicine, Children s Hospital, Harvard Medical School, Boston, MA 02115, USA
    J Cell Sci 112:2925-35. 1999
    ..These results present direct evidence for integrin:cadherin cross-regulation in which cadherin function is dependent on the presence of an integrin...
  20. ncbi Laminin-11
    J H Miner
    Department of Medicine Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Int J Biochem Cell Biol 31:811-6. 1999
    ..A greater understanding of laminin-11 assembly and basement membrane incorporation could provide a logical basis for therapy in merosin-deficient congenital muscular dystrophy...
  21. ncbi Distribution of the ten known laminin chains in the pathways and targets of developing sensory axons
    S I Lentz
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Comp Neurol 378:547-61. 1997
    ..g., gamma 1), continue to be expressed by Schwann cells into adulthood. In contrast to peripheral nerves and ganglia, laminin chains are expressed at low levels, if at all, in the developing spinal cord gray matter...
  22. pmc Molecular and functional defects in kidneys of mice lacking collagen alpha 3(IV): implications for Alport syndrome
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Cell Biol 135:1403-13. 1996
    ..We suggest that these alterations contribute, along with loss of collagen IV isoforms per se, to renal pathology...
  23. ncbi Regulation of renal laminin in mice with type II diabetes
    T S Ha
    Department of Medicine, University of Texas Health Science Center and A L Murphy Veterans Administration Hospital, San Antonio 78284, USA
    J Am Soc Nephrol 10:1931-9. 1999
    ....
  24. ncbi Molecular cloning of a novel laminin chain, alpha 5, and widespread expression in adult mouse tissues
    J H Miner
    Department of Anatomy and Neurobiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 270:28523-6. 1995
    ..Analysis of RNA expression showed that alpha 5 is widely expressed in adult tissues, with highest levels in lung, heart, and kidney. Our results suggest that alpha 5 may be a major laminin chain of adult basal laminae...
  25. ncbi Renal basement membrane components
    J H Miner
    Department of Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Kidney Int 56:2016-24. 1999
    ....
  26. pmc Proteinuria precedes podocyte abnormalities inLamb2-/- mice, implicating the glomerular basement membrane as an albumin barrier
    George Jarad
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri, USA
    J Clin Invest 116:2272-9. 2006
    ..Together these data show that the GBM serves as a barrier to protein in vivo and that the glomerular slit diaphragm alone is not sufficient to prevent the passage of albumin into the urinary space...
  27. pmc A hypomorphic mutation in the mouse laminin alpha5 gene causes polycystic kidney disease
    M Brendan Shannon
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 17:1913-22. 2006
    ..This constitutes the first evidence that a primary defect in an extracellular matrix component can cause PKD...
  28. ncbi Loss of alpha3/alpha4(IV) collagen from the glomerular basement membrane induces a strain-dependent isoform switch to alpha5alpha6(IV) collagen associated with longer renal survival in Col4a3-/- Alport mice
    Jeong Suk Kang
    Division of Nephrology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37232 2372, USA
    J Am Soc Nephrol 17:1962-9. 2006
    ..Therapeutically induced GBM deposition of alpha5/6(IV) collagen may provide a novel strategy for delaying renal failure in patients with autosomal recessive Alport syndrome...
  29. ncbi Molecular dissection of laminin alpha 5 in vivo reveals separable domain-specific roles in embryonic development and kidney function
    Yamato Kikkawa
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Dev Biol 296:265-77. 2006
    ....
  30. pmc Bigenic mouse models of focal segmental glomerulosclerosis involving pairwise interaction of CD2AP, Fyn, and synaptopodin
    Tobias B Huber
    Department of Pathology and Immunology and Department of Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Clin Invest 116:1337-45. 2006
    ..This demonstrates that bigenic heterozygosity can lead to FSGS and suggests that combined mutations in 2 or multiple podocyte genes may be a common etiology for glomerular disease...
  31. ncbi Podocyte-specific deletion of integrin-linked kinase results in severe glomerular basement membrane alterations and progressive glomerulosclerosis
    Chiraz El-Aouni
    Division of Nephrology, Department of Internal Medicine, University of Michigan, 1570 MSRB II, 1150 W Medical Center Drive, Ann Arbor, MI 48109 0676, USA
    J Am Soc Nephrol 17:1334-44. 2006
    ....
  32. ncbi Review: Lutheran/B-CAM: a laminin receptor on red blood cells and in various tissues
    Yamato Kikkawa
    Department of Pathophysiology, Cancer Research Institute, Sapparo Medical University, School of Medicine, Sapparo, Japan
    Connect Tissue Res 46:193-9. 2005
    ..It also is necessary to investigate further the interaction between Lu/B-CAM and laminin a5 in pathological processes, including sickle cell disease and cancer...
  33. pmc Transgenic isolation of skeletal muscle and kidney defects in laminin beta2 mutant mice: implications for Pierson syndrome
    Jeffrey H Miner
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 133:967-75. 2006
    ..We conclude that muscle defects in Lamb2(-/-) mice are responsible for the severe failure to thrive phenotype, and that renal replacement therapy alone will be an inadequate treatment for Pierson syndrome...
  34. ncbi Vascular endothelial growth factor a signaling in the podocyte-endothelial compartment is required for mesangial cell migration and survival
    Vera Eremina
    Department of Maternal and Fetal Health, The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Room 855Q, 600 University of Toronto, Ontario, Canada M5G 1X5
    J Am Soc Nephrol 17:724-35. 2006
    ..Together, these results demonstrate a key role for VEGF-A production in the podocyte for mesangial cell survival and differentiation...
  35. ncbi Laminin alpha5 is required for dental epithelium growth and polarity and the development of tooth bud and shape
    Satoshi Fukumoto
    Craniofacial Developmental Biology and Regeneration Branch and Oral and Pharyngeal Cancer Branch, NIDCR, National Institutes of Health, Bethesda, Maryland 20892, USA
    J Biol Chem 281:5008-16. 2006
    ....
  36. ncbi Abnormalities in neural crest cell migration in laminin alpha5 mutant mice
    Edward G Coles
    Division of Biology, California Institute of Technology, Pasadena, 91125, USA
    Dev Biol 289:218-28. 2006
    ..Thus, it is required for proper migration and timely differentiation of some neural crest populations...
  37. pmc Homozygous and compound heterozygous mutations in ZMPSTE24 cause the laminopathy restrictive dermopathy
    Casey L Moulson
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Invest Dermatol 125:913-9. 2005
    ..Abnormally aggregated lamin A/C was also observed. These results indicate that RD is an autosomal recessive laminopathy caused by inactivating ZMPSTE24 mutations that result in defective processing and nuclear accumulation of prelamin A...
  38. pmc Discs-large homolog 1 regulates smooth muscle orientation in the mouse ureter
    Zhen X Mahoney
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 103:19872-7. 2006
    ..Our results suggest that (i) besides its well documented role in regulating epithelial polarity, Dlgh1 also regulates smooth muscle orientation, and (ii) human DLG1 mutations may contribute to hereditary forms of hydronephrosis...
  39. ncbi The LG1-3 tandem of laminin alpha5 harbors the binding sites of Lutheran/basal cell adhesion molecule and alpha3beta1/alpha6beta1 integrins
    Yamato Kikkawa
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:14853-60. 2007
    ..Our results also suggest that the binding site for Lu/B-CAM on laminin alpha5 may overlap with that of integrins alpha3beta1 and alpha6beta1...
  40. pmc Laminins promote postsynaptic maturation by an autocrine mechanism at the neuromuscular junction
    Hiroshi Nishimune
    Department of Molecular and Cellular Biology, Harvard University, Cambridge, MA 02138, USA
    J Cell Biol 182:1201-15. 2008
    ..Together with previous studies implicating laminins as organizers of presynaptic differentiation, these results show that laminins coordinate post- with presynaptic maturation...
  41. pmc Podocyte-specific deletion of dicer alters cytoskeletal dynamics and causes glomerular disease
    Scott J Harvey
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Soc Nephrol 19:2150-8. 2008
    ..The unique architecture of podocytes may make them especially susceptible to cytoskeletal alterations initiated by aberrant miRNA dynamics...
  42. pmc Laminin alpha 5 influences the architecture of the mouse small intestine mucosa
    Zhen X Mahoney
    Department of Internal Medicine Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    J Cell Sci 121:2493-502. 2008
    ..Our results suggest that laminin alpha 5 has a crucial role in establishing and maintaining the specific mucosal pattern of the mouse small intestine...
  43. pmc Notch-deficient skin induces a lethal systemic B-lymphoproliferative disorder by secreting TSLP, a sentinel for epidermal integrity
    Shadmehr Demehri
    Department of Developmental Biology, Washington University School of Medicine, St Louis, Missouri, United States of America
    PLoS Biol 6:e123. 2008
    ..These observations demonstrate that local skin perturbations can drive a lethal systemic disease and have important implications for a wide range of humoral and autoimmune diseases with skin manifestations...
  44. pmc Beta1 integrin expression by podocytes is required to maintain glomerular structural integrity
    Ambra Pozzi
    Department of Medicine, Veterans Affairs Hospital, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Dev Biol 316:288-301. 2008
    ..Thus, expression of beta1 containing integrins by the podocyte is critical for maintaining the structural integrity of the glomerulus...
  45. doi Laminins and their roles in mammals
    Jeffrey H Miner
    Renal Division and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Microsc Res Tech 71:349-56. 2008
    ..In this review, I will summarize the in vivo studies in mice and humans that have contributed to this new knowledge...
  46. ncbi Pathogenesis of nonimmune glomerulopathies
    Christopher Kwoh
    Renal Division, Department of Medicine, Washington University School of Medicine, St Louis, Missouri 63113, USA
    Annu Rev Pathol 1:349-74. 2006
    ....
  47. ncbi Laminin compensation in collagen alpha3(IV) knockout (Alport) glomeruli contributes to permeability defects
    Dale R Abrahamson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, MS 3038, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:2465-72. 2007
    ....
  48. pmc Laminin alpha5 is necessary for submandibular gland epithelial morphogenesis and influences FGFR expression through beta1 integrin signaling
    Ivan T Rebustini
    Matrix and Morphogenesis Unit, Laboratory of Cell and Developmental Biology, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, MD 20892 4370, USA
    Dev Biol 308:15-29. 2007
    ..These data link changes in basement membrane composition during branching morphogenesis with FGFR expression and signaling...
  49. ncbi Partial rescue of glomerular laminin alpha5 mutations by wild-type endothelia produce hybrid glomeruli
    Dale R Abrahamson
    Department of Anatomy and Cell Biology, University of Kansas Medical Center, MS 3038, 3901 Rainbow Boulevard, Kansas City, KS 66160, USA
    J Am Soc Nephrol 18:2285-93. 2007
    ....
  50. pmc Disruption of glomerular basement membrane charge through podocyte-specific mutation of agrin does not alter glomerular permselectivity
    Scott J Harvey
    Washington University School of Medicine, Renal Division, St Louis, MO 63110, USA
    Am J Pathol 171:139-52. 2007
    ..Although agrin contributes significantly to the anionic charge to the GBM, both it and its charge are not needed for glomerular permselectivity. This calls into question whether charge selectivity is a feature of the GBM...
  51. ncbi Keratinocyte-specific expression of fatty acid transport protein 4 rescues the wrinkle-free phenotype in Slc27a4/Fatp4 mutant mice
    Casey L Moulson
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 282:15912-20. 2007
    ..We conclude that expression of FATP4 with an intact acyl-CoA synthetase domain in suprabasal keratinocytes is necessary for normal skin development and that FATP4 functions in establishing the cornified envelope...
  52. pmc Podocyte-derived BMP7 is critical for nephron development
    Itsuro Kazama
    Division of Nephrology, Children s Hospital Boston, Harvard Medical School, Boston, MA 02115, USA
    J Am Soc Nephrol 19:2181-91. 2008
    ..In summary, these results define a BMP7-mediated regulatory axis between glomeruli and proximal tubules during kidney development...
  53. ncbi The immortalized human corneal epithelial cells adhere to laminin-10 by using Lutheran glycoproteins and integrin alpha3beta1
    Sissi Hasenson
    Institute of Biomedicine Anatomy, University of Helsinki, Helsinki, Finland
    Exp Eye Res 81:415-21. 2005
    ..Quantitative adhesion assay showed that Lu together with integrin (Int) alpha3beta1 independently mediated the adhesion of HCE cells to Ln-10...
  54. ncbi Expression of laminin chains by central neurons: analysis with gene and protein trapping techniques
    Yong Yin
    Department of Anatomy and Neurobiology, Washington University School of Medicine, 660 S Euclid Avenue, St Louis, MO 63110, USA
    Genesis 36:114-27. 2003
    ..The co-trapping method may be generally useful for identifying proteins or isolating protein complexes associated with trapped gene products...
  55. ncbi CD2-associated protein haploinsufficiency is linked to glomerular disease susceptibility
    Jeong M Kim
    Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO 63110, USA
    Science 300:1298-300. 2003
    ..Two human patients with focal segmental glomerulosclerosis had a mutation predicted to ablate expression of one CD2AP allele, implicating CD2AP as a determinant of human susceptibility to glomerular disease...
  56. pmc Laminin-10 is crucial for hair morphogenesis
    Jie Li
    Program in Epithelial Biology, Stanford University School of Medicine, 269 Campus Drive, Room 2145, CA 94305, USA
    EMBO J 22:2400-10. 2003
    ..We conclude that laminin-10 is required for hair follicle development and report the first use of exogenous protein to correct a cutaneous developmental defect...
  57. pmc Cloning of wrinkle-free, a previously uncharacterized mouse mutation, reveals crucial roles for fatty acid transport protein 4 in skin and hair development
    Casey L Moulson
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 100:5274-9. 2003
    ..However, its function in vivo had not been determined. Our results demonstrate an unexpected yet critical role for FATP4 in skin and hair development and suggest Slc27a4 to be a candidate gene for restrictive dermopathy...
  58. pmc Glomerular-specific alterations of VEGF-A expression lead to distinct congenital and acquired renal diseases
    Vera Eremina
    The Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    J Clin Invest 111:707-16. 2003
    ..Our data demonstrate that tight regulation of VEGF-A signaling is critical for establishment and maintenance of the glomerular filtration barrier and strongly supports a pivotal role for VEGF-A in renal disease...
  59. ncbi Identification of the binding site for the Lutheran blood group glycoprotein on laminin alpha 5 through expression of chimeric laminin chains in vivo
    Yamato Kikkawa
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    J Biol Chem 277:44864-9. 2002
    ..Our results demonstrate that the alpha5 LG3 module is essential for Lu binding to laminin alpha5...
  60. ncbi Histopathology, ultrastructure, and clinical phenotypes in thin glomerular basement membrane disease variants
    Helen Liapis
    Department of Pathology, Renal Division and Cell Biology, Washington University School of Medicine, St Louis, MO 63110, USA
    Hum Pathol 33:836-45. 2002
    ..These patients have a TMD variant, but an Alport variant with a potentially transmissible severe defect different from benign hematuria cannot be excluded...
  61. ncbi A mutant form of the Wilms' tumor suppressor gene WT1 observed in Denys-Drash syndrome interferes with glomerular capillary development
    Thomas A Natoli
    Department of Medicine and Laboratory for Skeletal Disorders and Rehabilitation, Department of Orthopedic Surgery, Children s Hospital, Boston, Massachusetts 02115, USA
    J Am Soc Nephrol 13:2058-67. 2002
    ..These results suggest that WT1 controls the expression of growth factors that regulate glomerular capillary development and that abnormal capillary development might lead to glomerular disease...
  62. ncbi Laminin alpha 5 is required for lobar septation and visceral pleural basement membrane formation in the developing mouse lung
    Nguyet M Nguyen
    Pulmonary and Critical Care Medicine Division, Department of Internal Medicine, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Dev Biol 246:231-44. 2002
    ..Our finding of normal lung branching morphogenesis with abnormal lobar septation demonstrates that these processes are not obligatorily linked...
  63. ncbi Domain IV of mouse laminin beta1 and beta2 chains
    Takako Sasaki
    Max Planck Institut fur Biochemie, Martinsried, Germany
    Eur J Biochem 269:431-42. 2002
    ..Immunogold staining localized both beta chains primarily to basement membranes of kidney, muscle and various other tissues...
  64. pmc Quantitative trait loci influence renal disease progression in a mouse model of Alport syndrome
    Kaya L Andrews
    Renal Division, Department of Internal Medicine, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Am J Pathol 160:721-30. 2002
    ..Analysis with Map Manager QT revealed QTLs linked to markers on chromosomes 9 and 16. A more detailed understanding of how these QTLs act could lead to new approaches for therapy in diverse renal diseases...
  65. ncbi Laminin alpha5 chain is required for intestinal smooth muscle development
    Anne Laure Bolcato-Bellemin
    INSERM U381, Ontogenese et Pathologie du Systeme Digestif, Avenue Moliere, Strasbourg, France
    Dev Biol 260:376-90. 2003
    ....
  66. ncbi Gamma-secretase activity is dispensable for mesenchyme-to-epithelium transition but required for podocyte and proximal tubule formation in developing mouse kidney
    Hui Teng Cheng
    Department of Molecular Biology and Pharmacology, Washington University School of Medicine, Box 8103, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Development 130:5031-42. 2003
    ..These observations suggest that gamma-secretase activity, probably through activation of Notch, is required for maintaining a competent progenitor pool as well as for determining the proximal tubule and podocyte fates...
  67. ncbi Epithelial laminin alpha5 is necessary for distal epithelial cell maturation, VEGF production, and alveolization in the developing murine lung
    Nguyet M Nguyen
    Pulmonary and Critical Care Medicine, Washington University School of Medicine, St Louis, MO 63110, USA
    Dev Biol 282:111-25. 2005
    ....
  68. ncbi Transient expression of laminin alpha1 chain in regenerating murine liver: restricted localization of laminin chains and nidogen-1
    Yamato Kikkawa
    Department of Pathophysiology, Cancer Research Institute, Sapporo Medical University School of Medicine, South 1, West 17, Chuo Ku, Sapporo 060 8556, Japan
    Exp Cell Res 305:99-109. 2005
    ..In addition, SECs isolated from regenerating liver elongated pseudopodia on alpha1-containing laminin more so than did cells from normal liver. The transient expression of laminin alpha1 may promote formation of sinusoids after PHx...
  69. ncbi Building the glomerulus: a matricentric view
    Jeffrey H Miner
    Department of Medicine, Washington University School of Medicine, Renal Division, Box 8126, 660 S Euclid Avenue, St Louis, MO 63110, USA
    J Am Soc Nephrol 16:857-61. 2005
  70. pmc Coordinate control of axon defasciculation and myelination by laminin-2 and -8
    Dongren Yang
    Center for Research on Occupational and Environmental Toxicology, Oregon Health and Science University, Portland, OR 97239, USA
    J Cell Biol 168:655-66. 2005
    ..Purified Ln-2 and -8 directly enhanced in vitro Schwann cell proliferation in collaboration with autocrine factors, suggesting Lns control the onset of myelination by modulating responses to mitogens in vivo...
  71. ncbi A chemotactic peptide from laminin alpha 5 functions as a regulator of inflammatory immune responses via TNF alpha-mediated signaling
    Tracy L Adair-Kirk
    Division of Pulmonary and Care Medicine, Department of Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Immunol 174:1621-9. 2005
    ..These data suggest that interactions of inflammatory cells with basement membrane components may orchestrate immune responses by inducing expression of cytokines, recruitment of inflammatory cells, and release of proteinases...
  72. pmc Focusing on the glomerular slit diaphragm: podocin enters the picture
    Jeffrey H Miner
    Department of Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Pathol 160:3-5. 2002
  73. ncbi Laminin functions in tissue morphogenesis
    Jeffrey H Miner
    Renal Division, Department of Internal Medicine and Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110, USA
    Annu Rev Cell Dev Biol 20:255-84. 2004
    ..In this review we focus on the contributions of the laminins in invertebrate and vertebrate tissue morphogenesis...
  74. ncbi Compositional and structural requirements for laminin and basement membranes during mouse embryo implantation and gastrulation
    Jeffrey H Miner
    Renal Division, Washington University School of Medicine, St Louis, MO 63110, USA
    Development 131:2247-56. 2004
    ..These data suggest that both the molecular composition and the integrity of basement membranes are crucial for early developmental events...
  75. ncbi TGF-beta1 induces aberrant laminin chain and collagen type IV isotype expression in the glomerular basement membrane
    Qing Chai
    Research Laboratory for Biochemical Pathology, Institute for Experimental Clinical Research, Aarhus Kommunehospital, Aarhus, Denmark
    Nephron Exp Nephrol 94:e123-36. 2003
    ..We speculate that the endothelial cells could contribute to TGF-beta1-induced glomerulopathy and should be considered as target cells for early intervention in glomerular diseases associated with TGF-beta1 in man...
  76. ncbi Laminins alpha2 and alpha4 in pancreatic acinar basement membranes are required for basal receptor localization
    Jeffrey H Miner
    Department of Internal Medicine, Renal Division, Washington University School of Medicine, St Louis, Missouri, USA
    J Histochem Cytochem 52:153-6. 2004
    ..Importantly, these laminins were required for proper basal localization on acinar cells of two laminin receptors, dystroglycan and integrin alpha6beta4 ...
  77. pmc Beta1-integrins are critical for cerebellar granule cell precursor proliferation
    Sandra Blaess
    Howard Hughes Medical Institute and Developmental Genetics Program, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
    J Neurosci 24:3402-12. 2004
    ....
  78. ncbi Fatty acid transport protein 4 is the principal very long chain fatty acyl-CoA synthetase in skin fibroblasts
    Zhenzhen Jia
    Kennedy Krieger Institute, Johns Hopkins University School of Medicine, 707 N Broadway, Baltimore, MD 21205, USA
    J Biol Chem 282:20573-83. 2007
    ..FATP4-deficient cells also contained abnormal neutral lipid droplets. These additional defects indicate that metabolic abnormalities in these cells are not limited to very long chain fatty acids...
  79. ncbi A site on laminin alpha 5, AQARSAASKVKVSMKF, induces inflammatory cell production of matrix metalloproteinase-9 and chemotaxis
    Tracy L Adair-Kirk
    Division of Pulmonary and Critical Care Medicine, Department of Medicine, Washington University School of Medicine and Barnes Jewish Hospital, St Louis, MO 63110, USA
    J Immunol 171:398-406. 2003
    ..A scrambled version of the minimal peptide, KAKSFVMVSK, was inactive. These data indicate that laminin alpha5-derived peptides can induce inflammatory cell chemotaxis and metalloproteinase activity...
  80. doi Revisiting the glomerular charge barrier in the molecular era
    Scott J Harvey
    Renal Division, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Curr Opin Nephrol Hypertens 17:393-8. 2008
    ..Here we summarize studies employing genetic or other in-vivo strategies to investigate glomerular charge...
  81. ncbi Red cell traverse through thin glomerular basement membrane
    Helen Liapis
    Kidney Int 61:762-3. 2002
  82. ncbi Impaired glomerular maturation and lack of VEGF165b in Denys-Drash syndrome
    Valérie Anne Schumacher
    Institute of Human Genetics and Anthropology, Duesseldorg, Germany
    J Am Soc Nephrol 18:719-29. 2007
    ..The alteration in VEGF-A expression presented here may provide a mechanistic insight into the pathogenesis of DDS...
  83. ncbi Role of COL4A1 in small-vessel disease and hemorrhagic stroke
    Douglas B Gould
    Howard Hughes Medical Institute, Bar Harbor, ME, USA
    N Engl J Med 354:1489-96. 2006
    ..We concluded that mutation of COL4A1 may cause a spectrum of cerebrovascular phenotypes and that persons with COL4A1 mutations may be predisposed to hemorrhage, especially after environmental stress...