Research Topics
Species | KATRINA MEALEYSummaryAffiliation: Washington State University Country: USA Publications
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Publications
Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestineK L Mealey
Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
Xenobiotica 38:1305-12. 2008..8% of the duodenal mRNA CYP3A pool. In summary, these results represent an important step toward the systematic comparison of human and canine CYP3A enzymes, particularly in relation to oral bioavailability of substrate drugs...
ABCG2 transporter: therapeutic and physiologic implications in veterinary speciesK L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Vet Pharmacol Ther 35:105-12. 2012..Finally, data in rodent models suggest that ABCG2 may play an important role in regulating a number of physiologic pathways involved in protecting erythrocytes from oxidative damage...- Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in AustraliaKatrina L Mealey
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 6610, USA
Vet Parasitol 131:193-6. 2005..Results of this study indicate that a high percentage of herding breeds presenting to veterinarians in Australia harbor the MDR1 mutation, thus impacting some therapeutic decisions... - Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy catsK L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Vet Intern Med 18:43-6. 2004..Until supporting pharmacokinetic data are available, veterinarians and cat owners should not rely on the transdermal route of administration for treating cats with amitriptyline or buspirone... - PharmacogeneticsKatrina L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
Vet Clin North Am Small Anim Pract 36:961-73, v. 2006..Despite the fact that this branch of pharmacology is still in its infancy as a science, a number of important discoveries have already contributed to improved pharmacotherapy in human and veterinary patients... - P-glycoprotein contributes to the blood-brain, but not blood-cerebrospinal fluid, barrier in a spontaneous canine p-glycoprotein knockout modelKatrina L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
Drug Metab Dispos 36:1073-9. 2008..In summary, we have validated a novel P-glycoprotein-deficient canine model and have used the model to investigate transport of the P-glycoprotein substrate (99m)Tc-sestamibi at the blood-brain barrier and blood-CSF barrier... - ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristineK L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Vet Intern Med 22:996-1000. 2008..Whether or not the ABCB1-1Delta polymorphism affects susceptibility to toxicity of other P-glycoprotein substrate drugs has not been studied... - Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogeneticsKatrina L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
Vet Parasitol 158:215-22. 2008..However, at the manufacturer's recommended dose, all FDA-approved heartworm preventive products marketed in the United States are safe, even for dogs with the ABCB1 mutant/mutant genotype... 
An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogsKatrina L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
Comp Hepatol 9:6. 2010....- Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 geneK L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 6610, USA
Pharmacogenetics 11:727-33. 2001..Dogs that are homozygous for the deletion mutation display the ivermectin-sensitive phenotype, while those that are homozygous normal or heterozygous do not display increased sensitivity to ivermectin... - Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogsK L Mealey
Veterinary Clinical Pharmacology Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Vet Pharmacol Ther 33:453-60. 2010..However, small sample sizes and individual variability in CYP enzyme activity may have affected the power of the study to detect the impact of P-gp on oral bioavailability... - Therapeutic implications of the MDR-1 geneK L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Vet Pharmacol Ther 27:257-64. 2004..Furthermore, data in rodent models suggest that P-gp may play an important role in regulating the hypothalamic-pituitary-adrenal axis... - The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogsB Kukanich
Department of Molecular Biomedical Sciences, Comparative Pain and Pharmacology Research Laboratory, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
J Vet Pharmacol Ther 28:461-6. 2005.... - Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in ColliesO L Nelson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA
J Vet Intern Med 17:354-6. 2003 - Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1Delta mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiencyJ C Coelho
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA
J Vet Pharmacol Ther 32:417-21. 2009..It is likely that concurrent administration of a P-gp inhibitor such as ketoconazole will decrease P-gp-mediated biliary excretion of other substrate drugs as well... - Comparative pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in clinically normal horses and donkeysK L Mealey
Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77840, USA
Am J Vet Res 58:53-5. 1997..To compare plasma disposition of phenylbutazone and its metabolite oxyphenbutazone after i.v. administration of phenylbutazone in horses and donkeys... - Functional cystic thyroid adenoma in a catE Hofmeister
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164-6610, USA
J Am Vet Med Assoc 219:190-3. 2001..A necropsy was not performed, but histologic examination of a biopsy specimen of the mass indicated that it was a cystic thyroid adenoma... - Assessment of antiepileptic drugs as substrates for canine P-glycoproteinChadwick L West
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
Am J Vet Res 68:1106-10. 2007..To determine whether antiepileptic drugs (AEDs) are substrates for canine P-glycoprotein (P-gp). Sample Population-OS2.4/Doxo cells (canine osteosarcoma cells induced via exposure to doxorubicin to highly express P-gp)... - Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotypingKatrina L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
J Am Vet Med Assoc 233:921-4. 2008.... - Fecal polymerase chain reaction with 16S ribosomal RNA primers can detect the presence of gastrointestinal Helicobacter in dogsJoanne K Shinozaki
College of Veterinary Medicine, Washington State University, Pullman 99164-6010, USA
J Vet Intern Med 16:426-32. 2002..Fecal PCR is a useful test for detecting Helicobacter infection in dogs. This assay may be useful as a screening test for infection and could be used to address questions relevant to pathogenesis and therapy... - Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United StatesKatrina L Mealey
Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164-6610, USA
Am J Vet Res 63:479-81. 2002..Pharmacologic treatment with ivermectin, loperamide, vincristine, and other drugs that are substrates of P-glycoprotein, the MDR1 gene product, may result in neurologic toxicosis in a high percentage of Collies... - Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cellsKatrina L Mealey
Department of Veterinary Physiology and Pharmacology, Texas A and M University College of Veterinary Medicine, College Station, Texas 77843-4466, USA
Antimicrob Agents Chemother 46:755-61. 2002..Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance... - Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutationRosemary A Henik
Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
J Vet Intern Med 20:415-7. 2006 - Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivityKatrina L Mealey
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA
J Am Vet Med Assoc 223:1453-5, 1434. 2003..Because P-glycoprotein contributes to renal, biliary, and intestinal excretion of P-glycoprotein-substrate drugs, it is possible that drug excretion was delayed in this patient, resulting in clinical signs of toxicosis... - Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivityLaura L Sartor
Department of Medical Sciences, College of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
J Vet Intern Med 18:117-8. 2004 - Systemic Mycobacterium avium infection in a dog diagnosed by polymerase chain reaction analysis of buffy coatJames F Naughton
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164-6610, USA
J Am Anim Hosp Assoc 41:128-32. 2005..Polymerase chain reaction (PCR) analysis of a buffy-coat preparation identified M. avium... - Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineageMark W Neff
Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
Proc Natl Acad Sci U S A 101:11725-30. 2004.... - Evaluation of the flanking nucleotide sequences of sarcomeric hypertrophic cardiomyopathy substitution mutationsKathryn M Meurs
Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Grimes Street, Pullman, WA 99164, United States
Mutat Res 642:86-9. 2008..The large number of G to A and C to T mutations as well as the relative mutability of CG may suggest that deamination of methylated CpG is an important mechanism for mutation development in at least some of these cardiac genes... - Synovial T-cell lymphoma of the stifle in a dogSunshine M Lahmers
Department of Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99165, USA
J Am Anim Hosp Assoc 38:165-8. 2002..Despite finding a nonspecific, mixed inflammatory response on joint fluid cytopathology, histopathology demonstrated T-cell lymphoma of the synovium. Lameness may be the sole presenting clinical sign in canine lymphoma... - Pharmacokinetics of sulfamethoxazole and trimethoprim in donkeys, mules, and horsesKenneth E Peck
Texas Veterinary Medical Center, Texas A and M University, College Station 77843-4474, USA
Am J Vet Res 63:349-53. 2002..Donkeys eliminate the drugs rapidly, compared with horses. Ratios of trimethoprim and sulfamethoxazole optimum for antibacterial activity are maintained for only a short duration in horses, donkeys, and mules... - Questions reported risks of Salmonella infectionsDale Hancock
J Am Vet Med Assoc 221:192. 2002 - Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndromeJennifer H Yearley
New England Primate Research Center, Harvard Medical School, Division of Comparative Pathology, One Pine Hill Dr, PO Box 9102, Southborough, MA 01772, USA
J Am Vet Med Assoc 225:377-83. 2004..The high percentage of dogs with neurologic abnormalities was a concern, but whether this was related to Fanconi syndrome or represented a breed-related predisposition to neurologic disease could not be determined... - Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogsLinda G Martin
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610
Am J Vet Res 68:555-60. 2007..To determine the lowest of 5 doses of cosyntropin (1.0, 0.5, 0.1, 0.05, or 0.01 microg/kg) administered IV that stimulates maximal cortisol secretion in clinically normal dogs... - Transdermal absorption of a liposome-encapsulated formulation of lidocaine following topical administration in catsBoel A Fransson
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164, USA
Am J Vet Res 63:1309-12. 2002..On the basis of these data, topical administration of a liposome-encapsulated lidocaine formulation at a dose of 15 mg/kg appears to be safe for use in healthy adult cats... - Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeysMelissa D Sinclair
Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1
Am J Vet Res 67:1082-5. 2006.... - Pharmacokinetics of R(-) and S(+) carprofen after administration of racemic carprofen in donkeys and horsesKatrina L Mealey
Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164, USA
Am J Vet Res 65:1479-82. 2004..CONCLUSIONS AND CLINICAL RELEVANCE: Results have suggested that the dosing intervals for carprofen that are used in horses may not be appropriate for use in donkeys... - Comparison of plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis or clinically normal calvesClive C Gay
Field Disease Investigation Unit, College of Veterinary Medicine, Washington State University, Pullman, WA 99164-6610, USA
Am J Vet Res 65:1580-3. 2004....
Research Grants
- Canine model for assessing CNS access P-gp substratesKATRINA MEALEY; Fiscal Year: 2005....