KATRINA MEALEY

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. ncbi request reprint Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine
    K L Mealey
    Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Xenobiotica 38:1305-12. 2008
  2. doi request reprint Adverse drug reactions in veterinary patients associated with drug transporters
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Vet Clin North Am Small Anim Pract 43:1067-78. 2013
  3. doi request reprint ABCG2 transporter: therapeutic and physiologic implications in veterinary species
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Pharmacol Ther 35:105-12. 2012
  4. ncbi request reprint Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 6610, USA
    Vet Parasitol 131:193-6. 2005
  5. ncbi request reprint Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Intern Med 18:43-6. 2004
  6. ncbi request reprint Pharmacogenetics
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Vet Clin North Am Small Anim Pract 36:961-73, v. 2006
  7. doi request reprint P-glycoprotein contributes to the blood-brain, but not blood-cerebrospinal fluid, barrier in a spontaneous canine p-glycoprotein knockout model
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Drug Metab Dispos 36:1073-9. 2008
  8. doi request reprint ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Intern Med 22:996-1000. 2008
  9. doi request reprint Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Vet Parasitol 158:215-22. 2008
  10. pmc An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Comp Hepatol 9:6. 2010

Research Grants

Collaborators

Detail Information

Publications38

  1. ncbi request reprint Differential expression of CYP3A12 and CYP3A26 mRNAs in canine liver and intestine
    K L Mealey
    Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Xenobiotica 38:1305-12. 2008
    ..8% of the duodenal mRNA CYP3A pool. In summary, these results represent an important step toward the systematic comparison of human and canine CYP3A enzymes, particularly in relation to oral bioavailability of substrate drugs...
  2. doi request reprint Adverse drug reactions in veterinary patients associated with drug transporters
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Vet Clin North Am Small Anim Pract 43:1067-78. 2013
    ....
  3. doi request reprint ABCG2 transporter: therapeutic and physiologic implications in veterinary species
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Pharmacol Ther 35:105-12. 2012
    ..Finally, data in rodent models suggest that ABCG2 may play an important role in regulating a number of physiologic pathways involved in protecting erythrocytes from oxidative damage...
  4. ncbi request reprint Frequency of the mutant MDR1 allele associated with multidrug sensitivity in a sample of herding breed dogs living in Australia
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164 6610, USA
    Vet Parasitol 131:193-6. 2005
    ..Results of this study indicate that a high percentage of herding breeds presenting to veterinarians in Australia harbor the MDR1 mutation, thus impacting some therapeutic decisions...
  5. ncbi request reprint Systemic absorption of amitriptyline and buspirone after oral and transdermal administration to healthy cats
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Intern Med 18:43-6. 2004
    ..Until supporting pharmacokinetic data are available, veterinarians and cat owners should not rely on the transdermal route of administration for treating cats with amitriptyline or buspirone...
  6. ncbi request reprint Pharmacogenetics
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Vet Clin North Am Small Anim Pract 36:961-73, v. 2006
    ..Despite the fact that this branch of pharmacology is still in its infancy as a science, a number of important discoveries have already contributed to improved pharmacotherapy in human and veterinary patients...
  7. doi request reprint P-glycoprotein contributes to the blood-brain, but not blood-cerebrospinal fluid, barrier in a spontaneous canine p-glycoprotein knockout model
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Drug Metab Dispos 36:1073-9. 2008
    ..In summary, we have validated a novel P-glycoprotein-deficient canine model and have used the model to investigate transport of the P-glycoprotein substrate (99m)Tc-sestamibi at the blood-brain barrier and blood-CSF barrier...
  8. doi request reprint ABCB1-1Delta polymorphism can predict hematologic toxicity in dogs treated with vincristine
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Intern Med 22:996-1000. 2008
    ..Whether or not the ABCB1-1Delta polymorphism affects susceptibility to toxicity of other P-glycoprotein substrate drugs has not been studied...
  9. doi request reprint Canine ABCB1 and macrocyclic lactones: heartworm prevention and pharmacogenetics
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Vet Parasitol 158:215-22. 2008
    ..However, at the manufacturer's recommended dose, all FDA-approved heartworm preventive products marketed in the United States are safe, even for dogs with the ABCB1 mutant/mutant genotype...
  10. pmc An insertion mutation in ABCB4 is associated with gallbladder mucocele formation in dogs
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Comp Hepatol 9:6. 2010
    ....
  11. doi request reprint Oral bioavailability of P-glycoprotein substrate drugs do not differ between ABCB1-1Δ and ABCB1 wild type dogs
    K L Mealey
    Veterinary Clinical Pharmacology Laboratory, Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Pharmacol Ther 33:453-60. 2010
    ..However, small sample sizes and individual variability in CYP enzyme activity may have affected the power of the study to detect the impact of P-gp on oral bioavailability...
  12. ncbi request reprint Ivermectin sensitivity in collies is associated with a deletion mutation of the mdr1 gene
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 6610, USA
    Pharmacogenetics 11:727-33. 2001
    ..Dogs that are homozygous for the deletion mutation display the ivermectin-sensitive phenotype, while those that are homozygous normal or heterozygous do not display increased sensitivity to ivermectin...
  13. ncbi request reprint Therapeutic implications of the MDR-1 gene
    K L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Pharmacol Ther 27:257-64. 2004
    ..Furthermore, data in rodent models suggest that P-gp may play an important role in regulating the hypothalamic-pituitary-adrenal axis...
  14. ncbi request reprint The effects of inhibiting cytochrome P450 3A, p-glycoprotein, and gastric acid secretion on the oral bioavailability of methadone in dogs
    B Kukanich
    Department of Molecular Biomedical Sciences, Comparative Pain and Pharmacology Research Laboratory, College of Veterinary Medicine, North Carolina State University, Raleigh, NC, USA
    J Vet Pharmacol Ther 28:461-6. 2005
    ....
  15. ncbi request reprint Ivermectin toxicity in an Australian Shepherd dog with the MDR1 mutation associated with ivermectin sensitivity in Collies
    O L Nelson
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Vet Intern Med 17:354-6. 2003
  16. doi request reprint Biliary excretion of technetium-99m-sestamibi in wild-type dogs and in dogs with intrinsic (ABCB1-1Delta mutation) and extrinsic (ketoconazole treated) P-glycoprotein deficiency
    J C Coelho
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA, USA
    J Vet Pharmacol Ther 32:417-21. 2009
    ..It is likely that concurrent administration of a P-gp inhibitor such as ketoconazole will decrease P-gp-mediated biliary excretion of other substrate drugs as well...
  17. ncbi request reprint Comparative pharmacokinetics of phenylbutazone and its metabolite oxyphenbutazone in clinically normal horses and donkeys
    K L Mealey
    Department of Veterinary Physiology and Pharmacology, College of Veterinary Medicine, Texas A and M University, College Station 77840, USA
    Am J Vet Res 58:53-5. 1997
    ..To compare plasma disposition of phenylbutazone and its metabolite oxyphenbutazone after i.v. administration of phenylbutazone in horses and donkeys...
  18. ncbi request reprint Functional cystic thyroid adenoma in a cat
    E Hofmeister
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164-6610, USA
    J Am Vet Med Assoc 219:190-3. 2001
    ..A necropsy was not performed, but histologic examination of a biopsy specimen of the mass indicated that it was a cystic thyroid adenoma...
  19. ncbi request reprint Systemic Mycobacterium avium infection in a dog diagnosed by polymerase chain reaction analysis of buffy coat
    James F Naughton
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 6610, USA
    J Am Anim Hosp Assoc 41:128-32. 2005
    ..Polymerase chain reaction (PCR) analysis of a buffy-coat preparation identified M. avium...
  20. doi request reprint Evaluation of the flanking nucleotide sequences of sarcomeric hypertrophic cardiomyopathy substitution mutations
    Kathryn M Meurs
    Department of Veterinary Clinical Sciences, Washington State University College of Veterinary Medicine, Grimes Street, Pullman, WA 99164, United States
    Mutat Res 642:86-9. 2008
    ..The large number of G to A and C to T mutations as well as the relative mutability of CG may suggest that deamination of methylated CpG is an important mechanism for mutation development in at least some of these cardiac genes...
  21. ncbi request reprint Fecal polymerase chain reaction with 16S ribosomal RNA primers can detect the presence of gastrointestinal Helicobacter in dogs
    Joanne K Shinozaki
    College of Veterinary Medicine, Washington State University, Pullman 99164 6010, USA
    J Vet Intern Med 16:426-32. 2002
    ..Fecal PCR is a useful test for detecting Helicobacter infection in dogs. This assay may be useful as a screening test for infection and could be used to address questions relevant to pathogenesis and therapy...
  22. ncbi request reprint Frequency of the mutant MDR1 allele associated with ivermectin sensitivity in a sample population of collies from the northwestern United States
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, Washington State University, Pullman 99164 6610, USA
    Am J Vet Res 63:479-81. 2002
    ..To determine the frequency of the MDR1 gene mutation (polymorphism) associated with ivermectin sensitivity in a sample population of Collies in Washington and Idaho...
  23. ncbi request reprint Assessment of antiepileptic drugs as substrates for canine P-glycoprotein
    Chadwick L West
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Am J Vet Res 68:1106-10. 2007
    ..To determine whether antiepileptic drugs (AEDs) are substrates for canine P-glycoprotein (P-gp). Sample Population-OS2.4/Doxo cells (canine osteosarcoma cells induced via exposure to doxorubicin to highly express P-gp)...
  24. ncbi request reprint Increased toxicity of P-glycoprotein-substrate chemotherapeutic agents in a dog with the MDR1 deletion mutation associated with ivermectin sensitivity
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Am Vet Med Assoc 223:1453-5, 1434. 2003
    ..Because P-glycoprotein contributes to renal, biliary, and intestinal excretion of P-glycoprotein-substrate drugs, it is possible that drug excretion was delayed in this patient, resulting in clinical signs of toxicosis...
  25. ncbi request reprint Digoxin and mexiletine sensitivity in a Collie with the MDR1 mutation
    Rosemary A Henik
    Department of Medical Sciences, School of Veterinary Medicine, University of Wisconsin, Madison, USA
    J Vet Intern Med 20:415-7. 2006
  26. ncbi request reprint Loperamide toxicity in a collie with the MDR1 mutation associated with ivermectin sensitivity
    Laura L Sartor
    Department of Medical Sciences, College of Veterinary Medicine, University of Wisconsin, Madison, WI, USA
    J Vet Intern Med 18:117-8. 2004
  27. pmc Breed distribution and history of canine mdr1-1Delta, a pharmacogenetic mutation that marks the emergence of breeds from the collie lineage
    Mark W Neff
    Veterinary Genetics Laboratory, School of Veterinary Medicine, University of California, Davis, CA 95616, USA
    Proc Natl Acad Sci U S A 101:11725-30. 2004
    ....
  28. pmc Doxycycline induces expression of P glycoprotein in MCF-7 breast carcinoma cells
    Katrina L Mealey
    Department of Veterinary Physiology and Pharmacology, Texas A and M University College of Veterinary Medicine, College Station, Texas 77843 4466, USA
    Antimicrob Agents Chemother 46:755-61. 2002
    ..Doxycycline, a drug that has been used for treatment of bacterial infections in cancer patients, can induce functional P-gp expression in cancer cells, resulting in multidrug resistance...
  29. doi request reprint Breed distribution of the ABCB1-1Delta (multidrug sensitivity) polymorphism among dogs undergoing ABCB1 genotyping
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    J Am Vet Med Assoc 233:921-4. 2008
    ....
  30. ncbi request reprint Synovial T-cell lymphoma of the stifle in a dog
    Sunshine M Lahmers
    Department of Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99165, USA
    J Am Anim Hosp Assoc 38:165-8. 2002
    ..Despite finding a nonspecific, mixed inflammatory response on joint fluid cytopathology, histopathology demonstrated T-cell lymphoma of the synovium. Lameness may be the sole presenting clinical sign in canine lymphoma...
  31. ncbi request reprint Pharmacokinetics of sulfamethoxazole and trimethoprim in donkeys, mules, and horses
    Kenneth E Peck
    Texas Veterinary Medical Center, Texas A and M University, College Station 77843 4474, USA
    Am J Vet Res 63:349-53. 2002
    ..To compare serum disposition of sulfamethoxazole and trimethoprim after IV administration to donkeys, mules, and horses...
  32. ncbi request reprint Questions reported risks of Salmonella infections
    Dale Hancock
    J Am Vet Med Assoc 221:192. 2002
  33. ncbi request reprint Transdermal absorption of a liposome-encapsulated formulation of lidocaine following topical administration in cats
    Boel A Fransson
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman 99164, USA
    Am J Vet Res 63:1309-12. 2002
    ..To determine plasma disposition after dermal application of a liposome-encapsulated formulation of lidocaine in cats...
  34. ncbi request reprint Effect of low doses of cosyntropin on serum cortisol concentrations in clinically normal dogs
    Linda G Martin
    Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610
    Am J Vet Res 68:555-60. 2007
    ..To determine the lowest of 5 doses of cosyntropin (1.0, 0.5, 0.1, 0.05, or 0.01 microg/kg) administered IV that stimulates maximal cortisol secretion in clinically normal dogs...
  35. ncbi request reprint Comparative pharmacokinetics of meloxicam in clinically normal horses and donkeys
    Melissa D Sinclair
    Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, ON, Canada, N1G 2W1
    Am J Vet Res 67:1082-5. 2006
    ..To determine the disposition of a bolus of meloxicam (administered IV) in horses and donkeys (Equus asinus) and compare the relative pharmacokinetic variables between the species...
  36. ncbi request reprint Survival time, lifespan, and quality of life in dogs with idiopathic Fanconi syndrome
    Jennifer H Yearley
    New England Primate Research Center, Harvard Medical School, Division of Comparative Pathology, One Pine Hill Dr, PO Box 9102, Southborough, MA 01772, USA
    J Am Vet Med Assoc 225:377-83. 2004
    ..To evaluate survival time of dogs with idiopathic Fanconi syndrome...
  37. ncbi request reprint Comparison of plasma disposition of alkaloids after lupine challenge in cattle that had given birth to calves with lupine-induced arthrogryposis or clinically normal calves
    Clive C Gay
    Field Disease Investigation Unit, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 6610, USA
    Am J Vet Res 65:1580-3. 2004
    ....
  38. ncbi request reprint Pharmacokinetics of R(-) and S(+) carprofen after administration of racemic carprofen in donkeys and horses
    Katrina L Mealey
    Department of Veterinary Clinical Sciences, Washington State University, Pullman, WA 99164, USA
    Am J Vet Res 65:1479-82. 2004
    ..To compare plasma disposition of the R(-) and S(+) enantiomers of carprofen after IV administration of a bolus dose to donkeys and horses...

Research Grants1

  1. Canine model for assessing CNS access P-gp substrates
    KATRINA MEALEY; Fiscal Year: 2005
    ....