Travis McGuire

Summary

Affiliation: Washington State University
Country: USA

Publications

  1. ncbi Frequency of memory cytotoxic T lymphocytes to equine infectious anemia virus proteins in blood from carrier horses
    T C McGuire
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Virology 238:85-93. 1997
  2. ncbi Equine infectious anaemia virus proteins with epitopes most frequently recognized by cytotoxic T lymphocytes from infected horses
    T C McGuire
    Department of Veterinary Microbiology and Pathology and Department of Animal Sciences, Washington State University, Pullman, WA 99164 7040, USA
    J Gen Virol 81:2735-9. 2000
  3. ncbi Presentation and binding affinity of equine infectious anemia virus CTL envelope and matrix protein epitopes by an expressed equine classical MHC class I molecule
    Travis C McGuire
    Department of Veterinary Microbiology and Pathology, Washington State University College of Veterinary Medicine, Pullman, WA 99164, USA
    J Immunol 171:1984-93. 2003
  4. ncbi Cytotoxic T lymphocytes and neutralizing antibody in the control of equine infectious anemia virus
    Travis C McGuire
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 7040, USA
    Viral Immunol 15:521-31. 2002
  5. ncbi Cytotoxic T lymphocytes in protection against equine infectious anemia virus
    Travis C McGuire
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Anim Health Res Rev 5:271-6. 2004
  6. pmc Early detection of dominant Env-specific and subdominant Gag-specific CD8+ lymphocytes in equine infectious anemia virus-infected horses using major histocompatibility complex class I/peptide tetrameric complexes
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virology 339:110-26. 2005
  7. pmc Surface envelope glycoprotein is B-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Diagn Lab Immunol 12:797-800. 2005
  8. ncbi Equine infectious anemia virus-infected dendritic cells retain antigen presentation capability
    Julie A Rivera
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virology 335:145-54. 2005
  9. pmc Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals
    Kristin M Patton
    Department of Veterinary Microbiology and Pathology, Washington State University, Bustad Hall, Room 402, Pullman, Washington 99164 7040, USA
    Infect Immun 73:2083-93. 2005
  10. pmc Identification of vaccine candidate peptides in the NcSRS2 surface protein of Neospora caninum by using CD4+ cytotoxic T lymphocytes and gamma interferon-secreting T lymphocytes of infected holstein cattle
    Lauren M Staska
    Department of Veterinary Microbiology and Pathology, Bustad Hall, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 73:1321-9. 2005

Research Grants

Collaborators

Detail Information

Publications40

  1. ncbi Frequency of memory cytotoxic T lymphocytes to equine infectious anemia virus proteins in blood from carrier horses
    T C McGuire
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Virology 238:85-93. 1997
    ..These results should facilitate the identification of epitopes recognized by predominant CTLm from horses controlling a lentivirus infection...
  2. ncbi Equine infectious anaemia virus proteins with epitopes most frequently recognized by cytotoxic T lymphocytes from infected horses
    T C McGuire
    Department of Veterinary Microbiology and Pathology and Department of Animal Sciences, Washington State University, Pullman, WA 99164 7040, USA
    J Gen Virol 81:2735-9. 2000
    ..Based on these results, it is likely that a construct expressing the 359 amino acids constituting p15 and p26 would contain epitopes capable of stimulating CTL in most horses...
  3. ncbi Presentation and binding affinity of equine infectious anemia virus CTL envelope and matrix protein epitopes by an expressed equine classical MHC class I molecule
    Travis C McGuire
    Department of Veterinary Microbiology and Pathology, Washington State University College of Veterinary Medicine, Pullman, WA 99164, USA
    J Immunol 171:1984-93. 2003
    ..Since MHC class I 7-6 presented both epitopes, outbred horses with this allele can be immunized with these epitopes to optimize CTL responses and evaluate their effectiveness against lentiviral challenge...
  4. ncbi Cytotoxic T lymphocytes and neutralizing antibody in the control of equine infectious anemia virus
    Travis C McGuire
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, Washington 99164 7040, USA
    Viral Immunol 15:521-31. 2002
  5. ncbi Cytotoxic T lymphocytes in protection against equine infectious anemia virus
    Travis C McGuire
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Anim Health Res Rev 5:271-6. 2004
    ..A possible solution to CTL escape variants is the induction of high-avidity CTL to multiple EIAV epitopes...
  6. pmc Early detection of dominant Env-specific and subdominant Gag-specific CD8+ lymphocytes in equine infectious anemia virus-infected horses using major histocompatibility complex class I/peptide tetrameric complexes
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virology 339:110-26. 2005
    ....
  7. pmc Surface envelope glycoprotein is B-lymphocyte immunodominant in sheep naturally infected with ovine progressive pneumonia virus
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Diagn Lab Immunol 12:797-800. 2005
    ..Since these data indicate that SU is the immunodominant protein in most mature sheep persistently infected with OPPV, SU-specific diagnostic serological assays can be utilized for OPPV diagnosis...
  8. ncbi Equine infectious anemia virus-infected dendritic cells retain antigen presentation capability
    Julie A Rivera
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virology 335:145-54. 2005
    ..The maintenance of antigen processing and presenting function by EIAV-infected DC in vitro suggests that this function is maintained during in vivo infection...
  9. pmc Rhodococcus equi-specific cytotoxic T lymphocytes in immune horses and development in asymptomatic foals
    Kristin M Patton
    Department of Veterinary Microbiology and Pathology, Washington State University, Bustad Hall, Room 402, Pullman, Washington 99164 7040, USA
    Infect Immun 73:2083-93. 2005
    ..However, neither antibody bound alveolar macrophages, suggesting that the R. equi-specific, major histocompatibility complex-unrestricted lysis is not restricted by a surface molecule identified by these antibodies...
  10. pmc Identification of vaccine candidate peptides in the NcSRS2 surface protein of Neospora caninum by using CD4+ cytotoxic T lymphocytes and gamma interferon-secreting T lymphocytes of infected holstein cattle
    Lauren M Staska
    Department of Veterinary Microbiology and Pathology, Bustad Hall, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 73:1321-9. 2005
    ..These findings support investigation of subunit N. caninum vaccines incorporating NcSRS2 gene sequences or peptides for induction of NcSRS2 peptide-specific CTL and IFN-gamma-secreting T lymphocytes in cattle with varied MHC genotypes...
  11. pmc Lymphocyte proliferation responses induced to broadly reactive Th peptides did not protect against equine infectious anemia virus challenge
    Darrilyn G Fraser
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164 7040, USA
    Clin Diagn Lab Immunol 12:983-93. 2005
    ..Thus, lipopeptide-induced proliferative responses and enhanced Th and CTL responses early after virus challenge were unable to control challenge virus load and clinical disease...
  12. pmc Evaluation of high functional avidity CTL to Gag epitope clusters in EIAV carrier horses
    Chungwon Chung
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99165 7040, USA
    Virology 342:228-39. 2005
    ..Thus, not all carrier horses had high functional avidity CTL to Gag EC, but those that did had longer periods without disease episodes...
  13. pmc Identification of novel antigenic proteins in a complex Anaplasma marginale outer membrane immunogen by mass spectrometry and genomic mapping
    Job E Lopez
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 73:8109-18. 2005
    ..The identification of these novel antigenic proteins markedly expands current understanding of the composition of the protective immunogen and provides new candidates for vaccine development...
  14. pmc Development of specific immunoglobulin Ga (IgGa) and IgGb antibodies correlates with control of parasitemia in Babesia equi Infection
    Cristina W Cunha
    Washington State University, Department of Veterinary Microbiology and Pathology, Pullman, WA 99164 7040, USA
    Clin Vaccine Immunol 13:297-300. 2006
    ..The same IgG isotype profile induced during acute infection was obtained by equi merozoite antigen 1/saponin immunization...
  15. pmc Analysis of the Anaplasma marginale major surface protein 1 complex protein composition by tandem mass spectrometry
    Henriette Macmillan
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    J Bacteriol 188:4983-91. 2006
    ..The msp1beta sequences were highly conserved throughout infection. However, liquid chromatography-tandem mass spectrometry analysis identified only a single MSP1b protein, MSP1b1, within the MSP1 complex...
  16. pmc Validation of a competitive enzyme-linked immunosorbent assay for detection of antibodies against Babesia bovis
    Will L Goff
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Vaccine Immunol 13:1212-6. 2006
    ..Analysis of variance of the resulting optical densities and a test of homogeneity indicated no significant difference among the laboratories. Overall, the cELISA appears to have the attributes necessary for international application...
  17. pmc A single amino acid difference within the alpha-2 domain of two naturally occurring equine MHC class I molecules alters the recognition of Gag and Rev epitopes by equine infectious anemia virus-specific CTL
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164, USA
    J Immunol 177:7377-90. 2006
    ....
  18. ncbi Evaluation of E. ruminantium genes in DBA/2 mice as potential DNA vaccine candidates for control of heartwater
    Bigboy H Simbi
    Department of Pathobiology, College of Veterinary Medicine, University of Florida, Gainesville, FL 32610, USA
    Ann N Y Acad Sci 1078:424-37. 2006
    ....
  19. pmc Cloning and large-scale expansion of epitope-specific equine cytotoxic T lymphocytes using an anti-equine CD3 monoclonal antibody and human recombinant IL-2
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Vet Immunol Immunopathol 118:121-8. 2007
    ..Our results provide a reliable means to generate large numbers of epitope-specific equine CTL clones that are suitable for use in downstream applications, including functional assays and adoptive transfer studies...
  20. pmc Failure of low-dose recombinant human IL-2 to support the survival of virus-specific CTL clones infused into severe combined immunodeficient foals: lack of correlation between in vitro activity and in vivo efficacy
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, United States
    Vet Immunol Immunopathol 121:8-22. 2008
    ..Successful adoptive immunotherapy with CTL clones in immunodeficient horses will likely require higher doses of rhuIL-2, co-infusion of CD4+ T lymphocytes, or administration of equine IL-2...
  21. pmc Complete genome sequencing of Anaplasma marginale reveals that the surface is skewed to two superfamilies of outer membrane proteins
    Kelly A Brayton
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washingston State University, Pullman, WA 99164 7040, USA
    Proc Natl Acad Sci U S A 102:844-9. 2005
    ....
  22. pmc Identification of a novel Anaplasma marginale appendage-associated protein that localizes with actin filaments during intraerythrocytic infection
    Roger W Stich
    Department of Veterinary Preventive Medicine, The Ohio State University, 1900 Coffey Rd, Columbus, OH 43210, USA
    Infect Immun 72:7257-64. 2004
    ..Understanding how this protein influences the cycle of invasion, replication, and egress in the host cell may provide new insights into pathogen-host interactions...
  23. pmc Rhodococcus equi-infected macrophages are recognized and killed by CD8+ T lymphocytes in a major histocompatibility complex class I-unrestricted fashion
    Kristin M Patton
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 72:7073-83. 2004
    ..equi. The apparent lack of restriction via classical MHC class I molecules suggests a novel or nonclassical method of antigen processing and presentation, such as presentation by CD1 or other nonclassical MHC molecules...
  24. pmc Selective in vivo depletion of CD4(+) T lymphocytes with anti-CD4 monoclonal antibody during acute infection of calves with Anaplasma marginale
    Reginald A Valdez
    Animal Disease Research Unit, United States Department of Agriculture, Agricultural Research Service, Pullman, Washington 99163, USA
    Clin Diagn Lab Immunol 9:417-24. 2002
    ..This was in contrast to the prediction that significant depletion of CD4(+) T lymphocytes would abrogate resistance to acute infection...
  25. ncbi Lipopeptide stimulation of MHC class I-restricted memory cytotoxic T lymphocytes from equine infectious anemia virus-infected horses
    Sherritta L Ridgely
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Vaccine 20:1809-19. 2002
    ..The results suggest that these P3C-MAP-peptides can be used as immunogens to stimulate primary immune responses in vivo...
  26. pmc Identification of broadly recognized, T helper 1 lymphocyte epitopes in an equine lentivirus
    Darrilyn G Fraser
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Immunology 105:295-305. 2002
    ..Finally, CD4(+) T lymphocytes were required for proliferation responses, as shown by assays using CD4- versus CD8-depleted PBMC...
  27. ncbi Conservation of the unique rickettsial rRNA gene arrangement in Anaplasma
    Fred R Rurangirwa
    Department of Veterinary Microbiology and Pathology, Pullman, WA 99164 7040, USA
    Int J Syst Evol Microbiol 52:1405-9. 2002
    ..In contrast, the fmt gene located upstream of the 23S rRNA gene in most Rickettsia spp. is not maintained in A. marginale, consistent with the fmt arrangement being a relatively late event in the evolution of rickettsial species...
  28. pmc Major histocompatibility complex class II DR-restricted memory CD4(+) T lymphocytes recognize conserved immunodominant epitopes of Anaplasma marginale major surface protein 1a
    Wendy C Brown
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164, USA
    Infect Immun 70:5521-32. 2002
    ..The presence of multiple CD4(+) T-cell epitopes in the MSP1a HD, in addition to the neutralization-sensitive epitope, supports the testing of this immunogen for induction of protective immunity against A. marginale challenge...
  29. pmc Conformational dependence and conservation of an immunodominant epitope within the babesia equi erythrocyte-stage surface protein equi merozoite antigen 1
    Cristina W Cunha
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Clin Diagn Lab Immunol 9:1301-6. 2002
    ..97 and inhibiting equine antibodies has a median amino acid identity of 99.0% and a similarity of 100%. These data provide a molecular basis for the use of both EMA-1 and MAb 36/133.97 for the detection of antibodies against B. equi...
  30. ncbi Response of ELA-A1 horses immunized with lipopeptide containing an equine infectious anemia virus ELA-A1-restricted CTL epitope to virus challenge
    Sherritta L Ridgely
    Department of Veterinary Microbiology and Pathology, College of Veterinary Medicine, Washington State University, Pullman, WA 99164, USA
    Vaccine 21:491-506. 2003
    ..Results indicate that lipopeptide immunization had a protective effect against development of clinical disease following virus challenge...
  31. pmc Clearance of virulent but not avirulent Rhodococcus equi from the lungs of adult horses is associated with intracytoplasmic gamma interferon production by CD4+ and CD8+ T lymphocytes
    Stephen A Hines
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    Clin Diagn Lab Immunol 10:208-15. 2003
    ....
  32. pmc Competitive-inhibition enzyme-linked immunosorbent assay for detection of serum antibodies to caprine arthritis-encephalitis virus: diagnostic tool for successful eradication
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Diagn Lab Immunol 10:267-71. 2003
    ..At this cutoff value, there were 0 of 60 false-negative sera (100% sensitivity) and 5 of 140 false-positive sera (96.4% specificity). Additional studies utilized IP-monitored cELISA to establish a CAEV-free herd of 1,640 dairy goats...
  33. pmc Neospora caninum-infected cattle develop parasite-specific CD4+ cytotoxic T lymphocytes
    Lauren M Staska
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164, USA
    Infect Immun 71:3272-9. 2003
    ..caninum in the natural, outbred, bovine host will facilitate identification of immunogens and design of immunization strategies to induce parasite-specific CTL against transplacental N. caninum transmission in cattle...
  34. pmc Epitope specificity is critical for high and moderate avidity cytotoxic T lymphocytes associated with control of viral load and clinical disease in horses with equine infectious anemia virus
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Virology 313:537-52. 2003
    ..These results suggested that the epitope specificity of high- and moderate-avidity CTLm was an important determinant for disease outcome in the EIAV-infected horses examined...
  35. pmc Detection of serum antibodies to ovine progressive pneumonia virus in sheep by using a caprine arthritis-encephalitis virus competitive-inhibition enzyme-linked immunosorbent assay
    Lynn M Herrmann
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Diagn Lab Immunol 10:862-5. 2003
    ..5% sensitivity) and 0 of 15 false-positives (100% specificity). We conclude that the CAEV cELISA can be applied to detection of OPPV antibodies in sheep with high sensitivity and specificity...
  36. pmc CD4+ T lymphocytes from Anaplasma marginale major surface protein 2 (MSP2) vaccinees recognize naturally processed epitopes conserved in MSP3
    Wendy C Brown
    Program in Vector Borne Diseases, Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164 7040, USA
    Infect Immun 72:3688-92. 2004
    ..This T-lymphocyte response to conserved and partially conserved epitopes may contribute to the immunodominance of MSP2 and MSP3...
  37. pmc Adaptive immunity is the primary force driving selection of equine infectious anemia virus envelope SU variants during acute infection
    Robert H Mealey
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington 99164 7040, USA
    J Virol 78:9295-305. 2004
    ..Not only do these data indicate that adaptive immunity primarily drives the selection of EIAV SU variants, but also they demonstrate that other selective forces exist during acute infection...
  38. pmc CTL from EIAV carrier horses with diverse MHC class I alleles recognize epitope clusters in Gag matrix and capsid proteins
    Chungwon Chung
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99165 7040, USA
    Virology 327:144-54. 2004
    ..EC1 and EC3 were the most conserved EC and these more conserved broadly recognized EC may be most useful for CTL induction, helping overcome MHC class I polymorphism and antigenic variation...
  39. pmc Validation of a competitive enzyme-linked immunosorbent assay for detection of Babesia bigemina antibodies in cattle
    Will L Goff
    Animal Disease Research Unit, Agricultural Research Service, U S Department of Agriculture, Pullman, Washington 99164 6630, USA
    Clin Vaccine Immunol 15:1316-21. 2008
    ..8, indicating a high degree of reliability. Overall, the cELISA appears to have the attributes necessary for international application...
  40. ncbi Selecting peptides to optimize Th1 responses to an equine lentivirus using HLA-DR binding motifs and defined HIV-1 Th peptides
    Darrilyn G Fraser
    Department of Veterinary Microbiology and Pathology, Washington State University, Pullman 99164 7040, USA
    Immunogenetics 55:508-14. 2003
    ....

Research Grants17

  1. ROLE OF CD4+ TH1 LYMPHOCYTES IN PROTECTION AGAINST EIAV
    Travis McGuire; Fiscal Year: 2002
    ....
  2. IMMUNE CONTROL OF EQUINE INFECTIOUS ANEMIA LENTIVIRUS
    Travis McGuire; Fiscal Year: 2002
    ....
  3. IMMUNE CONTROL OF EQUINE INFECTIOUS ANEMIA LENTIVIRUS
    Travis McGuire; Fiscal Year: 1993
    ..3. Induce CTL in horses with vaccinia virus recombinants expressing defined epitopes of EIAV proteins. 4. Challenge immunized horses with homologous EIAV and with antigeni variants...
  4. EIAV vector targeting dendritic cells to induce CTL
    ROBERT MEALEY; Fiscal Year: 2005
    ..Thus, this proposal will test the hypothesis that targeting dendritic cells in vivo with an EIAV vector will induce CTL in horses to multiple viral proteins. ..