John W McDonald

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination
    John W McDonald
    Center for the Study of Nervous System Injury, Spinal Cord Injury Restorative Treatment and Research Program, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Prog Brain Res 137:299-309. 2002
  2. ncbi Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
    J W McDonald
    Center for the Study of Nervous System Injury, the Restorative Treatment and Research Center and Department of Neurology, Washington University School of Medicine, Box 8111, 660 S Euclid Ave, St Louis, Missouri 63110, USA
    Nat Med 5:1410-2. 1999
  3. ncbi Spinal-cord injury
    John W McDonald
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, and Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 359:417-25. 2002
  4. ncbi Late recovery following spinal cord injury. Case report and review of the literature
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosurg 97:252-65. 2002
  5. pmc Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury
    Sara J Taylor
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Control Release 113:226-35. 2006
  6. pmc Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats
    Daniel Becker
    International Center, for Spinal Cord Injury, Hugo Moser Research Institute, Department of Neurology, Johns Hopkins School of Medicine and Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Exp Neurol 222:211-8. 2010
  7. ncbi Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cells
    Sudhakar Vadivelu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurg Focus 19:E3. 2005
  8. ncbi Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain
    Sudhakar Vadivelu
    Center for the Study of Nervous System Injury and the Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosurg 103:124-35. 2005
  9. ncbi Repair of the injured spinal cord and the potential of embryonic stem cell transplantation
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurotrauma 21:383-93. 2004
  10. ncbi Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies
    Visar Belegu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Room 518, Baltimore, MD 21205, USA
    Neurosurg Clin N Am 18:143-68, xi. 2007

Collaborators

Detail Information

Publications31

  1. ncbi Repairing the damaged spinal cord: a summary of our early success with embryonic stem cell transplantation and remyelination
    John W McDonald
    Center for the Study of Nervous System Injury, Spinal Cord Injury Restorative Treatment and Research Program, Department of Neurology, Washington University School of Medicine, St Louis, MO 63110, USA
    Prog Brain Res 137:299-309. 2002
    ..The role of myelination and remyelination will be discussed in the context of regeneration strategies...
  2. ncbi Transplanted embryonic stem cells survive, differentiate and promote recovery in injured rat spinal cord
    J W McDonald
    Center for the Study of Nervous System Injury, the Restorative Treatment and Research Center and Department of Neurology, Washington University School of Medicine, Box 8111, 660 S Euclid Ave, St Louis, Missouri 63110, USA
    Nat Med 5:1410-2. 1999
    ..Furthermore, gait analysis demonstrated that transplanted rats showed hindlimb weight support and partial hindlimb coordination not found in 'sham-operated' controls or control rats transplanted with adult mouse neocortical cells...
  3. ncbi Spinal-cord injury
    John W McDonald
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, and Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, MO 63110, USA
    Lancet 359:417-25. 2002
    ..We also discuss new treatment options, including functional electric stimulation and part-weight-supported walking...
  4. ncbi Late recovery following spinal cord injury. Case report and review of the literature
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosurg 97:252-65. 2002
    ..The role of patterned neural activity in regeneration and recovery of function after SCI therefore appears a fruitful area for future investigation...
  5. pmc Delivery of neurotrophin-3 from fibrin enhances neuronal fiber sprouting after spinal cord injury
    Sara J Taylor
    Department of Biomedical Engineering, Washington University, St Louis, MO 63130, USA
    J Control Release 113:226-35. 2006
    ..Thus, controlled delivery of NT-3 from fibrin scaffolds enhanced the initial regenerative response by increasing neuronal fiber sprouting and cell migration into the lesion, while functional motor recovery was not observed in this model...
  6. pmc Functional electrical stimulation helps replenish progenitor cells in the injured spinal cord of adult rats
    Daniel Becker
    International Center, for Spinal Cord Injury, Hugo Moser Research Institute, Department of Neurology, Johns Hopkins School of Medicine and Kennedy Krieger Institute, Baltimore, MD 21205, USA
    Exp Neurol 222:211-8. 2010
    ..In uninjured rats, FES had no effect on cell birth/survival. This report suggests that controlled electrical activation of the CNS may enhance spontaneous regeneration after neurological injuries...
  7. ncbi Generating chimeric spinal cord: a novel model for transplantable oligodendrocyte progenitors derived from embryonic stem cells
    Sudhakar Vadivelu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA
    Neurosurg Focus 19:E3. 2005
    ..To identify and evaluate stem cell-derived oligodendrocytes obtained for cell transplantation therapies, the authors developed a novel model to examine single, adult oligodendrocytes in situ...
  8. ncbi Multi-germ layer lineage central nervous system repair: nerve and vascular cell generation by embryonic stem cells transplanted in the injured brain
    Sudhakar Vadivelu
    Center for the Study of Nervous System Injury and the Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosurg 103:124-35. 2005
    ..Here, the authors examined whether embryonic stem cell (ESC)-derived progenitors can selectively generate both neural and endothelial cells after transplantation in the damaged CNS...
  9. ncbi Repair of the injured spinal cord and the potential of embryonic stem cell transplantation
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri, USA
    J Neurotrauma 21:383-93. 2004
    ..These features of ES cells will produce a predictable and explosive growth in scientific tools that will translate into discoveries and rapid progress in neural repair...
  10. ncbi Restoring function after spinal cord injury: promoting spontaneous regeneration with stem cells and activity-based therapies
    Visar Belegu
    The International Center for Spinal Cord Injury, Kennedy Krieger Institute, Department of Neurology, Johns Hopkins University School of Medicine, 707 North Broadway, Room 518, Baltimore, MD 21205, USA
    Neurosurg Clin N Am 18:143-68, xi. 2007
    ....
  11. doi The changing field of rehabilitation: optimizing spontaneous regeneration and functional recovery
    John W McDonald
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Handb Clin Neurol 109:317-36. 2012
    ..We stress that lifelong ABRT is required to optimize return of function and to allow patients to benefit from any "cures" that will be discovered...
  12. doi Approaches to repairing the damaged spinal cord: overview
    Daniel Becker
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Handb Clin Neurol 109:445-61. 2012
    ..The ultimate goal is to harness the body's own potential to replace lost central nervous system cells by activation of endogenous progenitor cell repair mechanisms...
  13. ncbi Gap junctions and connexon hemichannels in human embryonic stem cells
    James E Huettner
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Stem Cells 24:1654-67. 2006
    ..Human ES cells provide a unique system for the study of human connexin proteins and their potential functions in cellular differentiation and the maintenance of pluripotency...
  14. ncbi Repairing the damaged spinal cord: from stem cells to activity-based restoration therapies
    John W McDonald
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Clin Neurosurg 51:207-27. 2004
  15. ncbi Stem cell transplantation and other novel techniques for promoting recovery from spinal cord injury
    Terence M Myckatyn
    Division of Plastic and Reconstructive Surgery, Washington University School of Medicine, 4444 Forest Park Boulevard, St Louis, MO 63108, USA
    Transpl Immunol 12:343-58. 2004
    ..The potential role of nerve transfers for reconstructing the injured spinal cord, particularly the cauda equina and lumbosacral plexus, are also described...
  16. ncbi Spinal cord injury: promising interventions and realistic goals
    John W McDonald
    Department of Neurology and Neurological Surgery, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Am J Phys Med Rehabil 82:S38-49. 2003
    ....
  17. ncbi Rodent models for treatment of spinal cord injury: research trends and progress toward useful repair
    Ephron S Rosenzweig
    Department of Neurology, Washington University School of Medicine, St Louis, Missouri, USA
    Curr Opin Neurol 17:121-31. 2004
    ..We have also catalogued the treatments used in studies published between October 2002 and November 2003, with special attention given to studies in which treatments were delayed for at least 4 days after injury...
  18. ncbi AMPA receptors are the major mediators of excitotoxic death in mature oligodendrocytes
    Elizabeth A Leuchtmann
    Center for the Study of Nervous System Injury, Washington University School of Medicine, Box 8518, St Louis, MO 63108, USA
    Neurobiol Dis 14:336-48. 2003
    ..We conclude that when mature oligodendrocytes die after exposure to kainate: (1) AMPA receptors are the most important mediators, (2) kainate receptors play a smaller role, and (3) death occurs predominantly by necrosis, not apoptosis...
  19. ncbi Restoring function after spinal cord injury
    Daniel Becker
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Restorative Treatment and Research Program, Washington University School of Medicine, St Louis, Missouri 63108, USA
    Neurologist 9:1-15. 2003
    ..Today, however, an understanding of the underlying pathophysiological mechanisms, the development of neuroprotective interventions, and progress toward regenerative interventions are increasing hope for functional restoration...
  20. ncbi Controlled release of neurotrophin-3 from fibrin gels for spinal cord injury
    Sara J Taylor
    Department of Biomedical Engineering, Washington University, St Louis, MO, USA
    J Control Release 98:281-94. 2004
    ..In a preliminary in vivo study, fibrin gels containing the HBDS and NT-3 showed increased neural fiber density in spinal cord lesions versus unmodified fibrin at 9 days...
  21. pmc Extensive neurological recovery from a complete spinal cord injury: a case report and hypothesis on the role of cortical plasticity
    Ann S Choe
    Department of Neurology, Johns Hopkins University School of Medicine Baltimore, MD, USA International Center for Spinal Cord Injury, Hugo W Moser Research Institute at Kennedy Krieger, Inc Baltimore, MD, USA F M Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute Baltimore, MD, USA
    Front Hum Neurosci 7:290. 2013
    ..This multimodal MR imaging study also shows the potential of rs-fMRI to measure the extent of cortical plasticity. ..
  22. ncbi Enhanced oligodendrocyte survival after spinal cord injury in Bax-deficient mice and mice with delayed Wallerian degeneration
    Hongxin Dong
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Restorative Treatment and Research Program, and Center for the Study of Nervous System Injury, Washington University School of Medicine, St Louis, Missouri 63108, USA
    J Neurosci 23:8682-91. 2003
    ..On the basis of these data, we hypothesize that the Wallerian degeneration of white matter axons that follows SCI removes axonal support and induces apoptotic death in oligodendrocytes by triggering Bax expression...
  23. pmc Functional reorganization and stability of somatosensory-motor cortical topography in a tetraplegic subject with late recovery
    Maurizio Corbetta
    Departments of Neurology, Radiology, Anatomy and Neurobiology, and Neurological Surgery, Washington University School of Medicine, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 99:17066-71. 2002
    ....
  24. ncbi Spinal cord injury
    C Sadowsky
    Department of Neurology, Spinal Cord Injury Neuro Rehabilitation Section, Washington University School of Medicine, St Louis, MO 63110, USA
    Disabil Rehabil 24:680-7. 2002
    ..This article is an overview of the newer therapeutic interventions employed in the care of the spinal cord injured individual and the theoretical rationale supporting them...
  25. ncbi Neurotrophin potentiation of iron-induced spinal cord injury
    J W McDonald
    Department of Neurology, Washington University School of Medicine, PO Box 8111, 660 S Euclid Avenue, St Louis, MO 63110 1093, USA
    Neuroscience 115:931-9. 2002
    ..These data support the hypothesis that the overall neuroprotective properties of neurotrophins in models of acute injury to the spinal cord may be limited by an underlying potentiation of free radical-mediated necrosis...
  26. pmc Neurogenesis and neuronal commitment following ischemia in a new mouse model for neonatal stroke
    S D Kadam
    Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA
    Brain Res 1208:35-45. 2008
    ..However, the total number of hippocampal SGZ-derived new neurons was reduced bilaterally; in contrast, the SVZ-derived neurogenesis was amplified...
  27. ncbi Neurons derived from embryonic stem (ES) cells resemble normal neurons in their vulnerability to excitotoxic death
    Y Qu
    Department of Neurology, Washington University School of Medicine, Box 8111, St, Louis, MO 63110, USA
    Exp Neurol 184:326-36. 2003
    ..Thus, ES cells, which are very amenable to genetic manipulation, provide a valid system for studying glutamate receptor-mediated toxicity at the molecular level...
  28. doi Neural stem cells reduce brain injury after unilateral carotid ligation
    Anne M Comi
    Division of Neurology and Developmental Medicine, Kennedy Krieger Institute, and Department of Neurology, Johns Hopkins School of Medicine, Baltimore, Maryland 21205, USA
    Pediatr Neurol 38:86-92. 2008
    ..Neural stem cells have the potential to ameliorate ischemic injury in the immature brain, although tumor development is a serious concern...
  29. ncbi Tissue-sparing effect of x-ray microplanar beams particularly in the CNS: is a bystander effect involved?
    F Avraham Dilmanian
    Medical Department, Brookhaven National Laboratory, Upton, NY 11973 5000, USA
    Exp Hematol 35:69-77. 2007
    ..The repairs apparently involve the microvasculature and the glial system. We evaluate a hypothesis on the involvement of bystander effects in these repairs...
  30. ncbi Correction addendum to: Late recovery following spinal cord injury
    John W McDonald
    J Neurosurg 97:405-6. 2002
  31. ncbi Demyelination and remyelination after spinal cord injury
    John W McDonald
    International Center for Spinal Cord Injury, Kennedy Krieger Institute and The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA
    J Neurotrauma 23:345-59. 2006
    ..This review focuses on concepts that are important for developing strategies of repair. The brightest young scientists will be attracted into this exciting field by its near-term potential for human application...