M J Manary

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint A large-scale operational study of home-based therapy with ready-to-use therapeutic food in childhood malnutrition in Malawi
    Zachary Linneman
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, Missouri 63110, USA
    Matern Child Nutr 3:206-15. 2007
  2. ncbi request reprint Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 55:550-4. 2006
  3. pmc Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial
    Macdonald J Ndekha
    Department of Community Health, College of Medicine, University of Malawi, Blantyre, Malawi
    BMJ 338:b1867. 2009
  4. pmc Children consuming cassava as a staple food are at risk for inadequate zinc, iron, and vitamin A intake
    Alison Gegios
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    Plant Foods Hum Nutr 65:64-70. 2010
  5. pmc The duration of diarrhea and fever is associated with growth faltering in rural Malawian children aged 6-18 months
    Ariana Weisz
    Washington University in St, Louis, One Children s Place, Campus Box 8116, St Louis, MO 63110, USA
    Nutr J 10:25. 2011
  6. pmc Consuming cassava as a staple food places children 2-5 years old at risk for inadequate protein intake, an observational study in Kenya and Nigeria
    Kevin Stephenson
    Department of Pediatrics, St Louis Children s Hospital, St Louis, MO, USA
    Nutr J 9:9. 2010
  7. ncbi request reprint Intensive nursing care of kwashiorkor in Malawi
    M J Manary
    Department of Paediatrics, College of Medicine, University of Malawi
    Acta Paediatr 89:203-7. 2000
  8. ncbi request reprint Protein quantity, not protein quality, accelerates whole-body leucine kinetics and the acute-phase response during acute infection in marasmic Malawian children
    M J Manary
    College of Medicine, University of Malawi, Blantyre
    Br J Nutr 92:589-95. 2004
  9. ncbi request reprint Local production and provision of ready-to-use therapeutic food (RUTF) spread for the treatment of severe childhood malnutrition
    Mark J Manary
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Food Nutr Bull 27:S83-9. 2006
  10. ncbi request reprint Whole-body leucine kinetics and the acute phase response during acute infection in marasmic Malawian children
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Pediatr Res 55:940-6. 2004

Collaborators

Detail Information

Publications36

  1. ncbi request reprint A large-scale operational study of home-based therapy with ready-to-use therapeutic food in childhood malnutrition in Malawi
    Zachary Linneman
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, Missouri 63110, USA
    Matern Child Nutr 3:206-15. 2007
    ..Home-based therapy with RUTF yields acceptable results without requiring formally medically trained personnel; further implementation in comparable settings should be considered...
  2. ncbi request reprint Cortisol and its action on the glucocorticoid receptor in malnutrition and acute infection
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    Metabolism 55:550-4. 2006
    ..The increased nuclear glucocorticoid receptor abundance in marasmus demonstrates that nutritional status modulates glucocorticoid receptor action by mechanisms in addition to circulating glucocorticoid concentrations...
  3. pmc Supplementary feeding with either ready-to-use fortified spread or corn-soy blend in wasted adults starting antiretroviral therapy in Malawi: randomised, investigator blinded, controlled trial
    Macdonald J Ndekha
    Department of Community Health, College of Medicine, University of Malawi, Blantyre, Malawi
    BMJ 338:b1867. 2009
    ..To investigate the effect of two different food supplements on body mass index (BMI) in wasted Malawian adults with HIV who were starting antiretroviral therapy...
  4. pmc Children consuming cassava as a staple food are at risk for inadequate zinc, iron, and vitamin A intake
    Alison Gegios
    Department of Pediatrics, St Louis Children s Hospital, Washington University School of Medicine, St Louis, MO 63110, USA
    Plant Foods Hum Nutr 65:64-70. 2010
    ..In Nigeria, 17% of children had adequate intake of vitamin A, 57% iron, and 41% zinc. Consumption of cassava is a risk factor for inadequate vitamin A, zinc and/or iron intake...
  5. pmc The duration of diarrhea and fever is associated with growth faltering in rural Malawian children aged 6-18 months
    Ariana Weisz
    Washington University in St, Louis, One Children s Place, Campus Box 8116, St Louis, MO 63110, USA
    Nutr J 10:25. 2011
    ..These results suggest that initiatives to reduce febrile and diarrheal diseases are needed in conjunction with improved complementary feeding to limit growth faltering in rural Malawi...
  6. pmc Consuming cassava as a staple food places children 2-5 years old at risk for inadequate protein intake, an observational study in Kenya and Nigeria
    Kevin Stephenson
    Department of Pediatrics, St Louis Children s Hospital, St Louis, MO, USA
    Nutr J 9:9. 2010
    ..This study tested the hypothesis that Nigerian and Kenyan children consuming cassava as their staple food are at greater risk for inadequate dietary protein intake than those children who consume less cassava...
  7. ncbi request reprint Intensive nursing care of kwashiorkor in Malawi
    M J Manary
    Department of Paediatrics, College of Medicine, University of Malawi
    Acta Paediatr 89:203-7. 2000
    ..When compared with 225 children treated in the same year at the same institution, who were carefully matched for severity of kwashiorkor, intensive nursing did not improve overall survival...
  8. ncbi request reprint Protein quantity, not protein quality, accelerates whole-body leucine kinetics and the acute-phase response during acute infection in marasmic Malawian children
    M J Manary
    College of Medicine, University of Malawi, Blantyre
    Br J Nutr 92:589-95. 2004
    ..The clinical benefits associated with a higher protein intake in marasmic, acutely infected children need further study...
  9. ncbi request reprint Local production and provision of ready-to-use therapeutic food (RUTF) spread for the treatment of severe childhood malnutrition
    Mark J Manary
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Food Nutr Bull 27:S83-9. 2006
    ..Ready-to-use therapeutic food (RUTF) spread has been shown to be very effective in the rehabilitation of severely malnourished children and facilitates home-based therapy of these children...
  10. ncbi request reprint Whole-body leucine kinetics and the acute phase response during acute infection in marasmic Malawian children
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Pediatr Res 55:940-6. 2004
    ..These data suggest that the cytokine stimulus for the acute-phase protein kinetic response to acute infection is present in marasmic children but that the acute-phase protein metabolic response is blunted by malnutrition...
  11. pmc Home based therapy for severe malnutrition with ready-to-use food
    M J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Arch Dis Child 89:557-61. 2004
    ..The standard treatment of severe malnutrition in Malawi often utilises prolonged inpatient care, and after discharge results in high rates of relapse...
  12. ncbi request reprint CO2 production during acute infection in malnourished Malawian children
    M J Manary
    Department of Pediatrics, Washington University School of Medicine St Louis, MO, USA
    Eur J Clin Nutr 58:116-20. 2004
    ..This study tested the hypotheses that the rate of CO2 production is less in marasmic children with acute infection when compared to well-nourished children, but greater when compared to uninfected marasmic children...
  13. ncbi request reprint Community-based dietary phytate reduction and its effect on iron status in Malawian children
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, MO 63110, USA
    Ann Trop Paediatr 22:133-6. 2002
    ..Phytate was removed by soaking maize flour in excess water with phytase and decanting the water before cooking the flour. Iron status, as measured by soluble transferrin receptor and zinc protoporphyrin, was improved but not normal...
  14. ncbi request reprint Zinc homeostasis in Malawian children consuming a high-phytate, maize-based diet
    Mark J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, USA
    Am J Clin Nutr 75:1057-61. 2002
    ..The gastrointestinal tract plays a central role in absorbing and conserving zinc, yet it has not been carefully studied in such children...
  15. ncbi request reprint Selenium status, kwashiorkor and congestive heart failure
    M J Manar
    College of Medicine, University of Malawi, Blanthre
    Acta Paediatr 90:950-2. 2001
    ..9 +/- 8.3 vs 41.1 +/- 11.9 microg/L, mean +/- SD, p = 0.03). This association was independent of serum albumin and selenium status was not associated with severity of symptoms, anthropometric indices or HIV infection...
  16. ncbi request reprint Protein metabolism in children with edematous malnutrition and acute lower respiratory infection
    M J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 65:1005-10. 1997
    ....
  17. ncbi request reprint Whole-body protein kinetics in marasmus and kwashiorkor during acute infection
    M J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 67:1205-9. 1998
    ..HIV infection and body composition did not explain the differences between marasmus and kwashiorkor. The accelerated rate of protein turnover in children with marasmus and acute infection requires further investigation...
  18. ncbi request reprint Whole-body protein kinetics in children with kwashiorkor and infection: a comparison of egg white and milk as dietary sources of protein
    M J Manary
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 66:643-8. 1997
    ..We conclude that by making the amino acid composition of the diet resemble that of APPs in the treatment of acute kwashiorkor, the rate of amino acid oxidation can be decreased...
  19. ncbi request reprint Home-based therapy with ready-to-use therapeutic food is of benefit to malnourished, HIV-infected Malawian children
    M J Ndekha
    College of Medicine, University of Malawi, Malawi
    Acta Paediatr 94:222-5. 2005
    ....
  20. ncbi request reprint Locally produced ready-to-use supplementary food is an effective treatment of moderate acute malnutrition in an operational setting
    L LaGrone
    Department of Pediatrics, Washington University, St Louis, USA
    Ann Trop Paediatr 30:103-8. 2010
    ..A randomised clinical effectiveness trial in 2007 showed CSB to be less effective than ready-to-use supplementary food (RUSF)...
  21. ncbi request reprint Supplemental feeding with ready-to-use therapeutic food in Malawian children at risk of malnutrition
    Monica P Patel
    Department of Pediatrics, University of Texas Southwestern Medical Center, Dallas, TX, USA
    J Health Popul Nutr 23:351-7. 2005
    ..The results of this preliminary work suggest that supplementary feeding with RUTF promotes better growth in children at risk of malnutrition than the standard fortified cereal/legume-blended food...
  22. ncbi request reprint Perturbed zinc homeostasis in rural 3-5-y-old Malawian children is associated with abnormalities in intestinal permeability attributed to tropical enteropathy
    Micah J Manary
    Department of Pediatrics, Washington University School of Medicine, and St Louis Children s Hospital, St Louis, MO 63110, USA
    Pediatr Res 67:671-5. 2010
    ..62, p<0.001). Net zinc retention (0.67+/-1.6 mg/d) was negatively correlated with the L:M (r=-0.47, p=0.02). This suggests that perturbed zinc homeostasis is associated with subclinical enteropathy in these children...
  23. ncbi request reprint The use of home-based therapy with ready-to-use therapeutic food to treat malnutrition in a rural area during a food crisis
    Rachel E Amthor
    Washington University in St Louis, MO, USA
    J Am Diet Assoc 109:464-7. 2009
    ..2+/-0.3 mm/d. Home-based therapy with ready-to-use therapeutic food administered by village health aides is an effective approach to treating malnutrition during food crises in areas lacking health services...
  24. ncbi request reprint The quality of the diet in Malawian children with kwashiorkor and marasmus
    Jesse Sullivan
    Department of Pediatrics, Washington University School of Medicine, St Louis Children s Hospital, One Children s Place, St Louis, Missouri, USA
    Matern Child Nutr 2:114-22. 2006
    ..06 (0.99) vs. 5.02 (1.10), mean (SD). Further research is needed to determine what role consumption of egg and tomato may play in the development of kwashiorkor...
  25. ncbi request reprint Urea production and leucine oxidation in malnourished children with and without acute infection
    Mark J Manary
    Washington University School of Medicine, St Louis, MO, USA
    Metabolism 51:1418-22. 2002
    ....
  26. pmc Supplementary feeding with fortified spreads results in higher recovery rates than with a corn/soy blend in moderately wasted children
    Danielle K Matilsky
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Nutr 139:773-8. 2009
    ..We conclude that FS are superior supplementary foods to CSB for moderately wasted Malawian children...
  27. pmc Complementary feeding with fortified spread and incidence of severe stunting in 6- to 18-month-old rural Malawians
    John C Phuka
    College of Medicine, University of Malawi, PO Box 431, Mangochi, Malawi
    Arch Pediatr Adolesc Med 162:619-26. 2008
    ..To compare growth and incidence of malnutrition in infants receiving long-term dietary supplementation with ready-to-use fortified spread (FS) or micronutrient-fortified maize-soy flour (likuni phala [LP])...
  28. ncbi request reprint Breast milk intake is not reduced more by the introduction of energy dense complementary food than by typical infant porridge
    Lauren Galpin
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Nutr 137:1828-33. 2007
    ..69 for effect of type of food). The results suggest that complementary feeding of Malawian infants with FS has the same effect on their breast milk intake as complementary feeding with traditional CSB porridge...
  29. doi request reprint Postintervention growth of Malawian children who received 12-mo dietary complementation with a lipid-based nutrient supplement or maize-soy flour
    John C Phuka
    College of Medicine, University of Malawi, Blantyre, Malawi
    Am J Clin Nutr 89:382-90. 2009
    ..We recently reported that complementary feeding of 6-18-mo-old infants with an LNS known as FS50 was associated with improved linear growth and a reduction in the incidence of severe stunting during the supplementation period...
  30. ncbi request reprint Comparison of home-based therapy with ready-to-use therapeutic food with standard therapy in the treatment of malnourished Malawian children: a controlled, clinical effectiveness trial
    Michael A Ciliberto
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 81:864-70. 2005
    ..Higher recovery rates have been seen in pilot studies of home-based therapy with ready-to-use therapeutic food (RUTF)...
  31. ncbi request reprint Home-based treatment of malnourished Malawian children with locally produced or imported ready-to-use food
    Heidi Sandige
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    J Pediatr Gastroenterol Nutr 39:141-6. 2004
    ..To determine the efficacy of home-based therapy with ready-to-use food (RTUF) in producing catch-up growth in malnourished children and to compare locally produced RTUF with imported RTUF for this purpose...
  32. ncbi request reprint A prospective assessment of food and nutrient intake in a population of Malawian children at risk for kwashiorkor
    Carol A Lin
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    J Pediatr Gastroenterol Nutr 44:487-93. 2007
    ..To determine what foods, nutrients, and dietary patterns are associated with development of kwashiorkor in populations of vulnerable 1- to 3-year-old Malawian children...
  33. ncbi request reprint An energy-dense complementary food is associated with a modest increase in weight gain when compared with a fortified porridge in Malawian children aged 6-18 months
    Carol A Lin
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA
    J Nutr 138:593-8. 2008
    ..FS was associated with better weight gain from 6-12 mo of age and may be useful in conjunction with additional interventions to improve infant growth in the developing world...
  34. ncbi request reprint Effect of Lactobacillus GG on intestinal integrity in Malawian children at risk of tropical enteropathy
    Lauren Galpin
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO, USA
    Am J Clin Nutr 82:1040-5. 2005
    ..The histology of tropical enteropathy resembles that seen in small-bowel bacterial overgrowth...
  35. pmc A randomized, double-blind, placebo-controlled trial of rifaximin, a nonabsorbable antibiotic, in the treatment of tropical enteropathy
    Indi Trehan
    Department of Pediatrics, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Gastroenterol 104:2326-33. 2009
    ..This study tested the hypothesis that treatment with a nonabsorbable, broad-spectrum antibiotic, rifaximin, reduces the L:M ratio in rural Malawian children, among whom tropical enteropathy is common...
  36. ncbi request reprint Home-based therapy for oedematous malnutrition with ready-to-use therapeutic food
    Michael A Ciliberto
    Department of Pediatrics, Washington University School of Medicine, St Louis, MO 63110, USA, and Paediatric Research Centre, Tampere University Hospital, Finland
    Acta Paediatr 95:1012-5. 2006
    ..Standard recommendations are that children with oedematous malnutrition receive inpatient therapy with a graduated feeding regimen. Aim: To investigate exclusive home-based therapy for children with oedematous malnutrition...