Shannon L Macauley

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. doi request reprint Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure-function studies associated with cerebellar Purkinje cell degeneration
    Shannon L Macauley
    Neuroscience, Genzyme Corporation, Framingham, MA 01701, USA
    Exp Neurol 214:181-92. 2008
  2. ncbi request reprint AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease
    Marco A Passini
    Neuroscience, Genzyme Corporation, One Mountain Road, Framingham, MA 01701, USA
    Mol Ther 11:754-62. 2005

Research Grants

  1. Cellular Pathology of Batten Disease
    Shannon Macauley; Fiscal Year: 2007

Detail Information

Publications2

  1. doi request reprint Neuropathology of the acid sphingomyelinase knockout mouse model of Niemann-Pick A disease including structure-function studies associated with cerebellar Purkinje cell degeneration
    Shannon L Macauley
    Neuroscience, Genzyme Corporation, Framingham, MA 01701, USA
    Exp Neurol 214:181-92. 2008
    ..This study further characterized the neuropathology associated with ASM deficiency, and identifies quantitative histological and behavioral endpoints for evaluation of therapeutic intervention in this authentic NP-A mouse model...
  2. ncbi request reprint AAV vector-mediated correction of brain pathology in a mouse model of Niemann-Pick A disease
    Marco A Passini
    Neuroscience, Genzyme Corporation, One Mountain Road, Framingham, MA 01701, USA
    Mol Ther 11:754-62. 2005
    ..These findings show that the ASMKO brain is responsive to ASM replacement and that retrograde transport of AAV2 functions as a platform for widespread gene delivery and reversal of pathology in affected brain...

Research Grants2

  1. Cellular Pathology of Batten Disease
    Shannon Macauley; Fiscal Year: 2007
    ..This will not only help improve the standard of care of these patients but also help alleviate the pain, suffering, and cost of care for patient's families. ..