Michael T Lynskey

Summary

Affiliation: Washington University School of Medicine
Country: USA

Publications

  1. ncbi request reprint Substance use and educational attainment
    Michael Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Addiction 101:1684-5. 2006
  2. ncbi request reprint An alternative model is feasible, but the gateway hypothesis has not been invalidated: comments on Morral et al
    Michael Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 97:1505-7. 2002
  3. ncbi request reprint Escalation of drug use in early-onset cannabis users vs co-twin controls
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    JAMA 289:427-33. 2003
  4. ncbi request reprint A longitudinal study of the effects of adolescent cannabis use on high school completion
    Michael T Lynskey
    National Drug and Alcohol Research Centre, University of New South Wales, NSW, Australia
    Addiction 98:685-92. 2003
  5. ncbi request reprint Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Arch Gen Psychiatry 61:1026-32. 2004
  6. ncbi request reprint Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 8:574-84. 2005
  7. pmc Associations of alcohol, nicotine, cannabis, and drug use/dependence with educational attainment: evidence from cotwin-control analyses
    Julia D Grant
    Midwest Alcoholism Research Center at Washington University, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Clin Exp Res 36:1412-20. 2012
  8. pmc Common genetic contributions to alcohol and cannabis use and dependence symptomatology
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 34:545-54. 2010
  9. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
  10. pmc Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addict Behav 33:235-51. 2008

Research Grants

Detail Information

Publications85

  1. ncbi request reprint Substance use and educational attainment
    Michael Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63108, USA
    Addiction 101:1684-5. 2006
  2. ncbi request reprint An alternative model is feasible, but the gateway hypothesis has not been invalidated: comments on Morral et al
    Michael Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 97:1505-7. 2002
  3. ncbi request reprint Escalation of drug use in early-onset cannabis users vs co-twin controls
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    JAMA 289:427-33. 2003
    ..Previous studies have reported that early initiation of cannabis (marijuana) use is a significant risk factor for other drug use and drug-related problems...
  4. ncbi request reprint A longitudinal study of the effects of adolescent cannabis use on high school completion
    Michael T Lynskey
    National Drug and Alcohol Research Centre, University of New South Wales, NSW, Australia
    Addiction 98:685-92. 2003
    ..To examine the extent to which weekly cannabis use during mid-adolescence may increase the risk of early school-leaving...
  5. ncbi request reprint Major depressive disorder, suicidal ideation, and suicide attempt in twins discordant for cannabis dependence and early-onset cannabis use
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Arch Gen Psychiatry 61:1026-32. 2004
    ..Previous research has reported both a moderate degree of comorbidity between cannabis dependence and major depressive disorder (MDD) and that early-onset cannabis use is associated with increased risks for MDD...
  6. ncbi request reprint Limitations of DSM-IV operationalizations of alcohol abuse and dependence in a sample of Australian twins
    Michael T Lynskey
    Queensland Institute of Medical Research, Brisbane, Queensland, Australia
    Twin Res Hum Genet 8:574-84. 2005
    ....
  7. pmc Associations of alcohol, nicotine, cannabis, and drug use/dependence with educational attainment: evidence from cotwin-control analyses
    Julia D Grant
    Midwest Alcoholism Research Center at Washington University, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Clin Exp Res 36:1412-20. 2012
    ..We tested whether alcohol, nicotine, and illicit drug use and dependence were associated with lifetime educational attainment after controlling for familial background characteristics...
  8. pmc Common genetic contributions to alcohol and cannabis use and dependence symptomatology
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 34:545-54. 2010
    ....
  9. pmc Alcohol consumption indices of genetic risk for alcohol dependence
    Julia D Grant
    Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Psychiatry 66:795-800. 2009
    ..A high genetic correlation between these measures would suggest that a continuous measure of consumption may have a useful role in the discovery of genes contributing to dependence risk...
  10. pmc Psychiatric and familial predictors of transition times between smoking stages: results from an offspring-of-twins study
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addict Behav 33:235-51. 2008
    ..Findings characterize a rarely examined aspect of the course of ND development and highlight critical distinctions in risk profiles across stages of tobacco involvement...
  11. pmc Transitions to regular smoking and to nicotine dependence in women using cannabis
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 95:107-14. 2008
    ..If there is evidence in its favor, the increased rates of cigarette smoking in cannabis users may prove to be the most significant public health problem associated with cannabis use...
  12. pmc Early cannabis use and DSM-IV nicotine dependence: a twin study
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 103:1896-904. 2008
    ..We examine whether cannabis use prior to age 17 years is associated with an increased likelihood of DSM-IV nicotine dependence and the extent to which genetic and environmental factors contribute to this association...
  13. pmc Evidence for an interaction between age at first drink and genetic influences on DSM-IV alcohol dependence symptoms
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 33:2047-56. 2009
    ..In this study, we examine whether age at first drink moderates genetic and environmental influences, via gene x environment interactions, on DSM-IV alcohol dependence symptoms...
  14. pmc Common heritable contributions to low-risk trauma, high-risk trauma, posttraumatic stress disorder, and major depression
    Carolyn E Sartor
    Department of Psychiatry, Yale School of Medicine, VA Connecticut Healthcare System, USA
    Arch Gen Psychiatry 69:293-9. 2012
    ....
  15. ncbi request reprint Exploring the inter-relationship of smoking age-at-onset, cigarette consumption and smoking persistence: genes or environment?
    Katherine I Morley
    Genetic Epidemiology Group, Queensland Institute of Medical Research, Queensland, Australia
    Psychol Med 37:1357-67. 2007
    ..We investigated the genetic and environmental contributions to covariation between smoking age-at-onset, cigarette consumption and smoking persistence...
  16. pmc A latent class analysis of DSM-IV and Fagerström (FTND) criteria for nicotine dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Nicotine Tob Res 13:972-81. 2011
    ....
  17. pmc Simultaneous cannabis and tobacco use and cannabis-related outcomes in young women
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Drug Alcohol Depend 101:8-12. 2009
    ....
  18. pmc An Australian twin study of cannabis and other illicit drug use and misuse, and other psychopathology
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Twin Res Hum Genet 15:631-41. 2012
    ....
  19. pmc Cannabinoid receptor genotype moderation of the effects of childhood physical abuse on anhedonia and depression
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Arch Gen Psychiatry 69:732-40. 2012
    ..The endocannabinoid system has been implicated in stress adaptation and the regulation of mood in rodent studies, but few human association studies have examined these links and replications are limited...
  20. pmc Peer substance involvement modifies genetic influences on regular substance involvement in young women
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 105:1844-53. 2010
    ..We examine mechanisms by which PSI influences the etiology of regular substance involvement (RSI), particularly in women...
  21. pmc Autosomal linkage analysis for cannabis use behaviors in Australian adults
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, 660 South Euclid Avenue, St Louis, MO 63108, USA
    Drug Alcohol Depend 98:185-90. 2008
    ....
  22. ncbi request reprint Childhood sexual abuse and risks for licit and illicit drug-related outcomes: a twin study
    Elliot C Nelson
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Psychol Med 36:1473-83. 2006
    ..This study examined the relationships between self-reported childhood sexual abuse (CSA) and drug-related outcomes in an Australian twin panel...
  23. ncbi request reprint Subtypes of illicit drug users: a latent class analysis of data from an Australian twin sample
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, United States of America
    Twin Res Hum Genet 9:523-30. 2006
    ..Aggregation of population-level data may obscure important subgroup differences in patterns of illicit drug use and psychiatric comorbidity. Further exploration of a 'self-medicating' subgroup is needed...
  24. ncbi request reprint Stimulant use and symptoms of abuse/dependence: epidemiology and associations with cannabis use--a twin study
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
    Drug Alcohol Depend 86:147-53. 2007
    ....
  25. ncbi request reprint Duration of cannabis use--a novel phenotype?
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Rd, Suite 1000, St Louis, MO 63110, United States
    Addict Behav 31:984-94. 2006
    ..While there were high genetic correlations in both women and men, lifetime duration of cannabis may be uniquely informative in assessing components of liability to cannabis use...
  26. pmc Childhood sexual abuse and the course of alcohol dependence development: findings from a female twin sample
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110, USA
    Drug Alcohol Depend 89:139-44. 2007
    ..Findings indicate that CSA and elevated risk for AD may be linked via early age at first drink and that progression from first drink to AD follows a similar course among women with and without histories of CSA...
  27. ncbi request reprint Risk for initiation of substance use as a function of age of onset of cigarette, alcohol and cannabis use: findings in a Midwestern female twin cohort
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Prev Med 43:125-8. 2006
    ..We investigated whether use and early-onset use of cigarettes, alcohol and cannabis contributed an increase in risk for initiation of subsequent psychoactive substances in women (N = 3729, mean age = 21.7)...
  28. pmc Genetic and environmental influences on the rate of progression to alcohol dependence in young women
    Carolyn E Sartor
    Washington University School of Medicine, St Louis, Missouri 63110, USA
    Alcohol Clin Exp Res 32:632-8. 2008
    ....
  29. pmc Examining the association of NRXN3 SNPs with borderline personality disorder phenotypes in heroin dependent cases and socio-economically disadvantaged controls
    Vassilis N Panagopoulos
    Department of Psychiatry, Washington University, School of Medicine, St Louis, MO 63110, USA
    Drug Alcohol Depend 128:187-93. 2013
    ..The current report focuses on the association of neurexin 3 (NRXN3) single nucleotide polymorphisms (SNPs) with BPD symptoms in heroin dependent cases and controls...
  30. pmc ANKK1, TTC12, and NCAM1 polymorphisms and heroin dependence: importance of considering drug exposure
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    JAMA Psychiatry 70:325-33. 2013
    ..The genetic contribution to liability for opioid dependence is well established; identification of the responsible genes has proved challenging...
  31. pmc No association of candidate genes with cannabis use in a large sample of Australian twin families
    Karin J H Verweij
    Queensland Statistical Genetics Laboratories, Queensland Institute of Medical Research, Brisbane, Australia
    Addict Biol 17:687-90. 2012
    ..05). The lack of replication may point to our limited understanding of the neurobiology of cannabis involvement and also to potential publication bias and false-positive findings in previous studies...
  32. pmc Patterns of use, sequence of onsets and correlates of tobacco and cannabis
    Arpana Agrawal
    Washington University School of Medicine, Dept of Psychiatry and the Midwest Alcoholism Research Center, Saint Louis, MO 63110, USA
    Addict Behav 36:1141-7. 2011
    ..In this study, we characterize patterns of cannabis and tobacco use (tobacco but not cannabis, cannabis but not tobacco or both) and compare the factors associated with onset of tobacco before cannabis and cannabis before tobacco...
  33. pmc Developing a quantitative measure of alcohol consumption for genomic studies on prospective cohorts
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Avenue, Box 8134, St Louis, Missouri 63110, USA
    J Stud Alcohol Drugs 70:157-68. 2009
    ..The purpose of this study was to develop a quantitative measure of alcohol consumption for gene-mapping studies...
  34. pmc Common genetic influences on the timing of first use for alcohol, cigarettes, and cannabis in young African-American women
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
    Drug Alcohol Depend 102:49-55. 2009
    ..Differences in findings may also reflect a distinct etiological pathway for substance use initiation in African-American women that could not be detected in previous studies...
  35. doi request reprint An autosomal linkage scan for cannabis use disorders in the nicotine addiction genetics project
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid Ave, Campus Box 8134, St Louis, MO 63110, USA
    Arch Gen Psychiatry 65:713-21. 2008
    ..Despite accumulating evidence that there is a genetic basis for cannabis use disorders (ie, abuse and dependence), few studies have identified genomic regions that may harbor biological risk and protective factors...
  36. pmc Correlates of alcohol abuse/dependence in early-onset alcohol-using women
    Mitchell B Jenkins
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, St Louis, MO 63110, USA
    Am J Addict 20:429-34. 2011
    ....
  37. pmc Timing of first alcohol use and alcohol dependence: evidence of common genetic influences
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, St Louis, MO 63110, USA
    Addiction 104:1512-8. 2009
    ..To estimate the magnitude of genetic and environmental influences on timing of first alcohol use and alcohol dependence (AD) and to quantify the overlap in these influences across the two alcohol-related outcomes...
  38. pmc A cotwin-control analysis of drug use and abuse/dependence risk associated with early-onset cannabis use
    Julia D Grant
    The Midwest Alcoholism Research Center at Washington University, Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addict Behav 35:35-41. 2010
    ..In contrast to previous research, there is limited evidence for increased risk associated with early-onset use in this sample of Vietnam-era veterans...
  39. ncbi request reprint Correlates of regular cigarette smoking in a population-based sample of Australian twins
    Arpana Agrawal
    Washington University School of Medicine, St Louis, MO 63108, USA
    Addiction 100:1709-19. 2005
    ..Design Members of monozygotic and dizygotic, including unlike-sex twin pairs (n = 6257) from a young adult cohort from the Australian Twin Registry...
  40. pmc Correlates of cannabis initiation in a longitudinal sample of young women: the importance of peer influences
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Prev Med 45:31-4. 2007
    ..In adolescent girls especially, rates of cannabis use have increased over the last decade, urging the need to characterize the potential correlates of onset of cannabis use during emerging adulthood...
  41. pmc Genetic influences on craving for alcohol
    Arpana Agrawal
    Washington University School of Medicine, Dept of Psychiatry, 660 S Euclid, CB 8134, Saint Louis, MO 63110, USA
    Addict Behav 38:1501-8. 2013
    ..However, little is known of its genetic underpinnings - specifically, whether genetic influences on craving are distinct from those influencing DSM-IV alcohol dependence...
  42. pmc Genetic and environmental influences on cannabis use initiation and problematic use: a meta-analysis of twin studies
    Karin J H Verweij
    Genetic Epidemiology, Queensland Institute of Medical Research, Brisbane, QLD, Australia
    Addiction 105:417-30. 2010
    ....
  43. pmc Genetically informative research on adolescent substance use: methods, findings, and challenges
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    J Am Acad Child Adolesc Psychiatry 49:1202-14. 2010
    ..To provide an overview of the genetic epidemiology of substance use and misuse in adolescents...
  44. pmc Developing a genetically informative measure of alcohol consumption using past-12-month indices
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid, CB 8134, St Louis, Missouri 63110, USA
    J Stud Alcohol Drugs 72:444-52. 2011
    ..The goal of this study was to develop a factor score derived from measures of past-12-month alcohol consumption...
  45. pmc Tobacco and cannabis co-occurrence: does route of administration matter?
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, 660 S Euclid, CB 8134, St Louis, MO 63110, United States
    Drug Alcohol Depend 99:240-7. 2009
    ..Qualitative research suggests that a shared route of administration (i.e. via inhalation) for the common forms of both tobacco (i.e. cigarettes) and cannabis (i.e. joints) may contribute to their co-occurring use...
  46. ncbi request reprint Psychiatric comorbidity and progression in drug use in adult male twins: implications for the design of genetic association studies
    Alexandre A Todorov
    Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, 660 South Euclid Avenue, Box 8134, St Louis, MO 63110 1502, United States
    Addict Behav 31:948-61. 2006
    ..We use the result of these analyses to show how the use of a particular drug disorder phenotype for selecting cases could impact final sample composition...
  47. ncbi request reprint Genetic epidemiology of alcohol-induced blackouts
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine and St Louis University School of Public Health, St Louis, O 63108, USA
    Arch Gen Psychiatry 61:257-63. 2004
    ..Alcohol-induced blackouts (ie, periods of anterograde amnesia) have received limited recent research attention...
  48. pmc Parental separation and early substance involvement: results from children of alcoholic and cannabis dependent twins
    Mary Waldron
    Department of Counseling and Educational Psychology, Indiana University School of Education, Bloomington, IN, United States Midwest Alcoholism Research Center, Department of Psychiatry, Washington University School of Medicine, St Louis, MO, United States Electronic address
    Drug Alcohol Depend 134:78-84. 2014
    ..We examined early substance involvement as a function of parental separation during childhood and parental alcohol and cannabis dependence...
  49. pmc Association of OPRD1 polymorphisms with heroin dependence in a large case-control series
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA Queensland Institute of Medical Research, Australia National Drug and Alcohol Research Centre, University of New South Wales, Australia Burnet Institute, Centre for Health Policy, Programs and Economics, School of Population Health, University of Melbourne, Australia
    Addict Biol 19:111-21. 2014
    ..Support was not found for similar association involving either OPRM1 or OPRK1 SNPs...
  50. pmc Do early experiences with cannabis vary in cigarette smokers?
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, 660 S Euclid, CB 8134, Saint Louis, MO 63110, USA
    Drug Alcohol Depend 128:255-9. 2013
    ....
  51. pmc Characterizing alcohol use disorders and suicidal ideation in young women
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, Saint Louis, Missouri, USA
    J Stud Alcohol Drugs 74:406-12. 2013
    ..Alcohol use disorders (AUDs) and suicidal ideation (SI) co-occur, yet few studies have investigated the risk and protective factors that infl uence their comorbidity...
  52. pmc The interpretability of family history reports of alcoholism in general community samples: findings in a midwestern U.S. twin birth cohort
    Mary Waldron
    School of Education, Indiana University, Bloomington, IN 47405, USA
    Alcohol Clin Exp Res 36:1091-8. 2012
    ..Although there is a long tradition in alcoholism research of using family history ratings, the interpretability of family history reports of alcoholism from general community samples has yet to be established...
  53. ncbi request reprint Early onset cannabis use and progression to other drug use in a sample of Dutch twins
    Michael T Lynskey
    Department of Psychiatry, Washington University in St Louis, MO 63110, USA
    Behav Genet 36:195-200. 2006
    ....
  54. pmc Mechanisms underlying the lifetime co-occurrence of tobacco and cannabis use in adolescent and young adult twins
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, United States
    Drug Alcohol Depend 108:49-55. 2010
    ..Given the high addictive potential of nicotine and the ubiquitous nature of cannabis use, this is a public health concern worthy of considerable attention...
  55. pmc Genetic epidemiology of self-reported lifetime DSM-IV major depressive disorder in a population-based twin sample of female adolescents
    Anne L Glowinski
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63108, USA
    J Child Psychol Psychiatry 44:988-96. 2003
    ..The goal of this study was the genetic analysis of MDD in an epidemiologically and genetically representative sample of adolescent female twins...
  56. pmc Correlates of later-onset cannabis use in the National Epidemiological Survey on Alcohol and Related Conditions (NESARC)
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, 660 S Euclid, CB 8134, Saint Louis, MO 63110, USA
    Drug Alcohol Depend 105:71-5. 2009
    ..However, there is growing evidence that cannabis onset occurs later in life as well and little is known of the risk and protective influences that are associated with late-onset cannabis initiation...
  57. pmc Marijuana expectancies and relationships with adolescent and adult marijuana use
    Sean D Kristjansson
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Drug Alcohol Depend 126:102-10. 2012
    ..Much expectancy research has been conducted in the context of alcohol; however, less is known about the structure of expectancies for marijuana and their associations with marijuana use outcomes...
  58. pmc The relationship between rs3779084 in the dopa decarboxylase (DDC) gene and alcohol consumption is mediated by drinking motives in regular smokers
    Sean D Kristjansson
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Clin Exp Res 36:162-70. 2012
    ....
  59. pmc Reporting bias in the association between age at first alcohol use and heavy episodic drinking
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Alcohol Clin Exp Res 35:1418-25. 2011
    ....
  60. pmc DSM-IV to DSM-5: the impact of proposed revisions on diagnosis of alcohol use disorders
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, Saint Louis, MO 63110, USA
    Addiction 106:1935-43. 2011
    ....
  61. ncbi request reprint A latent class analysis of illicit drug abuse/dependence: results from the National Epidemiological Survey on Alcohol and Related Conditions
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 102:94-104. 2007
    ..We examine the co-occurrence of abuse/dependence across different illicit drugs and test associations between these classes and major psychiatric disorders...
  62. pmc A family study of adult twins with and without a history of childhood abuse: stability of retrospective reports of maltreatment and associated family measures
    Elliot C Nelson
    Department of Psychiatry, Washington University School of Medicine, Midwest Alcoholism Research Center, St Louis, MO 63110, United States of America
    Twin Res Hum Genet 13:121-30. 2010
    ....
  63. pmc Risk for suicidal thoughts and behavior after childhood sexual abuse in women and men
    Saaniya Bedi
    Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO, USA
    Suicide Life Threat Behav 41:406-15. 2011
    ..Our findings suggest that these disorders partially mediate CSA-associated risk...
  64. pmc A genome-wide association study of DSM-IV cannabis dependence
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Saint Louis, MO 63110, USA
    Addict Biol 16:514-8. 2011
    ..While replication is required, this study represents an important first step toward clarifying the biological underpinnings of cannabis dependence...
  65. pmc A candidate gene association study of alcohol consumption in young women
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Alcohol Clin Exp Res 35:550-8. 2011
    ..We used data on a previously defined alcohol consumption factor score in a sample of 827 young women to investigate association with 1,014 single-nucleotide polymorphisms in genes related to addiction...
  66. doi request reprint Is there evidence for symptoms of cannabis withdrawal in the national epidemiologic survey of alcohol and related conditions?
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Am J Addict 17:199-208. 2008
    ..Evidence from this and prior studies demonstrating withdrawal strongly suggest that future editions of DSM need to reconsider the exclusion of withdrawal from criteria for cannabis dependence...
  67. pmc The association between DSM-IV nicotine dependence and stressful life events in the National Epidemiologic Survey on Alcohol and Related Conditions
    Emily Balk
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Am J Drug Alcohol Abuse 35:85-90. 2009
    ..While both ND and SLEs have been studied extensively in relation to other variables, there are few instances in which they have been investigated in concert...
  68. pmc Disentangling the complex association between childhood sexual abuse and alcohol-related problems: a review of methodological issues and approaches
    Carolyn E Sartor
    Department of Psychiatry, Washington University School of Medicine, 660 South Euclid Avenue, Campus Box 8134, Saint Louis, Missouri 63110, USA
    J Stud Alcohol Drugs 69:718-27. 2008
    ..Additional directions for research, including the incorporation of measured genes and the use of longitudinal designs, are proposed to further efforts to model the pathways from CSA to alcohol-related problems...
  69. ncbi request reprint Early-onset alcohol-use behaviors and subsequent alcohol-related driving risks in young women: a twin study
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, 4560 Clayton Road, Suite 1000, Saint Louis, Missouri 63110, USA
    J Stud Alcohol Drugs 68:798-804. 2007
    ..The purpose of this study was to estimate associations between early-onset alcohol use/intoxication and subsequent risks of alcohol-related driving risks in young women after control for familial liability for these behaviors...
  70. ncbi request reprint Estimating two-stage models for genetic influences on alcohol, tobacco or drug use initiation and dependence vulnerability in twin and family data
    Andrew C Heath
    Department of Psychiatry, Washington University School of Medicine, St Louis, Missouri, USA
    Twin Res 5:113-24. 2002
    ..Illustrative application of the model to Australian twin data on smoking confirmed substantial heritability of smoking persistence (42%) with minimal overlap with genetic influences on initiation...
  71. ncbi request reprint Are there genetic influences on addiction: evidence from family, adoption and twin studies
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO 63110, USA
    Addiction 103:1069-81. 2008
    ..With a focus on the classical twin design that utilizes data on monozygotic and dizygotic twins, we discuss support in favor of heritable influences on alcohol, nicotine, cannabis and other illicit drug dependence...
  72. ncbi request reprint A possible smoking susceptibility locus on chromosome 11p12: evidence from sex-limitation linkage analyses in a sample of Australian twin families
    Katherine I Morley
    Genetic Epidemiology, Queensland Institute of Medical Research, PO Royal Brisbane Hospital, Brisbane, Queensland, Australia
    Behav Genet 36:87-99. 2006
    ..We identified one region suggestive of linkage on chromosome 11p12. This locus, as well as another region identified on chromosome 6p12, replicates regions identified in previous studies...
  73. pmc Correlates of smoking cessation in a nationally representative sample of U.S. adults
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, Missouri 63110, USA
    Addict Behav 33:1223-6. 2008
    ....
  74. pmc DSM-IV alcohol abuse due to hazardous use: a less severe form of abuse?
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, CB 8134, St Louis, Missouri 63110, USA
    J Stud Alcohol Drugs 71:857-63. 2010
    ....
  75. ncbi request reprint Adolescent alcohol use is a risk factor for adult alcohol and drug dependence: evidence from a twin design
    Julia D Grant
    Department of Psychiatry, Midwest Alcoholism Research Center, Washington University School of Medicine, St Louis, MO 63110, USA
    Psychol Med 36:109-18. 2006
    ..Early alcohol use is associated with abuse and dependence of licit and illicit substances later in life. The role of genetic and environmental factors in this association is not conclusive...
  76. pmc Does gender contribute to heterogeneity in criteria for cannabis abuse and dependence? Results from the national epidemiological survey on alcohol and related conditions
    Arpana Agrawal
    Department of Psychiatry, Washington University School of Medicine, 660 S Euclid, Box 8134, St Louis, MO 63110, USA
    Drug Alcohol Depend 88:300-7. 2007
    ..We conclude that the criteria that serve as indicators of DSM-IV cannabis abuse and dependence do not function identically in men and women and that certain criteria (e.g. hazardous use) require further refinement...
  77. ncbi request reprint The role of childhood risk factors in initiation of alcohol use and progression to alcohol dependence
    Carolyn E Sartor
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 102:216-25. 2007
    ..To identify childhood risk factors that predict (a) age of first drink and (b) time from first use to alcohol dependence (AD) onset, using survival analysis...
  78. ncbi request reprint Alcohol and other drug use disorders among older-aged people
    Michael T Lynskey
    Department of Psychiatry, Washington University School of Medicine, St Louis, MO, USA
    Drug Alcohol Rev 22:125-33. 2003
    ..These include: interactions with prescribed medications, under-recognition and treatment of alcohol and drug problems, unintentional injury and social isolation. Finally, a brief discussion of treatment issues is provided...
  79. ncbi request reprint The genetic epidemiology of cannabis use, abuse and dependence
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 101:801-12. 2006
    ..The genetic etiology of cannabis use, abuse and dependence has elicited significant interest from genetic epidemiologists...
  80. pmc Cannabis involvement in individuals with bipolar disorder
    Arpana Agrawal
    Dept of Psychiatry, Washington University School of Medicine, Saint Louis, MO 63110, USA
    Psychiatry Res 185:459-61. 2011
    ..Rates of DSM-IV cannabis use disorders in those with BD were 29.4% and were independently and significantly associated with increased suicide attempts, greater likelihood of mixed episodes and greater disability attributable to BD...
  81. pmc Candidate genes for cannabis use disorders: findings, challenges and directions
    Arpana Agrawal
    Washington University School of Medicine, Department of Psychiatry, St Louis, MO 63110, USA
    Addiction 104:518-32. 2009
    ....
  82. ncbi request reprint Trajectories of adolescent alcohol and cannabis use into young adulthood
    George C Patton
    Centre for Adolescent Health, Murdoch Children s Research Institute, Royal Children s Hospital, University of Melbourne Victoria, Australia
    Addiction 102:607-15. 2007
    ..Both are commonly initiated in adolescence. To date little research has described trajectories of adolescent cannabis or alcohol use or compared their respective consequences in young adulthood...
  83. ncbi request reprint Screening for inhalant abuse in children and adolescents
    Michael T Lynskey
    Am Fam Physician 68:811-2. 2003
  84. ncbi request reprint Early reactions to cannabis predict later dependence
    David M Fergusson
    Christchurch Health and Development Study, Christchurch School of Medicine and Health Sciences, Christchurch, New Zealand
    Arch Gen Psychiatry 60:1033-9. 2003
    ..While there is a growing literature on the linkages between early subjective responses to nicotine and alcohol and later risks of nicotine or alcohol dependence, to date there has been no study of this issue in relation to cannabis...
  85. ncbi request reprint Life-time cannabis use and late onset mood and anxiety disorders
    Michael T Lynskey
    Addiction 102:1181-2. 2007

Research Grants9

  1. Cannabis and Other Illicit Drug Use: A Twin Study
    Michael Lynskey; Fiscal Year: 2005
    ..abstract_text> ..
  2. Cannabis Use, Abuse and Dependence: Exploring Phenotypes
    Michael Lynskey; Fiscal Year: 2005
    ..AIM 5: Based on these analyses, to formulate a model for unfolding of genetic influences on transitions in cannabis and the emergence of dependence symptoms. ..
  3. Cannabis Use, Abuse and Dependence: Exploring Phenotypes
    Michael Lynskey; Fiscal Year: 2006
    ..AIM 5: Based on these analyses, to formulate a model for unfolding of genetic influences on transitions in cannabis and the emergence of dependence symptoms. ..
  4. Cannabis and Other Illicit Drug Use: A Twin Study
    Michael Lynskey; Fiscal Year: 2006
    ..abstract_text> ..
  5. Cannabis Use, Abuse and Dependence: Exploring Phenotypes
    Michael Lynskey; Fiscal Year: 2007
    ..AIM 5: Based on these analyses, to formulate a model for unfolding of genetic influences on transitions in cannabis and the emergence of dependence symptoms. ..
  6. Cannabis and Other Illicit Drug Use: A Twin Study
    Michael Lynskey; Fiscal Year: 2007
    ..abstract_text> ..
  7. Cannabis and Other Illicit Drug Use: A Twin Study
    Michael Lynskey; Fiscal Year: 2009
    ..abstract_text> ..